Dehydration of detomidine hydrochloride monohydrate

European Journal of Pharmaceutical Sciences

Volumn 44, Issue 3, 2011, Pages 273-280

  Veldre, K ^a   Actis A ^a   Jaunbergs, J ^b  

^a UNIVERSITY OF LATVIA   (Latvia)

^b JSC Grindeks   (Latvia)

Author keywords

Detomidine; Drug solvates; Solid state kinetics; Thermal analysis; X ray diffraction

Indexed keywords

DETOMIDINE; DETOMIDINE HYDROCHLORIDE MONOHYDRATE; UNCLASSIFIED DRUG;

ARTICLE; KINETICS; PHASE TRANSITION; PRIORITY JOURNAL; SOLID STATE; THERMAL ANALYSIS; THERMODYNAMICS; X RAY DIFFRACTION;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; DESICCATION; DIFFERENTIAL THERMAL ANALYSIS; DRUG STABILITY; IMIDAZOLES; KINETICS; MODELS, CHEMICAL; PHASE TRANSITION; POWDER DIFFRACTION; THERMODYNAMICS; X-RAY DIFFRACTION;

EID: 80053899091     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.08.004     Document Type: Article

References (18)

1. A. Blumberga, and A. Actiš Thermodinamic stability of crystalline modifications of zopiclone Latvian Journal of Chemistry 2 2005 150 158 (in Latvian)
2. H.G. Brittain Polymorphism in pharmaceutical solids 2nd ed. 2009 Informa Healthcare New York p. 640
3. S.R. Byrn, R.R. Pfeiffer, and J.G. Stowell Solid-state chemistry of drugs 1999 SSCI West Lafayette, IN p. 574
4. Computer program: TOPAS, version 3, Bruker AXS, 2006.
5. Diffrac plus TOPAS Version 4.0 Techical Reference. Karlsruhe, Germany: Bruker advanced X-ray solutions. 2008, 158 p.
6. Computer program: Winplotr, version March 2007, T. Roisnel and J. Rodriguez-Carvajal, 2007.
7. R. Hilfiker Polymorphism in the Pharmaceutical Industry 2006 Willey-VCH Verlag Weinheim p. 414
8. S.F. Hulbert Models for solid-state reactions in powdered compacts: a review Journal of the Brazilian Ceramic Society 6 1969 11 20
9. A. Khawam, and D.R. Flanagan Basics and applications of solid state kinetics: a pharmaceutical perspective Journal of Pharmaceutical Sciences 95 2006 472 498
10. E. Laine, V. Tuominen, P. Kahela, L. Liponkoski, and R. Sjoholm Physicals studies of detomidine hydrochloride, a new drug substance Acta Pharm Suec N 20 1983 451
11. Lauri, H., Lajunen, J., Routsalainen, H., Turpeinen, U., Parhi, S., Kurkela, K., Karjalainen, A., 1984. The strucure, protonatian and thermal behaviour of 4(5)-(2,3-dimetilbenzil)imidazole (detomidine) hydrochloride monohydrate. Acta Pharm. Suec. N 21, 163.
12. D.R. Lide CRC Handbook of Chemistry and Physics 87th ed. 2006 CRC Press Boca Raton, Florida, USA 6
13. Mirkin, L.I., 1981. X-ray.., e, :, 496 (in Russian).
14. L. Orola, M.V. Veidis, and A. Actins Study of the phase diagram of sygethin Latvian Journal of Chemistry 2 2009 111 118
15. Diffrac plus TOPAS Version 4.0 Tutorial. Karlsruhe, Germany: Bruker advanced x-ray solutions. 2008, 118 p.
16. U. Turpeinen, H. Ruotsalainen, R. Pehkonen, L.H.J. Lajunen, and A. Karjalainen Crystal structure, thermal behaviour, protonation and mass spectroscopic studies of racemic 4-[1-(2, 3-dimethylfenyl)-ethyl]-1H-izmidazole hydrochlorides Acta Chemica Scandinavica B42 1988 537
17. V. Uvarov, and I. Popov Development and metrological characterization of quantitative x-ray diffraction phase analysis for the mixtures of cloperidol bisulphate polymorphs Journal of Pharmaceutical and Biomedical Analysis 46 2008 676 682
18. K. Veldre, and A. Actiš Dehydration of (±)-medetomidine hydrochloride monohydrate Latvian Journal of Chemistry 4 2008 341 351 (in Latvian)