First trimester pregnancy decidual natural killer cells contain and spontaneously release high quantities of granulysin

American Journal of Reproductive Immunology

Volumn 66, Issue 5, 2011, Pages 363-372

  Vujaklija, Danijela Veljkovic ^a,d   Gulic, Tamara ^a   Sucic, Sonja ^a,e   Nagata, Kinya ^b   Ogawa, Kazuyuki ^b   Laskarin, Gordana ^a   Saito, Shigeru ^c   Haller, Herman ^d   Rukavina, Daniel ^a  

^a UNIVERSITY OF RIJEKA   (Croatia)

^b BML   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

^d KBC RIJEKA   (Croatia)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Decidua; First trimester pregnancy; Granulysin; Natural killer cells; T lymphocytes

Indexed keywords

GRANULYSIN;

ADULT; ARTICLE; BLOOD; CELL CULTURE; CELL ISOLATION; CELL PERMEABILIZATION; CONTROLLED STUDY; DECIDUA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIRST TRIMESTER PREGNANCY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T LYMPHOCYTE;

ADULT; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD56; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; DECIDUA; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; PREGNANCY; PREGNANCY TRIMESTER, FIRST; T-LYMPHOCYTES; YOUNG ADULT;

EID: 80054013029     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2011.01015.x     Document Type: Article

References (25)

1. ++ population. Dev Immunol 1991; 1:169-190.
2. Rukavina D, Rubesa G, Gudelj L, Haller H, Podack ER: Characteristics of perforin expressing lymphocytes within the first trimester decidua of human pregnancy. Am J Reprod Immunol 1995; 33:394-404.
3. Bogovic Crncic T, Laskarin G, Juretic K, Strbo N, Dupor J, Srsen S, Randic L, Le Bouteiller P, Tabiasco J, Rukavina D: Perforin and Fas/FasL cytolytic pathways at the maternal-fetal interface. Am J Reprod Immunol 2005; 54:241-248.
4. Pena SV, Hanson DA, Carr BA, Goralski TJ, Krensky AM: Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins. J Immunol 1997; 158:2680-2688.
5. Manning WC, O'Farrell S, Goralski TJ, Krensky AM: Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation. J Immunol 1992; 148:4036-4042.
6. Hanson DA, Kaspar AA, Poulain FR, Krensky AM: Byosinthesis of granulysin, a novel cytolytic molecule. Mol Immunol 1999; 36:413-422.
7. Chung WH, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, Ho HC, Yang CH, Lu CF, Wu JY, Liao YD, Chen YT: Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 2008; 14:1343-1350.
8. Huang LP, Lyu SC, Clayberger C, Krensky AM: Granulysin-mediated tumor rejection in transgenic mice. J Immunol 2007; 178:77-84.
9. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL: An antimicrobial activity of cytolityc T cells mediated by granulysin. Science 1998; 282:121-125.
10. Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL: Granulysin, a T cell product, kills bacteria by altering membrane permeabilitiy. J Immunol 2000; 65:7102-7108.
11. Deng A, Chen S, Li Q, Lyu S-C, Clayberger C, Krensky AM: Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammaotry activator. J Immunol 2005; 174:5243-5248.
12. Tewary P, Yang D, de la Rosa G, Li Y, Finn MW, Krensky AM, Clayberger C, Oppenheim JJ: Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin. Blood 2010; 116:3465-3474.
13. Fleming DC, King AE, Williams AEW, Critchley HO, Kelly RW: Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium. Fertil Steril 2003; 79:856-863.
14. Winn VD, Haimov-Kochman R, Paquet AC, Yang YJ, Madhusudhan MS, Gormley M, Feng KT, Bernlohr DA, McDonagh S, Pereira L, Sali A, Fisher SJ: Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology 2007; 148:1059-1079.
15. Laskarin G, Redzovic A, Vukelic P, Veljkovic D, Gulic T, Haller H, Rukavina D: Phenotype of NK cells and cytotoxic/apoptotic mediators expression in ectopic pregnancy. Am J Reprod Immunol 2010; 64:347-358.
16. Laskarin G, Redzovic A, Rubesa Z, Mantovani A, Allavena P, Haller H, Vlastelic I, Rukavina D: Decidual natural killer cell tuning by autologous dendritic cells. Am J Reprod Immunol 2008; 59:433-445.
17. Ogawa K, Takamori Y, Suzuki K, Nagasawa M, Takano S, Kasahara Y, Nakamura Y, Kondo S, Sugamura K, Nakamura M, Nagata K: Granulysin in human serum as a marker of cell-mediated immunitiy. Eur J Immunol 2003; 33:1925-1933.
18. Nakashima A, Shiozaki A, Myojo S, Ito M, Tatematsu M, Sakai M, Takamori Y, Ogawa K, Nagata K, Saito S: Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion. Am J Pathol 2008; 173:653-664.
19. Sotosek V, Laskarin G, Strbo N, Dohr G, Blaschitz A, Podack ER, Rukavina D: Decidual macrophages are the population of decidual adherent cells which regulates perforin expression in cytolytic cells. Am J Reprod Immunol 1999; 42:76-82.
20. Strbo N, Laskarin G, Sotosek V, Randić LJ, Podack ER, Rukavina D: Modulation of perforin expression in the decidual and peripheral blood cytotoxic lymphocytes in culture. Am J Reprod Immunol 1999; 42:14-21.
21. Sakai M, Ogawa K, Shiozaki A, Yoneda S, Sasaki Y, Nagata K, Saito S: Serum granulysin is a marker for Th1 type immunity in pre-eclampsia. Clin Exp Immunol 2004; 136:114-119.
22. Larsen B, Hwang J: Mycoplasma, ureaplasma, and adverse pregnancy outcomes: a fresh look. Infect Dis Obstet Gynecol 2010; 2010: pii: 521921, 7. Doi:.
23. Marks E, Tam MA, Lycke NY: The female lower genital tract is a privileged compartment with IL-10 producing dendritic cells and poor Th1 immunity following Chlamydia trachomatis infection. PLoS Pathog 2010; 6:e1001179. Doi:.
24. King AE, Critchley HO, Kelly RW: Innate immune defences in the human endometrium. Reprod Biol Endocrinol 2003; 1:116.
25. Barman H, Walch M, Latinovic-Golic S, Dumrese C, Dolder M, Groscurth P, Ziegler U: Cholesterol in negatively charged lipid bilayers modulates the effect of the antimicrobial protein granulysin. J Membr Biol 2006; 212:29-39.