Light-induced trigeminal sensitization without central visual pathways: Another mechanism for photophobia

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 11, 2011, Pages 7852-7858

  Dolgonos, Sarah ^a   Ayyala, Haripriya ^b   Evinger, Craig ^b,c  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c SUNY EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORNEA; EYELID REFLEX; LIGHT DARK CYCLE; LIGHT INDUCED TRIGEMINAL SENSITIZATION; LIGHT INTENSITY; MALE; NONHUMAN; OPTIC NERVE LESION; PHOTOPHOBIA; PRIORITY JOURNAL; RAT; SENSITIZATION; TRIGEMINAL NERVE; VISUAL SYSTEM;

AIR; ANIMALS; BLINKING; CORNEA; DARK ADAPTATION; ELECTROMYOGRAPHY; LIGHT; MALE; OPTIC NERVE; PHOTOPHOBIA; RATS; RATS, SPRAGUE-DAWLEY; RETINA; TRIGEMINAL NERVE; VISUAL PATHWAYS;

EID: 80053626662     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7604     Document Type: Article

References (57)

1. Aslam TM, Haider D, Murray IJ. Principles of disability glare measurement: an ophthalmological perspective. Acta Ophthalmol Scand. 2007;85:354-360.
2. Nahar NK, Sheedy JE, Hayes J, Tai YC. Objective measurements of lower-level visual stress. Optom Vis Sci. 2007;84:620-629.
3. Sheedy JE, Hayes JN, Engle J. Is all asthenopia the same? Optom Vis Sci. 2003;80:732-739.
4. Sheedy JE, Truong SD, Hayes JR. What are the visual benefits of eyelid squinting? Optom Vis Sci. 2003;80:740-744.
5. Murray IJ, Plainis S, Carden D. The ocular stress monitor: a new device for measuring discomfort glare. Lighting Res Technol. 2002;34:231-239.
6. Nelson JD, Helms H, Fiscella R, Southwell Y, Hirsch JD. A new look at dry eye disease and its treatment. Adv Ther. 2000;17:84-93.
7. Gritz DC, Wong IG. Incidence and prevalence of uveitis in Northern California: the Northern California Epidemiology of Uveitis Study. Ophthalmology. 2004;111:491-500, discussion 500.
8. Lowder CY, Char DH. Uveitis: a review. West J Med. 1984;140: 421-432.
9. Tabbara KF, Sharara N. Dry eye syndrome. Drugs Today (Barc). 1998;34:447-453.
10. Adams WH, Digre KB, Patel BC, Anderson RL, Warner JE, Katz BJ. The evaluation of light sensitivity in benign essential blepharo-spasm. Am J Ophthalmol. 2006;142:82-87.
11. Emoto H, Suzuki Y, Wakakura M, et al. Photophobia in essential blepharospasm-a positron emission tomographic study. Mov Dis-ord. 2010;25:433-439.
12. Hallett M, Evinger C, Jankovic J, Stacy M. Update on blepharospasm: report from the BEBRF International Workshop. Neurology. 2008;71:1275-1282.
13. Chronicle EP, Mulleners WM. Visual system dysfunction in migraine: a review of clinical and psychophysical findings. Ceph-alalgia. 1996;16:525-535, discussion 523.
14. Drummond PD. A quantitative assessment of photophobia in migraine and tension headache. Headache. 1986;26:465-469.
15. Evans RW, Digre KB. Light sensitivity in migraineurs. Headache. 2003;43:917-920.
16. Main A, Dowson A, Gross M. Photophobia and phonophobia in migraineurs between attacks. Headache. 1997;37:492-495.
17. Vanagaite J, Pareja JA, Storen O, White LR, Sand T, Stovner LJ. Light-induced discomfort and pain in migraine. Cephalalgia. 1997; 17:733-741.
18. Kowacs PA, Piovesan EJ, Werneck LC, et al. Influence of intense light stimulation on trigeminal and cervical pain perception thresholds. Cephalalgia. 2001;21:184-188.
19. Noseda R, Kainz V, Jakubowski M, et al. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010;13:239-245.
20. Jan JE, Groenveld M, Anderson DP. Photophobia and cortical visual impairment. Dev Med Child Neurol. 1993;35:473-477.
21. Fine PG, Digre KB. A controlled trial of regional sympatholysis in the treatment of photo-oculodynia syndrome. J Neuroophthalmol. 1995;15:90-94.
22. Okamoto K, Tashiro A, Chang Z, Bereiter DA. Bright light activates a trigeminal nociceptive pathway. Pain. 2010;149:235-242.
23. Amini A, Digre K, Couldwell WT. Photophobia in a blind patient: an alternate visual pathway: case report. J Neurosurg. 2006;105: 765-768.
24. Custer PL, Reistad CE. Enucleation of blind, painful eyes. Ophthal Plast Reconstr Surg. 2000;16:326-329.
25. Henriquez VM, Evinger C. Modification of cornea-evoked reflex blinks in rats. Exp Brain Res. 2005;163:445-456.
26. Dauvergne C, Evinger C. Experiential modification of the trigemi-nal reflex blink circuit. J Neurosci. 2007;27:10414-10422.
27. Evinger C, Basso MA, Manning KA, Sibony PA, Pellegrini JJ, Horn AK. A role for the basal ganglia in nicotinic modulation of the blink reflex. Exp Brain Res. 1993;92:507-515.
28. Cruccu G, Agostino R, Berardelli A, Manfredi M. Excitability of the corneal reflex in man. Neurosci Lett. 1986;63:320-324.
29. Henriquez VM, Evinger C. The three-neuron corneal reflex circuit and modulation of second-order corneal responsive neurons. Exp Brain Res. 2007;179:691-702.
30. Pellegrini JJ, Horn AK, Evinger C. The trigeminally evoked blink reflex, I: neuronal circuits. Exp Brain Res. 1995;107:166-180.
31. Belmonte C, Acosta MC, Gallar J. Neural basis of sensation in intact and injured corneas. Exp Eye Res. 2004;78:513-525.
32. Acosta MC, Belmonte C, Gallar J. Sensory experiences in humans and single-unit activity in cats evoked by polymodal stimulation of the cornea. J Physiol. 2001;534:511-525.
33. Wolff H. Headache and Other Head Pain. New York: Oxford University Press; 1948:642.
34. Burke J, Hackley SA. Prepulse effects on the photic eyeblink reflex: evidence for startle-dazzle theory. Psychophysiology. 1997;34: 276-284.
35. Gruart A, Blazquez P, Delgado-Garcia JM. Kinematics of spontaneous, reflex, and conditioned eyelid movements in the alert cat. J Neurophysiol. 1995;74:226-248.
36. Manning KA, Evinger C. Different forms of blinks and their two-stage control. Exp Brain Res. 1986;64:579-588.
37. Tackmann W, Ettlin T, Barth R. Blink reflexes elicited by electrical, acoustic and visual stimuli, I: normal values and possible anatomical pathways. Eur Neurol. 1982;21:210-216.
38. Stringham JM, Fuld K, Wenzel AJ. Action spectrum for photophobia. J Opt Soc Am A Opt Image Sci Vis. 2003;20:1852-1858.
39. Stringham JM, Fuld K, Wenzel AJ. Spatial properties of photophobia. Invest Ophthalmol Vis Sci. 2004;45:3838-3848.
40. Ponder E, Kennedy WP. On the act of blinking. Exp Physiol. 1927;18:89-110.
41. Lam YW, Wong A, Canli T, Brown TH. Conditioned enhancement of the early component of the rat eyeblink reflex. Neurobiol Learn Mem. 1996;66:212-220.
42. Bangasser DA, Shors TJ. Acute stress impairs trace eye blink conditioning in females without altering the unconditioned response. Neurobiol Learn Mem. 2004;82:57-60.
43. Beck KD, Servatius RJ. Stress and cytokine effects on learning: what does sex have to do with it? Integr Physiol Behav Sci. 2003;38:179-188.
44. Vanagaite Vingen J, Stovner LJ. Photophobia and phonophobia in tension-type and cervicogenic headache. Cephalalgia. 1998;18: 313-318.
45. Kawasaki A, Purvin VA. Photophobia as the presenting visual symptom of chiasmal compression. J Neuroophthalmol. 2002; 22:3-8.
46. Fitzgerald ME, Gamlin PD, Zagvazdin Y, Reiner A. Central neural circuits for the light-mediated reflexive control of choroidal blood flow in the pigeon eye: a laser Doppler study. Vis Neurosci. 1996;13:655-669.
47. Fuchsjager-Mayrl G, Polska E, Malec M, Schmetterer L. Unilateral light-dark transitions affect choroidal blood flow in both eyes. Vision Res. 2001;41:2919-2924.
48. Okamoto K, Bereiter DF, Tashiro A, Bereiter DA. Ocular surface-evoked Fos-like immunoreactivity is enhanced in trigeminal sub-nucleus caudalis by prior exposure to endotoxin. Neuroscience. 2009;159:787-794.
49. Gutrecht JA, Lessell IM. Photophobia in trigeminal neuralgia. J Neuroophthalmol. 1994;14:122-123.
50. Drummond PD, Woodhouse A. Painful stimulation of the forehead increases photophobia in migraine sufferers. Cephalalgia. 1993; 13:321-324.
51. Yazulla S, Studholme KM. Vanilloid receptor like 1 (VRL1) immu-noreactivity in mammalian retina: colocalization with somatostatin and purinergic P2X1 receptors. J Comp Neurol. 2004;474:407-418.
52. Firth SI, Kaufman PL, De Jean BJ, Byers JM, Marshak DW. Inner-vation of the uvea by galanin and somatostatin immunoreactive axons in macaques and baboons. Exp Eye Res. 2002;75:49-60.
53. Lehtosalo JI, Uusitalo H, Palkama A. Sensory supply of the anterior uvea: a light and electron microscope study. Exp Brain Res. 1984;55:562-569.
54. Ruskell GL. Trigeminal innervation of the scleral spur in cynomol-gus monkeys. J Anat. 1994;184(pt 3):511-518.
55. Terenghi G, Polak JM, Ghatei MA, et al. Distribution and origin of calcitonin gene-related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye. J Comp Neurol. 1985; 233:506-516.
56. Uusitalo H, Krootila K, Palkama A. Calcitonin gene-related peptide (CGRP) immunoreactive sensory nerves in the human and guinea pig uvea and cornea. Exp Eye Res. 1989;48:467-475.
57. Wang ZY, Alm P, Hakanson R. Distribution and effects of pituitary adenylate cyclase-activating peptide in the rabbit eye. Neurosci-ence. 1995;69:297-308.