Development of recombinant Aleuria aurantia lectins with altered binding specificities to fucosylated glycans

Biochemical and Biophysical Research Communications

Volumn 414, Issue 1, 2011, Pages 84-89

  Romano, Patrick R ^a   Mackay, Andrew ^b   Vong, Minh ^b   deSa, Johann ^c   Lamontagne, Anne ^a   Comunale, Mary Ann ^a   Hafner, Julie ^d   Block, Timothy ^a   Lec, Ryszard ^c   Mehta, Anand ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b BARUCH S BLUMBERG INSTITUTE   (United States)

^c DREXEL UNIVERSITY   (United States)

^d Immunotope Inc   (United States)

Author keywords

Cancer; Fucosylation; Glycobiology; Hepatitis; Lectin

Indexed keywords

ALEURIA AURANTIA LECTIN; AURANTIIN; FUCOSE; GLYCAN; GLYCOPROTEIN; LECTIN; N ACETYLLACTOSAMINE SYNTHASE; UNCLASSIFIED DRUG;

ALEURIA AURANTIA; ARTICLE; BINDING AFFINITY; BINDING SITE; FUCOSYLATION; MUSHROOM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO SUGARS; FUCOSE; LECTINS; MUTAGENESIS, SITE-DIRECTED; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

ALEURIA AURANTIA; BASIDIOMYCOTA;

EID: 80054076675     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.027     Document Type: Article

References (34)

1. Rudd P.M., Dwek R.A. Glycosylation: heterogeneity and the 3D structure of proteins. Crit. Rev. Biochem. Mol. Biol. 1997, 32:1-100.
2. Aoyagi Y., Suzuki Y., Igarashi K., Yokota T., Mori S., Suda T., Naitoh A., Isemura M., Asakura H. Highly enhanced fucosylation of alpha-fetoprotein in patients with germ cell tumor. Cancer 1993, 72:615-618.
3. Saldova R., Fan Y., Fitzpatrick J.M., Watson R.W., Rudd P.M. Core fucosylation and alpha2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia. Glycobiology 2011, 21:195-205.
4. Abd Hamid U.M., Royle L., Saldova R., Radcliffe C.M., Harvey D.J., Storr S.J., Pardo M., Antrobus R., Chapman C.J., Zitzmann N., Robertson J.F., Dwek R.A., Rudd P.M. A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression. Glycobiology 2008, 18:1105-1118.
5. Saldova R., Royle L., Radcliffe C.M., Abd Hamid U.M., Evans R., Arnold J.N., Banks R.E., Hutson R., Harvey D.J., Antrobus R., Petrescu S.M., Dwek R.A., Rudd P.M. Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG. Glycobiology 2007, 17:1344-1356.
6. Tabares G., Radcliffe C.M., Barrabes S., Ramirez M., Aleixandre R.N., Hoesel W., Dwek R.A., Rudd P.M., Peracaula R., de Llorens R. Different glycan structures in prostate-specific antigen from prostate cancer sera in relation to seminal plasma PSA. Glycobiology 2006, 16:132-145.
7. White K.Y., Rodemich L., Nyalwidhe J.O., Comunale M.A., Clements M.A., Lance R.S., Schellhammer P.F., Mehta A.S., Semmes O.J., Drake R.R. Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids. J. Proteome Res. 2009, 8:620-630.
8. Naitoh A., Aoyagi Y., Asakura H. Highly enhanced fucosylation of serum glycoproteins in patients with hepatocellular carcinoma. J. Gastroenterol. Hepatol. 1999, 14:436-445.
9. Noda K., Miyoshi E., Gu J., Gao C.X., Nakahara S., Kitada T., Honke K., Suzuki K., Yoshihara H., Yoshikawa K., Kawano K., Tonetti M., Kasahara A., Hori M., Hayashi N., Taniguchi N. Relationship between elevated FX expression increased production of GDP-l-fucose a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. Cancer Res. 2003, 63:6282-6289.
10. Block T.M., Comunale M.A., Lowman M., Steel L.F., Romano P.R., Fimmel C., Tennant B.C., London W.T., Evans A.A., Blumberg B.S., Dwek R.A., Mattu T.S., Mehta A.S. Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans. Proc. Natl. Acad. Sci. U S A 2005, 102:779-784.
11. Comunale M.A., Lowman M., Long R.E., Krakover J., Philip R., Seeholzer S., Evans A.A., Hann H.W.L., Block T.M., Mehta A.S. Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma. J. Proteome Res. 2006, 6:308-315.
12. Goldman R., Ressom H.W., Varghese R.S., Goldman L., Bascug G., Loffredo C.A., Abdel-Hamid M., Gouda I., Ezzat S., Kyselova Z., Mechref Y., Novotny M.V. Detection of hepatocellular carcinoma using glycomic analysis. Clin. Cancer Res. 2009, 15:1808-1813.
13. Liu X.E., Desmyter L., Gao C.F., Laroy W., Dewaele S., Vanhooren V., Wang L., Zhuang H., Callewaert N., Libert C., Contreras R., Chen C. N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus. Hepatology 2007, 46:1426-1435.
14. Nakagawa T., Takeishi S., Kameyama A., Yagi H., Yoshioka T., Moriwaki K., Masuda T., Matsumoto H., Kato K., Narimatsu H., Taniguchi N., Miyoshi E. Glycomic analyses of glycoproteins in bile and serum during rat hepatocarcinogenesis. J Proteome Res. 2010, 9:4888-4896.
15. Nakagawa T., Miyoshi E., Yakushijin T., Hiramatsu N., Igura T., Hayashi N., Taniguchi N., Kondo A. Glycomic analysis of alpha-fetoprotein L3 in hepatoma cell lines and hepatocellular carcinoma patients. J. Proteome Res. 2008, 7:2222-2233.
16. Tanabe K., Deguchi A., Higashi M., Usuki H., Suzuki Y., Uchimura Y., Kuriyama S., Ikenaka K. Outer arm fucosylation of N-glycans increases in sera of hepatocellular carcinoma patients. Biochem. Biophys. Res. Commun. 2008, 374:219-225.
17. Olausson J., Tibell L., Jonsson B.H., Pahlsson P. Detection of a high affinity binding site in recombinant Aleuria aurantia lectin. Glycoconj. J. 2008, 25:753-762.
18. Fujihashi M., Peapus D.H., Kamiya N., Nagata Y., Miki K. Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites. Biochemistry 2003, 42:11093-11099.
19. Fujihashi M., Peapus D.H., Nakajima E., Yamada T., Saito J.I., Kita A., Higuchi Y., Sugawara Y., Ando A., Kamiya N., Nagata Y., Miki K. X-ray crystallographic characterization and phasing of a fucose-specific lectin from Aleuria aurantia. Acta Crystallogr. D Biol. Crystallogr. 2003, 59:378-380.
20. Guile G.R., Rudd P.M., Wing D.R., Prime S.B., Dwek R.A. A rapid high-resolution high-performance liquid chromatographic method for separating glycan mixtures and analyzing oligosaccharide profiles. Anal. Biochem. 1996, 240:210-226.
21. Mattu T.S., Pleass R.J., Willis A.C., Kilian M., Wormald M.R., Lellouch A.C., Rudd P.M., Woof J.M., Dwek R.A. The glycosylation structure of human serum IgA1 Fab and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. J. Biol. Chem. 1998, 273:2260-2272.
22. Rudd P.M., Mattu T.S., Zitzmann N., Mehta A., Colominas C., Hart E., Opdenakker G., Dwek R.A. Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans. Biotechnol. Genet. Eng. Rev. 1999, 16:1-21.
23. Comunale M.A., Rodemich-Betesh L., Hafner J., Wang M., Norton P., Di Bisceglie A.M., Block T., Mehta A. Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. PLoS ONE 2010, 5:e12419.
24. Comunale M.A., Wang M., Hafner J., Krakover J., Rodemich L., Kopenhaver B., Long R.E., Junaidi O., Bisceglie A.M., Block T.M., Mehta A.S. Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma. J. Proteome Res. 2009, 8:595-602.
25. Wang M., Long R.E., Comunale M.A., Junaidi O., Marrero J., Di Bisceglie A.M., Block T.M., Mehta A.S. Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma. Cancer Epidemiol. Biomarkers Prev. 2009, 18:1914-1921.
26. Collin M., Shannon O., Bjorck L. IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions. Proc. Natl. Acad. Sci. U S A 2008, 105:4265-4270.
27. Allhorn M., Olin A.I., Nimmerjahn F., Collin M. Human IgG/Fc gamma R interactions are modulated by streptococcal IgG glycan hydrolysis. PLoS ONE 2008, 3:e1413.
28. Balagopal A., Philp F.H., Astemborski J., Block T.M., Mehta A., Long R., Kirk G.D., Mehta S.H., Cox A.L., Thomas D.L., Ray S.C. Human immunodeficiency virus-related microbial translocation and progression of hepatitis C. Gastroenterology 2008, 135:226-233.
29. Mehta A.S., Long R.E., Comunale M.A., Wang M., Rodemich L., Krakover J., Philip R., Marrero J.A., Dwek R.A., Block T.M. Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis. J. Virol. 2008, 82:1259-1270.
30. Ergezen E., Hong S., Barbee K.A., Lec R. Real time monitoring of the effects of Heparan Sulfate Proteoglycan (HSPG) and surface charge on the cell adhesion process using thickness shear mode (TSM) sensor. Biosens. Bioelectron. 2007, 22:2256-2260.
31. Comunale M.A., Wang M., Rodemich-Betesh L., Hafner J., Lamontagne A., Klein A., Marrero J., Di Bisceglie A.M., Gish R., Block T., Mehta A. Novel Changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma, Cancer Epidemiol. Biomarkers Prev. 2011, 20:1222-1229.
32. Wimmerova M., Mitchell E., Sanchez J.F., Gautier C., Imberty A. Crystal structure of fungal lectin: six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin. J. Biol. Chem. 2003, 278:27059-27067.
33. Yamashita K., Taketa K., Nishi S., Fukushima K., Ohkura T. Sugar chains of human cord serum alpha-fetoprotein: characteristics of N-linked sugar chains of glycoproteins produced in human liver and hepatocellular carcinomas. Cancer Res. 1993, 53:2970-2975.
34. Ergezen E., Appel M., Shah P., Kresh J.Y., Lec R.M., Wootton D.M. Real-time monitoring of adhesion and aggregation of platelets using thickness shear mode (TSM) sensor. Biosens. Bioelectron. 2007, 23:575-582.