Living donor liver transplantation for hepatocellular carcinoma: A single center analysis of outcomes and impact of different selection criteria

Transplant International

Volumn 24, Issue 11, 2011, Pages 1075-1083

  Balci, Deniz ^a,b   Dayangac, Murat ^a   Yaprak, Onur ^a   Akin, Baris ^a   Duran, Cihan ^a   Killi, Refik ^a   Yuzer, Yildiray ^a   Tokat, Yaman ^b  

^a FLORENCE NIGHTINGALE HOSPITAL   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

donation; hepatocellular cancer; living donor; selection criteria

Indexed keywords

ADEFOVIR DIPIVOXIL; ALPHA FETOPROTEIN; CYCLOSPORIN; LAMIVUDINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ADD ON THERAPY; ADULT; AGED; ARTICLE; CANCER SURVIVAL; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HEPATITIS B; HUMAN; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT SELECTION; PREDICTION; PREOPERATIVE CARE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TUMOR DIFFERENTIATION; TUMOR VOLUME;

CARCINOMA, HEPATOCELLULAR; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PATIENT SELECTION; SURVIVAL ANALYSIS;

EID: 80053986989     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2011.01311.x     Document Type: Article

References (36)

1. El-Serag HB,. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 2004; 127: 27.
2. Hwang S, Lee SG, Joh JW, Suh KS, Kim DG,. Liver transplantation for adult patients with hepatocellular carcinoma in Korea: comparison between cadaveric donor and living donor liver transplantations. Liver Transpl 2005; 11: 1265.
3. de Villa VH, Lo CM, Chen CL,. Ethics and rationale of livingdonor liver transplantation in Asia. Transplantation 2003; 3 (Suppl.): S2.
4. Bozoklar A,. Organ donation in Turkey: perspective of transplant coordinators. Turkiye Klinikleri J General Surgery 2009; 2: 5.
5. Adam R, Karam V, Delvart V, et al. Living donor liver transplantation: a European liver transplant registry (ELTR) report on 2634 cases. Liver Transplant 2009; 15: s92.
6. Skagen C, Lucey M, Said A,. Liver transplantation: an update 2009. Curr Opin. Gastroenterol 2009; 25: 202.
7. Brown Jr RS,. Live donors in liver transplantation. Gastroenterology 2008; 134: 1802.
8. Mazzaferro V, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693.
9. Hwang S, Moon DB, Lee SG,. Liver transplantation and conventional surgery for advanced hepatocellular carcinoma. Transpl Int 2010; 23: 723.
10. Gondolesi GE, Roayaie S, Muñoz L, et al. Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria. Ann Surg 2004; 239: 142.
11. Takada Y, Ito T, Ueda M, et al. Living donor liver transplantation for patients with HCC exceeding the Milan criteria: a proposal of expanded criteria. Dig Dis 2007; 25: 299 302. (Pubitemid 350014956)
12. Onaca N, Davis GL, Goldstein RM, Jennings LW, Klintmalm GB,. Expanded criteria for liver transplantation in patients with hepatocellular carcinoma: a report from the International Registry of Hepatic Tumors in Liver Transplantation. Liver Transpl 2007; 13: 391.
13. Lee SG, Hwang S, Moon DB, et al. Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center. Liver Transpl 2008; 14: 935.
14. Toso C, Asthana S, Bigam DL, Shapiro J, Kneteman NM,. Reassessing selection criteria prior to liver transplantation for hepatocellular carcinoma utilizing the scientific registry of transplant recipients database. Hepatology 2009; 49: 832.
15. Mazzaferro V, Llovet JM, Miceli R, et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol 2009; 10: 35.
16. Taner CB, Dayangac M, Akin B, et al. Donor safety and remnant liver volume in living donor liver transplantation. Liver Transpl 2008; 14: 1174.
17. Sobin LH, Wittekind C, (eds). International Union Against Cancer (UICC). TNM Classification of Malignant Tumours, 6th edn. New York: Wiley-Liss, 2002: pp. 131-144.
18. Todo S, Furukawa H,. for the Japanese Study Group on Organ Transplantation. Living donor liver transplantation for adult patients with hepatocellular carcinoma. Experience in Japan. Ann Surg 2004; 240: 451.
19. Malago M, Sotiropoulos GC, Nadalin S, et al. Living donor liver transplantation for hepatocellular carcinoma: a single-center preliminary report. Liver Transpl 2006; 12: 934.
20. Roayaie S, Frischer J, Emre H, et al. Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 cm. Ann Surg 2002; 235: 533.
21. Kaihara S, Kiuchi T, Ueda M, et al. Living-donor liver transplantation for hepatocellular carcinoma. Transplantation 2003; 75: S37.
22. Balci D, Taner BC, Dayangac M, et al. Living donor liver transplantation for patients with hepatocellular carcinoma within and beyond milan criteria. Transpl Int 2007; 20: 13.
23. Llovet JM, Fuster J, Bruix J,. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation. Hepatology 1999; 30: 1434.
24. Yao FY, Bass NM, Nikolai B, et al. A follow-up analysis of the pattern and predictors of dropout from the waiting list for liver transplantation in patients with hepatocellular carcinoma: implications for the current organ allocation policy. Liver Transpl 2003; 9: 684.
25. Consensus conference: indications for liver transplantation, January 19 and 20, 2005, Lyon-Palais Des Congrès: text of recommendations (long version). Liver Transpl 2006; 12: 998. Available at.
26. Toso C, Kneteman NM, James Shapiro AM, Bigam DL,. The estimated number of patients with hepatocellular carcinoma selected for liver transplantation using expanded selection criteria. Transpl Int 2009; 22: 869.
27. Ito T, Takada Y, Ueda M, et al. Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation. Liver Transpl 2007; 13: 1637.
28. Zheng SS, Xu X, Wu J, et al. Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation 2008; 85: 1726.
29. Soejima Y, Taketomi A, Yoshizumi T, et al. Extended indication for living donor liver transplantation in patients with hepatocellular carcinoma. Transplantation 2007; 7: 893.
30. Vakili K, Pomposelli JJ, Cheah YL, et al. Living donor liver transplantation for hepatocellular carcinoma: Increased recurrence but improved survival. Liver Transpl 2009; 15: 1861.
31. Jonas S, Bechstein WO, Steinmuller T, et al. Vascular invasion and histologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001; 33: 1080.
32. Colecchia A, Scaioli E, Montrone L, et al. Pre-operative liver biopsy in cirrhotic patients with early hepatocellular carcinoma represents a safe and accurate diagnostic tool for tumour grading assessment. J Hepatol 2011; 54: 300.
33. Decaens T, Roudot-Thoraval F, Badran H, et al. Impact of tumour differentiation to select patients before liver transplantation for hepatocellular carcinoma. Liver Int 2011; 31: 794.
34. DuBay D, Sandroussi C, Sandhu L, et al. Liver transplantation for advanced hepatocellular carcinoma using poor tumor differentiation on biopsy as an exclusion criterion. Ann Surg 2011; 253: 166.
35. Sugihara S, Nakashima O, Kojiro M, et al. The morphologic transition in hepatocellular carcinoma. Cancer 1992; 70: 1488.
36. Hori T, Ueda M, Oike F, et al. Graft loss and poor outcomes after living-donor liver transplantation owing to arterioportal shunts caused by liver needle biopsies. Transplant Proc 2010; 42: 2642.