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Volumn 64, Issue 6, 2011, Pages 624-629

Sub-antimicrobial doxycycline for periodontitis reduces hemoglobin A1c in subjects with type 2 diabetes: A pilot study

Author keywords

Antibiotic dose doxycycline; Chronic periodontitis; HbA1c; Periodontal therapy; Sub antimicrobial dose doxycycline; Type 2 diabetes

Indexed keywords

DOXYCYCLINE HYCLATE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; ORAL ANTIDIABETIC AGENT; PLACEBO;

EID: 80054098536     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.06.024     Document Type: Article
Times cited : (43)

References (39)
  • 1
    • 0026321864 scopus 로고
    • Intravenous insulin simulates early insulin peak and reduces post-prandial hyperglycaemia/hyperinsulinaemia in type 2 (non-insulin-dependent) diabetes mellitus
    • S.D. Luzio, D.R. Owens, J. Vora, J. Dolben, and H. Smith Intravenous insulin simulates early insulin peak and reduces post-prandial hyperglycaemia/hyperinsulinaemia in type 2 (non-insulin-dependent) diabetes mellitus Diabetes Res 16 1991 63 67
    • (1991) Diabetes Res , vol.16 , pp. 63-67
    • Luzio, S.D.1    Owens, D.R.2    Vora, J.3    Dolben, J.4    Smith, H.5
  • 3
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing sp1 glycosylation
    • X.L. Du, D. Edelstein, L. Rossetti, I.G. Fantus, H. Goldberg, and F. Ziyadeh Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing sp1 glycosylation Proc Natl Acad Sci USA 97 2000 12222 12226
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12222-12226
    • Du, X.L.1    Edelstein, D.2    Rossetti, L.3    Fantus, I.G.4    Goldberg, H.5    Ziyadeh, F.6
  • 4
    • 0035180299 scopus 로고    scopus 로고
    • Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
    • DOI 10.1172/JCI200111235
    • X.L. Du, D. Edelstein, S. Dimmeler, Q. Ju, C. Sui, and M. Brownlee Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the akt site J Clin Invest 108 2001 1341 1348 (Pubitemid 33107762)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.9 , pp. 1341-1348
    • Du, X.L.1    Edelstein, D.2    Dimmeler, S.3    Ju, Q.4    Sui, C.5    Brownlee, M.6
  • 5
    • 85047691537 scopus 로고    scopus 로고
    • Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    • DOI 10.1172/JCI200318127
    • X. Du, T. Matsumura, D. Edelstein, L. Rossetti, Z. Zsengeller, and C. Szabo Inhibition of gapdh activity by poly(adp-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells J Clin Invest 112 2003 1049 1057 (Pubitemid 38056320)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.7 , pp. 1049-1057
    • Du, X.1    Matsumura, T.2    Edelstein, D.3    Rossetti, L.4    Zsengeller, Z.5    Szabo, C.6    Brownlee, M.7
  • 6
    • 0023950461 scopus 로고
    • Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
    • M. Brownlee, A. Cerami, and H. Vlassara Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications N Engl J Med 318 1988 1315 1321
    • (1988) N Engl J Med , vol.318 , pp. 1315-1321
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 7
    • 7044283721 scopus 로고    scopus 로고
    • The multiligand receptor rage as a progression factor amplifying immune and inflammatory responses
    • A.M. Schmidt, S.D. Yan, S.F. Yan, and D.M. Stern The multiligand receptor rage as a progression factor amplifying immune and inflammatory responses Diabetes 50 2001 2792 2808
    • (2001) Diabetes , vol.50 , pp. 2792-2808
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 10
    • 0035339878 scopus 로고    scopus 로고
    • The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin: A multicenter, randomized, double-blind, placebo-controlled trial
    • J.F. Yale, T.R. Valiquett, M.N. Ghazzi, J.K. Owens-Grillo, R.W. Whitcomb, and H.L. Foyt The effect of a thiazolidinedione drug, troglitazone, on glycemia in patients with type 2 diabetes mellitus poorly controlled with sulfonylurea and metformin. A multicenter, randomized, double-blind, placebo-controlled trial Ann Intern Med 134 2001 737 745 (Pubitemid 32402066)
    • (2001) Annals of Internal Medicine , vol.134 , Issue.9 , pp. 737-745
    • Yale, J.-F.1    Valiquett, T.R.2    Ghazzi, M.N.3    Owens-Grillo, J.K.4    Whitcomb, R.W.5    Foyt, H.L.6
  • 12
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: Scientific review
    • S.E. Inzucchi Oral antihyperglycemic therapy for type 2 diabetes: scientific review JAMA 287 2002 360 372 (Pubitemid 34256388)
    • (2002) Journal of the American Medical Association , vol.287 , Issue.3 , pp. 360-372
    • Inzucchi, S.E.1
  • 13
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group Lancet 352 1998 837 853
    • (1998) Lancet , vol.352 , pp. 837-853
  • 15
    • 0027469006 scopus 로고
    • Periodontal disease: The sixth complication of diabetes mellitus
    • H. Loe Periodontal disease. The sixth complication of diabetes DiabetesCare 16 1993 329 334 (Pubitemid 23013872)
    • (1993) Diabetes Care , vol.16 , Issue.1 , pp. 329-334
    • Loe, H.1
  • 16
    • 0012431804 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus Diabetes Care 26 Suppl. 1 2003 S5 S20
    • (2003) Diabetes Care , vol.26 , Issue.SUPPL. 1
  • 17
    • 4644336398 scopus 로고    scopus 로고
    • Association of hemoglobin A1c with cardiovascular disease and mortality in adults: The European prospective investigation into cancer in Norfolk
    • K.T. Khaw, N. Wareham, S. Bingham, R. Luben, A. Welch, and N. Day Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk Ann Intern Med 141 2004 413 420
    • (2004) Ann Intern Med , vol.141 , pp. 413-420
    • Khaw, K.T.1    Wareham, N.2    Bingham, S.3    Luben, R.4    Welch, A.5    Day, N.6
  • 19
    • 77950511412 scopus 로고    scopus 로고
    • Executive summary: Standards of medical care in diabetes - 2010
    • Executive summary: standards of medical care in diabetes - 2010 Diabetes Care 33 Suppl. 1 2010 S4 S10
    • (2010) Diabetes Care , vol.33 , Issue.SUPPL. 1
  • 20
    • 1042280188 scopus 로고    scopus 로고
    • Association between Acute-Phase Reactants and Advanced Glycation End Products in Type 2 Diabetes
    • DOI 10.2337/diacare.27.1.223
    • K.C. Tan, W.S. Chow, S. Tam, R. Bucala, and J. Betteridge Association between acute-phase reactants and advanced glycation end products in type 2 diabetes Diabetes Care 27 2004 223 228 (Pubitemid 38196736)
    • (2004) Diabetes Care , vol.27 , Issue.1 , pp. 223-228
    • Tan, K.C.B.1    Chow, W.-S.2    Tam, S.3    Bucala, R.4    Betteridge, J.5
  • 21
    • 0042266256 scopus 로고    scopus 로고
    • Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine
    • DOI 10.2337/diabetes.52.8.2110
    • R. Babaei-Jadidi, N. Karachalias, N. Ahmed, S. Battah, and P.J. Thornalley Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine Diabetes 52 2003 2110 2120 (Pubitemid 36919806)
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 2110-2120
    • Babaei-Jadidi, R.1    Karachalias, N.2    Ahmed, N.3    Battah, S.4    Thornalley, P.J.5
  • 23
    • 0142074864 scopus 로고    scopus 로고
    • Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts
    • DOI 10.1016/j.abb.2003.08.013
    • P.J. Thornalley Use of aminoguanidine (pimagedine) to prevent the formation of advanced glycation endproducts Arch Biochem Biophys 419 2003 31 40 (Pubitemid 37279141)
    • (2003) Archives of Biochemistry and Biophysics , vol.419 , Issue.1 , pp. 31-40
    • Thornalley, P.J.1
  • 25
    • 0030061699 scopus 로고    scopus 로고
    • Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats
    • J.L. Wautier, C. Zoukourian, O. Chappey, M.P. Wautier, P.J. Guillausseau, and R. Cao Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats J Clin Invest 97 1996 238 243
    • (1996) J Clin Invest , vol.97 , pp. 238-243
    • Wautier, J.L.1    Zoukourian, C.2    Chappey, O.3    Wautier, M.P.4    Guillausseau, P.J.5    Cao, R.6
  • 26
    • 0347360360 scopus 로고    scopus 로고
    • Long-Term Renal Effects of a Neutralizing RAGE Antibody in Obese Type 2 Diabetic Mice
    • DOI 10.2337/diabetes.53.1.166
    • A. Flyvbjerg, L. Denner, B.F. Schrijvers, R.G. Tilton, T.H. Mogensen, and S.R. Paludan Long-term renal effects of a neutralizing rage antibody in obese type 2 diabetic mice Diabetes 53 2004 166 172 (Pubitemid 38044711)
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 166-172
    • Flyvbjerg, A.1    Denner, L.2    Schrijvers, B.F.3    Tilton, R.G.4    Mogensen, T.H.5    Paludan, So.R.6    Rasch, R.7
  • 29
    • 0032200056 scopus 로고    scopus 로고
    • Tetracyclines inhibit protein glycation in experimental diabetes
    • M.E. Ryan, N.S. Ramamurthy, and L.M. Golub Tetracyclines inhibit protein glycation in experimental diabetes Adv Dent Res 12 1998 152 158
    • (1998) Adv Dent Res , vol.12 , pp. 152-158
    • Ryan, M.E.1    Ramamurthy, N.S.2    Golub, L.M.3
  • 33
    • 0036048123 scopus 로고    scopus 로고
    • Adjunctive benefits of subantimicrobial dose doxycycline in the management of severe, generalized, chronic periodontitis
    • M.J. Novak, L.P. Johns, R.C. Miller, and M.H. Bradshaw Adjunctive benefits of subantimicrobial dose doxycycline in the management of severe, generalized, chronic periodontitis J Periodontol 73 2002 762 769
    • (2002) J Periodontol , vol.73 , pp. 762-769
    • Novak, M.J.1    Johns, L.P.2    Miller, R.C.3    Bradshaw, M.H.4
  • 34
    • 0033804905 scopus 로고    scopus 로고
    • Long-term treatment with subantimicrobial dose doxycycline exerts no antibacterial effect on the subgingival microflora associated with adult periodontitis
    • C. Walker, J. Thomas, S. Nango, J. Lennon, J. Wetzel, and C. Powala Long-term treatment with subantimicrobial dose doxycycline exerts no antibacterial effect on the subgingival microflora associated with adult periodontitis J Periodontol 71 2000 1465 1471
    • (2000) J Periodontol , vol.71 , pp. 1465-1471
    • Walker, C.1    Thomas, J.2    Nango, S.3    Lennon, J.4    Wetzel, J.5    Powala, C.6
  • 35
    • 0033804875 scopus 로고    scopus 로고
    • Long-term use of subantimicrobial dose doxycycline does not lead to changes in antimicrobial susceptibility
    • J. Thomas, C. Walker, and M. Bradshaw Long-term use of subantimicrobial dose doxycycline does not lead to changes in antimicrobial susceptibility J Periodontol 71 2000 1472 1483
    • (2000) J Periodontol , vol.71 , pp. 1472-1483
    • Thomas, J.1    Walker, C.2    Bradshaw, M.3
  • 36
    • 0030635582 scopus 로고    scopus 로고
    • American diabetes association: Clinical practice recommendations 1997
    • American diabetes association: clinical practice recommendations 1997 Diabetes Care 20 Suppl. 1 1997 S1 S70
    • (1997) Diabetes Care , vol.20 , Issue.SUPPL. 1
  • 38
    • 0035235248 scopus 로고    scopus 로고
    • American diabetes association clinical practice recommendations 2001
    • American diabetes association clinical practice recommendations 2001 Diabetes Care 24 Suppl. 1 2001 S1 S133
    • (2001) Diabetes Care , vol.24 , Issue.SUPPL. 1
  • 39
    • 0033649532 scopus 로고    scopus 로고
    • American diabetes association: Clinical practice recommendations 2000
    • American diabetes association: clinical practice recommendations 2000 Diabetes Care 23 Suppl. 1 2000 S1 S116
    • (2000) Diabetes Care , vol.23 , Issue.SUPPL. 1


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