The vitamin D receptor gene is associated with Alzheimer's disease

Neuroscience Letters

Volumn 504, Issue 2, 2011, Pages 79-82

  Lehmann, Donald J ^a   Refsum, Helga ^a,b   Warden, Donald R ^a   Medway, Christopher ^c   Wilcock, Gordon K ^d   Smith, A David ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cognitive impairment; Cytokine; Hormone; Linkage disequilibrium; Splicing; Transcription factor

Indexed keywords

DNA; DOPAMINE BETA MONOOXYGENASE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; VITAMIN D RECEPTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; COGNITION; CONTROLLED STUDY; ENCEPHALITIS; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HUMAN; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; COHORT STUDIES; DNA; DOPAMINE BETA-HYDROXYLASE; HUMANS; INFLAMMATION; INTERLEUKIN-10; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CALCITRIOL; RISK;

EID: 80054006421     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.08.057     Document Type: Article

References (38)

1. Buell J.S., Dawson-Hughes B., Scott T.M., Weiner D.E., Dallal G.E., Qui W.Q., Bergethon P., Rosenberg I.H., Folstein M.F., Patz S., Bhadelia R.A., Tucker K.L. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 2010, 74:18-26.
2. Cantorna M.T Vitamin D and multiple sclerosis: an update. Nutr. Rev. 2008, 66:S135-S138.
3. Cantorna M.T., Woodward W.D., Hayes C.E., DeLuca H.F. 1,25-Dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4. J. Immunol. 1998, 160:5314-5319.
4. Chen Y., Kong J., Sun T., Li G., Szeto F.L., Liu W., Deb D.K., Wang Y., Zhao Q., Thadhani R., Li Y.C. 1,25-Dihydroxyvitamin D suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-kappaB activation. Arch. Biochem. Biophys. 2011, 507:241-247.
5. Choi B., Lee E.S., Sohn S. Vitamin D3 ameliorates herpes simplex virus-induced Behcet's disease-like inflammation in a mouse model through down-regulation of Toll-like receptors. Clin. Exp. Rheumatol. 2010, [Epub ahead of print].
6. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12 and serum total homocysteine levels in confirmed Alzheimer's disease. Arch. Neurol. 1998, 55:1449-1455.
7. Combarros O., van Duijn C.M., Hammond N., Belbin O., Arias-Vásquez A., Cortina-Borja M., Lehmann M.G., Aulchenko Y.S., Schuur M., Kölsch H., Heun R., Wilcock G.K., Brown K., Kehoe P.G., Harrison R., Coto E., Alvarez V., Deloukas P., Mateo I., Gwilliam R., Morgan K., Warden D.R., Smith A.D., Lehmann D.J. Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease. J. Neuroinflamm. 2009, 6:22.
8. Combarros O., Warden D.R., Hammond N., Cortina-Borja M., Belbin O., Lehmann M.G., Wilcock G.K., Brown K., Kehoe P.G., Barber R., Coto E., Alvarez V., Deloukas P., Gwilliam R., Heun R., Kölsch H., Mateo I., Oulhaj A., Arias-Vásquez A., Schuur M., Aulchenko Y.S., Ikram M.A., Breteler M.M., van Duijn C.M., Morgan K., Smith A.D., Lehmann D.J. The dopamine beta-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. BMC Med. Genet. 2010, 11:162.
9. Cortina-Borja M., Smith A.D., Combarros O., Lehmann D.J. The synergy factor: a statistic to measure interactions in complex diseases. BMC Res. Notes 2009, 2:105.
10. Desmet F.O., Hamroun D., Lalande M., Collod-Béroud G., Claustres M., Béroud C. Human Splicing Finder: an online bioinformatics tool to predict splicing signals. Nucleic Acids Res. 2009, 37:e67.
11. Evatt M.L., Delong M.R., Khazai N., Rosen A., Triche S., Tangpricha V. Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease. Arch. Neurol. 2008, 65:1348-1352.
12. Eyles D.W., Smith S., Kinobe R., Hewison M., McGrath J.J. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J. Chem. Neuroanat. 2005, 29:21-30.
13. Feinstein D.L., Heneka M.T., Gavrilyuk V., Dello Russo C., Weinberg G., Galea E. Noradrenergic regulation of inflammatory gene expression in brain. Neurochem. Int. 2002, 41:357-365.
14. Fernandes de Abreu D.A., Eyles D., Féron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 2009, 34(Suppl. 1):S265-S277.
15. Forouhi N.G., Luan J., Cooper A., Boucher B.J., Wareham N.J. Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes 2008, 57:2619-2625.
16. Garcion E., Wion-Barbot N., Montero-Menei C.N., Berger F., Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol. Metab. 2002, 13:100-105.
17. Gezen-Ak D., Dursun E., Ertan T., Hanagasi H., Gurvit H., Emre M., Eker E., Ozturk M., Engin F., Yilmazer S. Association between vitamin D receptor gene polymorphism and Alzheimer's disease. Tohoku J. Exp. Med. 2007, 212:275-282.
18. Giulietti A., van Etten E., Overbergh L., Stoffels K., Bouillon R., Mathieu C. Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory. Diabetes Res. Clin. Pract. 2007, 77:47-57.
19. Grant W.B. Does vitamin D reduce the risk of dementia?. J. Alzheimers Dis. 2009, 17:151-159.
20. Holmøy T., Moen S.M. Assessing vitamin D in the central nervous system. Acta Neurol. Scand. Suppl. 2010, 88-92.
21. Khoo A.L., Chai L.Y., Koenen H.J., Kullberg B.J., Joosten I., van der Ven A.J., Netea M.G. 1,25-Dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses. J. Infect. Dis. 2011, 203:122-130.
22. Khoo A.L., Chai L.Y., Koenen H.J., Sweep F.C., Joosten I., Netea M.G., van der Ven A.J. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clin. Exp. Immunol. 2011, 164:72-79.
23. Kuningas M., Mooijaart S.P., Jolles J., Slagboom P.E., Westendorp R.G., van Heemst D. VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol. Aging 2009, 30:466-473.
24. Llewellyn D.J., Lang I.A., Langa K.M., Muniz-Terrera G., Phillips C.L., Cherubini A., Ferrucci L., Melzer D. Vitamin D and risk of cognitive decline in elderly persons. Arch. Intern. Med. 2010, 170:1135-1141.
25. Luedecking-Zimmer E., DeKosky S.T., Nebes R., Kamboh M.I. Association of the 3' UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease. Am. J. Med. Genet. 2003, 117B:114-117.
26. Matilainen J.M., Räsänen A., Gynther P., Väisänen S. The genes encoding cytokines IL-2, IL-10 and IL-12B are primary 1alpha, 25(OH)2D3 target genes. J. Steroid Biochem. Mol. Biol. 2010, 121:142-145.
27. Miller J.W. Vitamin D and cognitive function in older adults: are we concerned about vitamin D-mentia?. Neurology 2010, 74:13-15.
28. Morrison N.A., Qi J.C., Tokita A., Kelly P.J., Crofts L., Nguyen T.V., Sambrook P.N., Eisman J.A. Prediction of bone density from vitamin D receptor alleles. Nature 1994, 367:284-287.
29. Nonn L., Peng L., Feldman D., Peehl D.M. Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Cancer Res. 2006, 66:4516-4524.
30. Pogge E. Vitamin D and Alzheimer's disease: is there a link?. Consult. Pharm. 2010, 25:440-450.
31. Stio M., Martinesi M., Bruni S., Treves C., Mathieu C., Verstuyf A., d'Albasio G., Bagnoli S., Bonanomi A.G. The vitamin D analogue TX 527 blocks NF-kappaB activation in peripheral blood mononuclear cells of patients with Crohn's disease. J. Steroid Biochem. Mol. Biol. 2007, 103:51-60.
32. Tuohimaa P., Keisala T., Minasyan A., Cachat J., Kalueff A. Vitamin D, nervous system and aging. Psychoneuroendocrinology 2009, 34:S278-S286.
33. van der Wielen R.P, Löwik M.R., van den Berg H., de Groot L.C., Haller J., Moreiras O., van Staveren W.A. Serum vitamin D concentrations among elderly people in Europe. Lancet 1995, 346:207-210.
34. Wang T.J., Pencina M.J., Booth S.L., Jacques P.F., Ingelsson E., Lanier K., Benjamin E.J., D'Agostino R.B., Wolf M., Vasan R.S. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008, 117:503-511.
35. Warden D.R., Refsum H. Detection of single-nucleotide polymorphisms by PCR with universal energy transfer-labeled primers: application to folate- and cobalamin-related genes. Clin. Chem. 2005, 51:1713-1716.
36. Wenham P.R., Price W.H., Blundell G. Apolipoprotein E genotyping by one-stage PCR. Lancet 1991, 337:1158-1159.
37. Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog. Biophys. Mol. Biol. 2006, 92:39-48.
38. Zmuda J.M., Cauley J.A., Ferrell R.E. Molecular epidemiology of vitamin D receptor gene variants. Epidemiol. Rev. 2000, 22:203-217.