Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: An assessment of risk factors

International Journal of Radiation Oncology Biology Physics

Volumn 81, Issue 3, 2011, Pages 812-818

  Kelsey, Chris R ^a   Horwitz, Mitchell E ^a   Chino, Junzo P ^a   Craciunescu, Oana ^a   Steffey, Beverly ^a   Folz, Rodney J ^b   Chao, Nelson J ^a   Rizzieri, David A ^a   Marks, Lawrence B ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Allogeneic; Pneumonitis; Pulmonary toxicity; Stem cell transplant; Total body irradiation

Indexed keywords

ALLOGENEIC; PNEUMONITIS; PULMONARY TOXICITY; STEM CELL TRANSPLANT; TOTAL BODY IRRADIATION;

CHEMOTHERAPY; IRRADIATION; MULTIVARIANT ANALYSIS; REGRESSION ANALYSIS; STEM CELLS;

TOXICITY;

CYCLOPHOSPHAMIDE; CYCLOSPORIN; ETOPOSIDE; FLUDARABINE; HEPARIN; MELPHALAN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ANAPHYLAXIS; ARTICLE; BACTERIAL PNEUMONIA; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; COUGHING; DISEASE SEVERITY; DRUG MEGADOSE; DYSPNEA; FEMALE; HUMAN; HYPOXIA; LOW DRUG DOSE; LUNG HEMORRHAGE; LUNG TOXICITY; MAJOR CLINICAL STUDY; MALE; MYCOSIS; MYELOABLATIVE CONDITIONING; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; OVERALL SURVIVAL; PLEURA EFFUSION; PRIORITY JOURNAL; RESPIRATORY FAILURE; RISK FACTOR; VEIN OCCLUSION; WHOLE BODY RADIATION;

ACUTE DISEASE; ADULT; ANALYSIS OF VARIANCE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYCLOPHOSPHAMIDE; ETOPOSIDE; FEMALE; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HUMANS; LUNG; MALE; MELPHALAN; MIDDLE AGED; PNEUMONIA; RETROSPECTIVE STUDIES; RISK FACTORS; STEM CELL TRANSPLANTATION; TRANSPLANTATION CONDITIONING; VIDARABINE; WHOLE-BODY IRRADIATION; YOUNG ADULT;

EID: 80053578907     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.06.058     Document Type: Article

References (23)

1. R.T. Doocey, C.L. Toze, and J.M. Connors Allogeneic haematopoietic stem-cell transplantation for relapsed and refractory aggressive histology non-Hodgkin lymphoma Br J Haematol 131 2005 223 230 (Pubitemid 43899690)
2. A.K. Fielding, J.M. Rowe, and S.M. Richards Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: Results from the International ALL Trial MRC UKALLXII/ECOG2993 Blood 113 2009 4489 4496
3. M.L. Sorror, B.E. Storer, and D.G. Maloney Outcomes after allogeneic hematopoietic cell transplantation with nonmyeloablative or myeloablative conditioning regimens for treatment of lymphoma and chronic lymphocytic leukemia Blood 111 2008 446 452
4. A. Sureda, S. Robinson, and C. Canals Reduced-intensity conditioning compared with conventional allogeneic stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma: An analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation J Clin Oncol 26 2008 455 462 (Pubitemid 351171699)
5. A. Devergie, D. Blaise, and M. Attal Allogeneic bone marrow transplantation for chronic myeloid leukemia in first chronic phase: A randomized trial of busulfan-cytoxan versus cytoxan-total body irradiation as preparative regimen: A report from the French Society of Bone Marrow Graft (SFGM) Blood 85 1995 2263 2268
6. A.R. Hartman, S.F. Williams, and J.J. Dillon Survival, disease-free survival and adverse effects of conditioning for allogeneic bone marrow transplantation with busulfan/cyclophosphamide vs total body irradiation: A meta-analysis Bone Marrow Transplant 22 1998 439 443 (Pubitemid 28412473)
7. N. Kroger, T. Zabelina, and W. Kruger Comparison of total body irradiation vs busulfan in combination with cyclophosphamide as conditioning for unrelated stem cell transplantation in CML patients Bone Marrow Transplant 27 2001 349 354 (Pubitemid 32201342)
8. O. Ringden, M. Remberger, and T. Ruutu Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: Long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group Blood 93 1999 2196 2201 (Pubitemid 29153620)
9. J.Y. Cahn, J.P. Klein, and S.J. Lee Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: A joint Societe Francaise de Greffe de Moelle et Therapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) prospective study Blood 106 2005 1495 1500 (Pubitemid 41129621)
10. H. Glucksberg, R. Storb, and A. Fefer Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors Transplantation 18 1974 295 304
11. E.M. Kaplan P. Non-parametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
12. T.J. Keane, J. Van Dyk, and W.D. Rider Idiopathic interstitial pneumonia following bone marrow transplantation: The relationship with total body irradiation Int J Radiat Oncol Biol Phys 7 1981 1365 1370 (Pubitemid 12241701)
13. y Pino, J.L. Torres, D.S. Bross, and W.C. Lam Risk factors in interstitial pneumonitis following allogenic bone marrow transplantation Int J Radiat Oncol Biol Phys 8 1982 1301 1307 (Pubitemid 12031978)
14. R.S. Weiner, M.M. Bortin, and R.P. Gale Interstitial pneumonitis after bone marrow transplantation. Assessment of risk factors Ann Intern Med 104 1986 168 175 (Pubitemid 16134699)
15. V.T. Ho, E. Weller, and S.J. Lee Prognostic factors for early severe pulmonary complications after hematopoietic stem cell transplantation Biol Blood Marrow Transplant 7 2001 223 229 (Pubitemid 32433249)
16. N.S. Majhail, K. Parks, and T.E. Defor Diffuse alveolar hemorrhage and infection-associated alveolar hemorrhage following hematopoietic stem cell transplantation: Related and high-risk clinical syndromes Biol Blood Marrow Transplant 12 2006 1038 1046 (Pubitemid 44597153)
17. T. Fukuda, R.C. Hackman, and K.A. Guthrie Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplantation Blood 102 2003 2777 2785 (Pubitemid 37248846)
18. S. Nusair, R. Breuer, and M.Y. Shapira Low incidence of pulmonary complications following nonmyeloablative stem cell transplantation Eur Respir J 23 2004 440 445 (Pubitemid 38344383)
19. S. Sampath, T.E. Schultheiss, and J. Wong Dose response and factors related to interstitial pneumonitis after bone marrow transplant Int J Radiat Oncol Biol Phys 63 2005 876 884 (Pubitemid 41400079)
20. S.A. Carruthers, and M.M. Wallington Total body irradiation and pneumonitis risk: A review of outcomes Br J Cancer 90 2004 2080 2084 (Pubitemid 38869709)
21. C. Huisman, H.M. van der Straaten, and M.R. Canninga-van Dijk Pulmonary complications after T-cell-depleted allogeneic stem cell transplantation: Low incidence and strong association with acute graft-versus-host disease Bone Marrow Transplant 38 2006 561 566 (Pubitemid 44509549)
22. A.K. Singh, S.E. Karimpour, and B.N. Savani Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant Int J Radiat Oncol Biol Phys 66 2006 520 527 (Pubitemid 44332742)
23. D.A. Horak, G.M. Schmidt, and J.A. Zaia Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation Chest 102 1992 1484 1490