Retinol-binding protein 4 correlates with triglycerides but not insulin resistance in prepubertal children with and without premature adrenarche

Journal of Pediatric Endocrinology and Metabolism

Volumn 24, Issue 9-10, 2011, Pages 683-687

  Sopher, Aviva B ^a   Gerken, Adrienne T ^a   Lee, Eun Ju ^a   Blaner, William E ^a   Deeds, Stefanie ^a   Gallagher, Dympna ^a   Shungu, Dikoma C ^b   Mao, Xiangling ^b   Hassoun, Abeer ^a   McMahon, Donald J ^a   Oberfield, Sharon E ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Insulin resistance; Premature adrenarche; Premature pubarche; Retinol binding protein 4

Indexed keywords

ANDROSTENEDIONE; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PRASTERONE SULFATE; RETINOL BINDING PROTEIN 4; TESTOSTERONE; TRIACYLGLYCEROL;

AMBULATORY CARE; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; BODY COMPOSITION; BODY MASS; CHILD; CHILDHOOD DISEASE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOPROTEIN BLOOD LEVEL; MALE; METABOLIC DISORDER; ORAL GLUCOSE TOLERANCE TEST; PRECOCIOUS PUBERTY; PREMATURE ADRENARCHE; PREPUBERTY; PRESCHOOL CHILD; RISK ASSESSMENT; SCHOOL CHILD; TESTOSTERONE BLOOD LEVEL;

ADRENARCHE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; HORMONES; HUMANS; INSULIN RESISTANCE; MALE; MORBIDITY; PUBERTY; PUBERTY, PRECOCIOUS; RETINOL-BINDING PROTEINS, PLASMA; RISK FACTORS; TRIGLYCERIDES;

EID: 80054071365     PISSN: 0334018X     EISSN: 21910251     Source Type: Journal    
DOI: 10.1515/JPEM.2011.322     Document Type: Article

References (25)

1. Korth-Schutz A, Levine LS, New MI. Evidence for the adrenal source of androgens in precocious adenarche. Acta Endocrinol (Copenh) 1976;82:242-52.
2. Diaz A, Bhandari S, Sison C, Vogiatzi M. Characteristics of children with premature pubarche in the New York metropolitan area. Horm Res 2008;70:150-4.
3. Utriainen P, Jääskeläinen J, Romppanen J, Voutilainen R. Childhood metabolic syndrome and its components in premature adrenarche. J Clin Endocrinol Metab 2007;92:4282-5. (Pubitemid 350074744)
4. Ibáñez L, Potau N, Verdis R, Zampolli M, Terzi C, et al. Post pubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. J Clin Endocrinol Metab 1993;76:1599-1603. (Pubitemid 23164385)
5. Tamori Y, Sakaue H, Kasuga M. RBP4, an unexpected adipokine. Nature Medicine 2006;12:30-1. (Pubitemid 43050050)
6. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, et al. Serum retinol-binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356-62. (Pubitemid 41065039)
7. Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastoenterology 2008;134:1369-75. (Pubitemid 351615354)
8. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, et al. Retinol-binding protein 4 and insulin resistance in lean, obese and diabetic subjects. N Engl J Med 2006;354:2552-63. (Pubitemid 43882351)
9. Stefan N, Hennige AM, Staiger H, Machann J, Schick F, et al. High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care 2007;30:1173-8. (Pubitemid 46684644)
10. Broch M, Gómez JM, Auguet MT, Vilarrasa N, Pastor R, et al. Association of retinol-binding protein-4 (RBP4) with lipid parameters in obese women. Obes Surg 2010;20:1258-64.
11. Lee D, Lee J, Im JA. Association of serum retinol binding protein 4 and insulin resistance in apparently healthy adolescents. Metabolism 2007;56:327-31. (Pubitemid 46209223)
12. Aeberli I, Biebenger R, Lehmann R, L'Allemand D, Spinas GA, et al. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab 2007;92:4359-65. (Pubitemid 350074757)
13. Chan T, Tsai Y, Chiu P, Chen Y, Lee C, et al. Serum retinolbinding protein 4 levels in nonobese women with polycystic ovary syndrome. Fertil Steril 2010;93:869-73.
14. Yildiz BO, Bozdag G, Otegan U, Harmanci A, Boynukalin K, et al. Visfatin and retinol-binding protein 4 concentrations in lean, glucose-tolerant women with PCOS. Reprod BioMed Online 2010;20:150-5.
15. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, et al. CDC growth charts: United States. Adv Data 2000;314:1-27.
16. Silfen ME, Manibo AM, McMahon DJ, Levine LS, Murphy AR, et al. Comparison of simple measures of insulin sensitivity in young girls with premature adrenarche: the fasting glucose to insulin ratio may be a simple and useful measure. J Clin Endocrinol Metab 2001;86:2863-8. (Pubitemid 32545753)
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9. (Pubitemid 15018832)
18. Avignon A, Boegner C, Mariano-Goulart D, Colette C, Monnier L. Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state. Int J Obes Relat Metab Disord 1999;23:512-7. (Pubitemid 29237734)
19. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-70. (Pubitemid 29418240)
20. Le Floch JP, Escuyer P, Baudin E, Baudon D, Perlemuter L. Blood glucose area under the curve. Methodological aspects. Diabetes Care 1990;13:172-5. (Pubitemid 20056207)
21. Goodman E, Graham TE, Dolan LM, Daniels SR, Goodman ER, et al. The relationship of retinol binding protein 4 to changes in insulin resistance and cardiometabolic risk in overweight black adolescents. J Pediatr 2009;154:67-73. e1.
22. Yeste D, Vendrell J, Tomasini R, Gallart LL, Clemente M, et al. Retinol-binding protein 4 levels in obese children and adolescents with glucose intolerance. Horm Res Paediatr 2010;73:335-40.
23. Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care 2007;30:89-94. (Pubitemid 46052504)
24. Kanaka-Gantenbein C, Margeli A, Pervanidou P, Sakka S, Mastorakos G, et al. Retinol binding protein-4 and lipocalin-2 in childhood and adolescent obesity: when children are not just "small adults." Clin Chem 2008;54:1176-82. (Pubitemid 352009694)
25. Baglopal P, Graham TE, Kahn BB, Altomare A, Funanage V, et al. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab 2007;92:1971-4. (Pubitemid 46997219)