Doxepin is more effective than nortriptyline and placebo for the treatment of diarrhea-predominant irritable bowel syndrome: A randomized triple-blind placebo-controlled trial

Tehran University Medical Journal

Volumn 69, Issue 6, 2011, Pages 352-358

  Ghadir, Mohammad Reza ^a   Habibinejad, Hosseinali ^b   Heidari, Akram ^a   Vahedi, Homayoun ^c  

^a QOM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Doxepin; Irritable bowel syndrome; Nortriptyline

Indexed keywords

DOXEPIN; NORTRIPTYLINE; PLACEBO;

ABDOMINAL PAIN; ARTICLE; BLOATING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG RESPONSE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

EID: 80053935559     PISSN: 16831764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. th ed. New York: McGraw Hill; 2008. p. 1889.
2. th ed. Philadelphia: Saunders; 2006. p. 2533.
3. Talley NJ, Kellow JE, Boyce P, Tennant C, Huskic S, Jones M. Antidepressant therapy (imipramine and citalopram) for irritable bowel syndrome: a double-blind, randomized, placebocontrolled trial. Dig Dis Sci 2008;53(1):108-15.
4. Kato O, Misawa H. Treatment of diarrhea-predominant irritable bowel syndrome with paroxetine. Prim Care Companion J Clin Psychiatry 2005;7(4):202.
5. Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Efficacy of tricyclic antidepressants in irritable bowel syndrome: a metaanalysis. World J Gastroenterol 2009;15(13):1548-53.
6. Farthing MJ. Functional diarrhea. Curr Gastroenterol Rep 2005;7(5):350-7.
7. Vahedi H, Merat S, Momtahen S, Kazzazi AS, Ghaffari N, Olfati G, et al. Clinical trial: the effect of amitriptyline in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 2008;27(8):678-84.
8. Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut 2005;54(5):601-7.
9. Mayer EA. Clinical practice. Irritable bowel syndrome. N Engl J Med 2008;358(16):1692-9.
10. Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis. Gut 2009;58(3):367-78.
11. Wang WA, Qian JM, Pan GZ. Treatment of refractory irritable bowel syndrome with subclinical dosage of antidepressants. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003;25(1):74-8.
12. Friedrich M, Grady SE, Wall GC. Effects of antidepressants in patients with irritable bowel syndrome and comorbid depression. Clin Ther 2010;32(7):1221-33.
13. Mertz HR. Irritable bowel syndrome. N Engl J Med 2003;349(22):2136-46.
14. Halpert A, Dalton CB, Diamant NE, Toner BB, Hu Y, Morris CB, et al. Clinical response to tricyclic antidepressants in functional bowel disorders is not related to dosage. Am J Gastroenterol 2005;100(3):664-71.
15. Rajagopalan M, Kurian G, John J. Symptom relief with amitriptyline in the irritable bowel syndrome. J Gastroenterol Hepatol 1998;13(7):738-41.
16. Greenbaum DS, Mayle JE, Vanegeren LE, Jerome JA, Mayor JW, Greenbaum RB, et al. Effects of desipramine on irritable bowel syndrome compared with atropine and placebo. Dig Dis Sci 1987;32(3):257-66.
17. Sato M, Murakami M. Treatment for irritable bowel syndrome: psychotropic drugs, antidepressants and so on. Nihon Rinsho 2006;64(8):1495-500.
18. Vij JG, Jiloha RG, Kumar N, Madhu SV, Malika V, Anand BS. Effect of antidepressant drug (doxepin) on irritable bowel syndrome patients. Indian J Psychiatr 1991;33:243-6.