Fatal Pandemic (H1N1) 2009 Influenza A Virus Infection in a Pennsylvania Domestic Cat

Zoonoses and Public Health

Volumn 58, Issue 7, 2011, Pages 500-507

  Campagnolo, E R ^a,b   Rankin, J T ^b   Daverio, S A ^c   Hunt, E A ^b   Lute, J R ^b   Tewari, D ^d   Acland, H M ^d   Ostrowski, S R ^a   Moll, M E ^b   Urdaneta, V V ^b   Ostroff, S M ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b PENNSYLVANIA DEPARTMENT OF HEALTH   (United States)

^c Williamsport West Veterinary Hospital   (United States)

^d Pennsylvania Veterinary Laboratory   (United States)

Author keywords

Cardiomyopathy; Cat; Fatal; Influenza A virus; Influenza like illness; Pandemic; Pennsylvania; PH1N1; Pneumonia; Veterinary public health; Zoonoses

Indexed keywords

2009 H1N1 INFLUENZA; ARTICLE; AUTOPSY; CAT; DISEASE TRANSMISSION; FATALITY; FEMALE; LABORATORY TEST; NONHUMAN; PRIORITY JOURNAL; RADIOGRAPHY; UNITED STATES;

ANIMALS; CAT DISEASES; CATS; FATAL OUTCOME; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MALE; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; PENNSYLVANIA;

FELIS CATUS; INFLUENZA A VIRUS;

EID: 80053916997     PISSN: 18631959     EISSN: 18632378     Source Type: Journal    
DOI: 10.1111/j.1863-2378.2011.01390.x     Document Type: Article

References (39)

1. AVMA, 2007: Extralabel Drug Use (ELDU). An Information Outline of the Animal Medicinal Drug Use Clarification Act (AMDUCA). Brochure, Schaumburg, IL.
2. AVMA, 2008: One Health: A New Professional Imperative. One Health Initiative Task Force: Final Report. July 15. Schaumburg, IL.
3. AVMA, 2009: Public Health: Frequently Asked Questions About 2009 H1N1 Flu Virus. Available at: (accessed on 15 April 2010).
4. AVMA, 2010: Public Health: Frequently Asked Questions About 2009 H1N1 Flu Virus. Available at: (accessed on 15 April 2010).
5. Bratincsák, A., H. G. El-Said, J. S. Bradley, K. Shayan, P. D. Grossfeld, and C. R. Cannavino, 2010: Fulminant myocarditis associated with pandemic H1N1 influenza A virus in children. J. Am. Coll. Cardiol. 55, 928-929.
6. CDC, 2009a: H1N1 Flu (Swine Flu). Available at: (accessed on 14 January 2010).
7. CDC, 2009b: Compendium of Measures to Prevent Disease Associated with Animals in Public Settings, 2009. MMWR.National Association of State Public Health Veterinarians, Inc. (NASPHV), Atlanta, GA, USA. May1/Vol.58/No.RR-5.
8. CDC, 2010: H1N1 Flu (Swine Flu): Resources for Laboratories. CDC Protocol of Realtime RTPCR for Swine Influenza A(H1N1). Available at: (accessed on 5 May 2010).
9. FAO, 2010: H5N1 in Cats. Available at: (accessed on 23 April 2010).
10. FDA, 1994: Animal Medicinal Drug Use Clarification Act (AMDUCA) of 1994. Federal Food, Drug, and Cosmetic Act (FD&C Act). January 25. Washington, DC.
11. Garten, R. J., C. T. Davis, C. A. Russell, B. Shu, S. Lindstrom, A. Balish, W. M. Sessions, X. Xu, E. Skepner, V. Deyde, M. Okomo-Adhiambo, L. Gubareva, J. Barnes, C. B. Smith, S. L. Emery, M. J. Hillman, P. Rivailler, J. Smagala, M. de Graaf, D. F. Burke, R. A. M. Fouchier, C. Pappas, C. M. Alpuche-Aranda, H. López-Gatell, H. Olivera, I. López, C. A. Myers, D. Faix, P.J. Blair, C. Yu, K. M. Keene, P. D. Dotson Jr., D. Boxrud, A. R. Sambol, S. H. Abid, K. St. George, T. Bannerman, A. L. Moore, D. J. Stringer, P. Blevins, G. J. Demmler-Harrison, M. Ginsberg, P. Kriner, S. Waterman, S. Smole, H. F. Guevara, E. A. Belongia, P. A. Clark, S. T. Beatrice, R. Donis, J. Katz, L. Finelli, C. B. Bridges, M. Shaw, D. B. Jernigan, T. M. Uyeki, D. J. Smith, A. I. Klimov, and N. J. Cox, 2009: Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 325, 197-201.
12. Greaves, K., J. S. Oxford, C. P. Price, G. H. Clarke, and T. Crake, 2003: The prevalence of myocarditis and skeletal muscle injury during acute viral infection in adults: measurement of cardiac troponins I and T in 152 patients with acute influenza infection. Arch. Intern. Med. 163, 165-168.
13. Gross, E. R., J. W. Gander, A. Reichstein, R. A. Cowles, C. J. Stolar, and W. Middlesworth, 2010: Fulminant pH1N1-09 influenza-associated myocarditis in pediatric patients. Pediatr. Crit. Care Med. 12, 1-3.
14. Harasawa, R., H. Mizusawa, and K. Koshimizu, 1986: A reliable and sensitive method for detecting mycoplasmas in cell cultures. Microbiol. Immunol. 30, 919-921.
15. Hinshaw, V. S., R. G. Webster, B. C. Easterday, and W. J. Bean, 1981: Replication of avian influenza A viruses in mammals. Infect. Immun. 34, 354-361.
16. Hristovski, M., A. Cvetkovik, I. Cvetkovik, and V. Dukoska, 2010: Concept of one health - a new professional imperative. Maced. J. Med. Sci. 3, 229-232.
17. Kitaura, Y., H. Deguchi, F. Terasaki, A. Ukimura, H. Morita, and T. Tatsumi, 2003: Influenza myocarditis-pathophysiology and developmental mechanism of myocarditis. Nippon Rinsho. 61, 1945-1952.
18. Klopfleisch, R., P. U. Wilf, W. Uhl, S. Gerst, T. Harder, E. Starick, T. W. Vahlenkamp, T. C. Mettenleiter, and J. P. Teifke, 2007: Distribution of lesions and antigen of highly pathogenic avian influenza virus A/Swan/Germany/R65/06 (H5N1) infection in domestic cats after presumptive infection by wild birds. Vet. Pathol. 44, 261-268.
19. Kuiken, T., and J. K. Taubenberger, 2008: Pathology of human influenza revisited. Vaccine 26 (Suppl 4), D59-D66. Review.
20. Kuiken, T., G. Rimmelzwaan, D. van Riel, G. van Amerongen, M. Baars, R. Fouchier, and A. Osterhaus, 2004: Avian H5N1 influenza in cats. Science 306, 241.
21. Löhr, C. V., E. E. DeBess, R. J. Baker, S. L. Hiett, K. A. Hoffman, V. J. Murdoch, K. A. Fischer, D. M. Mulrooney, R. L. Selman, and W. M. Hammill-Black, 2010: Pathology and viral antigen distribution of lethal pneumonia in domestic cats due to pandemic (H1N1) 2009 influenza A virus. Vet. Pathol. 47, 378-386.
22. Marano, N., and M. Pappiaoanou, 2004: Historical, new, and reemerging links between human and animal health. Emerg. Infect. Dis. 10, 2065-2066.
23. Nolte, K. B., P. Alakija, G. Oty, M. W. Shaw, K. Subbarao, J. Guarner, W. J. Shieh, J. E. Dawson, T. Morken, N. J. Cox, and S. R. Zaki, 2000: Influenza A virus infection complicated by fatal myocarditis. Am. J. Forensic Med. Pathol. 21, 375-379.
24. NVSL-SOP-BPA-9024, 2009: 2009 H1N1 Influenza Virus Isolation. Ames, Iowa.
25. NVSL-SOP-BPA-9034, 2010: Real-Time Rt-Pcr for the Detection of Swine Influenza Virus and Identification of Novel N1 Subtypes in Clinical Samples. Ames, Iowa.
26. NVSL-SOP-BPA-9035, 2010: Amplification and Purification of PCR Products for Direct Sequencing of Hemagglutinin, Neuraminidase and Matrix Genes of Swine Influenza Virus. Ames, Iowa.
27. One Health Initiative, 2008: One Health Initiative will Unite Human and Veterinary Medicine. Available at: (accessed on 2 February 2010).
28. Pennsylvania Department of Health Bureau of Laboratories BOL, 2009: 2008/09 Influenza Virology Surveillance Data. Pennsylvania Laboratory Information Management System (LIMS) Available at: (accessed 9 Apr 2010).
29. Pereda, A., J. Cappuccio, M. A. Quiroga, E. Baumeister, L. Insarralde, M. Ibar, R. Sanguinetti, M. L. Cannilla, D. Franzese, O. E. Escobar Cabrera, M. I. Craig, A. Rimondi, M. Machuca, R. T. Debenedetti, C. Zenobi, L. Barral, R. Balzano, S. Capalbo, A. Risso, and C. J. Perfumo, 2010: Pandemic (H1N1) 2009 outbreak on a pig farm, Argentina. Emerg. Infect. Dis. 16, 304-307.
30. ProMED, 2009a: Archive Number 20091020.3600. Available at: .
31. ProMED, 2009b: Archive Number 20091128.4079. Available at: .
32. ProMED, 2009c: Archive Number 20091115.3947. Available at: .
33. ProMED, 2009d: Archive Number 20091105.3816. Available at: .
34. Rimmelzwaan, G., D. van Riel, M. Baars, T. M. Bestebroer, G. van Amerongen, R. Fouchier, A. Osterhaus, and T. Kuiken, 2006: Influenza A (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts. Am. J. Pathol. 168, 176-183.
35. Sponseller, B. A., E. Strait, A. Jergens, J. Trujillo, K. Harmon, L. Koster et al., 2010: Influenza pandemic (H1N1) 2009 virus infection in domestic cat. Emerg. Infect. Dis. 16, 534-537.
36. USDA, 2009: Final results 2009 Pandemic H1N1 Influenza. Available at: (accessed on 8 April 2010).
37. USDA, 2010: Final Results 2010 Pandemic H1N1 Influenza. Available at: (accessed on 8 April 2010).
38. USDA-APHIS, 2010: H1N1 Influenza. Available at: (accessed on 2 February 2010).
39. WHO, 2010: H5N1 Avian Influenza: Timeline. Available at: (accessed on 23 April, 2010).