Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 39, 2011, Pages 16212-16216

  Zhao, Jing ^a,b   Du, Yuhong ^a   Horton, John R ^a   Upadhyay, Anup K ^a   Lou, Bin ^a   Bai, Yan ^a   Zhang, Xing ^a   Du, Lupei ^c   Li, Minyong ^c   Wang, Binghe ^c   Zhang, Lixin ^a,d   Barbieri, Joseph T ^e   Khuri, Fadlo R ^a   Cheng, Xiaodong ^a   Fu, Haian ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c GEORGIA STATE UNIVERSITY   (United States)

^d INSTITUTE OF MICROBIOLOGY   (China)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Small molecule 14 3 3 modulator

Indexed keywords

4 [2 [4 FORMYL 6 METHYL 5 OXO 3 (PHOSPHONATOOXYMETHYL)PYRIDIN 2 YLIDENE]HYDRAZINYL]BENZOATE; EXOENZYME S; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROLINE RICH PROTEIN; PROTEIN 14 3 3; PROTEIN INHIBITOR; RAF PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN COS7; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME INACTIVATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

14-3-3 PROTEINS; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE POLARIZATION; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 80053645046     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100012108     Document Type: Article

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