Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate γ-carboxylation

Matrix Biology

Volumn 30, Issue 7-8, 2011, Pages 369-378

  Neacsu, Cristian Dan ^a   Grosch, Melanie ^b   Tejada, Mercedes ^b   Winterpacht, Andreas ^b   Paulsson, Mats ^a   Wagener, Raimund ^a   Tagariello, Andreas ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Cartilage; Glutamate carboxylation; GRP; UCMA; Vitamin K; Zebrafish

Indexed keywords

4 CARBOXYGLUTAMIC ACID; AGGRECAN; COLLAGEN TYPE 2; WARFARIN;

ARTICLE; BONE DEVELOPMENT; BONE DISEASE; CHROMOSOME 4; EMBRYOPATHY; GENE; GENE DUPLICATION; GENE STRUCTURE; GROWTH RETARDATION; HUMAN; NONHUMAN; NOTOCHORD; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UCMAA GENE; UCMAB GENE; ZEBRA FISH;

1-CARBOXYGLUTAMIC ACID; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CARTILAGE; CLONING, MOLECULAR; COLLAGEN TYPE II; COMPUTATIONAL BIOLOGY; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; LARVA; MICE; MOLECULAR SEQUENCE DATA; NOTOCHORD; PHENOTYPE; PROTEIN ISOFORMS; PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STAINING AND LABELING; TIME FACTORS; WARFARIN; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO; MAMMALIA;

EID: 80053929352     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2011.07.002     Document Type: Article

References (25)

1. Baas D., Malbouyres M., Haftek-Terreau Z., Le G.D., Ruggiero F. Craniofacial cartilage morphogenesis requires zebrafish col11a1 activity. Matrix Biol. 2009, 28:490-502.
2. Christiansen H.E., Lang M.R., Pace J.M., Parichy D.M. Critical early roles for col27a1a and col27a1b in zebrafish notochord morphogenesis, vertebral mineralization and post-embryonic axial growth. PLoS One 2009, 4:e8481.
3. Fang M., Adams J.S., McMahan B.L., Brown R.J., Oxford J.T. The expression patterns of minor fibrillar collagens during development in zebrafish. Gene Expr. Patterns 2010, 10:315-322.
4. Gansner J.M., Gitlin J.D. Essential role for the alpha 1 chain of type VIII collagen in zebrafish notochord formation. Dev. Dyn. 2008, 237:3715-3726.
5. Gansner J.M., Mendelsohn B.A., Hultman K.A., Johnson S.L., Gitlin J.D. Essential role of lysyl oxidases in notochord development. Dev. Biol. 2007, 307:202-213.
6. Gavaia P.J., Simes D.C., Ortiz-Delgado J.B., Viegas C.S., Pinto J.P., Kelsh R.N., Sarasquete M.C., Cancela M.L. Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Gene Expr. Patterns 2006, 6:637-652.
7. Hall J.G., Pauli R.M., Wilson K.M. Maternal and fetal sequelae of anticoagulation during pregnancy. Am. J. Med. 1980, 68:122-140.
8. Hanumanthaiah R., Thankavel B., Day K., Gregory M., Jagadeeswaran P. Developmental expression of vitamin K-dependent gamma-carboxylase activity in zebrafish embryos: effect of warfarin. Blood Cells Mol. Dis. 2001, 27:992-999.
9. Hwang E.M., Kim D.G., Lee B.J., Choi J., Kim E., Park N., Kang D., Han J., Choi W.S., Hong S.G., Park J.Y. Alternative splicing generates a novel non-secretable cytosolic isoform of NELL2. Biochem. Biophys. Res. Commun. 2007, 353:805-811.
10. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., Schilling T.F. Stages of embryonic development of the zebrafish. Dev. Dyn. 1995, 203:253-310.
11. Lee N.K., Sowa H., Hinoi E., Ferron M., Ahn J.D., Confavreux C., Dacquin R., Mee P.J., McKee M.D., Jung D.Y., Zhang Z., Kim J.K., Mauvais-Jarvis F., Ducy P., Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell 2007, 130:456-469.
12. LeJeune M., Tomavo N., Tian T.V., Flourens A., Marchand N., Camuzeaux B., Mallein-Gerin F., Duterque-Coquillaud M. Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein. Exp. Cell Res. 2010, 316:203-215.
13. Luo G., Ducy P., McKee M.D., Pinero G.J., Loyer E., Behringer R.R., Karsenty G. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 1997, 386:78-81.
14. Pagnon-Minot A., Malbouyres M., Haftek-Terreau Z., Kim H.R., Sasaki T., Thisse C., Thisse B., Ingham P.W., Ruggiero F., Le G.D. Collagen XV, a novel factor in zebrafish notochord differentiation and muscle development. Dev. Biol. 2008, 316:21-35.
15. Pauli R.M., Lian J.B., Mosher D.F., Suttie J.W. Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. Am. J. Hum. Genet. 1987, 41:566-583.
16. Sachdev S.W., Dietz U.H., Oshima Y., Lang M.R., Knapik E.W., Hiraki Y., Shukunami C. Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis. Mech. Dev. 2001, 105:157-162.
17. Stemple D.L. Structure and function of the notochord: an essential organ for chordate development. Development 2005, 132:2503-2512.
18. Surmann-Schmitt C., Dietz U., Kireva T., Adam N., Park J., Tagariello A., Heinegard D., Schlotzer-Schrehardt U., Deutzmann R., von der M.K., Stock M. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. J. Biol. Chem. 2008, 283:7082-7093.
19. Tagariello A., Luther J., Streiter M., dt-Koziel L., Wuelling M., Surmann-Schmitt C., Stock M., Adam N., Vortkamp A., Winterpacht A. Ucma-a novel secreted factor represents a highly specific marker for distal chondrocytes. Matrix Biol. 2008, 27:3-11.
20. Thisse C., Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat. Protoc. 2008, 3:59-69.
21. Viegas C.S., Simes D.C., Laize V., Williamson M.K., Price P.A., Cancela M.L. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J. Biol. Chem. 2008, 283:36655-36664.
22. Viegas C.S., Cavaco S., Neves P.L., Ferreira A., Joao A., Williamson M.K., Price P.A., Cancela M.L., Simes D.C. Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. Am. J. Pathol. 2009, 175:2288-2298.
23. Walker M.B., Kimmel C.B. A two-color acid-free cartilage and bone stain for zebrafish larvae. Biotech. Histochem. 2007, 82:23-28.
24. Warman M.L., Cormier-Daire V., Hall C., Krakow D., Lachman R., Lemerrer M., Mortier G., Mundlos S., Nishimura G., Rimoin D.L., Robertson S., Savarirayan R., Sillence D., Spranger J., Unger S., Zabel B., Superti-Furga A. Nosology and classification of genetic skeletal disorders: 2010 revision. Am. J. Med. Genet. A 2011, 155:943-968.
25. Yan Y.L., Hatta K., Riggleman B., Postlethwait J.H. Expression of a type II collagen gene in the zebrafish embryonic axis. Dev. Dyn. 1995, 203:363-376.