A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 40, 2011, Pages 16759-16764

  Onyango, Patrick ^a   Feinberg, Andrew P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense RNA; DNA methylation; Epigenetics; Genomic; Imprinting

Indexed keywords

ARTICLE; CHORIOCARCINOMA; CHROMOSOME 11P; COLONY FORMATION; GENE EXPRESSION; GENE LOCUS; GENE OVEREXPRESSION; H19 OPPOSITE TUMOR SUPPRESSOR GENE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; NEPHROBLASTOMA; NUCLEOLUS; NUCLEUS ACCUMBENS; OPEN READING FRAME; PRIORITY JOURNAL; RHABDOID TUMOR; RHABDOMYOSARCOMA; RNA INTERFERENCE; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

BLOTTING, NORTHERN; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEOLUS; CHROMOSOMES, HUMAN, PAIR 11; CLONING, MOLECULAR; CPG ISLANDS; DNA PRIMERS; DNA, ANTISENSE; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOPRECIPITATION; NUCLEAR PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, UNTRANSLATED; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; WILMS TUMOR;

PRIMATES;

EID: 80053633503     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110904108     Document Type: Article

References (34)

1. Arney KL (2003) H19 and Igf2: Enhancing the confusion? Trends Genet 19:17-23.
2. Tremblay KD, Duran KL, Bartolomei MS (1997) A 5′ 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol Cell Biol 17:4322-4329. (Pubitemid 27318108)
3. Thorvaldsen JL, Duran KL, Bartolomei MS (1998) Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev 12:3693-3702. (Pubitemid 29019650)
4. Ripoche MA, Kress C, Poirier F, Dandolo L (1997) Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element. Genes Dev 11: 1596-1604. (Pubitemid 27274403)
5. Hark AT, et al. (2000) CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405:486-489. (Pubitemid 30367428)
6. Bell AC, Felsenfeld G (2000) Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405:482-485. (Pubitemid 30367427)
7. Jones BK, Levorse JM, Tilghman SM (1998) Igf2 imprinting does not require its own DNA methylation or H19 RNA. Genes Dev 12:2200-2207. (Pubitemid 28348043)
8. Leighton PA, Ingram RS, Eggenschwiler J, Efstratiadis A, Tilghman SM (1995) Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature 375: 34-39.
9. Rainier S, et al. (1993) Relaxation of imprinted genes in human cancer. Nature 362: 747-749. (Pubitemid 23125977)
10. Weksberg R, et al. (2001) Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1. Hum Mol Genet 10:2989-3000. (Pubitemid 34083485)
11. Feinberg AP, Tycko B (2004) The history of cancer epigenetics. Nat Rev Cancer 4: 143-153. (Pubitemid 38198742)
12. Sparago A, et al. (2004) Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. Nat Genet 36:958-960. (Pubitemid 39167491)
13. Feinberg AP, Williams BR (2003) Wilms tumor as a model for cancer biology. Tumor Suppressor Genes, ed El-Deiry WS (Humana, Totowa, NJ), Vol 1, pp 239-248.
14. Dao D, et al. (1999) Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: Inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Hum Mol Genet 8:1337-1352. (Pubitemid 29329004)
15. Karnik P, Chen P, Paris M, Yeger H, Williams BR (1998) Loss of heterozygosity at chromosome 11p15 in Wilms tumors: Identification of two independent regions. Oncogene 17:237-240. (Pubitemid 28371897)
16. Scrable H, et al. (1989) A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting. Proc Natl Acad Sci USA 86:7480-7484. (Pubitemid 19254480)
17. Overall ML, Spencer J, Bakker M, Dziadek M, Smith PJ (1996) p57K1P2 is expressed in Wilms' tumor with LOH of 11p15.5. Genes Chromosomes Cancer 17:56-59. (Pubitemid 26327935)
18. Rachmilewitz J, et al. (1995) H19 expression and tumorigenicity of choriocarcinoma derived cell lines. Oncogene 11:863-870.
19. Hao Y, Crenshaw T, Moulton T, Newcomb E, Tycko B (1993) Tumour-suppressor activity of H19 RNA. Nature 365:764-767. (Pubitemid 23339885)
20. Tsang WP, et al. (2010) Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis 31:350-358.
21. Berteaux N, et al. (2008) A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression. Mol Cell Biol 28:6731-6745.
22. Gupta RA, et al. (2010) Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464:1071-1076.
23. Juan V, Crain C, Wilson C (2000) Evidence for evolutionarily conserved secondary structure in the H19 tumor suppressor RNA. Nucleic Acids Res 28:1221-1227. (Pubitemid 30107694)
24. Cai X, Cullen BR (2007) The imprinted H19 noncoding RNA is a primary microRNA precursor. RNA 13:313-316. (Pubitemid 46327534)
25. ENCODE Project Consortium; Birney E, et al. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447:799-816.
26. Lyle R, et al. (2000) The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1. Nat Genet 25:19-21. (Pubitemid 30257030)
27. Lee JT, Davidow LS, Warshawsky D (1999) Tsix, a gene antisense to Xist at the X-in-activation centre. Nat Genet 21:400-404. (Pubitemid 29159577)
28. Lee MP, et al. (1999) Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting. Proc Natl Acad Sci USA 96:5203-5208. (Pubitemid 29214561)
29. Yu Y, et al. (1999) NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. Proc Natl Acad Sci USA 96:214-219. (Pubitemid 29036079)
30. Jin T, Guo F, Serebriiskii IG, Howard A, Zhang YZ (2007) A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks. Proteins 68:427-437. (Pubitemid 46981937)
31. Coverley D, Marr J, Ainscough J (2005) Ciz1 promotes mammalian DNA replication. J Cell Sci 118:101-112. (Pubitemid 40277108)
32. Richardson CJ, et al. (2004) SKAR is a specific target of S6 kinase 1 in cell growth control. Curr Biol 14:1540-1549. (Pubitemid 39290051)
33. Bera TK, et al. (2002) POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Proc Natl Acad Sci USA 99:16975-16980. (Pubitemid 36034083)
34. Popesco MC, et al. (2006) Human lineage-specific amplification, selection, and neuronal expression of DUF1220 domains. Science 313:1304-1307. (Pubitemid 44330957)