Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: Involvement of integrin receptor α5β1 in the process

European Journal of Nutrition

Volumn 50, Issue 6, 2011, Pages 465-478

  Sen, Triparna ^a   Chatterjee, Amitava ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

Author keywords

Breast cancer; EGCG; Epidermal growth factor receptor; Fibronectin; MMP 9; Signaling

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIGALLOCATECHIN GALLATE; FIBRONECTIN; FOCAL ADHESION KINASE; GELATINASE B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; VERY LATE ACTIVATION ANTIGEN 5;

ARTICLE; BREAST CANCER; CANCER CELL; CELL ADHESION; CELL ASSAY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GEL MOBILITY SHIFT ASSAY; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MMP 9 GENE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CATECHIN; CELL ADHESION; CELL LINE, TUMOR; DOWN-REGULATION; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FEMALE; FIBRONECTINS; FOCAL ADHESION KINASE 1; GENE SILENCING; HUMANS; INTEGRIN ALPHA5BETA1; MATRIX METALLOPROTEINASE 9; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 80053896962     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-010-0158-z     Document Type: Article

References (38)

1. C Muller-Tidow J Schwable B Steffen N Tidow B Brandt K Becker E Schulze-Bahr H Halfter U Vogt R Metzger PM Schneider T Buchner C Brandts WE Berdel H Serve 2004 High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets Clin Cancer Res 10 1241 1249 10.1158/1078-0432.CCR-0954-03 (Pubitemid 38365213)
2. B Rothhut C Ghoneim F Antonicelli M Soula-Rothhut 2007 Epidermal growth factor stimulates matrix metalloproteinase-9 expression and invasion in human follicular thyroid carcinoma cells through Focal adhesion kinase Biochimie 89 613 624 10.1016/j.biochi.2007.01.015 1:CAS:528:DC%2BD2sXkvFGktbk%3D (Pubitemid 46680369)
3. DJ Riese 2nd DF Stern 1998 Specificity within the EGF family/ErbB receptor family signaling network Bioessays 20 41 48 10.1002/(SICI)1521- 1878(199801)20:1<41::AID-BIES7>3.0.CO;2-V (Pubitemid 28111330)
4. A Wells 1999 EGF receptor The international journal of biochemistry & cell biology 31 637 643 10.1016/S1357-2725(99)00015-1 1:CAS:528: DyaK1MXkt1CjsrY%3D (Pubitemid 29248872)
5. J Rubin Grandis A Chakraborty MF Melhem Q Zeng DJ Tweardy 1997 Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells Oncogene 15 409 416 10.1038/sj.onc.1201188 1:STN:280: DyaK2szosVyltA%3D%3D (Pubitemid 27370990)
6. MD Schaller JT Parsons 1993 Focal adhesion kinase: an integrin-linked protein tyrosine kinase Trends Cell Biol 3 258 262 10.1016/0962-8924(93)90053-4 1:CAS:528:DyaK3sXlslKgs78%3D (Pubitemid 23214974)
7. GW McLean NO Carragher E Avizienyte J Evans VG Brunton MC Frame 2005 The role of focal-adhesion kinase in cancer-a new therapeutic opportunity Nature reviews 5 505 515 10.1038/nrc1647 1:CAS:528:DC%2BD2MXmtFOns7k%3D (Pubitemid 40942827)
8. SK Mitra DA Hanson DD Schlaepfer 2005 Focal adhesion kinase: in command and control of cell motility Nat Rev Mol Cell Biol 6 56 68 10.1038/nrm1549 1:CAS:528:DC%2BD2MXlvVWm (Pubitemid 40064899)
9. LA Cohen JL Guan 2005 Mechanisms of focal adhesion kinase regulation Current cancer drug targets 5 629 643 10.2174/156800905774932798 1:CAS:528:DC%2BD2MXhtlegsbfK (Pubitemid 41789601)
10. DJ Sieg CR Hauck D Ilic CK Klingbeil E Schaefer CH Damsky DD Schlaepfer 2000 FAK integrates growth-factor and integrin signals to promote cell migration Nat Cell Biol 2 249 256 10.1038/35010517 1:CAS:528:DC%2BD3cXktlOqs7o%3D
11. CC Bancroft Z Chen J Yeh JB Sunwoo NT Yeh S Jackson C Jackson C Van Waes 2002 Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3 K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines Int J Cancer 99 538 548 10.1002/ijc.10398 1:CAS:528:DC%2BD38XjsFansLw%3D (Pubitemid 34461606)
12. J Li ML Lin GJ Wiepz AG Guadarrama PJ Bertics 1999 Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor J Biol Chem 274 11209 11219 10.1074/jbc.274.16.11209 1:CAS:528:DyaK1MXis1Gmtrw%3D (Pubitemid 29191113)
13. EH Danen RM Lafrenie S Miyamoto KM Yamada 1998 Integrin signaling: cytoskeletal complexes, MAP kinase activation, and regulation of gene expression Cell Adhes Commun 6 217 224 10.3109/15419069809004477 1:CAS:528: DyaK1cXnslKnsb0%3D
14. SM Schoenwaelder K Burridge 1999 Bidirectional signaling between the cytoskeleton and integrins Curr Opin Cell Biol 11 274 286 10.1016/S0955-0674(99) 80037-4 1:CAS:528:DyaK1MXisFWltr4%3D (Pubitemid 29164045)
15. MA Schwartz MH Ginsberg 2002 Networks and crosstalk: integrin signalling spreads Nat Cell Biol 4 E65 E68 10.1038/ncb0402-e65 1:CAS:528: DC%2BD38XivV2jtr4%3D (Pubitemid 34308840)
16. L Moro M Venturino C Bozzo L Silengo F Altruda L Beguinot G Tarone P Defilippi 1998 Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival The EMBO journal 17 6622 6632 10.1093/emboj/17.22.6622 1:CAS:528:DyaK1cXnvF2jt78%3D (Pubitemid 28521796)
17. PE Van den Steen B Dubois I Nelissen PM Rudd RA Dwek G Opdenakker 2002 Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9) Crit Rev Biochem Mol Biol 37 375 536 10.1080/10409230290771546 (Pubitemid 36071972)
18. R Roskoski Jr 2004 The ErbB/HER receptor protein-tyrosine kinases and cancer Biochem Biophys Res Commun 319 1 11 10.1016/j.bbrc.2004.04.150 1:CAS:528:DC%2BD2cXkt1Cgtbg%3D (Pubitemid 38670153)
19. S Moulik T Sen A Dutta A Banerji C Ghosh S Das A Chatterjee 2008 Phosphatidylinositol 3-Kinase and NF-kB Involved in Epidermal Growth Factor-Induced Matrix Metalloproteinase-9 Expression J Cancer Mol 4 55 60 1:CAS:528:DC%2BD1cXot1Ons7w%3D (Pubitemid 351902825)
20. N Ahmad DK Feyes AL Nieminen R Agarwal H Mukhtar 1997 Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells J Natl Cancer Inst 89 1881 1886 10.1093/jnci/89.24.1881 1:CAS:528:DyaK1cXhvFKrsA%3D%3D (Pubitemid 28009824)
21. YC Liang SY Lin-shiau CF Chen JK Lin 1997 Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells J Cell Biochem 67 55 65 10.1002/(SICI)1097-4644(19971001)67:1<55::AID-JCB6>3.0. CO;2-V 1:CAS:528:DyaK2sXmvFCnt7c%3D (Pubitemid 27430323)
22. S Pianetti S Guo KT Kavanagh GE Sonenshein 2002 Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells Cancer Res 62 652 655 1:CAS:528:DC%2BD38Xht1Krtb4%3D (Pubitemid 34126935)
23. HS Kim MH Kim M Jeong YS Hwang SH Lim BA Shin BW Ahn YD Jung 2004 EGCG blocks tumor promoter-induced MMP-9 expression via suppression of MAPK and AP-1 activation in human gastric AGS cells Anticancer Res 24 747 753 1:CAS:528:DC%2BD2cXkvVensLc%3D (Pubitemid 38625017)
24. Yang J, Wei D, Liu J (2005) Repressions of MMP-9 expression and NF-kappa B localization are involved in inhibition of lung carcinoma 95-D cell invasion by (-)-epigallocatechin-3-gallate. Biomedicine Pharmacother 59:98-103 (Pubitemid 40424556)
25. T Sen S Moulik A Dutta PR Choudhury A Banerji S Das M Roy A Chatterjee 2009 Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7 Life sciences 84 194 204 10.1016/j.lfs.2008.11.018 1:CAS:528: DC%2BD1MXhtVCrtb8%3D
26. Sen T, Dutta A, Maity G, Chatterjee A (2010) Fibronectin induces matrix metalloproteinase-9 (MMP-9) in human laryngeal carcinoma cells by involving multiple signaling pathways. Biochimie [Epub ahead of print]
27. P Oc H Modjtahedi P Rhys-Evans WJ Court GM Box SA Eccles 2000 Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells Cancer Res 60 1121 1128 (Pubitemid 30129555)
28. JE Nutt GC Durkan JK Mellon J Lunec 2003 Matrix metalloproteinases (MMPs) in bladder cancer: the induction of MMP9 by epidermal growth factor and its detection in urine BJU Int 91 99 104 10.1046/j.1464-410X.2003.04020.x 1:CAS:528:DC%2BD3sXhsFOitL0%3D (Pubitemid 36098805)
29. CR Hauck DJ Sieg DA Hsia JC Loftus WA Gaarde BP Monia DD Schlaepfer 2001 Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells Cancer Res 61 7079 7090 1:CAS:528:DC%2BD3MXnsVehs7k%3D (Pubitemid 32946499)
30. MA Olayioye RM Neve HA Lane NE Hynes 2000 The ErbB signaling network: receptor heterodimerization in development and cancer The EMBO journal 19 3159 3167 10.1093/emboj/19.13.3159 1:CAS:528:DC%2BD3cXlt1ajtLY%3D (Pubitemid 30428195)
31. JW Soh EH Lee R Prywes IB Weinstein 1999 Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element Mol Cell Biol 19 1313 1324 1:CAS:528:DyaK1MXhtVKhtLs%3D (Pubitemid 29046873)
32. J Yao S Xiong K Klos N Nguyen R Grijalva P Li D Yu 2001 Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells Oncogene 20 8066 8074 10.1038/sj.onc.1204944 1:CAS:528:DC%2BD3MXptlKktLc%3D (Pubitemid 34028331)
33. Q Qiu M Yang BK Tsang A Gruslin 2004 EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3 K and MAPK signalling pathways Reproduction (Cambridge, England) 128 355 363 1:CAS:528:DC%2BD2cXot1Kitb8%3D (Pubitemid 39242711)
34. DD Schlaepfer T Hunter 1997 Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src J Biol Chem 272 13189 13195 10.1074/jbc.272.20.13189 1:CAS:528:DyaK2sXjtlakt7c%3D (Pubitemid 27216745)
35. L Trusolino G Serini G Cecchini C Besati FS Ambesi-Impiombato PC Marchisio R De Filippi 1998 Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion J Cell Biol 142 1145 1156 10.1083/jcb.142.4.1145 1:CAS:528:DyaK1cXls1ehs70%3D (Pubitemid 28402067)
36. NN Mon H Hasegawa AA Thant P Huang Y Tanimura T Senga M Hamaguchi 2006 A role for focal adhesion kinase signaling in tumor necrosis factor-alpha- dependent matrix metalloproteinase-9 production in a cholangiocarcinoma cell line, CCKS1 Cancer Res 66 6778 6784 10.1158/0008-5472.CAN-05-4159 1:CAS:528:DC%2BD28XmsVals78%3D (Pubitemid 44085637)
37. V Givant-Horwitz B Davidson R Reich 2004 Laminin-induced signaling in tumor cells: the role of the M(r) 67, 000 laminin receptor Cancer Res 64 3572 3579 10.1158/0008-5472.CAN-03-3424 1:CAS:528:DC%2BD2cXktVWhsbY%3D (Pubitemid 38657934)
38. JF Sah S Balasubramanian RL Eckert EA Rorke 2004 Epigallocatechin-3- gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases J Biol Chem 279 12755 12762 10.1074/jbc.M312333200 1:CAS:528:DC%2BD2cXitl2gt7Y%3D (Pubitemid 38445847)