Preferential accumulation within tumors and in vivo imaging by functionalized luminescent dendrimer lanthanide complexes

Biomaterials

Volumn 32, Issue 35, 2011, Pages 9343-9352

  Alcala, Marco A ^a   Shade, Chad M ^b   Uh, Hyounsoo ^b   Kwan, Shu Ying ^c   Bischof, Matthias ^b   Thompson, Zachary P ^b   Gogick, Kristy A ^b   Meier, Adam R ^d   Strein, Timothy G ^d   Bartlett, David L ^a   Modzelewski, Ruth A ^a   Lee, Yong J ^a   Petoud, Stéphane ^b,e   Brown, Charles K ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c CARNEGIE MELLON UNIVERSITY   (United States)

^d BUCKNELL UNIVERSITY   (United States)

^e CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

Author keywords

Animal model; Functionalized dendrimer; Hepatic arterial infusion; Hepatic tumor; Luminescence imaging

Indexed keywords

ANIMAL MODEL; ARTERIAL INFUSION; FUNCTIONALIZED DENDRIMERS; HEPATIC TUMORS; LUMINESCENCE IMAGING;

DENDRIMERS; DIRECT INJECTION; EUROPIUM; LUMINESCENCE; PHOTOBLEACHING; POSITIVE IONS; RATS; TUMORS;

FUNCTIONAL POLYMERS;

DENDRIMER; EUROPIUM; EUROPIUM INCORPORATED GENERATION 3 POLY(AMINOAMINE) 4 AMINO 1,8 NAPHTHALIMIDE DENDRIMER; LANTHANIDE; NAPHTHALIMIDE DERIVATIVE; POLYAMIDOAMINE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEACHING; CANCER CELL; COLON ADENOCARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; GASTRODUODENAL ARTERY; IN VIVO STUDY; LIVER TUMOR; LUMINESCENCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTITUTION REACTION;

ANIMALS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DENDRIMERS; DIAGNOSTIC IMAGING; ELECTROPHORESIS; EUROPIUM; INFUSIONS, INTRA-ARTERIAL; LIVER NEOPLASMS; LUMINESCENCE; MALE; RATS; SPECTROMETRY, FLUORESCENCE; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 80053613998     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.07.076     Document Type: Article

References (33)

1. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., et al. Cancer statistics. CA Cancer J Clin 2008, 2008(58):71-96.
2. Park J.O., Brown C.K. Colorectal cancer. Holland - Frei manual of cancer medicine 2005, 184-204. BC Decker Inc, Hamilton. C.K. Brown, B.I. Rini, P.P. Connell, M.C. Posner (Eds.).
3. Abdalla E.K., Vauthey J.-N., Ellis L.M., Ellis V., Pollock R., Broglio K.R., et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg 2004, 239:818-827.
4. Fiorentini G., Aliberti C., Benea G., Montagnani F., Mambrini A., Ballardini P.L., et al. TACE of liver metastases from colorectal cancer adopting irinotecan-eluting beads: beneficial effect of palliative intra-arterial lidocaine and post-procedure supportive therapy on the control of side effects. Hepatogastroenterology 2008, 55:2077-2082.
5. Bartlett D.L., Libutti S.K., Figg W.D., Fraker D.L., Alexander H.R. Isolated hepatic perfusion for unresectable hepatic metastases from colorectal cancer. Surgery 2001, 129:176-187.
6. Agarwal A., Asthana A., Gupta U., Jain N.K. Tumour and dendrimers: a review on drug delivery aspects. J Pharm Pharmacol 2008, 60:671-688.
7. Medina S.H., El-Sayed M.E.H. Dendrimers as carriers for delivery of chemotherapeutic agents. Chem Rev 2009, 109:3141-3157.
8. Tekade R.K., Kumar P.V., Jain N.K. Dendrimers in oncology: an expanding horizon. Chem Rev 2008, 109:49-87.
9. Majoros I.J., Myc A., Thomas T., Mehta C.B., Baker J.R. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality. Biomacromolecules 2006, 7:572-579.
10. Wolinsky J.B., Grinstaff M.W. Therapeutic and diagnostic applications of dendrimers for cancer treatment. Adv Drug Del Rev 2008, 60:1037-1055.
11. Kaminskas L.M., Kelly B.D., McLeod V.M., Boyd B.J., Krippner G.Y., Williams E.D., et al. Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimers. Mol Pharm 2009, 6:1190-1204.
12. Stiriba S.-E., Frey H., Haag R. Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy. Angew Chem Int Ed 2002, 41:1329-1334.
13. Dykes G.M. Dendrimers: a review of their appeal and applications. J Chem Technol Biotechnol 2001, 76:903-918.
14. Nockemann P., Beurer E., Driesen K., Van Deun R., Van Hecke K., Van Meervelt L., et al. Photostability of a highly luminescent europium β-diketonate complex in imidazolium ionic liquids. Chem Commun 2005, 4354-4356.
15. Yuan D., Brown R.G., Hepworth J.D., Alexiou M.S., Tyman J.H.P. The synthesis and fluorescence of novel N-substituted-1,8-naphthylimides. J Heterocycl Chem 2008, 45:397-404.
16. Cross J.P., Lauz M., Badger P.D., Petoud S. Polymetallic lanthanide complexes with PAMAM-naphthalimide dendritic ligands: luminescent lanthanide complexes formed in solution. J Am Chem Soc 2004, 126:16278-16279.
17. Aebischer A., Gumy F., Bünzli J.-C.G. Intrinsic quantum yields and radiative lifetimes of lanthanide tris(dipicolinates). PCCP 2009, 11:1346-1353.
18. Wittmer A., Khazaie K., Berger M.R. Quantitative detection of lac-Z-transfected CC531 colon carcinoma cells in an orthotopic rat liver metastasis model. Clin Exp Metastasis 1999, 17:369-376.
19. Bouvet M., Tsuji K., Yang M., Jiang P., Moossa A.R., Hoffman R.M. In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases. Cancer Res 2006, 66:11293-11297.
20. Kollmar O., Schilling M.K., Menger M.D. Experimental liver metastasis: standards for local cell implantation to study isolated tumor growth in mice. Clin Exp Metastasis 2004, 21:453-460.
21. Hagenaars M., Ensink N.G., Basse P.H., Hokland M., Nannmark U., Eggermont A.M.M., et al. The microscopic anatomy of experimental rat CC531 colon tumour metastases: consequences for immunotherapy?. Clin Exp Metastasis 2000, 18:189-196.
22. Imaoka T., Horiguchi H., Yamamoto K. Metal assembly in novel dendrimers with porphyrin cores. J Am Chem Soc 2003, 125:340-341.
23. Dougherty T.J. Photosensitizers: therapy and detection of malignant tumors. Photochem Photobiol 1987, 45:879-889.
24. Svenson S., Tomalia D.A. Dendrimers in biomedical applications-reflections on the field. Adv Drug Del Rev 2005, 57:2106-2129.
25. Maiti P.K., Çagin T., Wang G., Goddard W.A. Structure of PAMAM dendrimers: generations 1 through 11. Macromolecules 2004, 37:6236-6254.
26. Urano Y., Asanuma D., Hama Y., Koyama Y., Barrett T., Kamiya M., et al. Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nat Med 2008, 15:104-109.
27. Liu P, Zhang A, Zhou M, Xu Y, Xu LX. Real time 3D detection of nanoparticle liposomes extravasation using laser confocal microscopy. Eng Med Biol Soc 2004 IEMBS '04 26th Annual International Conference of the IEEE2004. p. 2662-2665.
28. di Tomaso E., Capen D., Haskell A., Hart J., Logie J.J., Jain R.K., et al. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Res 2005, 65:5740-5749.
29. Weller G.E.R., Wong M.K.K., Modzelewski R.A., Lu E., Klibanov A.L., Wagner W.R., et al. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res 2005, 65:533-539.
30. Dunehoo A.L., Anderson M., Majumdar S., Kobayashi N., Berkland C., Siahaan T.J. Cell adhesion molecules for targeted drug delivery. J Pharm Sci 2006, 95:1856-1872.
31. Brown C.K., Modzelewski R.A., Johnson C.S., Wong M.K. A novel approach for the identification of unique tumor vasculature binding peptides using an E. coli peptide display library. Ann Surg Oncol 2000, 7:743-749.
32. Ruoslahti E. Drug targeting to specific vascular sites. Drug Discov Today 2002, 7:1138-1143.
33. Ruoslahti E., Bhatia S.N., Sailor M.J. Targeting of drugs and nanoparticles to tumors. J Cell Biol 2010, 188:759-768.