Effects of cell spatial organization and size distribution on ultrasound backscattering

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

Volumn 58, Issue 10, 2011, Pages 2118-2131

  Saha, Ratan K ^a   Kolios, Michael C ^a  

^a RYERSON UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACKSCATTER SIGNALS; CELL AGGREGATES; CELL MICROSTRUCTURES; CELLULAR AGGREGATES; CENTER FREQUENCY; ENVELOPE STATISTICS; FLUID SPHERES; GAUSSIAN PULSE; INCIDENT BEAMS; INTEGRATED BACKSCATTERING; MONTE CARLO ALGORITHMS; NAKAGAMI DISTRIBUTION; RANDOM DISTRIBUTION; RAYLEIGH DISTRIBUTIONS; SCATTERING AMPLITUDES; SPATIAL ORGANIZATION; ULTRASOUND BACKSCATTER; ULTRASOUND BACKSCATTERING; ULTRASOUND PULSE; ULTRASOUND TISSUE CHARACTERIZATION; ULTRASOUND WAVES;

ACOUSTIC WAVE BACKSCATTERING; BANDWIDTH; COMPUTER SIMULATION; CYTOLOGY; GAUSSIAN BEAMS; GRAPHIC METHODS; SCATTERING; SIZE DISTRIBUTION; SPHERES; STATISTICAL METHODS; TISSUE;

ULTRASONICS;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; CELL AGGREGATION; CELL NUCLEUS; CELL SIZE; CELLS; COMPUTER SIMULATION; CYTOLOGY; ECHOGRAPHY; ERYTHROCYTE; MONTE CARLO METHOD; NEOPLASM; PATHOLOGY; RADIATION SCATTERING; SIGNAL NOISE RATIO; SIGNAL PROCESSING;

ALGORITHMS; CELL AGGREGATION; CELL NUCLEUS; CELL SIZE; CELLS; COMPUTER SIMULATION; ERYTHROCYTES; MODELS, BIOLOGICAL; MONTE CARLO METHOD; NEOPLASMS; SCATTERING, RADIATION; SIGNAL PROCESSING, COMPUTER-ASSISTED; SIGNAL-TO-NOISE RATIO; ULTRASONOGRAPHY;

EID: 80054065112     PISSN: 08853010     EISSN: None     Source Type: Journal    
DOI: 10.1109/TUFFC.2011.2061     Document Type: Article

References (37)

1. M. C. Kolios, G. J. Czarnota, M. Lee, J. W. Hunt, and M. D. Sherar, "Ultrasonic spectral parameter characterization of apoptosis," Ultrasound Med. Biol., vol. 28, no. 5, pp. 589-597, 2002.
2. R. M. Vlad, N. M. Alajez, A. Giles, M. C. Kolios, and G. J. Czarnota, "Quantative ultrasound characterization of cancer radiotherapy effects in vitro," Int. J. Radiat. Oncol. Biol. Phys., vol. 72, no. 4, pp. 1236-1243, 2008.
3. A. S. Tunis, G. J. Czarnota, A. Giles, M. D. Sherar, J. W. Hunt, and M. C. Kolios, "Monitoring structural changes in cells with high frequency ultrasound signal statistics," Ultrasound Med. Biol., vol. 31, no. 8, pp. 1041-1049, 2005.
4. G. J. Czarnota, M. C. Kolios, J. Abraham, M. Portnoy, F. P. Ottensmeyer, J. W. Hunt, and M. D. Sherar, "Ultrasonic imaging of apoptosis: High-resolution non-invasive imaging of programmed cell death in vitro, in situ and in vivo," Br. J. Cancer, vol. 81, no. 3, pp. 520-527, 1999.
5. G. J. Czarnota, M. C. Kolios, H. Vaziri, S. Benchimol, F. P. Ottensmeyer, M. D. Sherar, and J. W. Hunt, "Ultrasonic imaging of viable, dead and apoptotic cells," Ultrasound Med. Biol., vol. 23, no. 6, pp. 961-965, 1997.
6. F. G. Blankenberg, "In vivo detection of apoptosis," J. Nucl. Med., vol. 49, suppl. 2, pp. 81S-95S, 2008.
7. F. L. Lizzi, M. Greenbaum, E. J. Feleppa, M. Elbaum, and D. J. Coleman, "Theoretical framework for spectrum analysis in ultrasonic tissue characterization," J. Acoust. Soc. Am., vol. 73, no. 4, pp. 1366-1373, 1983.
8. M. L. Oelze, W. D. O'Brien Jr., J. P. Blue, and J. F. Zachary, "Differentiation and characterization of rat mammary fibroadenomas and 4T1 mouse carcinomas using quantitative ultrasound imaging," IEEE Trans. Med. Imaging, vol. 23, no. 6, pp. 764-771, 2004.
9. M. F. Insana, R. F. Wagner, D. G. Brown, and T. J. Hall, "Describing small-scale structure in random media using pulse-echo ultrasound," J. Acoust. Soc. Am., vol. 87, no. 1, pp. 179-192, 1990.
10. M. L. Oelze and J. F. Zachary, "Examination of cancer in mouse models using high-frequency quantitative ultrasound," Ultrasound Med. Biol., vol. 32, no. 11, pp. 1639-1648, 2006.
11. J. W. Hunt, A. E. Worthington, and A. T. Kerr, "The subtleties of ultrasound images of an ensemble of cells: Simulation from regular and more random distributions of scatterers," Ultrasound Med. Biol., vol. 21, no. 3, pp. 329-341, 1995.
12. J. W. Hunt, A. E. Worthington, A. Xuan, M. C. Kolios, G. J. Czarnota, and M. D. Sherar, "A model based upon pseudo regular spacing of cells combined with the randomisation of the nuclei can explain the significant changes in high-frequency ultrasound signals during apoptosis," Ultrasound Med. Biol., vol. 28, no. 2, pp. 217-226, 2002.
13. K. K. Shung and G. A. Thieme, Ultrasound Scattering in Biological Tissues. Boca Raton, FL: CRC Press, 1993.
14. D. Savéry and G. Cloutier, "Effect of red cell clustering and anisotropy on ultrasound blood backscatter: A Monte Carlo study," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 52, no. 1, pp. 94-103, 2005.
15. F. T. H. Yu and G. Cloutier, "Experimental ultrasound characterization of red blood cell aggregation using the structure factor size estimator (SFSE)," J. Acoust. Soc. Am., vol. 122, no. 1, pp. 645-656, 2007.
16. R. K. Saha and G. Cloutier, "Monte Carlo study on ultrasound backscattering by three-dimensional distributions of red blood cells," Phys. Rev. E, vol. 78, no. 6, art. no. 061919, 2008.
17. R. M. Vlad, R. K. Saha, N. M. Alajez, S. Ranieri, G. J. Czarnota, and M. C. Kolios, "An increase in cellular size variance contributes to the increase in ultrasound backscatter during cell death," Ultrasound Med. Biol., vol. 36, no. 9, pp. 1546-1558, 2010.
18. P. M. Shankar, "A general statistical model for ultrasonic backscattering from tissues," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 47, no. 3, pp. 727-736, 2000.
19. B. I. Raju and M. A. Srinivasan, "Statistics of envelope of highfrequency ultrasonic backscatter from human skin in vivo," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 49, no. 7, pp. 871-882, 2002.
20. F. Destrempes and G. Cloutier, "A critical review and uniformized representation of statistical distributions modeling the ultrasound echo envelope," Ultrasound Med. Biol., vol. 36, no. 7, pp. 1037-1051, 2010.
21. P. M. Morse and K. U. Ingard, Theoretical Acoustics. New York, NY: McGraw-Hill, 1968, ch. 8.
22. V. Twersky, "Low-frequency scattering by correlated distributions of randomly oriented particles," J. Acoust. Soc. Am., vol. 81, no. 5, pp. 1609-1618, 1987.
23. K. K. Shung, Y. W. Yuan, D. Y. Fei, and J. M. Tarbell, "Effect of flow disturbance on ultrasonic backscatter from blood," J. Acoust. Soc. Am., vol. 75, no. 4, pp. 1265-1272, 1984.
24. G. E. Sleefe and P. P. Lele, "Tissue characterization based on scatterer number density estimation," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 35, no. 6, pp. 749-757, 1988.
25. V. Dutt and J. F. Greenleaf, "Ultrasound echo envelope analysis using a homodyned K distribution signal model," Ultrason. Imaging, vol. 16, no. 4, pp. 265-287, 1994.
26. R. K. Saha and S. K. Sharma, "Validity of a modified Born approximation for a pulsed plane wave in acoustic scattering problems," Phys. Med. Biol., vol. 50, no. 12, pp. 2823-2836, 2005.
27. P. M. Shankar, "Ultrasonic tissue characterization using a generalized Nakagami model," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 48, no. 6, pp. 1716-1720, 2001.
28. D. P. Hruska and M. L. Oelze, "Improved parameter estimates based on the homodyned K distibution," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 56, no. 11, pp. 2471-2481, 2009.
29. R. C. Waag, J. O. Nilsson, and J. P. Astheimer, "Characterization of volume scattering power spectra in isotropic media from power spectra of scattering by planes," J. Acoust. Soc. Am., vol. 74, no. 5, pp. 1555-1571, 1983.
30. L. R. Taggart, R. E. Baddour, A. Giles, G. J. Czarnota, and M. C. Kolios, "Ultrasonic characterization of whole cells and isolated nuclei," Ultrasound Med. Biol., vol. 33, no. 3, pp. 389-401, 2007.
31. E. L. Hinrichsen, J. Feder, and T. Jøssang, "Random packing of disks in two dimensions," Phys. Rev. A, vol. 41, no. 8, pp. 4199-4209, 1990.
32. R. E. Baddour and M. C. Kolios, "The fluid and elastic nature of nucleated cells: Implications from the cellular backscatter response," J. Acoust. Soc. Am., vol. 121, no. 1, pp. EL16-EL22, 2007.
33. O. Falou, M. Rui, A. E. Kaffas, J. C. Kumaradas, and M. C. Kolios, "The measurement of ultrasound scattering from individual micronsized objects and its application in single cell scattering," J. Acoust. Soc. Am., vol. 128, no. 2, pp. 894-902, 2010.
34. E. L. Hinrichsen, J. Feder, and T. Jøssang, "Geometry of random sequential adsorption," J. Stat. Phys., vol. 44, no. 5-6, pp. 793-827, 1986.
35. M. I. Daoud and J. C. Lacefield, "Stochastic modeling of normal and tumor tissue microstructure for high-frequency ultrasound imaging simulations," IEEE Trans. Biomed. Eng., vol. 56, no. 12, pp. 2806-2815, 2009.
36. T. Aste, "Circle, sphere, and drop packing," Phys. Rev. E, vol. 53, no. 3, pp. 2571-2579, 1996.
37. O lympus NDT Inc., (2009, Dec. 21) Panametrics Ultrasound Transducers: Wedges, Cables, Test Blocks. [Online]. Available: http:// www.olympus-ims.com/ data/File/panametrics/panametrics-UT. en.pdf