-
1
-
-
0037401894
-
Intracellular signal transduction pathways activated by ceramide and its metabolites
-
Ruvolo, P. P. Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol. Res., 2003, 47 (5), 383-92.
-
(2003)
Pharmacol. Res
, vol.47
, Issue.5
, pp. 383-392
-
-
Ruvolo, P.P.1
-
2
-
-
33845336495
-
Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
-
Zheng, W.; Kollmeyer, J.; Symolon, H.; Momin, A.; Munter, E.; Wang, E.; Kelly, S.; Allegood, J. C.; Liu, Y.; Peng, Q.; Ramaraju, H.; Sullards, M. C.; Cabot, M.; Merrill, A. H., Jr. Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim. Biophys. Acta, 2006, 1758 (12), 1864-1884.
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, Issue.12
, pp. 1864-1884
-
-
Zheng, W.1
Kollmeyer, J.2
Symolon, H.3
Momin, A.4
Munter, E.5
Wang, E.6
Kelly, S.7
Allegood, J.C.8
Liu, Y.9
Peng, Q.10
Ramaraju, H.11
Sullards, M.C.12
Cabot, M.13
Merrill Jr., A.H.14
-
3
-
-
78751518056
-
Dysregulation of sphingolipid metabolism in cancer
-
Ryland, L. K.; Fox, T. E.; Liu, X.; Loughran, T. P.; Kester, M. Dysregulation of sphingolipid metabolism in cancer. Cancer Biol. Ther., 2011, 11 (2), 138-149.
-
(2011)
Cancer Biol. Ther
, vol.11
, Issue.2
, pp. 138-149
-
-
Ryland, L.K.1
Fox, T.E.2
Liu, X.3
Loughran, T.P.4
Kester, M.5
-
4
-
-
0033231485
-
Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis
-
Liu, Y. Y.; Han, T. Y.; Giuliano, A. E.; Ichikawa, S.; Hirabayashi, Y.; Cabot, M. C. Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis. Exp. Cell Res., 1999, 252 (2), 464-470.
-
(1999)
Exp. Cell Res
, vol.252
, Issue.2
, pp. 464-470
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Ichikawa, S.4
Hirabayashi, Y.5
Cabot, M.C.6
-
5
-
-
0037203344
-
Glucosylceramide synthase and apoptosis
-
Bleicher, R. J.; Cabot, M. C. Glucosylceramide synthase and apoptosis. Biochim. Biophys. Acta, 2002, 1585 (2-3), 172-178.
-
(2002)
Biochim. Biophys. Acta
, vol.1585
, Issue.2-3
, pp. 172-178
-
-
Bleicher, R.J.1
Cabot, M.C.2
-
6
-
-
0000255378
-
Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
-
Liu, Y. Y.; Han, T. Y.; Giuliano, A. E.; Cabot, M. C. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. J. Biol. Chem., 1999, 274 (2), 1140-1146.
-
(1999)
J. Biol. Chem
, vol.274
, Issue.2
, pp. 1140-1146
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Cabot, M.C.4
-
7
-
-
0346992148
-
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells
-
Meng, A.; Luberto, C.; Meier, P.; Bai, A.; Yang, X.; Hannun, Y. A.; Zhou, D. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp. Cell Res., 2004, 292 (2), 385-392.
-
(2004)
Exp. Cell Res
, vol.292
, Issue.2
, pp. 385-392
-
-
Meng, A.1
Luberto, C.2
Meier, P.3
Bai, A.4
Yang, X.5
Hannun, Y.A.6
Zhou, D.7
-
8
-
-
77957781517
-
Ceramide-1-phosphate in cell survival and inflammatory signaling
-
Gomez-Munoz, A.; Gangoiti, P.; Granado, M. H.; Arana, L.; Ouro, A. Ceramide-1-phosphate in cell survival and inflammatory signaling. Adv. Exp. Med. Biol., 2010, 688, 118-130.
-
(2010)
Adv. Exp. Med. Biol
, vol.688
, pp. 118-130
-
-
Gomez-Munoz, A.1
Gangoiti, P.2
Granado, M.H.3
Arana, L.4
Ouro, A.5
-
9
-
-
0031439924
-
Coordinate regulation of stress-and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
-
Jarvis, W. D.; Fornari, F. A., Jr.; Auer, K. L.; Freemerman, A. J.; Szabo, E.; Birrer, M. J.; Johnson, C. R.; Barbour, S. E.; Dent, P.; Grant, S. Coordinate regulation of stress-and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. Mol. Pharmacol., 1997, 52 (6), 935-947.
-
(1997)
Mol. Pharmacol
, vol.52
, Issue.6
, pp. 935-947
-
-
Jarvis, W.D.1
Fornari Jr., F.A.2
Auer, K.L.3
Freemerman, A.J.4
Szabo, E.5
Birrer, M.J.6
Johnson, C.R.7
Barbour, S.E.8
Dent, P.9
Grant, S.10
-
10
-
-
0031693199
-
Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells
-
Klostergaard, J.; Auzenne, E.; Leroux, E. Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells. Leuk Res, 1998, 22 (11), 1049-56.
-
(1998)
Leuk Res
, vol.22
, Issue.11
, pp. 1049-1056
-
-
Klostergaard, J.1
Auzenne, E.2
Leroux, E.3
-
11
-
-
54049137693
-
N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing
-
Wang, H.; Maurer, B. J.; Liu, Y. Y.; Wang, E.; Allegood, J. C.; Kelly, S.; Symolon, H.; Liu, Y.; Merrill, A. H., Jr.; Gouaze-Andersson, V.; Yu, J. Y.; Giuliano, A. E.; Cabot, M. C. N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. Mol. Cancer Ther., 2008, 7 (9), 2967-2976.
-
(2008)
Mol. Cancer Ther
, vol.7
, Issue.9
, pp. 2967-2976
-
-
Wang, H.1
Maurer, B.J.2
Liu, Y.Y.3
Wang, E.4
Allegood, J.C.5
Kelly, S.6
Symolon, H.7
Liu, Y.8
Merrill Jr., A.H.9
Gouaze-Andersson, V.10
Yu, J.Y.11
Giuliano, A.E.12
Cabot, M.C.13
-
12
-
-
79551614173
-
Regulation of sphingosine kinase and sphingolipid signaling
-
Pitson, S. M. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem. Sci., 2011, 36 (2), 97-107.
-
(2011)
Trends Biochem. Sci
, vol.36
, Issue.2
, pp. 97-107
-
-
Pitson, S.M.1
-
13
-
-
0036139580
-
Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-Ndimethylsphingosine
-
Jendiroba, D. B.; Klostergaard, J.; Keyhani, A.; Pagliaro, L.; Freireich, E. J. Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-Ndimethylsphingosine. Leuk. Res., 2002, 26 (3), 301-310.
-
(2002)
Leuk. Res
, vol.26
, Issue.3
, pp. 301-310
-
-
Jendiroba, D.B.1
Klostergaard, J.2
Keyhani, A.3
Pagliaro, L.4
Freireich, E.J.5
-
14
-
-
77956605840
-
Therapeutic applications of bioactive sphingolipids in hematological malignancies
-
Ekiz, H. A.; Baran, Y. Therapeutic applications of bioactive sphingolipids in hematological malignancies. Int. J. Cancer, 2010, 127 (7), 1497-1506.
-
(2010)
Int. J. Cancer
, vol.127
, Issue.7
, pp. 1497-1506
-
-
Ekiz, H.A.1
Baran, Y.2
-
15
-
-
33845284855
-
Sphingolipid players in the leukemia arena
-
Ricci, C.; Onida, F.; Ghidoni, R. Sphingolipid players in the leukemia arena. Biochim. Biophys. Acta, 2006, 1758 (12), 2121-2132.
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, Issue.12
, pp. 2121-2132
-
-
Ricci, C.1
Onida, F.2
Ghidoni, R.3
-
16
-
-
0035433420
-
Four deaths and a funeral: From caspases to alternative mechanisms
-
Leist, M.; Jaattela, M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol., 2001, 2 (8), 589-598.
-
(2001)
Nat. Rev. Mol. Cell Biol
, vol.2
, Issue.8
, pp. 589-598
-
-
Leist, M.1
Jaattela, M.2
-
17
-
-
0027968517
-
Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramideactivated protein kinase
-
Liu, J.; Mathias, S.; Yang, Z.; Kolesnick, R. N. Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramideactivated protein kinase. J. Biol. Chem., 1994, 269 (4), 3047-3052.
-
(1994)
J. Biol. Chem
, vol.269
, Issue.4
, pp. 3047-3052
-
-
Liu, J.1
Mathias, S.2
Yang, Z.3
Kolesnick, R.N.4
-
18
-
-
0030000464
-
Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis
-
Karasavvas, N.; Erukulla, R. K.; Bittman, R.; Lockshin, R.; Zakeri, Z. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. Eur. J. Biochem., 1996, 236 (2), 729-37
-
(1996)
Eur. J. Biochem
, vol.236
, Issue.2
, pp. 729-737
-
-
Karasavvas, N.1
Erukulla, R.K.2
Bittman, R.3
Lockshin, R.4
Zakeri, Z.5
-
19
-
-
0028122397
-
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
-
Wolff, R. A.; Dobrowsky, R. T.; Bielawska, A.; Obeid, L. M.; Hannun, Y. A. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J. Biol. Chem., 1994, 269 (30), 19605-19609.
-
(1994)
J. Biol. Chem
, vol.269
, Issue.30
, pp. 19605-19609
-
-
Wolff, R.A.1
Dobrowsky, R.T.2
Bielawska, A.3
Obeid, L.M.4
Hannun, Y.A.5
-
20
-
-
0028838235
-
Phosphorylation of Raf by ceramide-activated protein kinase
-
Yao, B.; Zhang, Y.; Delikat, S.; Mathias, S.; Basu, S.; Kolesnick, R. Phosphorylation of Raf by ceramide-activated protein kinase. Nature, 1995, 378 (6554), 307-310.
-
(1995)
Nature
, vol.378
, Issue.6554
, pp. 307-310
-
-
Yao, B.1
Zhang, Y.2
Delikat, S.3
Mathias, S.4
Basu, S.5
Kolesnick, R.6
-
21
-
-
0032993377
-
Lipid signaling in CD95-mediated apoptosis
-
Malisan, F.; Testi, R. Lipid signaling in CD95-mediated apoptosis. FEBS Lett., 1999, 452 (1-2), 100-103.
-
(1999)
FEBS Lett
, vol.452
, Issue.1-2
, pp. 100-103
-
-
Malisan, F.1
Testi, R.2
-
22
-
-
0030803278
-
Fas-or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153
-
Brenner, B.; Koppenhoefer, U.; Weinstock, C.; Linderkamp, O.; Lang, F.; Gulbins, E. Fas-or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J. Biol. Chem., 1997, 272 (35), 22173-22181.
-
(1997)
J. Biol. Chem
, vol.272
, Issue.35
, pp. 22173-22181
-
-
Brenner, B.1
Koppenhoefer, U.2
Weinstock, C.3
Linderkamp, O.4
Lang, F.5
Gulbins, E.6
-
23
-
-
0030473287
-
Sphingomyelin breakdown and cell fate
-
Testi, R. Sphingomyelin breakdown and cell fate. Trends Biochem. Sci., 1996, 21 (12), 468-471.
-
(1996)
Trends Biochem. Sci
, vol.21
, Issue.12
, pp. 468-471
-
-
Testi, R.1
-
24
-
-
0034614414
-
N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells
-
Bieberich, E.; Kawaguchi, T.; Yu, R. K. N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells. J. Biol. Chem., 2000, 275 (1), 177-181.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.1
, pp. 177-181
-
-
Bieberich, E.1
Kawaguchi, T.2
Yu, R.K.3
-
25
-
-
0032514918
-
BAD enables ceramide to signal apoptosis via Ras and Raf-1
-
Basu, S.; Bayoumy, S.; Zhang, Y.; Lozano, J.; Kolesnick, R. BAD enables ceramide to signal apoptosis via Ras and Raf-1. J. Biol. Chem., 1998, 273 (46), 30419-30426.
-
(1998)
J. Biol. Chem
, vol.273
, Issue.46
, pp. 30419-30426
-
-
Basu, S.1
Bayoumy, S.2
Zhang, Y.3
Lozano, J.4
Kolesnick, R.5
-
26
-
-
0035406884
-
Oxidative stressinduced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C
-
Bezombes, C.; Plo, I.; Mansat-De Mas, V.; Quillet-Mary, A.; Negre-Salvayre, A.; Laurent, G.; Jaffrezou, J. P. Oxidative stressinduced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C. Faseb J., 2001, 15 (9), 1583-1585.
-
(2001)
Faseb J
, vol.15
, Issue.9
, pp. 1583-1585
-
-
Bezombes, C.1
Plo, I.2
Mansat-Demas, V.3
Quillet-Mary, A.4
Negre-Salvayre, A.5
Laurent, G.6
Jaffrezou, J.P.7
-
27
-
-
0028846952
-
Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells
-
Sawai, H.; Okazaki, T.; Yamamoto, H.; Okano, H.; Takeda, Y.; Tashima, M.; Sawada, H.; Okuma, M.; Ishikura, H.; Umehara, H.; et al. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem., 1995, 270 (45), 27326-27331.
-
(1995)
J. Biol. Chem
, vol.270
, Issue.45
, pp. 27326-27331
-
-
Sawai, H.1
Okazaki, T.2
Yamamoto, H.3
Okano, H.4
Takeda, Y.5
Tashima, M.6
Sawada, H.7
Okuma, M.8
Ishikura, H.9
Umehara, H.10
-
28
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
-
Verheij, M.; Bose, R.; Lin, X. H.; Yao, B.; Jarvis, W. D.; Grant, S.; Birrer, M. J.; Szabo, E.; Zon, L. I.; Kyriakis, J. M.; Haimovitz-Friedman, A.; Fuks, Z.; Kolesnick, R. N. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature, 1996, 380 (6569), 75-79.
-
(1996)
Nature
, vol.380
, Issue.6569
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, W.D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
Haimovitz-Friedman, A.11
Fuks, Z.12
Kolesnick, R.N.13
-
29
-
-
0034738785
-
Involvement of SAPK/JNK pathway in Xray-induced rapid cell death of human T-cell leukemia cell line MOLT-4
-
Enomoto, A.; Suzuki, N.; Hirano, K.; Matsumoto, Y.; Morita, A.; Sakai, K.; Koyama, H. Involvement of SAPK/JNK pathway in Xray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. Cancer Lett., 2000, 155 (2), 137-144.
-
(2000)
Cancer Lett
, vol.155
, Issue.2
, pp. 137-144
-
-
Enomoto, A.1
Suzuki, N.2
Hirano, K.3
Matsumoto, Y.4
Morita, A.5
Sakai, K.6
Koyama, H.7
-
30
-
-
0029148314
-
Inhibition of tumor necrosis factor alpha-and ceramide-induced internucleosomal DNA fragmentation by herbimycin A in U937 cells
-
Ji, L.; Zhang, G.; Hirabayashi, Y. Inhibition of tumor necrosis factor alpha-and ceramide-induced internucleosomal DNA fragmentation by herbimycin A in U937 cells. Biochem. Biophys. Res. Commun., 1995, 212 (2), 640-647.
-
(1995)
Biochem. Biophys. Res. Commun
, vol.212
, Issue.2
, pp. 640-647
-
-
Ji, L.1
Zhang, G.2
Hirabayashi, Y.3
-
31
-
-
0027511687
-
Programmed cell death induced by ceramide
-
Obeid, L. M.; Linardic, C. M.; Karolak, L. A.; Hannun, Y. A. Programmed cell death induced by ceramide. Science, 1993, 259 (5102), 1769-1771.
-
(1993)
Science
, vol.259
, Issue.5102
, pp. 1769-1771
-
-
Obeid, L.M.1
Linardic, C.M.2
Karolak, L.A.3
Hannun, Y.A.4
-
32
-
-
0030692005
-
Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2
-
Zhang, P.; Liu, B.; Kang, S. W.; Seo, M. S.; Rhee, S. G.; Obeid, L. M. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J. Biol. Chem., 1997, 272 (49), 30615-30618.
-
(1997)
J. Biol. Chem
, vol.272
, Issue.49
, pp. 30615-30618
-
-
Zhang, P.1
Liu, B.2
Kang, S.W.3
Seo, M.S.4
Rhee, S.G.5
Obeid, L.M.6
-
33
-
-
0035313216
-
Modulation of ceramide-induced NF-kappaB binding activity and apoptotic response by caffeic acid in U937 cells: Comparison with other antioxidants
-
Nardini, M.; Leonardi, F.; Scaccini, C.; Virgili, F. Modulation of ceramide-induced NF-kappaB binding activity and apoptotic response by caffeic acid in U937 cells: comparison with other antioxidants. Free Radic. Biol. Med., 2001, 30 (7), 722-733.
-
(2001)
Free Radic. Biol. Med
, vol.30
, Issue.7
, pp. 722-733
-
-
Nardini, M.1
Leonardi, F.2
Scaccini, C.3
Virgili, F.4
-
34
-
-
0030893370
-
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis
-
Zhang, P.; Liu, B.; Jenkins, G. M.; Hannun, Y. A.; Obeid, L. M. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J. Biol. Chem., 1997, 272 (15), 9609-9612.
-
(1997)
J. Biol. Chem
, vol.272
, Issue.15
, pp. 9609-9612
-
-
Zhang, P.1
Liu, B.2
Jenkins, G.M.3
Hannun, Y.A.4
Obeid, L.M.5
-
35
-
-
0029942653
-
Daunorubicininduced internucleosomal DNA fragmentation in acute myeloid cell lines
-
Quillet-Mary, A.; Mansat, V.; Duchayne, E.; Come, M. G.; Allouche, M.; Bailly, J. D.; Bordier, C.; Laurent, G. Daunorubicininduced internucleosomal DNA fragmentation in acute myeloid cell lines. Leukemia, 1996, 10 (3), 417-425.
-
(1996)
Leukemia
, vol.10
, Issue.3
, pp. 417-425
-
-
Quillet-Mary, A.1
Mansat, V.2
Duchayne, E.3
Come, M.G.4
Allouche, M.5
Bailly, J.D.6
Bordier, C.7
Laurent, G.8
-
36
-
-
0030006040
-
Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
-
Jaffrezou, J. P.; Levade, T.; Bettaieb, A.; Andrieu, N.; Bezombes, C.; Maestre, N.; Vermeersch, S.; Rousse, A.; Laurent, G. Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. Embo. J., 1996, 15 (10), 2417-2424.
-
(1996)
Embo. J
, vol.15
, Issue.10
, pp. 2417-2424
-
-
Jaffrezou, J.P.1
Levade, T.2
Bettaieb, A.3
Andrieu, N.4
Bezombes, C.5
Maestre, N.6
Vermeersch, S.7
Rousse, A.8
Laurent, G.9
-
37
-
-
0030712182
-
The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
-
Mansat, V.; Laurent, G.; Levade, T.; Bettaieb, A.; Jaffrezou, J. P. The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. Cancer Res., 1997, 57 (23), 5300-5304.
-
(1997)
Cancer Res
, vol.57
, Issue.23
, pp. 5300-5304
-
-
Mansat, V.1
Laurent, G.2
Levade, T.3
Bettaieb, A.4
Jaffrezou, J.P.5
-
38
-
-
1842376234
-
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
-
Mansat, V.; Bettaieb, A.; Levade, T.; Laurent, G.; Jaffrezou, J. P. Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. Faseb J., 1997, 11 (8), 695-702.
-
(1997)
Faseb J
, vol.11
, Issue.8
, pp. 695-702
-
-
Mansat, V.1
Bettaieb, A.2
Levade, T.3
Laurent, G.4
Jaffrezou, J.P.5
-
39
-
-
40249087168
-
Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin
-
Furlong, S. J.; Ridgway, N. D.; Hoskin, D. W. Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin. Int. J. Oncol., 2008, 32 (3), 537-544.
-
(2008)
Int. J. Oncol
, vol.32
, Issue.3
, pp. 537-544
-
-
Furlong, S.J.1
Ridgway, N.D.2
Hoskin, D.W.3
-
40
-
-
0037155897
-
Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line
-
Murate, T.; Suzuki, M.; Hattori, M.; Takagi, A.; Kojima, T.; Tanizawa, T.; Asano, H.; Hotta, T.; Saito, H.; Yoshida, S.; Tamiya-Koizumi, K. Up-regulation of acid sphingomyelinase during retinoic acid-induced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line. J. Biol. Chem., 2002, 277 (12), 9936-9943.
-
(2002)
J. Biol. Chem
, vol.277
, Issue.12
, pp. 9936-9943
-
-
Murate, T.1
Suzuki, M.2
Hattori, M.3
Takagi, A.4
Kojima, T.5
Tanizawa, T.6
Asano, H.7
Hotta, T.8
Saito, H.9
Yoshida, S.10
Tamiya-Koizumi, K.11
-
41
-
-
34347221936
-
Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity
-
Dbaibo, G. S.; Kfoury, Y.; Darwiche, N.; Panjarian, S.; Kozhaya, L.; Nasr, R.; Abdallah, M.; Hermine, O.; El-Sabban, M.; de The, H.; Bazarbachi, A. Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. Haematologica, 2007, 92 (6), 753-762.
-
(2007)
Haematologica
, vol.92
, Issue.6
, pp. 753-762
-
-
Dbaibo, G.S.1
Kfoury, Y.2
Darwiche, N.3
Panjarian, S.4
Kozhaya, L.5
Nasr, R.6
Abdallah, M.7
Hermine, O.8
El-Sabban, M.9
de The, H.10
Bazarbachi, A.11
-
42
-
-
55849099564
-
Ceramide promotes apoptosis in chronic myelogenous leukemiaderived K562 cells by a mechanism involving caspase-8 and JNK
-
Nica, A. F.; Tsao, C. C.; Watt, J. C.; Jiffar, T.; Kurinna, S.; Jurasz, P.; Konopleva, M.; Andreeff, M.; Radomski, M. W.; Ruvolo, P. P. Ceramide promotes apoptosis in chronic myelogenous leukemiaderived K562 cells by a mechanism involving caspase-8 and JNK. Cell Cycle, 2008, 7 (21), 3362-3370.
-
(2008)
Cell Cycle
, vol.7
, Issue.21
, pp. 3362-3370
-
-
Nica, A.F.1
Tsao, C.C.2
Watt, J.C.3
Jiffar, T.4
Kurinna, S.5
Jurasz, P.6
Konopleva, M.7
Andreeff, M.8
Radomski, M.W.9
Ruvolo, P.P.10
-
43
-
-
77953357940
-
Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches
-
Chapman, J. V.; Gouaze-Andersson, V.; Messner, M. C.; Flowers, M.; Karimi, R.; Kester, M.; Barth, B. M.; Liu, X.; Liu, Y. Y.; Giuliano, A. E.; Cabot, M. C. Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches. Biochem. Pharmacol., 2010, 80 (3), 308-315.
-
(2010)
Biochem. Pharmacol
, vol.80
, Issue.3
, pp. 308-315
-
-
Chapman, J.V.1
Gouaze-Andersson, V.2
Messner, M.C.3
Flowers, M.4
Karimi, R.5
Kester, M.6
Barth, B.M.7
Liu, X.8
Liu, Y.Y.9
Giuliano, A.E.10
Cabot, M.C.11
-
44
-
-
0028881514
-
Interaction of tamoxifen with the multidrug resistance P-glycoprotein
-
Callaghan, R.; Higgins, C. F. Interaction of tamoxifen with the multidrug resistance P-glycoprotein. Br. J. Cancer, 1995, 71 (2), 294-299.
-
(1995)
Br. J. Cancer
, vol.71
, Issue.2
, pp. 294-299
-
-
Callaghan, R.1
Higgins, C.F.2
-
45
-
-
22544457473
-
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids
-
Eckford, P. D.; Sharom, F. J. The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids. Biochem. J., 2005, 389 (Pt 2), 517-526.
-
(2005)
Biochem. J
, vol.389
, Issue.Pt 2
, pp. 517-526
-
-
Eckford, P.D.1
Sharom, F.J.2
-
46
-
-
0034717893
-
A. ABC transporters in lipid transport
-
Borst, P.; Zelcer, N.; van Helvoort, A. ABC transporters in lipid transport. Biochim. Biophys. Acta, 2000, 1486 (1), 128-144.
-
(2000)
Biochim. Biophys. Acta
, vol.1486
, Issue.1
, pp. 128-144
-
-
Borst, P.1
Zelcer, N.2
van Helvoort, A.3
-
47
-
-
0007544439
-
MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
-
van Helvoort, A.; Smith, A. J.; Sprong, H.; Fritzsche, I.; Schinkel, A. H.; Borst, P.; van Meer, G. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell, 1996, 87 (3), 507-517.
-
(1996)
Cell
, vol.87
, Issue.3
, pp. 507-517
-
-
van Helvoort, A.1
Smith, A.J.2
Sprong, H.3
Fritzsche, I.4
Schinkel, A.H.5
Borst, P.6
van Meer, G.7
-
48
-
-
1542319939
-
Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis
-
De Rosa, M. F.; Sillence, D.; Ackerley, C.; Lingwood, C. Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. J. Biol. Chem., 2004, 279 (9), 7867-7876.
-
(2004)
J. Biol. Chem
, vol.279
, Issue.9
, pp. 7867-7876
-
-
de Rosa, M.F.1
Sillence, D.2
Ackerley, C.3
Lingwood, C.4
-
49
-
-
62549106143
-
Combination treatment with arsenic trioxide and irradiation enhances apoptotic effects in U937 cells through increased mitotic arrest and ROS generation
-
Ho, S. Y.; Chen, W. C.; Chiu, H. W.; Lai, C. S.; Guo, H. R.; Wang, Y. J. Combination treatment with arsenic trioxide and irradiation enhances apoptotic effects in U937 cells through increased mitotic arrest and ROS generation. Chem. Biol. Interact., 2009, 179 (2-3), 304-313.
-
(2009)
Chem. Biol. Interact
, vol.179
, Issue.2-3
, pp. 304-313
-
-
Ho, S.Y.1
Chen, W.C.2
Chiu, H.W.3
Lai, C.S.4
Guo, H.R.5
Wang, Y.J.6
-
50
-
-
74849083369
-
Rosmarinic acid sensitizes cell death through suppression of TNFalpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells
-
Moon, D. O.; Kim, M. O.; Lee, J. D.; Choi, Y. H.; Kim, G. Y. Rosmarinic acid sensitizes cell death through suppression of TNFalpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells. Cancer Lett., 2010, 288 (2), 183-191.
-
(2010)
Cancer Lett
, vol.288
, Issue.2
, pp. 183-191
-
-
Moon, D.O.1
Kim, M.O.2
Lee, J.D.3
Choi, Y.H.4
Kim, G.Y.5
-
51
-
-
0142057512
-
N-(4-Hydroxyphenyl)retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species
-
Goto, H.; Takahashi, H.; Fujii, H.; Ikuta, K.; Yokota, S. N-(4-Hydroxyphenyl)retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species. Int. J. Hematol., 2003, 78 (3), 219-225.
-
(2003)
Int. J. Hematol
, vol.78
, Issue.3
, pp. 219-225
-
-
Goto, H.1
Takahashi, H.2
Fujii, H.3
Ikuta, K.4
Yokota, S.5
-
52
-
-
77956897107
-
NDimethyl phytosphingosine sensitizes HL-60/MX2, a multidrugresistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF
-
Kim, B. M.; Choi, Y. J.; Lee, Y. H.; Joe, Y. A.; Hong, S. H. N, NDimethyl phytosphingosine sensitizes HL-60/MX2, a multidrugresistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF. Apoptosis, 2010, 15 (8), 982-993
-
(2010)
Apoptosis
, vol.15
, Issue.8
, pp. 982-993
-
-
Kim, B.M.1
Choi, Y.J.2
Lee, Y.H.3
Joe, Y.A.4
Hong, S.H.N.5
-
53
-
-
7444232546
-
Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radic
-
Kowaltowski, A. J.; Fenton, R. G.; Fiskum, G. Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radic. Biol. Med., 2004, 37 (11), 1845-1853.
-
(2004)
Biol. Med
, vol.37
, Issue.11
, pp. 1845-1853
-
-
Kowaltowski, A.J.1
Fenton, R.G.2
Fiskum, G.3
-
54
-
-
79956191022
-
Role of oxidative stress and DNA damage in human carcinogenesis
-
Kryston, T. B.; Georgiev, A. B.; Pissis, P.; Georgakilas, A. G. Role of oxidative stress and DNA damage in human carcinogenesis. Mutat. Res., 2011, 711 (1-2), 193-201.
-
(2011)
Mutat. Res
, vol.711
, Issue.1-2
, pp. 193-201
-
-
Kryston, T.B.1
Georgiev, A.B.2
Pissis, P.3
Georgakilas, A.G.4
-
55
-
-
0037983267
-
Antioxidant enzymes and human diseases
-
Mates, J. M.; Perez-Gomez, C.; Nunez de Castro, I. Antioxidant enzymes and human diseases. Clin. Biochem., 1999, 32 (8), 595-603.
-
(1999)
Clin. Biochem
, vol.32
, Issue.8
, pp. 595-603
-
-
Mates, J.M.1
Perez-Gomez, C.2
de Castro, N.I.3
-
56
-
-
77954735594
-
Superoxide dismutase mimics: Chemistry, pharmacology, and therapeutic potential
-
Batinic-Haberle, I.; Reboucas, J. S.; Spasojevic, I. Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid. Redox. Signal., 2011, 13 (6), 877-918.
-
(2011)
Antioxid. Redox. Signal
, vol.13
, Issue.6
, pp. 877-918
-
-
Batinic-Haberle, I.1
Reboucas, J.S.2
Spasojevic, I.3
-
57
-
-
30044434594
-
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
-
Rosato, R. R.; Maggio, S. C.; Almenara, J. A.; Payne, S. G.; Atadja, P.; Spiegel, S.; Dent, P.; Grant, S. The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide. Mol. Pharmacol., 2006, 69 (1), 216-225.
-
(2006)
Mol. Pharmacol
, vol.69
, Issue.1
, pp. 216-225
-
-
Rosato, R.R.1
Maggio, S.C.2
Almenara, J.A.3
Payne, S.G.4
Atadja, P.5
Spiegel, S.6
Dent, P.7
Grant, S.8
-
58
-
-
0034614095
-
Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism
-
Maurer, B. J.; Melton, L.; Billups, C.; Cabot, M. C.; Reynolds, C. P. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J. Natl. Cancer Inst., 2000, 92 (23), 1897-1909.
-
(2000)
J. Natl. Cancer Inst
, vol.92
, Issue.23
, pp. 1897-1909
-
-
Maurer, B.J.1
Melton, L.2
Billups, C.3
Cabot, M.C.4
Reynolds, C.P.5
-
59
-
-
0027332981
-
N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid
-
Delia, D.; Aiello, A.; Lombardi, L.; Pelicci, P. G.; Grignani, F.; Formelli, F.; Menard, S.; Costa, A.; Veronesi, U.; et al. N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid. Cancer Res., 1993, 53 (24), 6036-6041.
-
(1993)
Cancer Res
, vol.53
, Issue.24
, pp. 6036-6041
-
-
Delia, D.1
Aiello, A.2
Lombardi, L.3
Pelicci, P.G.4
Grignani, F.5
Formelli, F.6
Menard, S.7
Costa, A.8
Veronesi, U.9
-
60
-
-
0036100132
-
N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes
-
O'Donnell, P. H.; Guo, W. X.; Reynolds, C. P.; Maurer, B. J. N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes. Leukemia, 2002, 16 (5), 902-910.
-
(2002)
Leukemia
, vol.16
, Issue.5
, pp. 902-910
-
-
O'Donnell, P.H.1
Guo, W.X.2
Reynolds, C.P.3
Maurer, B.J.4
-
61
-
-
43149117910
-
Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation
-
Kang, M. H.; Wan, Z.; Kang, Y. H.; Sposto, R.; Reynolds, C. P. Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation. J. Natl. Cancer Inst., 2008, 100 (8), 580-595.
-
(2008)
J. Natl. Cancer Inst
, vol.100
, Issue.8
, pp. 580-595
-
-
Kang, M.H.1
Wan, Z.2
Kang, Y.H.3
Sposto, R.4
Reynolds, C.P.5
-
62
-
-
34047146501
-
4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2
-
Morales, M. C.; Perez-Yarza, G.; Rementeria, N. N.; Boyano, M. D.; Apraiz, A.; Gomez-Munoz, A.; Perez-Andres, E.; Asumendi, A. 4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2. Free Radic. Res., 2007, 41 (5), 591-601.
-
(2007)
Free Radic. Res
, vol.41
, Issue.5
, pp. 591-601
-
-
Morales, M.C.1
Perez-Yarza, G.2
Rementeria, N.N.3
Boyano, M.D.4
Apraiz, A.5
Gomez-Munoz, A.6
Perez-Andres, E.7
Asumendi, A.8
-
63
-
-
33846549131
-
Reactive oxygen species mediate N-(4-hydroxyphenyl)retinamide-induced cell death in malignant T cells and are inhibited by the HTLV-I oncoprotein Tax
-
Darwiche, N.; Abou-Lteif, G.; Bazarbachi, A. Reactive oxygen species mediate N-(4-hydroxyphenyl)retinamide-induced cell death in malignant T cells and are inhibited by the HTLV-I oncoprotein Tax. Leukemia, 2007, 21 (2), 261-269.
-
(2007)
Leukemia
, vol.21
, Issue.2
, pp. 261-269
-
-
Darwiche, N.1
Abou-Lteif, G.2
Bazarbachi, A.3
-
64
-
-
42649146188
-
The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells
-
Lai, W. L.; Wong, N. S. The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells. Exp. Cell Res., 2008, 314 (8), 1667-1682.
-
(2008)
Exp. Cell Res
, vol.314
, Issue.8
, pp. 1667-1682
-
-
Lai, W.L.1
Wong, N.S.2
-
65
-
-
79651469605
-
Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells
-
Jiang, L.; Pan, X.; Chen, Y.; Wang, K.; Du, Y.; Zhang, J. Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells. Biochem. Biophys. Res. Commun., 2011, 405 (2), 314-318.
-
(2011)
Biochem. Biophys. Res. Commun
, vol.405
, Issue.2
, pp. 314-318
-
-
Jiang, L.1
Pan, X.2
Chen, Y.3
Wang, K.4
Du, Y.5
Zhang, J.6
-
66
-
-
34249818765
-
Improved oral delivery of N-(4-hydroxyphenyl)retinamide with a novel LYM-XSORB organized lipid complex
-
Maurer, B. J.; Kalous, O.; Yesair, D. W.; Wu, X.; Janeba, J.; Maldonado, V.; Khankaldyyan, V.; Frgala, T.; Sun, B. C.; McKee, R. T.; Burgess, S. W.; Shaw, W. A.; Reynolds, C. P. Improved oral delivery of N-(4-hydroxyphenyl)retinamide with a novel LYM-XSORB organized lipid complex. Clin. Cancer. Res., 2007, 13 (10), 3079-3086.
-
(2007)
Clin. Cancer. Res
, vol.13
, Issue.10
, pp. 3079-3086
-
-
Maurer, B.J.1
Kalous, O.2
Yesair, D.W.3
Wu, X.4
Janeba, J.5
Maldonado, V.6
Khankaldyyan, V.7
Frgala, T.8
Sun, B.C.9
McKee, R.T.10
Burgess, S.W.11
Shaw, W.A.12
Reynolds, C.P.13
-
67
-
-
0033615649
-
Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore
-
Pastorino, J. G.; Tafani, M.; Rothman, R. J.; Marcinkeviciute, A.; Hoek, J. B.; Farber, J. L.; Marcineviciute, A. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J. Biol. Chem., 1999, 274 (44), 31734-31739
-
(1999)
J. Biol. Chem
, vol.274
, Issue.44
, pp. 31734-31739
-
-
Pastorino, J.G.1
Tafani, M.2
Rothman, R.J.3
Marcinkeviciute, A.4
Hoek, J.B.5
Farber, J.L.6
Marcineviciute, A.7
-
68
-
-
0030863670
-
Requirement for GD3 ganglioside in CD95-and ceramide-induced apoptosis
-
De Maria, R.; Lenti, L.; Malisan, F.; d'Agostino, F.; Tomassini, B.; Zeuner, A.; Rippo, M. R.; Testi, R. Requirement for GD3 ganglioside in CD95-and ceramide-induced apoptosis. Science, 1997, 277 (5332), 1652-1655
-
(1997)
Science
, vol.277
, Issue.5332
, pp. 1652-1655
-
-
de Maria, R.1
Lenti, L.2
Malisan, F.3
D'Agostino, F.4
Tomassini, B.5
Zeuner, A.6
Rippo, M.R.7
Testi, R.8
-
69
-
-
1842375100
-
Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
-
Quillet-Mary, A.; Jaffrezou, J. P.; Mansat, V.; Bordier, C.; Naval, J.; Laurent, G. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem., 1997, 272 (34), 21388-21395
-
(1997)
J. Biol. Chem
, vol.272
, Issue.34
, pp. 21388-21395
-
-
Quillet-Mary, A.1
Jaffrezou, J.P.2
Mansat, V.3
Bordier, C.4
Naval, J.5
Laurent, G.6
-
70
-
-
0030856714
-
Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
-
Gudz, T. I.; Tserng, K. Y.; Hoppel, C. L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J. Biol. Chem., 1997, 272 (39), 24154-24158.
-
(1997)
J. Biol. Chem
, vol.272
, Issue.39
, pp. 24154-24158
-
-
Gudz, T.I.1
Tserng, K.Y.2
Hoppel, C.L.3
-
71
-
-
0035525748
-
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
-
Cuvillier, O.; Levade, T. Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood, 2001, 98 (9), 2828-2836.
-
(2001)
Blood
, vol.98
, Issue.9
, pp. 2828-2836
-
-
Cuvillier, O.1
Levade, T.2
-
72
-
-
78149435655
-
Haplophytin-A induces caspase-8-mediated apoptosis via the formation of death-inducing signaling complex in human promyelocytic leukemia HL-60 cells
-
Won, K. J.; Chung, K. S.; Lee, Y. S.; Alia, M. S.; Pervez, M. K.; Fatima, S.; Choi, J. H.; Lee, K. T. Haplophytin-A induces caspase-8-mediated apoptosis via the formation of death-inducing signaling complex in human promyelocytic leukemia HL-60 cells. Chem. Biol. Interact., 2010, 188 (3), 505-511.
-
(2010)
Chem. Biol. Interact
, vol.188
, Issue.3
, pp. 505-511
-
-
Won, K.J.1
Chung, K.S.2
Lee, Y.S.3
Alia, M.S.4
Pervez, M.K.5
Fatima, S.6
Choi, J.H.7
Lee, K.T.8
-
73
-
-
77956184488
-
Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway
-
Xu, H. L.; Yu, X. F.; Qu, S. C.; Zhang, R.; Qu, X. R.; Chen, Y. P.; Ma, X. Y.; Sui, D. Y. Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur. J. Pharmacol., 2010, 645 (1-3), 14-22.
-
(2010)
Eur. J. Pharmacol
, vol.645
, Issue.1-3
, pp. 14-22
-
-
Xu, H.L.1
Yu, X.F.2
Qu, S.C.3
Zhang, R.4
Qu, X.R.5
Chen, Y.P.6
Ma, X.Y.7
Sui, D.Y.8
-
74
-
-
0034717184
-
Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
-
Cuvillier, O.; Edsall, L.; Spiegel, S. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J. Biol. Chem., 2000, 275 (21), 15691-15700.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.21
, pp. 15691-15700
-
-
Cuvillier, O.1
Edsall, L.2
Spiegel, S.3
-
75
-
-
0033974782
-
Ceramide in the eukaryotic stress response
-
Hannun, Y. A.; Luberto, C. Ceramide in the eukaryotic stress response. Trends Cell Biol., 2000, 10 (2), 73-80.
-
(2000)
Trends Cell Biol
, vol.10
, Issue.2
, pp. 73-80
-
-
Hannun, Y.A.1
Luberto, C.2
-
76
-
-
0030774818
-
CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition
-
Tepper, A. D.; Cock, J. G.; de Vries, E.; Borst, J.; van Blitterswijk, W. J. CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition. J. Biol. Chem., 1997, 272 (39), 24308-24312.
-
(1997)
J. Biol. Chem
, vol.272
, Issue.39
, pp. 24308-24312
-
-
Tepper, A.D.1
Cock, J.G.2
de Vries, E.3
Borst, J.4
van Blitterswijk, W.J.5
-
77
-
-
0032900335
-
Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95-and DNA damage-induced apoptosis
-
Tepper, A. D.; de Vries, E.; van Blitterswijk, W. J.; Borst, J. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95-and DNA damage-induced apoptosis. J. Clin. Invest., 1999, 103 (7), 971-978.
-
(1999)
J. Clin. Invest
, vol.103
, Issue.7
, pp. 971-978
-
-
Tepper, A.D.1
de Vries, E.2
van Blitterswijk, W.J.3
Borst, J.4
-
78
-
-
0035860393
-
Baxdependent apoptosis induced by ceramide in HL-60 cells
-
Kim, H. J.; Mun, J. Y.; Chun, Y. J.; Choi, K. H.; Kim, M. Y. Baxdependent apoptosis induced by ceramide in HL-60 cells. FEBS Lett., 2001, 505 (2), 264-268.
-
(2001)
FEBS Lett
, vol.505
, Issue.2
, pp. 264-268
-
-
Kim, H.J.1
Mun, J.Y.2
Chun, Y.J.3
Choi, K.H.4
Kim, M.Y.5
-
79
-
-
0035879052
-
Temporal relationships between ceramide production, caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosis
-
Rodriguez-Lafrasse, C.; Alphonse, G.; Broquet, P.; Aloy, M. T.; Louisot, P.; Rousson, R. Temporal relationships between ceramide production, caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosis. Biochem J., 2001, 357 (Pt 2), 407-416.
-
(2001)
Biochem J
, vol.357
, Issue.Pt 2
, pp. 407-416
-
-
Rodriguez-Lafrasse, C.1
Alphonse, G.2
Broquet, P.3
Aloy, M.T.4
Louisot, P.5
Rousson, R.6
-
80
-
-
77956231050
-
HDAC inhibitors with different gene regulation activities depend on the mitochondrial pathway for the sensitization of leukemic T cells to TRAIL-induced apoptosis
-
Morales, J. C.; Ruiz-Magana, M. J.; Carranza, D.; Ortiz-Ferron, G.; Ruiz-Ruiz, C. HDAC inhibitors with different gene regulation activities depend on the mitochondrial pathway for the sensitization of leukemic T cells to TRAIL-induced apoptosis. Cancer Lett., 2010, 297 (1), 91-100.
-
(2010)
Cancer Lett
, vol.297
, Issue.1
, pp. 91-100
-
-
Morales, J.C.1
Ruiz-Magana, M.J.2
Carranza, D.3
Ortiz-Ferron, G.4
Ruiz-Ruiz, C.5
-
81
-
-
73149093206
-
Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D
-
Ballot, C.; Kluza, J.; Martoriati, A.; Nyman, U.; Formstecher, P.; Joseph, B.; Bailly, C.; Marchetti, P. Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D. Mol. Cancer Ther., 2009, 8 (12), 3307-3317.
-
(2009)
Mol. Cancer Ther
, vol.8
, Issue.12
, pp. 3307-3317
-
-
Ballot, C.1
Kluza, J.2
Martoriati, A.3
Nyman, U.4
Formstecher, P.5
Joseph, B.6
Bailly, C.7
Marchetti, P.8
-
82
-
-
9344222195
-
Bcl-2 interrupts the ceramide-mediated pathway of cell death
-
Zhang, J.; Alter, N.; Reed, J. C.; Borner, C.; Obeid, L. M.; Hannun, Y. A. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc. Natl. Acad. Sci. U.S.A., 1996, 93 (11), 5325-5328.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A
, vol.93
, Issue.11
, pp. 5325-5328
-
-
Zhang, J.1
Alter, N.2
Reed, J.C.3
Borner, C.4
Obeid, L.M.5
Hannun, Y.A.6
-
83
-
-
0028050242
-
Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation
-
Quintans, J.; Kilkus, J.; McShan, C. L.; Gottschalk, A. R.; Dawson, G. Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem. Biophys. Res. Commun., 1994, 202 (2), 710-714.
-
(1994)
Biochem. Biophys. Res. Commun
, vol.202
, Issue.2
, pp. 710-714
-
-
Quintans, J.1
Kilkus, J.2
McShan, C.L.3
Gottschalk, A.R.4
Dawson, G.5
-
84
-
-
0038027936
-
Daunorubicin-and mitoxantronetriggered phosphatidylcholine hydrolysis: Implication in druginduced ceramide generation and apoptosis
-
Bettaieb, A.; Plo, I.; Mansat-De Mas, V.; Quillet-Mary, A.; Levade, T.; Laurent, G.; Jaffrezou, J. P. Daunorubicin-and mitoxantronetriggered phosphatidylcholine hydrolysis: implication in druginduced ceramide generation and apoptosis. Mol. Pharmacol., 1999, 55 (1), 118-125.
-
(1999)
Mol. Pharmacol
, vol.55
, Issue.1
, pp. 118-125
-
-
Bettaieb, A.1
Plo, I.2
Mansat-De mas, V.3
Quillet-Mary, A.4
Levade, T.5
Laurent, G.6
Jaffrezou, J.P.7
-
85
-
-
0034706927
-
Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells
-
Biswal, S. S.; Datta, K.; Acquaah-Mensah, G. K.; Kehrer, J. P. Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells. Toxicology, 2000, 154 (1-3), 45-53.
-
(2000)
Toxicology
, vol.154
, Issue.1-3
, pp. 45-53
-
-
Biswal, S.S.1
Datta, K.2
Acquaah-Mensah, G.K.3
Kehrer, J.P.4
-
86
-
-
0029148660
-
Ceramide synthase mediates daunorubicininduced apoptosis: An alternative mechanism for generating death signals
-
Bose, R.; Verheij, M.; Haimovitz-Friedman, A.; Scotto, K.; Fuks, Z.; Kolesnick, R. Ceramide synthase mediates daunorubicininduced apoptosis: an alternative mechanism for generating death signals. Cell, 1995, 82 (3), 405-414.
-
(1995)
Cell
, vol.82
, Issue.3
, pp. 405-414
-
-
Bose, R.1
Verheij, M.2
Haimovitz-Friedman, A.3
Scotto, K.4
Fuks, Z.5
Kolesnick, R.6
-
87
-
-
0032776873
-
Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells
-
Turnbull, K. J.; Brown, B. L.; Dobson, P. R. Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells. Leukemia, 1999, 13 (7), 1056-1061.
-
(1999)
Leukemia
, vol.13
, Issue.7
, pp. 1056-1061
-
-
Turnbull, K.J.1
Brown, B.L.2
Dobson, P.R.3
-
88
-
-
0033054696
-
Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide
-
Myrick, D.; Blackinton, D.; Klostergaard, J.; Kouttab, N.; Maizel, A.; Wanebo, H.; Mehta, S. Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide. Leuk. Res., 1999, 23 (6), 569-578.
-
(1999)
Leuk. Res
, vol.23
, Issue.6
, pp. 569-578
-
-
Myrick, D.1
Blackinton, D.2
Klostergaard, J.3
Kouttab, N.4
Maizel, A.5
Wanebo, H.6
Mehta, S.7
-
89
-
-
0024795059
-
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
-
Okazaki, T.; Bell, R. M.; Hannun, Y. A. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem., 1989, 264 (32), 19076-19080.
-
(1989)
J. Biol. Chem
, vol.264
, Issue.32
, pp. 19076-19080
-
-
Okazaki, T.1
Bell, R.M.2
Hannun, Y.A.3
-
90
-
-
33751501999
-
A pilot phase II trial of valspodar modulation of multidrug resistance to paclitaxel in the treatment of metastatic carcinoma of the breast (E1195): A trial of the Eastern Cooperative Oncology Group
-
Carlson, R. W.; O'Neill, A. M.; Goldstein, L. J.; Sikic, B. I.; Abramson, N.; Stewart, J. A.; Davidson, N. E.; Wood, W. C. A pilot phase II trial of valspodar modulation of multidrug resistance to paclitaxel in the treatment of metastatic carcinoma of the breast (E1195): a trial of the Eastern Cooperative Oncology Group. Cancer Invest., 2006, 24 (7), 677-681.
-
(2006)
Cancer Invest
, vol.24
, Issue.7
, pp. 677-681
-
-
Carlson, R.W.1
O'Neill, A.M.2
Goldstein, L.J.3
Sikic, B.I.4
Abramson, N.5
Stewart, J.A.6
Davidson, N.E.7
Wood, W.C.8
-
91
-
-
0141569478
-
Modulation of resistance to idarubicin by the cyclosporin PSC 833 (valspodar) in multidrugresistant cells
-
Lacayo, N. J.; Duran, G. E.; Sikic, B. I. Modulation of resistance to idarubicin by the cyclosporin PSC 833 (valspodar) in multidrugresistant cells. J. Exp. Ther. Oncol., 2003, 3 (3), 127-135.
-
(2003)
J. Exp. Ther. Oncol
, vol.3
, Issue.3
, pp. 127-135
-
-
Lacayo, N.J.1
Duran, G.E.2
Sikic, B.I.3
-
92
-
-
0034574938
-
Selective susceptibility of transformed T lymphocytes to induction of apoptosis by PSC 833, an inhibitor of Pglycoprotein
-
Azare, J.; Pankova-Kholmyansky, I.; Salnikow, K.; Cohen, D.; Flescher, E. Selective susceptibility of transformed T lymphocytes to induction of apoptosis by PSC 833, an inhibitor of Pglycoprotein. Oncol. Res., 2000, 12 (8), 315-323.
-
(2000)
Oncol. Res
, vol.12
, Issue.8
, pp. 315-323
-
-
Azare, J.1
Pankova-Kholmyansky, I.2
Salnikow, K.3
Cohen, D.4
Flescher, E.5
-
93
-
-
0032541179
-
The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation
-
Cabot, M. C.; Han, T. Y.; Giuliano, A. E. The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation. FEBS Lett., 1998, 431 (2), 185-188.
-
(1998)
FEBS Lett
, vol.431
, Issue.2
, pp. 185-188
-
-
Cabot, M.C.1
Han, T.Y.2
Giuliano, A.E.3
-
94
-
-
0033963286
-
SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein
-
Goulding, C. W.; Giuliano, A. E.; Cabot, M. C. SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein. Cancer Lett., 2000, 149 (1-2), 143-151.
-
(2000)
Cancer Lett
, vol.149
, Issue.1-2
, pp. 143-151
-
-
Goulding, C.W.1
Giuliano, A.E.2
Cabot, M.C.3
-
95
-
-
0035885948
-
Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT(388)-granulocyte-macrophage colony-stimulating factor (GMCSF), a truncated diphtheria toxin fused to human GM-CSF
-
Senchenkov, A.; Han, T. Y.; Wang, H.; Frankel, A. E.; Kottke, T. J.; Kaufmann, S. H.; Cabot, M. C. Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT(388)-granulocyte-macrophage colony-stimulating factor (GMCSF), a truncated diphtheria toxin fused to human GM-CSF. Blood, 2001, 98 (6), 1927-1934.
-
(2001)
Blood
, vol.98
, Issue.6
, pp. 1927-1934
-
-
Senchenkov, A.1
Han, T.Y.2
Wang, H.3
Frankel, A.E.4
Kottke, T.J.5
Kaufmann, S.H.6
Cabot, M.C.7
-
96
-
-
0032127605
-
Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by diphtheria fusion toxin, DT388-GMCSF
-
Frankel, A. E.; Hall, P. D.; McLain, C.; Safa, A. R.; Tagge, E. P.; Kreitman, R. J. Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by diphtheria fusion toxin, DT388-GMCSF. Bioconjug. Chem., 1998, 9 (4), 490-496.
-
(1998)
Bioconjug. Chem
, vol.9
, Issue.4
, pp. 490-496
-
-
Frankel, A.E.1
Hall, P.D.2
McLain, C.3
Safa, A.R.4
Tagge, E.P.5
Kreitman, R.J.6
-
97
-
-
20244379085
-
Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocytemacrophage colony-stimulating factor fusion protein
-
Hogge, D. E.; Willman, C. L.; Kreitman, R. J.; Berger, M.; Hall, P. D.; Kopecky, K. J.; McLain, C.; Tagge, E. P.; Eaves, C. J.; Frankel, A. E. Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocytemacrophage colony-stimulating factor fusion protein. Blood, 1998, 92 (2), 589-595.
-
(1998)
Blood
, vol.92
, Issue.2
, pp. 589-595
-
-
Hogge, D.E.1
Willman, C.L.2
Kreitman, R.J.3
Berger, M.4
Hall, P.D.5
Kopecky, K.J.6
McLain, C.7
Tagge, E.P.8
Eaves, C.J.9
Frankel, A.E.10
-
98
-
-
0032400865
-
Diphtheria toxin fused to granulocytemacrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia
-
Frankel, A. E.; Lilly, M.; Kreitman, R.; Hogge, D.; Beran, M.; Freedman, M. H.; Emanuel, P. D.; McLain, C.; Hall, P.; Tagge, E.; Berger, M.; Eaves, C. Diphtheria toxin fused to granulocytemacrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Blood, 1998, 92 (11), 4279-4286.
-
(1998)
Blood
, vol.92
, Issue.11
, pp. 4279-4286
-
-
Frankel, A.E.1
Lilly, M.2
Kreitman, R.3
Hogge, D.4
Beran, M.5
Freedman, M.H.6
Emanuel, P.D.7
McLain, C.8
Hall, P.9
Tagge, E.10
Berger, M.11
Eaves, C.12
-
99
-
-
0036098391
-
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia
-
Frankel, A. E.; Powell, B. L.; Hall, P. D.; Case, L. D.; Kreitman, R. J. Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. Clin. Cancer Res., 2002, 8 (5), 1004-1013.
-
(2002)
Clin. Cancer Res
, vol.8
, Issue.5
, pp. 1004-1013
-
-
Frankel, A.E.1
Powell, B.L.2
Hall, P.D.3
Case, L.D.4
Kreitman, R.J.5
-
100
-
-
12344250749
-
Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factorinduced hepatotoxicity is mediated by Kupffer cells
-
Westcott, M. M.; Abi-Habib, R. J.; Cohen, K. A.; Willingham, M. C.; Liu, S.; Bugge, T. H.; Leppla, S. H.; Frankel, A. E. Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factorinduced hepatotoxicity is mediated by Kupffer cells. Mol. Cancer Ther., 2004, 3 (12), 1681-1689.
-
(2004)
Mol. Cancer Ther
, vol.3
, Issue.12
, pp. 1681-1689
-
-
Westcott, M.M.1
Abi-Habib, R.J.2
Cohen, K.A.3
Willingham, M.C.4
Liu, S.5
Bugge, T.H.6
Leppla, S.H.7
Frankel, A.E.8
-
101
-
-
33646349775
-
Fresh frozen plasma and platelet concentrates may increase plasma anti-diphtheria toxin IgG concentrations: Implications for diphtheria fusion protein therapy
-
Hall, P. D.; Sinha, D.; Frankel, A. E. Fresh frozen plasma and platelet concentrates may increase plasma anti-diphtheria toxin IgG concentrations: Implications for diphtheria fusion protein therapy. Cancer Immunol. Immunother., 2006, 55 (8), 928-932.
-
(2006)
Cancer Immunol Immunother
, vol.55
, Issue.8
, pp. 928-932
-
-
Hall, P.D.1
Sinha, D.2
Frankel, A.E.3
-
102
-
-
0033561621
-
Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism
-
Mengubas, K.; Riordan, F. A.; Bravery, C. A.; Lewin, J.; Owens, D. L.; Mehta, A. B.; Hoffbrand, A. V.; Wickremasinghe, R. G. Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism. Oncogene, 1999, 18 (15), 2499-2506.
-
(1999)
Oncogene
, vol.18
, Issue.15
, pp. 2499-2506
-
-
Mengubas, K.1
Riordan, F.A.2
Bravery, C.A.3
Lewin, J.4
Owens, D.L.5
Mehta, A.B.6
Hoffbrand, A.V.7
Wickremasinghe, R.G.8
-
103
-
-
0034708594
-
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
-
Perry, D. K.; Carton, J.; Shah, A. K.; Meredith, F.; Uhlinger, D. J.; Hannun, Y. A. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem., 2000, 275 (12), 9078-9084.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.12
, pp. 9078-9084
-
-
Perry, D.K.1
Carton, J.2
Shah, A.K.3
Meredith, F.4
Uhlinger, D.J.5
Hannun, Y.A.6
-
104
-
-
0032081313
-
Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843
-
Laethem, R. M.; Hannun, Y. A.; Jayadev, S.; Sexton, C. J.; Strum, J. C.; Sundseth, R.; Smith, G. K. Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood, 1998, 91 (11), 4350-4360.
-
(1998)
Blood
, vol.91
, Issue.11
, pp. 4350-4360
-
-
Laethem, R.M.1
Hannun, Y.A.2
Jayadev, S.3
Sexton, C.J.4
Strum, J.C.5
Sundseth, R.6
Smith, G.K.7
-
105
-
-
0037455808
-
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylationdependent novel antifolates in multiple human leukemia sublines
-
Liani, E.; Rothem, L.; Bunni, M. A.; Smith, C. A.; Jansen, G.; Assaraf, Y. G. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylationdependent novel antifolates in multiple human leukemia sublines. Int. J. Cancer, 2003, 103 (5), 587-599.
-
(2003)
Int. J. Cancer
, vol.103
, Issue.5
, pp. 587-599
-
-
Liani, E.1
Rothem, L.2
Bunni, M.A.3
Smith, C.A.4
Jansen, G.5
Assaraf, Y.G.6
-
106
-
-
20144382254
-
The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates
-
Wielinga, P.; Hooijberg, J. H.; Gunnarsdottir, S.; Kathmann, I.; Reid, G.; Zelcer, N.; van der Born, K.; de Haas, M.; van der Heijden, I.; Kaspers, G.; Wijnholds, J.; Jansen, G.; Peters, G.; Borst, P. The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res., 2005, 65 (10), 4425-4430.
-
(2005)
Cancer Res
, vol.65
, Issue.10
, pp. 4425-4430
-
-
Wielinga, P.1
Hooijberg, J.H.2
Gunnarsdottir, S.3
Kathmann, I.4
Reid, G.5
Zelcer, N.6
van der Born, K.7
de Haas, M.8
van der Heijden, I.9
Kaspers, G.10
Wijnholds, J.11
Jansen, G.12
Peters, G.13
Borst, P.14
-
107
-
-
4544332170
-
Assessment of drug resistance in acute myeloid leukemia. Expert
-
Funato, T.; Harigae, H.; Abe, S.; Sasaki, T. Assessment of drug resistance in acute myeloid leukemia. Expert Rev. Mol. Diagn., 2004, 4 (5), 705-713.
-
(2004)
Rev. Mol. Diagn
, vol.4
, Issue.5
, pp. 705-713
-
-
Funato, T.1
Harigae, H.2
Abe, S.3
Sasaki, T.4
-
108
-
-
0029078604
-
In vitro drug sensitivity of leukemic progenitors and Pglycoprotein expression in adult acute myeloid leukemia: Correlation with induction treatment outcome
-
Basara, N.; Radosevic-Radojkovic, N.; Colovic, M.; Boskovic, D.; Rolovic, Z. In vitro drug sensitivity of leukemic progenitors and Pglycoprotein expression in adult acute myeloid leukemia: correlation with induction treatment outcome. Eur. J. Haematol., 1995, 55 (2), 83-87.
-
(1995)
Eur. J. Haematol
, vol.55
, Issue.2
, pp. 83-87
-
-
Basara, N.1
Radosevic-Radojkovic, N.2
Colovic, M.3
Boskovic, D.4
Rolovic, Z.5
-
109
-
-
0026602155
-
Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis
-
Campos, L.; Guyotat, D.; Archimbaud, E.; Calmard-Oriol, P.; Tsuruo, T.; Troncy, J.; Treille, D.; Fiere, D. Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood, 1992, 79 (2), 473-476.
-
(1992)
Blood
, vol.79
, Issue.2
, pp. 473-476
-
-
Campos, L.1
Guyotat, D.2
Archimbaud, E.3
Calmard-Oriol, P.4
Tsuruo, T.5
Troncy, J.6
Treille, D.7
Fiere, D.8
-
110
-
-
18344411220
-
P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias
-
Damiani, D.; Michieli, M.; Ermacora, A.; Candoni, A.; Raspadori, D.; Geromin, A.; Stocchi, R.; Grimaz, S.; Masolini, P.; Michelutti, A.; Scheper, R. J.; Baccarani, M. P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias. Haematologica, 1998, 83 (4), 290-297.
-
(1998)
Haematologica
, vol.83
, Issue.4
, pp. 290-297
-
-
Damiani, D.1
Michieli, M.2
Ermacora, A.3
Candoni, A.4
Raspadori, D.5
Geromin, A.6
Stocchi, R.7
Grimaz, S.8
Masolini, P.9
Michelutti, A.10
Scheper, R.J.11
Baccarani, M.12
-
111
-
-
13344282085
-
Clinical relevance of P-glycoprotein expression in de novo acute myeloid leukemia
-
Del Poeta, G.; Stasi, R.; Aronica, G.; Venditti, A.; Cox, M. C.; Bruno, A.; Buccisano, F.; Masi, M.; Tribalto, M.; Amadori, S.; Papa, G. Clinical relevance of P-glycoprotein expression in de novo acute myeloid leukemia. Blood, 1996, 87 (5), 1997-2004.
-
(1996)
Blood
, vol.87
, Issue.5
, pp. 1997-2004
-
-
Del Poeta, G.1
Stasi, R.2
Aronica, G.3
Venditti, A.4
Cox, M.C.5
Bruno, A.6
Buccisano, F.7
Masi, M.8
Tribalto, M.9
Amadori, S.10
Papa, G.11
-
112
-
-
0028244591
-
P-glycoprotein expression on acute myeloid leukaemia blast cells at diagnosis predicts response to chemotherapy and survival
-
Wood, P.; Burgess, R.; MacGregor, A.; Yin, J. A. P-glycoprotein expression on acute myeloid leukaemia blast cells at diagnosis predicts response to chemotherapy and survival. Br. J. Haematol., 1994, 87 (3), 509-514.
-
(1994)
Br. J. Haematol
, vol.87
, Issue.3
, pp. 509-514
-
-
Wood, P.1
Burgess, R.2
Macgregor, A.3
Yin, J.A.4
-
113
-
-
9444223257
-
P-glycoprotein expression in patients with acute leukemia-clinical relevance
-
Nussler, V.; Pelka-Fleischer, R.; Zwierzina, H.; Nerl, C.; Beckert, B.; Gieseler, F.; Diem, H.; Ledderose, G.; Gullis, E.; Sauer, H.; Wilmanns, W. P-glycoprotein expression in patients with acute leukemia-clinical relevance. Leukemia, 1996, 10 Suppl 3, S23-S31.
-
(1996)
Leukemia
, vol.10
, Issue.SUPPL. 3
, pp. 23-31
-
-
Nussler, V.1
Pelka-Fleischer, R.2
Zwierzina, H.3
Nerl, C.4
Beckert, B.5
Gieseler, F.6
Diem, H.7
Ledderose, G.8
Gullis, E.9
Sauer, H.10
Wilmanns, W.11
-
114
-
-
0031052883
-
Multidrug resistance gene expression in acute myeloid leukemia: Major prognosis significance for in vivo drug resistance to induction treatment
-
Hunault, M.; Zhou, D.; Delmer, A.; Ramond, S.; Viguie, F.; Cadiou, M.; Perrot, J. Y.; Levy, V.; Rio, B.; Cymbalista, F.; Zittoun, R.; Marie, J. P. Multidrug resistance gene expression in acute myeloid leukemia: major prognosis significance for in vivo drug resistance to induction treatment. Ann. Hematol., 1997, 74 (2), 65-71.
-
(1997)
Ann. Hematol
, vol.74
, Issue.2
, pp. 65-71
-
-
Hunault, M.1
Zhou, D.2
Delmer, A.3
Ramond, S.4
Viguie, F.5
Cadiou, M.6
Perrot, J.Y.7
Levy, V.8
Rio, B.9
Cymbalista, F.10
Zittoun, R.11
Marie, J.P.12
-
115
-
-
0030729284
-
MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukaemia
-
van den Heuvel-Eibrink, MM.; van der Holt, B.; te Boekhorst, PA.; Pieters, R.; Schoester, M.; Lowenberg, B.; Sonneveld, P. MDR 1 expression is an independent prognostic factor for response and survival in de novo acute myeloid leukaemia. Br. J. Haematol., 1997, 99 (1), 76-83.
-
(1997)
Br. J. Haematol
, vol.99
, Issue.1
, pp. 76-83
-
-
van den Heuvel-Eibrink, M.M.1
van der Holt, B.2
Te, B.P.A.3
Pieters, R.4
Schoester, M.5
Lowenberg, B.6
Sonneveld, P.7
-
116
-
-
0032956842
-
Use of standardized flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia
-
Pallis, M.; Turzanski, J.; Harrison, G.; Wheatley, K.; Langabeer, S.; Burnett, A. K.; Russell, N. H. Use of standardized flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia. Br. J. Haematol., 1999, 104 (2), 307-312.
-
(1999)
Br. J. Haematol
, vol.104
, Issue.2
, pp. 307-312
-
-
Pallis, M.1
Turzanski, J.2
Harrison, G.3
Wheatley, K.4
Langabeer, S.5
Burnett, A.K.6
Russell, N.H.7
-
117
-
-
33644819773
-
P-glycoprotein (P-170) expression in acute leukemias
-
Abd El-Ghaffar, H. A.; Aladle, D. A.; Farahat, S. E.; Abd El-Hady, N. P-glycoprotein (P-170) expression in acute leukemias. Hematology, 2006, 11 (1), 35-41.
-
(2006)
Hematology
, vol.11
, Issue.1
, pp. 35-41
-
-
Abd El-Ghaffar, H.A.1
Aladle, D.A.2
Farahat, S.E.3
Abd El-Hady, N.4
-
118
-
-
71949122848
-
Rapid induction of P-glycoprotein mRNA and protein expression by cytarabine in HL-60 cells
-
Prenkert, M.; Uggla, B.; Tina, E.; Tidefelt, U.; Strid, H. Rapid induction of P-glycoprotein mRNA and protein expression by cytarabine in HL-60 cells. Anticancer Res., 2009, 29 (10), 4071-4076.
-
(2009)
Anticancer Res
, vol.29
, Issue.10
, pp. 4071-4076
-
-
Prenkert, M.1
Uggla, B.2
Tina, E.3
Tidefelt, U.4
Strid, H.5
-
119
-
-
8844245584
-
Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: Frequent expression and possible correlation with shorter disease-free survival
-
Suvannasankha, A.; Minderman, H.; O'Loughlin, K. L.; Nakanishi, T.; Ford, L. A.; Greco, W. R.; Wetzler, M.; Ross, D. D.; Baer, M. R. Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival. Br. J. Haematol., 2004, 127 (4), 392-398.
-
(2004)
Br. J. Haematol
, vol.127
, Issue.4
, pp. 392-398
-
-
Suvannasankha, A.1
Minderman, H.2
O'Loughlin, K.L.3
Nakanishi, T.4
Ford, L.A.5
Greco, W.R.6
Wetzler, M.7
Ross, D.D.8
Baer, M.R.9
-
120
-
-
40649100954
-
MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia
-
Ho, M. M.; Hogge, D. E.; Ling, V. MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia. Exp. Hematol., 2008, 36 (4), 433-442.
-
(2008)
Exp. Hematol
, vol.36
, Issue.4
, pp. 433-442
-
-
Ho, M.M.1
Hogge, D.E.2
Ling, V.3
-
121
-
-
0036100195
-
Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)
-
van den Heuvel-Eibrink, MM.; Wiemer, EA.; Prins, A.; Meijerink, JP.; Vossebeld, PJ.; van der Holt, B.; Pieters, R.; Sonneveld, P. Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML). Leukemia, 2002, 16 (5), 833-839.
-
(2002)
Leukemia
, vol.16
, Issue.5
, pp. 833-839
-
-
van den Heuvel-Eibrink, M.M.1
Wiemer, E.A.2
Prins, A.3
Meijerink, J.P.4
Vossebeld, P.J.5
van der Holt, B.6
Pieters, R.7
Sonneveld, P.8
-
122
-
-
0035992274
-
P-glycoprotein in acute myeloid leukaemia: Therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype
-
Pallis, M.; Turzanski, J.; Higashi, Y.; Russell, N. P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype. Leuk. Lymphoma, 2002, 43 (6), 1221-1228.
-
(2002)
Leuk. Lymphoma
, vol.43
, Issue.6
, pp. 1221-1228
-
-
Pallis, M.1
Turzanski, J.2
Higashi, Y.3
Russell, N.4
-
123
-
-
77950472831
-
Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: A report from the Children's Oncology Group
-
O'Brien, M. M.; Lacayo, N. J.; Lum, B. L.; Kshirsagar, S.; Buck, S.; Ravindranath, Y.; Bernstein, M.; Weinstein, H.; Chang, M. N.; Arceci, R. J.; Sikic, B. I.; Dahl, G. V. Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: a report from the Children's Oncology Group. Pediatr. Blood Cancer, 2010, 54 (5), 694-702.
-
(2010)
Pediatr. Blood Cancer
, vol.54
, Issue.5
, pp. 694-702
-
-
O'Brien, M.M.1
Lacayo, N.J.2
Lum, B.L.3
Kshirsagar, S.4
Buck, S.5
Ravindranath, Y.6
Bernstein, M.7
Weinstein, H.8
Chang, M.N.9
Arceci, R.J.10
Sikic, B.I.11
Dahl, G.V.12
-
124
-
-
77956578835
-
P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808
-
Kolitz, J. E.; George, S. L.; Marcucci, G.; Vij, R.; Powell, B. L.; Allen, S. L.; DeAngelo, D. J.; Shea, T. C.; Stock, W.; Baer, M. R.; Hars, V.; Maharry, K.; Hoke, E.; Vardiman, J. W.; Bloomfield, C. D.; Larson, R. A. P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808. Blood, 2010, 116 (9), 1413-1421.
-
(2010)
Blood
, vol.116
, Issue.9
, pp. 1413-1421
-
-
Kolitz, J.E.1
George, S.L.2
Marcucci, G.3
Vij, R.4
Powell, B.L.5
Allen, S.L.6
Deangelo, D.J.7
Shea, T.C.8
Stock, W.9
Baer, M.R.10
Hars, V.11
Maharry, K.12
Hoke, E.13
Vardiman, J.W.14
Bloomfield, C.D.15
Larson, R.A.16
-
125
-
-
79951530814
-
Novel and emerging drugs for acute myeloid leukemia: Pharmacology and therapeutic activity
-
Robak, T.; Szmigielska-Kaplon, A.; Pluta, A.; Grzybowska-Izydorczyk, O.; Wolska, A.; Czemerska, M.; Wierzbowska, A. Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity. Curr. Med. Chem., 2011, 18 (5), 638-666.
-
(2011)
Curr. Med. Chem
, vol.18
, Issue.5
, pp. 638-666
-
-
Robak, T.1
Szmigielska-Kaplon, A.2
Pluta, A.3
Grzybowska-Izydorczyk, O.4
Wolska, A.5
Czemerska, M.6
Wierzbowska, A.7
-
126
-
-
77952312245
-
Recent advances in the research of P-glycoprotein inhibitors
-
Yang, K.; Wu, J.; Li, X. Recent advances in the research of P-glycoprotein inhibitors. Biosci. Trends, 2008, 2 (4), 137-146.
-
(2008)
Biosci. Trends
, vol.2
, Issue.4
, pp. 137-146
-
-
Yang, K.1
Wu, J.2
Li, X.3
-
127
-
-
33745746815
-
Pharmacological strategies for overcoming multidrug resistance
-
Nobili, S.; Landini, I.; Giglioni, B.; Mini, E. Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets, 2006, 7 (7), 861-879.
-
(2006)
Curr. Drug Targets
, vol.7
, Issue.7
, pp. 861-879
-
-
Nobili, S.1
Landini, I.2
Giglioni, B.3
Mini, E.4
-
128
-
-
67649786798
-
Recent advances in the development of P-gp inhibitors
-
Baumert, C.; Hilgeroth, A. Recent advances in the development of P-gp inhibitors. Anticancer Agents Med. Chem., 2009, 9 (4), 415-436.
-
(2009)
Anticancer Agents Med. Chem
, vol.9
, Issue.4
, pp. 415-436
-
-
Baumert, C.1
Hilgeroth, A.2
-
129
-
-
0037211554
-
Modulation of P-glycoprotein but not MRP1-or BCRP-mediated drug resistance by LY335979
-
Shepard, R. L.; Cao, J.; Starling, J. J.; Dantzig, A. H. Modulation of P-glycoprotein but not MRP1-or BCRP-mediated drug resistance by LY335979. Int. J. Cancer, 2003, 103 (1), 121-125.
-
(2003)
Int. J. Cancer
, vol.103
, Issue.1
, pp. 121-125
-
-
Shepard, R.L.1
Cao, J.2
Starling, J.J.3
Dantzig, A.H.4
-
130
-
-
40349095136
-
Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)
-
Tang, R.; Faussat, A. M.; Perrot, J. Y.; Marjanovic, Z.; Cohen, S.; Storme, T.; Morjani, H.; Legrand, O.; Marie, J. P. Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML). BMC Cancer, 2008, 8, 51.
-
(2008)
BMC Cancer
, vol.8
, pp. 51
-
-
Tang, R.1
Faussat, A.M.2
Perrot, J.Y.3
Marjanovic, Z.4
Cohen, S.5
Storme, T.6
Morjani, H.7
Legrand, O.8
Marie, J.P.9
-
131
-
-
70349176240
-
Is resistance useless? Multidrug resistance and collateral sensitivity
-
Hall, M. D.; Handley, M. D.; Gottesman, M. M. Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol Sci, 2009, 30 (10), 546-56.
-
(2009)
Trends Pharmacol Sci
, vol.30
, Issue.10
, pp. 546-556
-
-
Hall, M.D.1
Handley, M.D.2
Gottesman, M.M.3
-
132
-
-
33845346454
-
Glycosphingolipids and drug resistance
-
Gouaze-Andersson, V.; Cabot, M. C. Glycosphingolipids and drug resistance. Biochim. Biophys. Acta, 2006, 1758 (12), 2096-2103.
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, Issue.12
, pp. 2096-2103
-
-
Gouaze-Andersson, V.1
Cabot, M.C.2
-
133
-
-
80054083939
-
Ceramide and Multidrug Resistance
-
Second ed.; Gewirtz, D. A.; Holt, S. E.; Grant, S., Eds. Humana Press Inc: Totowa, NJ,
-
Cabot, M. C., Ceramide and Multidrug Resistance. In Apoptosis, Senescence, and Cancer, Second ed.; Gewirtz, D. A.; Holt, S. E.; Grant, S., Eds. Humana Press Inc: Totowa, NJ, 2007; pp 299-312.
-
(2007)
Apoptosis, Senescence, and Cancer
, pp. 299-312
-
-
Cabot, M.C.1
-
134
-
-
1542358155
-
Ceramide synthesis and metabolism as a target for cancer therapy
-
Reynolds, C. P.; Maurer, B. J.; Kolesnick, R. N. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett., 2004, 206 (2), 169-180.
-
(2004)
Cancer Lett
, vol.206
, Issue.2
, pp. 169-180
-
-
Reynolds, C.P.1
Maurer, B.J.2
Kolesnick, R.N.3
-
135
-
-
0035399826
-
Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity
-
Olshefski, R. S.; Ladisch, S. Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity. Int. J. Cancer., 2001, 93 (1), 131-138.
-
(2001)
Int. J. Cancer
, vol.93
, Issue.1
, pp. 131-138
-
-
Olshefski, R.S.1
Ladisch, S.2
-
136
-
-
0029761340
-
Accumulation of glucosylceramides in multidrug-resistant cancer cells
-
Lavie, Y.; Cao, H.; Bursten, S. L.; Giuliano, A. E.; Cabot, M. C. Accumulation of glucosylceramides in multidrug-resistant cancer cells. J. Biol. Chem., 1996, 271 (32), 19530-19536.
-
(1996)
J. Biol. Chem
, vol.271
, Issue.32
, pp. 19530-19536
-
-
Lavie, Y.1
Cao, H.2
Bursten, S.L.3
Giuliano, A.E.4
Cabot, M.C.5
-
137
-
-
4444364174
-
Overexpression of glucosylceramide synthase and Pglycoprotein in cancer cells selected for resistance to natural product chemotherapy
-
Gouaze, V.; Yu, J. Y.; Bleicher, R. J.; Han, T. Y.; Liu, Y. Y.; Wang, H.; Gottesman, M. M.; Bitterman, A.; Giuliano, A. E.; Cabot, M. C. Overexpression of glucosylceramide synthase and Pglycoprotein in cancer cells selected for resistance to natural product chemotherapy. Mol. Cancer Ther., 2004, 3 (5), 633-639.
-
(2004)
Mol. Cancer Ther
, vol.3
, Issue.5
, pp. 633-639
-
-
Gouaze, V.1
Yu, J.Y.2
Bleicher, R.J.3
Han, T.Y.4
Liu, Y.Y.5
Wang, H.6
Gottesman, M.M.7
Bitterman, A.8
Giuliano, A.E.9
Cabot, M.C.10
-
138
-
-
0037203344
-
Glucosylceramide synthase and apoptosis
-
Bleicher, R. J.; Cabot, M. C. Glucosylceramide synthase and apoptosis. Biochim. Biophys. Acta, 2002, 1585 (2-3), 172-178.
-
(2002)
Biochim. Biophys. Acta
, vol.1585
, Issue.2-3
, pp. 172-178
-
-
Bleicher, R.J.1
Cabot, M.C.2
-
139
-
-
18144371163
-
Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
-
Gouaze, V.; Liu, Y. Y.; Prickett, C. S.; Yu, J. Y.; Giuliano, A. E.; Cabot, M. C. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res., 2005, 65 (9), 3861-3867.
-
(2005)
Cancer Res
, vol.65
, Issue.9
, pp. 3861-3867
-
-
Gouaze, V.1
Liu, Y.Y.2
Prickett, C.S.3
Yu, J.Y.4
Giuliano, A.E.5
Cabot, M.C.6
-
140
-
-
0036176510
-
Mechanisms of cancer drug resistance
-
Gottesman, M. M. Mechanisms of cancer drug resistance. Annu Rev Med, 2002, 53, 615-27.
-
(2002)
Annu Rev Med
, vol.53
, pp. 615-627
-
-
Gottesman, M.M.1
-
141
-
-
0024820183
-
The direct activation of human multidrug resistance gene (MDR1) by anticancer agents
-
Kohno, K.; Sato, S.; Takano, H.; Matsuo, K.; Kuwano, M. The direct activation of human multidrug resistance gene (MDR1) by anticancer agents. Biochem. Biophys. Res. Commun., 1989, 165 (3), 1415-1421.
-
(1989)
Biochem. Biophys. Res. Commun
, vol.165
, Issue.3
, pp. 1415-1421
-
-
Kohno, K.1
Sato, S.2
Takano, H.3
Matsuo, K.4
Kuwano, M.5
-
142
-
-
0027506202
-
Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs
-
Chaudhary, P. M.; Roninson, I. B. Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. Natl. Cancer Inst., 1993, 85 (8), 632-639.
-
(1993)
J. Natl. Cancer Inst
, vol.85
, Issue.8
, pp. 632-639
-
-
Chaudhary, P.M.1
Roninson, I.B.2
-
143
-
-
0000255378
-
Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
-
Liu, Y. Y.; Han, T. Y.; Giuliano, A. E.; Cabot, M. C. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. J. Biol. Chem., 1999, 274 (2), 1140-1146.
-
(1999)
J. Biol. Chem
, vol.274
, Issue.2
, pp. 1140-1146
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Cabot, M.C.4
-
144
-
-
0035079539
-
Ceramide glycosylation potentiates cellular multidrug resistance
-
Liu, Y. Y.; Han, T. Y.; Giuliano, A. E.; Cabot, M. C. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J., 2001, 15 (3), 719-730.
-
(2001)
FASEB J
, vol.15
, Issue.3
, pp. 719-730
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Cabot, M.C.4
-
145
-
-
0034629305
-
Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance
-
Liu, Y. Y.; Han, T. Y.; Giuliano, A. E.; Hansen, N.; Cabot, M. C. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance. J. Biol. Chem., 2000, 275 (10), 7138-7143.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.10
, pp. 7138-7143
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Hansen, N.4
Cabot, M.C.5
-
146
-
-
1542467760
-
Development of a mammalian Tet-on expression cell line: Glucosylceramide synthase regulates TNFalpha-induced apoptosis
-
Liu, Y. Y.; Cabot, M. C. Development of a mammalian Tet-on expression cell line: glucosylceramide synthase regulates TNFalpha-induced apoptosis. Methods Mol. Biol., 2004, 249, 177-192.
-
(2004)
Methods Mol. Biol
, vol.249
, pp. 177-192
-
-
Liu, Y.Y.1
Cabot, M.C.2
-
147
-
-
0033231485
-
Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis
-
Liu, Y. Y.; Han, T. Y.; Giuliano, A. E.; Ichikawa, S.; Hirabayashi, Y.; Cabot, M. C. Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis. Exp. Cell Res., 1999, 252 (2), 464-470.
-
(1999)
Exp. Cell Res
, vol.252
, Issue.2
, pp. 464-470
-
-
Liu, Y.Y.1
Han, T.Y.2
Giuliano, A.E.3
Ichikawa, S.4
Hirabayashi, Y.5
Cabot, M.C.6
-
148
-
-
0038985463
-
Stress-induced apoptosis and the sphingomyelin pathway
-
Pena, L. A.; Fuks, Z.; Kolesnick, R. Stress-induced apoptosis and the sphingomyelin pathway. Biochem. Pharmacol., 1997, 53 (5), 615-621.
-
(1997)
Biochem. Pharmacol
, vol.53
, Issue.5
, pp. 615-621
-
-
Pena, L.A.1
Fuks, Z.2
Kolesnick, R.3
-
149
-
-
85047696581
-
Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis
-
Di Sano, F.; Di Bartolomeo, S.; Fazi, B.; Fiorentini, C.; Matarrese, P.; Spinedi, A.; Piacentini, M. Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis. Cell Death Differ., 2002, 9 (6), 693-695.
-
(2002)
Cell Death Differ
, vol.9
, Issue.6
, pp. 693-695
-
-
Di Sano, F.1
Di Bartolomeo, S.2
Fazi, B.3
Fiorentini, C.4
Matarrese, P.5
Spinedi, A.6
Piacentini, M.7
-
150
-
-
0036259133
-
Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation
-
Deng, W.; Li, R.; Guerrera, M.; Liu, Y.; Ladisch, S. Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation. Glycobiology, 2002, 12 (3), 145-152.
-
(2002)
Glycobiology
, vol.12
, Issue.3
, pp. 145-152
-
-
Deng, W.1
Li, R.2
Guerrera, M.3
Liu, Y.4
Ladisch, S.5
-
151
-
-
2142769665
-
Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells
-
Liu, Y. Y.; Han, T. Y.; Yu, J. Y.; Bitterman, A.; Le, A.; Giuliano, A. E.; Cabot, M. C. Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. J. Lipid Res., 2004, 45 (5), 933-940.
-
(2004)
J. Lipid Res
, vol.45
, Issue.5
, pp. 933-940
-
-
Liu, Y.Y.1
Han, T.Y.2
Yu, J.Y.3
Bitterman, A.4
Le, A.5
Giuliano, A.E.6
Cabot, M.C.7
-
152
-
-
39749144761
-
Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells
-
Xie, P.; Shen, Y. F.; Shi, Y. P.; Ge, S. M.; Gu, Z. H.; Wang, J.; Mu, H. J.; Zhang, B.; Qiao, W. Z.; Xie, K. M. Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells. Leuk. Res., 2008, 32 (3), 475-480.
-
(2008)
Leuk. Res
, vol.32
, Issue.3
, pp. 475-480
-
-
Xie, P.1
Shen, Y.F.2
Shi, Y.P.3
Ge, S.M.4
Gu, Z.H.5
Wang, J.6
Mu, H.J.7
Zhang, B.8
Qiao, W.Z.9
Xie, K.M.10
-
153
-
-
2442620446
-
Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines
-
Grazide, S.; Terrisse, A. D.; Lerouge, S.; Laurent, G.; Jaffrezou, J. P. Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines. J. Biol. Chem., 2004, 279 (18), 18256-18261.
-
(2004)
J. Biol. Chem
, vol.279
, Issue.18
, pp. 18256-18261
-
-
Grazide, S.1
Terrisse, A.D.2
Lerouge, S.3
Laurent, G.4
Jaffrezou, J.P.5
-
154
-
-
12244284610
-
Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia
-
Itoh, M.; Kitano, T.; Watanabe, M.; Kondo, T.; Yabu, T.; Taguchi, Y.; Iwai, K.; Tashima, M.; Uchiyama, T.; Okazaki, T. Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. Clin. Cancer Res., 2003, 9 (1), 415-423.
-
(2003)
Clin. Cancer Res
, vol.9
, Issue.1
, pp. 415-423
-
-
Itoh, M.1
Kitano, T.2
Watanabe, M.3
Kondo, T.4
Yabu, T.5
Taguchi, Y.6
Iwai, K.7
Tashima, M.8
Uchiyama, T.9
Okazaki, T.10
-
155
-
-
64549125120
-
Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity
-
Gerrard, G.; Butters, T. D.; Ganeshaguru, K.; Mehta, A. B. Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity. Eur. J. Pharmacol., 2009, 609 (1-3), 34-39.
-
(2009)
Eur. J. Pharmacol
, vol.609
, Issue.1-3
, pp. 34-39
-
-
Gerrard, G.1
Butters, T.D.2
Ganeshaguru, K.3
Mehta, A.B.4
-
156
-
-
78751643035
-
The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60: Acute myeloid leukemia cells
-
Cakir, Z.; Saydam, G.; Sahin, F.; Baran, Y. The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60: acute myeloid leukemia cells. J. Cancer Res. Clin. Oncol., 2010, 137 (2), 279-286.
-
(2010)
J. Cancer Res. Clin. Oncol
, vol.137
, Issue.2
, pp. 279-286
-
-
Cakir, Z.1
Saydam, G.2
Sahin, F.3
Baran, Y.4
-
157
-
-
34249737950
-
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
-
Baran, Y.; Salas, A.; Senkal, C. E.; Gunduz, U.; Bielawski, J.; Obeid, L. M.; Ogretmen, B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J. Biol. Chem., 2007, 282 (15), 10922-10934.
-
(2007)
J. Biol. Chem
, vol.282
, Issue.15
, pp. 10922-10934
-
-
Baran, Y.1
Salas, A.2
Senkal, C.E.3
Gunduz, U.4
Bielawski, J.5
Obeid, L.M.6
Ogretmen, B.7
-
158
-
-
58449109188
-
In vitro anti-leukaemia activity of sphingosine kinase inhibitor
-
Ricci, C.; Onida, F.; Servida, F.; Radaelli, F.; Saporiti, G.; Todoerti, K.; Deliliers, G. L.; Ghidoni, R. In vitro anti-leukaemia activity of sphingosine kinase inhibitor. Br. J. Haematol., 2009, 144 (3), 350-357.
-
(2009)
Br. J. Haematol
, vol.144
, Issue.3
, pp. 350-357
-
-
Ricci, C.1
Onida, F.2
Servida, F.3
Radaelli, F.4
Saporiti, G.5
Todoerti, K.6
Deliliers, G.L.7
Ghidoni, R.8
-
159
-
-
0035888295
-
-
Morjani, H.; Aouali, N.; Belhoussine, R.; Veldman, R. J.; Levade, T.; Manfait, M. Elevation of glucosylceramide in multidrugresistant cancer cells and accumulation in cytoplasmic droplets. Int. J. Cancer, 2001, 94 (2), 157-165.
-
(2001)
Elevation of Glucosylceramide In Multidrugresistant Cancer Cells and Accumulation In Cytoplasmic Droplets
, vol.94
, Issue.2
, pp. 157-165
-
-
Morjani, H.1
Aouali, N.2
Belhoussine, R.3
Veldman, R.J.4
Levade, T.5
Manfait, M.6
-
160
-
-
0035066434
-
Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia
-
Ferrao, P.; Sincock, P.; Cole, S.; Ashman, L. Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia. Leuk. Res., 2001, 25 (5), 395-405.
-
(2001)
Leuk. Res
, vol.25
, Issue.5
, pp. 395-405
-
-
Ferrao, P.1
Sincock, P.2
Cole, S.3
Ashman, L.4
-
161
-
-
0028590133
-
P-glycoprotein expression in the Golgi apparatus of multidrugresistant cells
-
Molinari, A.; Cianfriglia, M.; Meschini, S.; Calcabrini, A.; Arancia, G. P-glycoprotein expression in the Golgi apparatus of multidrugresistant cells. Int. J. Cancer., 1994, 59 (6), 789-795.
-
(1994)
Int. J. Cancer
, vol.59
, Issue.6
, pp. 789-795
-
-
Molinari, A.1
Cianfriglia, M.2
Meschini, S.3
Calcabrini, A.4
Arancia, G.5
-
162
-
-
33644830452
-
Mitochondrial localization and activity of P-glycoprotein in doxorubicin-resistant K562 cells
-
Munteanu, E.; Verdier, M.; Grandjean-Forestier, F.; Stenger, C.; Jayat-Vignoles, C.; Huet, S.; Robert, J.; Ratinaud, M. H. Mitochondrial localization and activity of P-glycoprotein in doxorubicin-resistant K562 cells. Biochem. Pharmacol., 2006, 71 (8), 1162-1174.
-
(2006)
Biochem. Pharmacol
, vol.71
, Issue.8
, pp. 1162-1174
-
-
Munteanu, E.1
Verdier, M.2
Grandjean-Forestier, F.3
Stenger, C.4
Jayat-Vignoles, C.5
Huet, S.6
Robert, J.7
Ratinaud, M.H.8
-
163
-
-
78649955814
-
Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity
-
Chapman, J. V.; Gouaze-Andersson, V.; Cabot, M. C. Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity. Int. J. Oncol., 2010, 37 (6), 1591-1597.
-
(2010)
Int. J. Oncol
, vol.37
, Issue.6
, pp. 1591-1597
-
-
Chapman, J.V.1
Gouaze-Andersson, V.2
Cabot, M.C.3
-
164
-
-
35348991132
-
Pre-and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
-
Halter, D.; Neumann, S.; van Dijk, S. M.; Wolthoorn, J.; de Maziere, A. M.; Vieira, O. V.; Mattjus, P.; Klumperman, J.; van Meer, G.; Sprong, H. Pre-and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis. J. Cell. Biol., 2007, 179 (1), 101-115.
-
(2007)
J. Cell. Biol
, vol.179
, Issue.1
, pp. 101-115
-
-
Halter, D.1
Neumann, S.2
van Dijk, S.M.3
Wolthoorn, J.4
de Maziere, A.M.5
Vieira, O.V.6
Mattjus, P.7
Klumperman, J.8
van Meer, G.9
Sprong, H.10
-
165
-
-
6444244528
-
Subcellular detection and localization of the drug transporter Pglycoprotein in cultured tumor cells
-
Molinari, A.; Calcabrini, A.; Meschini, S.; Stringaro, A.; Crateri, P.; Toccacieli, L.; Marra, M.; Colone, M.; Cianfriglia, M.; Arancia, G. Subcellular detection and localization of the drug transporter Pglycoprotein in cultured tumor cells. Curr. Protein Pept. Sci., 2002, 3 (6), 653-670.
-
(2002)
Curr. Protein Pept. Sci
, vol.3
, Issue.6
, pp. 653-670
-
-
Molinari, A.1
Calcabrini, A.2
Meschini, S.3
Stringaro, A.4
Crateri, P.5
Toccacieli, L.6
Marra, M.7
Colone, M.8
Cianfriglia, M.9
Arancia, G.10
-
166
-
-
80054059363
-
The effect of Pglycoprotein antagonists on short-chain ceramide cytotoxicity in cancer cells
-
Cabot, M. C.; Karimi, R.; Chapman, J. V.; Kester, M.; Shanmugavelandy, S.; Rosenberg, D. W.; Madigan, J. The effect of Pglycoprotein antagonists on short-chain ceramide cytotoxicity in cancer cells. Faseb J., 2011, 25, 739.5.
-
(2011)
Faseb J
, vol.25
, Issue.739
, pp. 5
-
-
Cabot, M.C.1
Karimi, R.2
Chapman, J.V.3
Kester, M.4
Shanmugavelandy, S.5
Rosenberg, D.W.6
Madigan, J.7
-
167
-
-
79958838496
-
P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells
-
Chapman, J. V.; Gouaze-Andersson, V.; Karimi, R.; Messner, M. C.; Cabot, M. C. P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells. Exp. Cell Res., 2011, 317 (12), 1736-1745.
-
(2011)
Exp. Cell Res
, vol.317
, Issue.12
, pp. 1736-1745
-
-
Chapman, J.V.1
Gouaze-Andersson, V.2
Karimi, R.3
Messner, M.C.4
Cabot, M.C.5
-
168
-
-
0036045129
-
P-glycoprotein modulates ceramidemediated sensitivity of human breast cancer cells to tubulin-binding anticancer drugs
-
Shabbits, J. A.; Mayer, L. D. P-glycoprotein modulates ceramidemediated sensitivity of human breast cancer cells to tubulin-binding anticancer drugs. Mol. Cancer Ther., 2002, 1 (3), 205-213.
-
(2002)
Mol. Cancer Ther
, vol.1
, Issue.3
, pp. 205-213
-
-
Shabbits, J.A.1
Mayer, L.D.2
-
169
-
-
12344336357
-
Pglycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway
-
Turzanski, J.; Grundy, M.; Shang, S.; Russell, N.; Pallis, M. Pglycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. Exp. Hematol., 2005, 33 (1), 62-72.
-
(2005)
Exp. Hematol
, vol.33
, Issue.1
, pp. 62-72
-
-
Turzanski, J.1
Grundy, M.2
Shang, S.3
Russell, N.4
Pallis, M.5
-
170
-
-
0031899553
-
Glucosylceramide: A marker for multiple-drug resistant cancers
-
Lucci, A.; Cho, W. I.; Han, T. Y.; Giuliano, A. E.; Morton, D. L.; Cabot, M. C. Glucosylceramide: a marker for multiple-drug resistant cancers. Anticancer Res., 1998, 18 (1B), 475-480.
-
(1998)
Anticancer Res
, vol.18
, Issue.1 B
, pp. 475-480
-
-
Lucci, A.1
Cho, W.I.2
Han, T.Y.3
Giuliano, A.E.4
Morton, D.L.5
Cabot, M.C.6
-
171
-
-
0033194699
-
Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics
-
Lucci, A.; Han, T. Y.; Liu, Y. Y.; Giuliano, A. E.; Cabot, M. C. Modification of ceramide metabolism increases cancer cell sensitivity to cytotoxics. Int. J. Oncol., 1999, 15 (3), 541-546.
-
(1999)
Int. J. Oncol
, vol.15
, Issue.3
, pp. 541-546
-
-
Lucci, A.1
Han, T.Y.2
Liu, Y.Y.3
Giuliano, A.E.4
Cabot, M.C.5
-
172
-
-
0031019309
-
Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
-
Lavie, Y.; Cao, H.; Volner, A.; Lucci, A.; Han, T. Y.; Geffen, V.; Giuliano, A. E.; Cabot, M. C. Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells. J. Biol. Chem., 1997, 272 (3), 1682-1687.
-
(1997)
J. Biol. Chem
, vol.272
, Issue.3
, pp. 1682-1687
-
-
Lavie, Y.1
Cao, H.2
Volner, A.3
Lucci, A.4
Han, T.Y.5
Geffen, V.6
Giuliano, A.E.7
Cabot, M.C.8
-
173
-
-
46749095012
-
A role for ceramide in driving cancer cell resistance to doxorubicin
-
Liu, Y. Y.; Yu, J. Y.; Yin, D.; Patwardhan, G. A.; Gupta, V.; Hirabayashi, Y.; Holleran, W. M.; Giuliano, A. E.; Jazwinski, S. M.; Gouaze-Andersson, V.; Consoli, D. P.; Cabot, M. C. A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J., 2008, 22 (7), 2541-2551.
-
(2008)
FASEB J
, vol.22
, Issue.7
, pp. 2541-2551
-
-
Liu, Y.Y.1
Yu, J.Y.2
Yin, D.3
Patwardhan, G.A.4
Gupta, V.5
Hirabayashi, Y.6
Holleran, W.M.7
Giuliano, A.E.8
Jazwinski, S.M.9
Gouaze-Andersson, V.10
Consoli, D.P.11
Cabot, M.C.12
-
174
-
-
0035032521
-
Taxol-induced ceramide generation and apoptosis in human breast cancer cells. Cancer Chemother
-
Charles, A. G.; Han, T. Y.; Liu, Y. Y.; Hansen, N.; Giuliano, A. E.; Cabot, M. C. Taxol-induced ceramide generation and apoptosis in human breast cancer cells. Cancer Chemother. Pharmacol., 2001, 47 (5), 444-450.
-
(2001)
Pharmacol
, vol.47
, Issue.5
, pp. 444-450
-
-
Charles, A.G.1
Han, T.Y.2
Liu, Y.Y.3
Hansen, N.4
Giuliano, A.E.5
Cabot, M.C.6
-
175
-
-
79952028218
-
The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function
-
Chai, L.; McLaren, R. P.; Byrne, A.; Chuang, W. L.; Huang, Y.; Dufault, M. R.; Pacheco, J.; Madhiwalla, S.; Zhang, X.; Zhang, M.; Teicher, B. A.; Carter, K.; Cheng, S. H.; Leonard, J. P.; Xiang, Y.; Vasconcelles, M.; Goldberg, M. A.; Copeland, D. P.; Klinger, K. W.; Lillie, J.; Madden, S. L.; Jiang, Y. A. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int. J. Oncol., 2011, 38 (3), 701-711.
-
(2011)
Int. J. Oncol
, vol.38
, Issue.3
, pp. 701-711
-
-
Chai, L.1
McLaren, R.P.2
Byrne, A.3
Chuang, W.L.4
Huang, Y.5
Dufault, M.R.6
Pacheco, J.7
Madhiwalla, S.8
Zhang, X.9
Zhang, M.10
Teicher, B.A.11
Carter, K.12
Cheng, S.H.13
Leonard, J.P.14
Xiang, Y.15
Vasconcelles, M.16
Goldberg, M.A.17
Copeland, D.P.18
Klinger, K.W.19
Lillie, J.20
Madden, S.L.21
Jiang, Y.A.22
more..
-
176
-
-
0035181465
-
Mechanisms of tamoxifen-induced apoptosis
-
Mandlekar, S.; Kong, A. N. Mechanisms of tamoxifen-induced apoptosis. Apoptosis, 2001, 6 (6), 469-477.
-
(2001)
Apoptosis
, vol.6
, Issue.6
, pp. 469-477
-
-
Mandlekar, S.1
Kong, A.N.2
-
177
-
-
0032499771
-
The drug efflux protein, P-glycoprotein, additionally protects drugresistant tumor cells from multiple forms of caspase-dependent apoptosis
-
Smyth, M. J.; Krasovskis, E.; Sutton, V. R.; Johnstone, R. W. The drug efflux protein, P-glycoprotein, additionally protects drugresistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc. Natl. Acad. Sci. U.S.A., 1998, 95 (12), 7024-7029.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A
, vol.95
, Issue.12
, pp. 7024-7029
-
-
Smyth, M.J.1
Krasovskis, E.2
Sutton, V.R.3
Johnstone, R.W.4
-
178
-
-
0032950954
-
P-glycoprotein protects leukemia cells against caspase-dependent, but not caspaseindependent, cell death
-
Johnstone, R. W.; Cretney, E.; Smyth, M. J. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspaseindependent, cell death. Blood, 1999, 93 (3), 1075-1085.
-
(1999)
Blood
, vol.93
, Issue.3
, pp. 1075-1085
-
-
Johnstone, R.W.1
Cretney, E.2
Smyth, M.J.3
-
179
-
-
0031964966
-
Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833
-
Bezombes, C.; Maestre, N.; Laurent, G.; Levade, T.; Bettaieb, A.; Jaffrezou, J. P. Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833. Faseb J., 1998, 12 (1), 101-109.
-
(1998)
Faseb J
, vol.12
, Issue.1
, pp. 101-109
-
-
Bezombes, C.1
Maestre, N.2
Laurent, G.3
Levade, T.4
Bettaieb, A.5
Jaffrezou, J.P.6
-
180
-
-
0036073348
-
Influence of ceramide metabolism on Pglycoprotein function in immature acute myeloid leukemia KG1a cells
-
Plo, I.; Lehne, G.; Beckstrom, K. J.; Maestre, N.; Bettaieb, A.; Laurent, G.; Lautier, D. Influence of ceramide metabolism on Pglycoprotein function in immature acute myeloid leukemia KG1a cells. Mo.l Pharmacol., 2002, 62 (2), 304-312.
-
(2002)
Mo.l Pharmacol
, vol.62
, Issue.2
, pp. 304-312
-
-
Plo, I.1
Lehne, G.2
Beckstrom, K.J.3
Maestre, N.4
Bettaieb, A.5
Laurent, G.6
Lautier, D.7
-
181
-
-
77953294709
-
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling
-
Liu, Y. Y.; Gupta, V.; Patwardhan, G. A.; Bhinge, K.; Zhao, Y.; Bao, J.; Mehendale, H.; Cabot, M. C.; Li, Y. T.; Jazwinski, S. M. Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol. Cancer, 2010, 9, 145.
-
(2010)
Mol. Cancer
, vol.9
, pp. 145
-
-
Liu, Y.Y.1
Gupta, V.2
Patwardhan, G.A.3
Bhinge, K.4
Zhao, Y.5
Bao, J.6
Mehendale, H.7
Cabot, M.C.8
Li, Y.T.9
Jazwinski, S.M.10
-
182
-
-
47949121835
-
Rapid distribution of liposomal shortchain ceramide in vitro and in vivo. Drug Metab
-
Zolnik, B. S.; Stern, S. T.; Kaiser, J. M.; Heakal, Y.; Clogston, J. D.; Kester, M.; McNeil, S. E. Rapid distribution of liposomal shortchain ceramide in vitro and in vivo. Drug Metab. Dispos., 2008, 36 (8), 1709-1715.
-
(2008)
Dispos
, vol.36
, Issue.8
, pp. 1709-1715
-
-
Zolnik, B.S.1
Stern, S.T.2
Kaiser, J.M.3
Heakal, Y.4
Clogston, J.D.5
Kester, M.6
McNeil, S.E.7
-
183
-
-
78549233741
-
Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
-
Liu, X.; Ryland, L.; Yang, J.; Liao, A.; Aliaga, C.; Watts, R.; Tan, S. F.; Kaiser, J.; Shanmugavelandy, S. S.; Rogers, A.; Loughran, K.; Petersen, B.; Yuen, J.; Meng, F.; Baab, K. T.; Jarbadan, N. R.; Broeg, K.; Zhang, R.; Liao, J.; Sayers, T. J.; Kester, M.; Loughran, T. P., Jr. Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. Blood, 2010, 116 (20), 4192-4201.
-
(2010)
Blood
, vol.116
, Issue.20
, pp. 4192-4201
-
-
Liu, X.1
Ryland, L.2
Yang, J.3
Liao, A.4
Aliaga, C.5
Watts, R.6
Tan, S.F.7
Kaiser, J.8
Shanmugavelandy, S.S.9
Rogers, A.10
Loughran, K.11
Petersen, B.12
Yuen, J.13
Meng, F.14
Baab, K.T.15
Jarbadan, N.R.16
Broeg, K.17
Zhang, R.18
Liao, J.19
Sayers, T.J.20
Kester, M.21
Loughran Jr., T.P.22
more..
|