A reversal learning task detects cognitive deficits in a Dachshund model of late-infantile neuronal ceroid lipofuscinosis

Genes, Brain and Behavior

Volumn 10, Issue 7, 2011, Pages 798-804

  Sanders, D N ^a,d   Kanazono, S ^b   Wininger, F A ^b   Whiting, R E H ^b,c   Flournoy, C A ^a,b   Coates, J R ^b   Castaner, L J ^a,b   O'Brien, D P ^b   Katz, M L ^a,b  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d PLYMOUTH STATE UNIVERSITY   (United States)

Author keywords

Canine model; Ceroid lipofuscinosis; CLN2; Cognitive decline; Neurodegeneration; Reversal learning

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; ELECTRORETINOGRAPHY; EXPERIMENTAL DOG; INFANT DISEASE; LEARNING; MAZE TEST; MOTOR DYSFUNCTION; NEUROLOGIC EXAMINATION; NEURONAL CEROID LIPOFUSCINOSIS; NEWBORN; NONHUMAN; OPHTHALMOSCOPY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; TASK PERFORMANCE; VISUAL DISORDER;

AMINOPEPTIDASES; ANIMALS; CASE-CONTROL STUDIES; CEREBELLAR ATAXIA; COGNITION DISORDERS; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DISEASE MODELS, ANIMAL; DOGS; ELECTRORETINOGRAPHY; FEMALE; FRAMESHIFT MUTATION; MALE; MAZE LEARNING; NEURONAL CEROID-LIPOFUSCINOSES; REVERSAL LEARNING; SERIAL LEARNING; SERINE PROTEASES;

CANIS FAMILIARIS;

EID: 80053634990     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2011.00718.x     Document Type: Article

References (26)

1. Awano, T., Katz, M.L., O'Brien, D.P., Sohar, I., Lobel, P., Coates, J.R., Khan, S., Johnson, G.C., Giger, U. & Johnson, G.S. (2006) A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile dachshund with neuronal ceroid lipofuscinosis. Mol Genet Metab 89, 254-260.
2. Buschman, T.J. & Miller, E.K. (2007) Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices. Science 315, 1860-1862.
3. Cotman, C.W., Head, E., Muggenburg, B.A., Zicker, S. & Milgram, N.W. (2002) Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging 23, 809-818.
4. Deadwyler, S.A. & Hampson, R.E. (2004) Differential but complementary mnemonic functions of the hippocampus and subiculum. Neuron 42, 465-476.
5. de Lahunta, A. & Glass, E. (2009) Visual System-Special Somatic Afferent System. Veterinary Neuroanatomy and Clinical Neurology, 3rd edn. Elsevier, St. Louis.
6. Hainsworth, D.P., Liu, G.T., Hamm, C.W. & Katz, M.L. (2009) Funduscopic and angiographic appearance in the neuronal ceroid lipofuscinoses. Retina 29, 657-668.
7. International Batten Disease Consortium. (1995) Isolation of a novel gene underlying Batten disease, CLN3. Cell 82, 949-957.
8. Katz, M.L., Coates, J.R., Cooper, J.J., O'Brien, D.P., Jeong, M. & Narfstrom, K. (2008) Retinal pathology in a canine model of late infantile neuronal ceroid lipofuscinosis. Invest Ophthalmol Vis Sci 49, 2686-2895.
9. Lorenz, M.D., Coates, J.R. & Kent, M. (2011) Neurologic History, Neuroanatomy and Neurologic Examination, 5th edn. Elsevier, St. Louis.
10. Maggs, D.J., Miller, P.E., Ofri, R. & Slatter, D.H. (2008) Slatter's Fundamentals of Veterinary Ophthalmology. Saunders - Elsevier, St. Louis.
11. Marmor, M., Fulton, A., Holder, G., Miyake, Y., Brigell, M. & Bach, M. (2009) Standard for clinical electroretinography (2008 update). Doc Ophthalmol 118, 69-77.
12. Milgram, N.W., Zicker, S.C., Head, E., Muggenburg, B.A., Murphey, H., Ikeda-Douglas, C.J. & Cotman, C.W. (2002) Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging 23, 737-745.
13. Ranta, S., Zhang, Y., Ross, B., Lonka, L., Takkunen, E., Messer, A., Sharp, J., Wheeler, R., Kusumi, K., Mole, S., Liu, W., Soares, M.B., Bonaldo, M.F., Hirvasniemi, A., de la Chapelle, A., Gilliam, T.C. & Lehesjoki, A.E. (1999) The neuronal ceroid lipofuscinoses in human EPMR and mnd mutant mice are associated with mutations in CLN8. Nat Genet 23, 233-236.
14. Robleto, K. & Thompson, R.F. (2008) Extinction of a classically conditioned response: red nucleus and interpositus. J Neurosci 28, 2651-2658.
15. Savukoski, M., Klockars, T., Holmberg, V., Santavuori, P., Lander, E.S. & Peltonen, L. (1998) CLN5, a novel gene encoding a putative transmembrane protein mutated in Finnish variant late infantile neuronal ceroid lipofuscinosis. Nat Genet 19, 286-288.
16. Siintola, E., Partanen, S., Stromme, P., Haapanen, A., Haltia, M., Maehlen, J., Lehesjoki, A.E., Tyynela, J. (2006) Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis. Brain 129, 1438-1445.
17. Siintola, E., Topcu, M., Aula, N., Lohi, H., Minassian, B.A., Paterson, A.D., Liu, X.Q., Wilson, C., Lahtinen, U., Anttonen, A.K. & Lehesjoki, A.E. (2007) The novel neuronal ceroid lipofuscinosis gene MFSD8 encodes a putative lysosomal transporter. Am J Hum Genet 81, 136-146.
18. Sleat, D.E., Ding, L., Wang, S., Zhao, C., Wang, Y., Xin, W., Zheng, H., Moore, D.F., Sims, K.B. & Lobel, P. (2009) Mass spectrometry-based protein profiling to determine the cause of lysosomal storage diseases of unknown etiology. Mol Cell Proteomics 8, 1708-1718.
19. Steinfeld, R., Heim, P., von Gregory, H., Meyer, K., Ullrich, K., Goebel, H.H. & Kohlschutter, A. (2002) Late infantile neuronal ceroid lipofuscinosis: quantitative description of the clinical course in patients with CLN2 mutations. Am J Med Genet 112, 347-354.
20. Tapp, P.D., Siwak, C.T., Estrada, J., Head, E., Muggenburg, B.A., Cotman, C.W. & Milgram, N.W. (2003) Size and reversal learning in the Beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem 10, 64-73.
21. Treisman, A.M. & Gelade, G. (1980) A feature-integration theory of attention. Cogn Psychol 12, 97-136.
22. Vesa, J., Hellsten, E., Verkruyse, L.A., Camp, L.A., Rapola, J., Santavuori, P., Hofmann, S.L. & Peltonen, L. (1995) Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis. Nature 376, 584-587.
23. Watson, D., Sullivan, J., Frank, J. & Stanton, M. (2006) Serial reversal learning of position discrimination in developing rats. Dev Psychobiol 48, 79-94.
24. Weleber, R.G. (1998) The dystrophic retina in multisystem disorders: the electroretinogram in neuronal ceroid lipofuscinoses. Eye 12, 580-590.
25. Wheeler, R.B., Sharp, J.D., Schultz, R.A., Joslin, J.M., Williams, R.E. & Mole, S.E. (2002) The gene mutated in variant late-infantile neuronal ceroid lipofuscinosis (CLN6) and in nclf mutant mice encodes a novel predicted transmembrane protein. Am J Hum Genet 70, 537-542.
26. Wisniewski, K.E., Kida, E., Golabek, A.A., Kaczmarski, W., Connell, F. & Zhong, N. (2001) Neuronal ceroid lipofuscinoses: classification and diagnosis. Adv Genet 45, 1-34.