Evaluation of the genotoxic potential of single-wall carbon nanotubes by using a battery of in vitro and in vivo genotoxicity assays

Regulatory Toxicology and Pharmacology

Volumn 61, Issue 2, 2011, Pages 192-198

  Naya, Masato ^a   Kobayashi, Norihiro ^a   Mizuno, Kohei ^b   Matsumoto, Kyomu ^c   Ema, Makoto ^a   Nakanishi, Junko ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c INSTITUTE OF ENVIRONMENTAL TOXICOLOGY   (Japan)

Author keywords

Genotoxicity; In vitro; In vivo; Single wall carbon nanotubes

Indexed keywords

SINGLE WALLED NANOTUBE;

AMES TEST; ARTICLE; BACTERIAL REVERSE MUTATION ASSAY; BONE MARROW; CHROMOSOMAL ABERRATION TEST; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; ERYTHROCYTE; ESCHERICHIA COLI; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METABOLIC ACTIVATION; MICRONUCLEUS; MICRONUCLEUS TEST; NONHUMAN; NUMERICAL CHROMOSOME ABERRATION; PRIORITY JOURNAL; RISK ASSESSMENT; SALMONELLA TYPHIMURIUM; STRUCTURAL CHROMOSOME ABERRATION; TOXICITY TESTING;

ANIMALS; BIOTRANSFORMATION; BONE MARROW; CHROMOSOME ABERRATIONS; ELECTRIC POWER SUPPLIES; ERYTHROCYTES; ERYTHROCYTES, ABNORMAL; ESCHERICHIA COLI; FEMALE; MALE; MICE; MICE, INBRED ICR; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTATION; NANOTUBES, CARBON; SALMONELLA TYPHIMURIUM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MUS; SALMONELLA TYPHIMURIUM;

EID: 80053587356     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.07.008     Document Type: Article

References (31)

1. Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens with the Salmonella/mammalian microsome mutagenicity test. Mutat. Res. 1975, 31:347-364.
2. Di Sotto A., Chiaretti M., Carru G.A., Bellucci S., Mazzanti G. Multi-walled carbon nanotubes: lack of mutagenic activity in the bacterial reverse mutation assay. Toxicol. Lett. 2009, 184:192-197.
3. Elespuru R.K., Agarwal R., Atrachi A.H., Bigger C.A., Heflich R.H., Jagannath D.R., Levy D.D., Moore M.M., Ouyang Y., Robinson T.W., Sotomayor E., Cimino M.C., Dearfield K.L. Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays. Toxicol. Sci. 2009, 109:172-179.
4. Elgrabli D., Abella-Gallart S., Aguerre-Chariol O., Robidel F., Rogerieux F., Boczkowski J., Lacroix G. Effect of BSA on carbon nanotube dispersion for in vivo and in vitro studies. Nanotoxicology 2007, 1:266-278.
5. 60 fullerenes and single-walled carbon nanotubes. Environ. Health Perspect. 2009, 117:703-708.
6. Gatehouse D., Haworth S., Cebula T., Gocke E., Kier L., Matsushima T., Melcion C., Nohmi T., Ohta T., Venitt S., Zeiger E. Recommendations for the performance of bacterial mutation assays. Mutat. Res. 1994, 312:217-233.
7. Hata K., Futaba D.N., Mizuno K., Namai T., Yumura M., Iijima S. Water-assisted highly efficient synthesis of impurity-free single-walled carbon nanotube. Science 2004, 306(5700):1362-1364.
8. ICH Harmonised Tripartite Guideline, 1998. http://www.ich.org/products/guidelines/safety/article/safety-guidelines.html.
9. Ishidate M., Sofuni T., Yoshikawa K., Hayashi M., Nohmi T., Sawada M., Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem. Toxicol. 1984, 22:623-636.
10. 60 fullerenes in the FE1-Muta™ mouse lung epithelial cells. Environ. Mol. Mutagen. 2008, 49:476-487.
11. Kastenbaum M.A., Bowman K.O. Tables for determining the statistical significance of mutation frequencies. Mutat. Res. 1970, 9:527-549.
12. Kisin E.R., Murray A.R., Keane M.J., Shi X.C., Schwegler-Berry D., Gorelik O., Arepalli S., Castranova V., Wallace W.E., Kagan V.E., Shvedova A. Singlewalled carbon nanotubes: Geno and cytotoxic effects in lung fibroblast V79 cells. J. Toxicol. Environ. Health Part A 2007, 70:2071-2079.
13. Landsiedel R., Kapp M.D., Schulz M., Wiench K., Oesch F. Genotoxicity investigations on nanomaterials: methods, preparation, characterization of test material, potential artifacts and limitations - many questions, some answers. Mutation Res. 2009, 681:241-258.
14. Lanone S., Boczkowski J. Biomedical applications and potential health risks of nanomaterials: molecular mechanisms. Curr. Mol. Med. 2006, 6:651-663.
15. Li Z., Hulderman T., Salmen R., Chapman R., Leonard S.S., Young S.H., Shevedova A., Luster M.I., Simeonova P. Cardiovascular effects of pulmonary exposure to single-walled carbon nanotubes. Environ. Health Perspect. 2007, 115:377-382.
16. Lindberg H.K., Falck G.C.-M., Suhonen A., Vippola M., Vanhala E., Catalan J., Savolainen K., Norppa H. Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibers in human bronchial epithelial cells in vitro. Toxicol. Lett. 2009, 186:166-173.
17. Møller P., Jacobsen N.R., Folkmann A.K., Danielsen P.H., Mikkeksen L., Hemmingsen J.G., Vesterdal L.K., Forchhammer L., Wallin H., Loft S. Role of oxidative damage in toxicity of particles. Free Rad. Res. 2010, 44:1-46.
18. Muller J., Decordier I., Peter H., Hoet P.H., Lombaert N., Thomassen L., Huaux F., Lison D., Kirsch-Volders M. Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells. Carcinogenesis 2008, 29:427-433.
19. OECD-SIDS, 2003. http://www.oecd.org/document/7/0,3746,en_2649_34379_1947463_1_1_1_1,00.html#Chapter_2.
20. Pacurari M., Yin X.J., Zao J., Ding M., Leonard S.S., Schwegler-Berry D., Ducatman B.S., Sbarra D., Hoover M.D., Castranova V., Vallyathan V. Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-κB, and Akt in normal and malignant human mesothelial cells. Environ. Health Perspect. 2008, 116:1211-1217.
21. Poland C.A., Duffin R., Kinloch I., Maynard A., Wallace W.A.H., Seaton A., Stone V., Brown S., MacNee W., Donaldson K. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nature Nanotechnol. 2008, 3:423-428.
22. Savolainen K., Alenius H., Norppa H., Pylkkänen L., Tuomi T., Krasper G. Risk assessment of engineered nanomaterials and nanotechnologies - a review. Toxicology 2010, 269:92-104.
23. Schins R.P.F., Knaapen A.M. Genotoxicity of poorly soluble particles. Inhal. Toxicol. 2007, 19(Suppl. 1):189-198.
24. Shevedova A.A., Kisin E.R., Murray A.R., Gorelik O., Arepalli S., Castranova V., Young S.H., Gao F., Tyurina Y.Y., Oury T.D., Kagan V.E. Vitamin E deficiency enhances pulmonary response and oxidative stress induced by single-walled carbon nanotubes in C57/6 mice. Toxicol. Appl. Pharmacol. 2007, 221:339-348.
25. Shevedova A.A., Kisin E.R., Murray A.R., Jonhnson V.J., Gorelik O., Arepalli S., Hubbs A.F., Mercer R.R., Kohavong P., Sussman N., Jin J., Yin J., Stone S., Chen B.T., Deye G., Maynard A., Castranova V., Baron P.A., Kagan V.E. Inhalation vs. aspiration of single-walled carbon nanotubes in C57/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295:L552-L565.
26. Singh N., Manshian B., Jenkins G.L.S., Griffiths S.M., Williams P.M., Maffeis T.G.G., Wright C.J., Doak S.H. NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 2009, 30:3891-3914.
27. - mouse by intraperitoneal application of multi-wall carbon nanotube. J. Toxicol. Sci. 2008, 33:105-116.
28. US FDA, 2000. Bacterial reverse mutation test, in Redbook 2000 Chapter IV.1.a. available from: http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/FoodIngredientsandPackaging/Redbook/ucm078330.htm.
29. 2 particles as a component of nanoparticle risk management. Toxicol. Lett. 2007, 171:99-110.
30. Wirnitzer U., Herbold B., Voetz M., Ragot J. Studies on the in vitro genotoxicity of baytubes®, agglomerates of engineered multi-walled carbon-nanotubes (MWCNT). Toxicol. Lett. 2009, 186:160-165.
31. Zeni O., Palumbo R., Bernini R., Zeni L., Sarti M., Scarfi M.R. Cytotoxicity investigation on cultured human blood cells treated with single-walled carbon nanotubes. Sensor 2008, 8:488-494.