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Volumn 45, Issue 10, 2011, Pages 1248-1255

Ofatumumab: A novel anti-CD20 monoclonal antibody for treatment of refractory chronic lymphocytic leukemia;Ofatumumab: Un novedoso anticuerpo monoclonal anti-cd20 para el tratamiento de la leucemia linfocítica crónica (LLC) refractaria

Author keywords

CD 20 monoclonal antibody; Chronic lymphocytic leukemia; HuMax Cd20; Ofatumumab

Indexed keywords

ALEMTUZUMAB; CD20 ANTIBODY; CETIRIZINE; CYCLOPHOSPHAMIDE; FLUDARABINE; MONOCLONAL ANTIBODY; OFATUMUMAB; PREDNISONE; RITUXIMAB;

EID: 80053940562     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1P780     Document Type: Review
Times cited : (22)

References (29)
  • 2
    • 1442306830 scopus 로고    scopus 로고
    • Current approach to diagnosis and management of chronic lymphocytic leukemia
    • Shanafelt TD, Call TG. Current approach to diagnosis and management of chronic lymphocytic leukemia. Mayo Clin Proc 2004;79:388-98.
    • (2004) Mayo Clin Proc , vol.79 , pp. 388-398
    • Shanafelt, T.D.1    Call, T.G.2
  • 3
    • 40749132494 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia
    • Dighiero G, Hamblin TJ. Chronic lymphocytic leukemia. Lancet 2008; 371:1017-29.
    • (2008) Lancet , vol.371 , pp. 1017-1029
    • Dighiero, G.1    Hamblin, T.J.2
  • 4
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd JC, Rai K, Peterson BL, et al. Addition of rituximab to fludarabine may prolong progression free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood 2005;105:49-53.
    • (2005) Blood , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3
  • 5
    • 76949091824 scopus 로고    scopus 로고
    • First-line treatment with fludarabine, cyclophosphamide, and rituximab improves overall survival in previously untreated patients with advanced chronic lymphocytic leukemia (CLL): Results of a randomized phase III trial on behalf of an international group of investigators and the German CLL Study Group (abstract 535)
    • Hallek M, Fingerle-Rowson G, Fink AM, et al. First-line treatment with fludarabine, cyclophosphamide, and rituximab improves overall survival in previously untreated patients with advanced chronic lymphocytic leukemia (CLL): results of a randomized phase III trial on behalf of an international group of investigators and the German CLL Study Group (abstract 535). Blood 2009;114:223-4.
    • (2009) Blood , vol.114 , pp. 223-224
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.M.3
  • 6
    • 84857658302 scopus 로고    scopus 로고
    • The NCCN clinical practice guidelines in oncology non-Hodgkin's lymphomas (version 1.2011)
    • accessed, May 20
    • The NCCN clinical practice guidelines in oncology non-Hodgkin's lymphomas (version 1.2011). 2010 National Comprehensive Cancer Network, Inc. www.NCCN.org (accessed 2011 May 20).
    • (2011) 2010 National Comprehensive Cancer Network
  • 7
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010;376: 1164-74.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 8
    • 35148849255 scopus 로고    scopus 로고
    • The natural history of fludarabine-refractory chronic lymphocytic leukemia patients who fail alemtuzumab or have bulky lymphadenopathy
    • Tam CS, O'Brien S, Lerner S, et al. The natural history of fludarabine-refractory chronic lymphocytic leukemia patients who fail alemtuzumab or have bulky lymphadenopathy. Leuk Lymphoma 2007;48:1931-9.
    • (2007) Leuk Lymphoma , vol.48 , pp. 1931-1939
    • Tam, C.S.1    O'Brien, S.2    Lerner, S.3
  • 9
    • 33745324686 scopus 로고    scopus 로고
    • The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
    • Teeling JL, Mackus WJ, Wiegman LJ, et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol 2006;177:362-71.
    • (2006) J Immunol , vol.177 , pp. 362-371
    • Teeling, J.L.1    Mackus, W.J.2    Wiegman, L.J.3
  • 10
    • 73949084380 scopus 로고    scopus 로고
    • Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma
    • Li B, Zhao L, Guo H, et al. Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma. Blood 2009;114:5007-15.
    • (2009) Blood , vol.114 , pp. 5007-5015
    • Li, B.1    Zhao, L.2    Guo, H.3
  • 11
    • 38349138517 scopus 로고    scopus 로고
    • Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody
    • Bleeker WK, Munk ME, Mackus WJ, et al. Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody. Br J Haematol 2008;140:303-12.
    • (2008) Br J Haematol , vol.140 , pp. 303-312
    • Bleeker, W.K.1    Munk, M.E.2    Mackus, W.J.3
  • 12
    • 80053943645 scopus 로고    scopus 로고
    • Package insert, Research Triangle Park, NC: GlaxoSmithKline
    • Package insert. Arzerra (ofatumumab). Research Triangle Park, NC: GlaxoSmithKline, September 2010.
    • (2010) Arzerra (ofatumumab)
  • 13
    • 84857644790 scopus 로고    scopus 로고
    • Cancer therapy evaluation program, common terminology criteria for adverse events, version 4.0, DCTD, NCI, NIH, accessed 2011 Jun 1
    • Cancer therapy evaluation program, common terminology criteria for adverse events, version 4.0, DCTD, NCI, NIH, DHHS. Published August 9, 2006. http://ctep.cancer.gov (accessed 2011 Jun 1).
    • (2006) DHHS. Published August , pp. 9
  • 14
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A Phase 1-2 study
    • Coiffier B, Lepretre S, Pedersen LM, et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a Phase 1-2 study. Blood 2008;111:1094-100.
    • (2008) Blood , vol.111 , pp. 1094-1100
    • Coiffier, B.1    Lepretre, S.2    Pedersen, L.M.3
  • 15
    • 77950502126 scopus 로고    scopus 로고
    • Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
    • Wierda WG, Kipps TJ, Mayer J, et al. Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J Clin Oncol 2010;28:1749-55.
    • (2010) J Clin Oncol , vol.28 , pp. 1749-1755
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 16
    • 80053992189 scopus 로고    scopus 로고
    • Final analysis from the international trial of single-agent ofatumumab in patients with fludarabine-refractory chronic lymphocytic leukemia (abstract 921)
    • Wierda WG, Kipps TJ, Mayer J, et al. Final analysis from the international trial of single-agent ofatumumab in patients with fludarabine-refractory chronic lymphocytic leukemia (abstract 921). American Society of Hematology Annual Meeting Proceedings Part 2. 2010.
    • (2010) American Society of Hematology Annual Meeting Proceedings Part , pp. 2
    • Wierda, W.G.1    Kipps, T.J.2    Mayer, J.3
  • 17
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai KR, Peterson BL, Appelbaum FR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000;343:1750-7.
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 18
    • 80053948171 scopus 로고    scopus 로고
    • Advancing therapy for chronic lymphocytic leukemia-the role of rituximab
    • Hillmen P. Advancing therapy for chronic lymphocytic leukemia-the role of rituximab. Semin Oncol 2002;29(suppl 2):22-6.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 2 , pp. 22-26
    • Hillmen, P.1
  • 19
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 2007;35:5616-23.
    • (2007) J Clin Oncol , vol.35 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.B.2    Robak, T.3
  • 20
    • 80053988289 scopus 로고    scopus 로고
    • Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: Results of a Phase II trial (abstract 2464)
    • Badoux X, O'Brien S, Wierda WG, et al. Combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia: results of a Phase II trial (abstract 2464). ASH Annual Meeting Proceedings Part 2. 2010.
    • (2010) ASH Annual Meeting Proceedings Part , pp. 2
    • Badoux, X.1    O'Brien, S.2    Wierda, W.G.3
  • 21
    • 76149128849 scopus 로고    scopus 로고
    • Ofatumumab combined with fludarabine and cyclophosphamide (O -FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): Results from a randomized, multi-center, international, two-dose, parallel group, phase II trial (abstract 207)
    • Wierda WG, Kipps TJ, Durig J, et al. Ofatumumab combined with fludarabine and cyclophosphamide (O -FC) shows high activity in patients with previously untreated chronic lymphocytic leukemia (CLL): results from a randomized, multi-center, international, two-dose, parallel group, phase II trial (abstract 207). Blood 2009;114:90.
    • (2009) Blood , vol.114 , pp. 90
    • Wierda, W.G.1    Kipps, T.J.2    Durig, J.3
  • 22
    • 47049124865 scopus 로고    scopus 로고
    • First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: Results of a phase 1/2 trial
    • Hagenbeek A, Gadeberg O, Johnson P, et al. First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial. Blood 2008;111:5486-95.
    • (2008) Blood , vol.111 , pp. 5486-5495
    • Hagenbeek, A.1    Gadeberg, O.2    Johnson, P.3
  • 23
    • 80053969268 scopus 로고    scopus 로고
    • Ofatumumab monotherapy for treatment of patients with relapsed/progressive diffuse large B-cell lymphoma: Results from a multi-center Phase II study (abstract 3955)
    • Coiffier B, Bosly A, Wu KL, et al. Ofatumumab monotherapy for treatment of patients with relapsed/progressive diffuse large B-cell lymphoma: results from a multi-center Phase II study (abstract 3955). ASH Annual Meeting Proceedings Part 2. 2010.
    • (2010) ASH Annual Meeting Proceedings Part , pp. 2
    • Coiffier, B.1    Bosly, A.2    Wu, K.L.3
  • 24
    • 46749118571 scopus 로고    scopus 로고
    • Ofatumumab (HuMax-CD20), a fully human CD20 monoclonal antibody, in the treatment of rheumatoid arthritis. Early results from an ongoing, double-blind, randomized, placebo controlled clinical trial
    • Ostergaard M, Baslund B, Rigby W, et al. Ofatumumab (HuMax-CD20), a fully human CD20 monoclonal antibody, in the treatment of rheumatoid arthritis. Early results from an ongoing, double-blind, randomized, placebo controlled clinical trial. Ann Rheum Dis 2007;66(suppl 2):124.
    • (2007) Ann Rheum Dis , vol.66 , Issue.SUPPL. 2 , pp. 124
    • Ostergaard, M.1    Baslund, B.2    Rigby, W.3
  • 28
    • 79551543248 scopus 로고    scopus 로고
    • Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: Meta-analysis and examination of FDA safety reports
    • Evens AM, Jovanovic BD, Su YC, et al. Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: meta-analysis and examination of FDA safety reports. Ann Oncol 2011;22:1170-80.
    • (2011) Ann Oncol , vol.22 , pp. 1170-1180
    • Evens, A.M.1    Jovanovic, B.D.2    Su, Y.C.3
  • 29
    • 80054006874 scopus 로고    scopus 로고
    • Montvale, NJ: Thomson Healthcare Inc.
    • Red book. 2010 ed. Montvale, NJ: Thomson Healthcare Inc., 2010.
    • (2010) Ed , pp. 2010
    • Book, R.1


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