An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Danilov, Sergei M ^a   Gordon, Kerry ^b   Nesterovitch, Andrew B ^c   Lünsdorf, Heinrich ^d   Chen, Zhenlong ^a   Castellon, Maricela ^a   Popova, Isolda A ^e   Kalinin, Sergey ^a   Mendonca, Emma ^f   Petukhov, Pavel A ^a   Schwartz, David E ^a   Minshall, Richard D ^a   Sturrock, Edward D ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c RUSH MEDICAL COLLEGE   (United States)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e NORTHWESTERN UNIVERSITY   (United States)

^f University of Illinois at Chicago   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; DIMER; DIPEPTIDYL CARBOXYPEPTIDASE; EPITOPE; MONOMER; MUTANT PROTEIN; SERINE; ANGIOTENSIN CONVERTING ENZYME SECRETASE; PROTEINASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DOMAIN; WILD TYPE; ANIMAL; BINDING SITE; BIOLOGY; BLOOD; CELL MEMBRANE; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; GENETICS; HAMSTER; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CELL MEMBRANE; CHO CELLS; COMPUTATIONAL BIOLOGY; CRICETINAE; CRICETULUS; DNA MUTATIONAL ANALYSIS; ENDOPEPTIDASES; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; PEPTIDYL-DIPEPTIDASE A; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 80053589501     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025952     Document Type: Article

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