Quantification of epithelial cell differentiation in mammary glands and carcinomas from DMBA- and MNU-exposed rats

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Sharma, Deepak ^a   Smits, Bart M G ^a   Eichelberg, Mark R ^a   Meilahn, Amanda L ^a   Muelbl, Matthew J ^a   Haag, Jill D ^a   Gould, Michael N ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; BETA1 INTEGRIN; BETA3 INTEGRIN; CD24 ANTIGEN; CD31 ANTIGEN; CD45 ANTIGEN; CD61 ANTIGEN; CELL PROTEIN; CELL SURFACE PROTEIN; DIMETHYLBENZ[A]ANTHRACENE; FOCAL ADHESION KINASE 1; LECTIN; METHYLNITROSOUREA; PHALLOIDIN; 7,12 DIMETHYLBENZ[A]ANTHRACENE; BIOLOGICAL MARKER; MEMBRANE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; BREAST EPITHELIUM; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; MAMMARY GLAND; MYOEPITHELIUM CELL; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CARCINOMA; CELL DIVISION; CELL MEMBRANE; EXPERIMENTAL NEOPLASM; METABOLISM; PATHOLOGY; UDDER;

ARACHIS HYPOGAEA; RATTUS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTIGENS, SURFACE; BIOLOGICAL MARKERS; CARCINOMA; CELL DIFFERENTIATION; CELL DIVISION; CELL MEMBRANE; CELL PROLIFERATION; EPITHELIAL CELLS; FEMALE; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; MODELS, BIOLOGICAL; RATS; UP-REGULATION;

EID: 80053992247     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026145     Document Type: Article

References (36)

1. Huggins C, Grand LC, Brillantes FP, (1961) Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression. Nature 189: 204-207.
2. Gullino PM, Pettigrew HM, Grantham FH, (1975) N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Inst 54: 401-414.
3. Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, et al. (1990) Comparative study of human and rat mammary tumorigenesis. Lab Invest 62: 244-278.
4. Singh M, McGinley JN, Thompson HJ, (2000) A comparison of the histopathology of premalignant and malignant mammary gland lesions induced in sexually immature rats with those occurring in the human. Lab Invest 80: 221-231.
5. Nandi S, Guzman RC, Yang J, (1995) Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proc Natl Acad Sci U S A 92: 3650-3657.
6. Thompson HJ, McGinley J, Rothhammer K, Singh M, (1998) Ovarian hormone dependence of pre-malignant and malignant mammary gland lesions induced in pre-pubertal rats by 1-methyl-1-nitrosourea. Carcinogenesis 19: 383-386.
7. Russo J, Russo IH, (1996) Experimentally induced mammary tumors in rats. Breast Cancer Res Treat 39: 7-20.
8. Thompson HJ, McGinley JN, Rothhammer K, Singh M, (1995) Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis 16: 2407-2411.
9. Samuelson DJ, Hesselson SE, Aperavich BA, Zan Y, Haag JD, et al. (2007) Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Proc Natl Acad Sci U S A 104: 6299-6304.
10. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, et al. (2006) Purification and unique properties of mammary epithelial stem cells. Nature 439: 993-997.
11. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, et al. (2006) Generation of a functional mammary gland from a single stem cell. Nature 439: 84-88.
12. Visvader JE, (2009) Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 23: 2563-2577.
13. Dundas SR, Ormerod MG, Gusterson BA, O'Hare MJ, (1991) Characterization of luminal and basal cells flow-sorted from the adult rat mammary parenchyma. J Cell Sci 100 (Pt 3): 459-471.
14. Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, et al. (2007) Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol 9: 201-209.
15. Gugliotta P, Sapino A, Macri L, Skalli O, Gabbiani G, et al. (1988) Specific demonstration of myoepithelial cells by anti-alpha smooth muscle actin antibody. J Histochem Cytochem 36: 659-663.
16. White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, et al. (2004) Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 6: 159-170.
17. Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, et al. (2005) Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. Embo J 24: 1942-1953.
18. Taddei I, Deugnier MA, Faraldo MM, Petit V, Bouvard D, et al. (2008) Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol 10: 716-722.
19. Guan JL, (2010) Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life 62: 268-276.
20. Luo M, Fan H, Nagy T, Wei H, Wang C, et al. (2009) Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res 69: 466-474.
21. Zhao J, Guan JL, (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28: 35-49.
22. Kim ND, Clifton KH, (1993) Characterization of rat mammary epithelial cell subpopulations by peanut lectin and anti-Thy-1.1 antibody and study of flow-sorted cells in vivo. Exp Cell Res 207: 74-85.
23. Kornberg LJ, Earp HS, Turner CE, Prockop C, Juliano RL, (1991) Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins. Proc Natl Acad Sci U S A 88: 8392-8396.
24. Guan JL, Shalloway D, (1992) Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358: 690-692.
25. Miller JA, (1970) Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. Cancer Res 30: 559-576.
26. Rudland PS, Barraclough R, (1988) Stem cells in mammary gland differentiation and cancer. J Cel lSci Supp l 10: 95-114.
27. Rudland PS, (1991) Generation of lobuloalveolar development from isolated rat mammary ducts and end buds. J Histochem Cytochem 39: 1257-1266.
28. Rudland PS, Warburton MJ, Monaghan P, Ritter MA, (1982) Thy-1 antigen on normal and neoplastic rat mammary tissues: changes in location and amount of antigen during differentiation of cultured stem cells. J Natl Cancer Inst 68: 799-811.
29. Russo IH, Russo J, (1978) Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[a]anthracene. J Natl Cancer Inst 61: 1439-1449.
30. Papaconstantinou AD, Shanmugam I, Shan L, Schroeder IS, Qiu C, et al. (2006) Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[a]anthracene. Int J Cancer 118: 17-24.
31. Ariazi JL, Haag JD, Lindstrom MJ, Gould MN, (2005) Mammary glands of sexually immature rats are more susceptible than those of mature rats to the carcinogenic, lethal, and mutagenic effects of N-nitroso-N-methylurea. Mol Carcinog 43: 155-164.
32. Shan L, Yu M, Snyderwine EG, (2005) Gene expression profiling of chemically induced rat mammary gland cancer. Carcinogenesis 26: 503-509.
33. Zarbl H, Sukumar S, Arthur AV, Martin-Zanca D, Barbacid M, (1985) Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315: 382-385.
34. Lahlou H, Sanguin-Gendreau V, Zuo D, Cardiff RD, McLean GW, et al. (2007) Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A 104: 20302-20307.
35. Smits BM, Sharma D, Samuelson DJ, Woditschka S, Mau B, et al. (2011) The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions. Breast Cancer Res 13: R81.
36. Clifton KH, Tanner MA, Gould MN, (1986) Assessment of radiogenic cancer initiation frequency per clonogenic rat mammary cell in vivo. Cancer Res 46: 2390-2395.