Fully automated and reproducible radiosynthesis of high specific activity [ 11C]raclopride and [ 11C]Pittsburgh compound-B using the combination of two commercial synthesizers

Nuclear Medicine Communications

Volumn 32, Issue 11, 2011, Pages 1011-1017

  Gómez Vallejo, Vanessa ^a   Llop, Jordi ^a  

^a CIC BIOMAGUNE   (Spain)

Author keywords

11C Pittsburgh compound B; 11C raclopride; positron emission tomography

Indexed keywords

METHANE; METHYL IODIDE; PITTSBURGH COMPOUND B; RACLOPRIDE C 11;

ANIMAL EXPERIMENT; ARTICLE; CYCLOTRON; DRUG SYNTHESIS; METHYLATION; NONHUMAN; RADIATION EXPOSURE; RADIOACTIVITY; RADIOCHEMISTRY; RAT;

ANILINE COMPOUNDS; CARBON RADIOISOTOPES; HYDROCARBONS, IODINATED; ISOTOPE LABELING; MESYLATES; METHYLATION; RACLOPRIDE; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; THIAZOLES;

EID: 80053575439     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/MNM.0b013e32834b45a3     Document Type: Article

References (22)

1. Elsinga PH, Hatano K, Ishiwata K. PET tracers for imaging of the dopaminergic system. Curr Med Chem 2006; 13:2139-2152.
2. Van Laere K, Clerinx K, DHondt E, De Groot T, VandenbergheW. Combined striatal binding and cerebral influx analysis of dynamic 11C-raclopride PET improves early differentiation between multiple-system atrophy and parkinson disease. J Nucl Med 2010; 51:588-595.
3. Scheinin NM, Aalto S, Koikkalainen J, Lö tjö nen J, Karrasch M, Kemppainen N, et al. Follow-up of [11C]PIB uptake and brain volume in patients with alzheimer disease and controls. Neurology 2009; 73: 1186-1192.
4. Okello A, Koivunen J, Edison P, Archer HA, Turkheimer FE, Någren K, et al. Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study. Neurology 2009; 73:754-760.
5. Ehrin E, Farde L, De Paulis T, Eriksson L, Greitz T, Johnström P, et al. Preparation of 11C-labelled raclopride, a new potent dopamine receptor antagonist: Preliminary PET studies of cerebral dopamine receptors in the monkey. Appl Radiat Isot 1985; 36:269-273.
6. Ehrin E, Gawell L, Hogberg T, De Pauli T, Strom P. Synthesis of [methoxy-3H]-and [methoxy-11C]-labelled raclopride. Specific dopamine-D2 receptor ligands. J Label Compd Radiopharm 1987; 24:931-940. (Pubitemid 17122030)
7. Langer O, Nagren K, Dolle F, Lundkvist C, Sandell J, Swahn CG, et al. Precursor synthesis and radiolabelling of the dopamine D2 receptor ligand [11C]raclopride from [11C]methyl triflate. J Label Compd Radiopharm 1999; 42:1183-1193.
8. Iwata R, Pascali C, Bogni A, Miyake Y, Yanai K, Ido T. A simple loop method for the automated preparation of (11C)raclopride from (11C)methyl triflate. Appl Radiat Isot 2001; 55:17-22. (Pubitemid 32322454)
9. Mathis CA, Wang Y, Holt DP, Huang GF, Debnath ML, Klunk WE. Synthesis and evaluation of 11C-labelled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem 2003; 46:2740-2754. (Pubitemid 36702542)
10. Solbach C, Uebele M, Reischl G, Machulla HJ. Efficient radiosynthesis of carbon-11 labelled uncharged thioflavin T derivatives using [11C]methyl triflate for b-amyloid imaging in Alzheimers disease with PET. Appl Radiat Isotop 2005; 62:591-595. (Pubitemid 40215555)
11. Wilson AA, Garcia A, Chestakova A, Kung H, Houle S. A rapid one-step radiosynthesis of the b-amyloid imaging radiotracer N-methyl-[11C]2-(4- methylaminophenyl)-6-hydroxybenzothiazole ([11C]-6-OH-BTA-1). J Label Compd Radiopharm 2004; 47:679-682. (Pubitemid 39390042)
12. Verdurand M, Bort G, Tadino V, Bonnefoi F, Le Bars D, Zimmer L. Automated radiosynthesis of the Pittsburg compound-B using a commercial synthesizer. Nucl Med Commun 2008; 29:920-926.
13. European Pharmacopoeia 6th Edition, 2007.
14. Langstrom B, Lundqvist H. The preparation of 11C-methyl iodide and its use in the synthesis of 11C-methyl-L-methionine. Appl Radiat Isot 1976; 27:357-363.
15. Buckley KR, Huser J, Jivan S, McDonald R, Ruth TJ. [11C]Methane production in small volume, high pressure gas targets. Radiochim Acta 2000; 88:201-205.
16. Helus F, Hanisch M, Layer K, Maier-BorstW. Yield ratio of [11C]-CO2, [11C]-CO and [11C]-CH4 from the irradiation of N2/H2 mixtures in the gas target. J Label Compd Radiopharm 1986; 23:1195-1198. (Pubitemid 17209863)
17. Larsen P, Ulin J, Dahlstrom K. A new method for production of 11C-labelled methyl iodide from 11C-methane. J Label Compd Radiopharm 1995; 37: 73-75.
18. Link JM, Clark JC, Larsen P, Krohn KA. Production of [11C]methyl iodide by reaction of 11CH4 with I2. J Label Compd Radiopharm 1995; 37: 76-78.
19. Noguchi J, Suzuki K. Automated synthesis of the ultra high specific activity of [11C]Ro154513 and its application in an extremely low concentration region to an ARG study. Nucl Med Biol 2003; 30:335-343. (Pubitemid 36556249)
20. Noguchi J, Zhang MR, Suzuki K. Application of ultra high specific activity [11C]compounds to in vitro ARG. J Label Compd Radiopharm 2003; 46:s240.
21. Ishiwata K, Ishii S-I, Senda M. An alternative synthesis of [11C]raclopride for routine use. Ann Nuc Med 1999; 13:195-197. (Pubitemid 29357308)
22. Wilson AA, Garcia A, Houle S, Vasdev N. Utility of commercial radiosynthetic modules in captive solvent [11C]-methylation reactions. J Label Compd Radiopharm 2009; 52:490-492.