The effect of age and comedication on lamotrigine clearance, tolerability, and efficacy

Epilepsia

Volumn 52, Issue 10, 2011, Pages 1905-1913

  Arif, Hiba ^a   Svoronos, Alexandra ^a   Resor Jr , Stanley R ^a   Buchsbaum, Richard ^b   Hirsch, Lawrence J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Columbia University ^*  (United States)

Author keywords

Antiepileptic drug; Drug interactions; Elderly; Older adults; Pharmacokinetics

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; ETIRACETAM; FELBAMATE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

ADOLESCENT; ADULT; AGED; ANXIETY; AREA UNDER THE CURVE; ARTICLE; BALANCE DISORDER; BEHAVIOR CHANGE; COGNITIVE DEFECT; COMPARATIVE STUDY; DEPRESSION; DIZZINESS; DROWSINESS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG ERUPTION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG RETENTION; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPILEPSY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PRIORITY JOURNAL; PSYCHOSIS; SEIZURE; SIDE EFFECT; SLEEP DISORDER; TONIC SEIZURE; TREMOR; UNSPECIFIED SIDE EFFECT; VISUAL DISORDER;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; DRUG INTERACTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTURAL BALANCE; SLEEP STAGES; TREMOR; TRIAZINES; YOUNG ADULT;

EID: 80053574606     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03217.x     Document Type: Article

References (23)

1. GlaxoSmithKline,. (August 2005) Lamotrigine [package insert]. Glaxo Smith Kline, Research Triangle park, NC.
2. Armijo JA, Bravo J, Cuadrado A, Herranz JL,. (1999) Lamotrigine serum concentration-to-dose ratio: influence of age and concomitant antiepileptic drugs and dosage implications. Ther Drug Monit 21: 182-190. (Pubitemid 29168896)
3. Berry DJ, Besag FM, Pool F, Natarajan J, Doose D,. (2002) Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 43: 818-823. (Pubitemid 34857856)
4. Chan V, Morris RG, Ilett KF, Tett SE,. (2001) Population pharmacokinetics of lamotrigine. Ther Drug Monit 23: 630-635. (Pubitemid 33086490)
5. Doose DR, Brodie MJ, Wilson EA, Chadwick D, Oxbury J, Berry DJ, Schwabe S, Bialer M,. (2003) Topiramate and lamotrigine pharmacokinetics during repetitive monotherapy and combination therapy in epilepsy patients. Epilepsia 44: 917-922. (Pubitemid 36842181)
6. Gilliam F, Vazquez B, Sackellares JC, Chang GY, Messenheimer J, Nyberg J, Risner ME, Rudd GD,. (1998) An active-control trial of lamotrigine monotherapy for partial seizures. Neurology 51: 1018-1025. (Pubitemid 28473394)
7. Hirsch LJ, Weintraub D, Du Y, Buchsbaum R, Spencer HT, Hager M, Straka T, Bazil CW, Adams DJ, Resor SR Jr, Morrell MJ,. (2004) Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. Neurology 63: 1022-1026. (Pubitemid 39287910)
8. Hussein Z, Posner J,. (1997) Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data. Br J Clin Pharmacol 43: 457-465. (Pubitemid 27224004)
9. Liston HL, Markowitz JS, Devane CL,. (2001) Drug glucuronidation in clinical psychopharmacology. J Clin Psychopharmacol 21: 500-515. (Pubitemid 32937433)
10. Matsuo F, Gay P, Madsen J, Tolman KG, Rollins DE, Risner ME, Lai AA,. (1996) Lamotrigine high-dose tolerability and safety in patients with epilepsy: a double-blind, placebo-controlled, eleven-week study. Epilepsia 37: 857-862. (Pubitemid 26313731)
11. May TW, Rambeck B, Jurgens U,. (1996) Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. Ther Drug Monit 18: 523-531. (Pubitemid 26330471)
12. May TW, Rambeck B, Jurgens U,. (1999) Influence of oxcarbazepine and methsuximide on lamotrigine concentrations in epileptic patients with and without valproic acid comedication: results of a retrospective study. Ther Drug Monit 21: 175-181. (Pubitemid 29168895)
13. Messenheimer J, Ramsay RE, Willmore LJ, Leroy RF, Zielinski JJ, Mattson R, Pellock JM, Valakas AM, Womble G, Risner M,. (1994) Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, cross-over trial. Epilepsia 35: 113-121. (Pubitemid 24074474)
14. Paul F, Veauthier C, Fritz G, Lehmann TN, Aktas O, Zipp F, Meencke HJ,. (2007) Perioperative fluctuations of lamotrigine serum levels in patients undergoing epilepsy surgery. Seizure 16: 479-484. (Pubitemid 47209237)
15. Pennell PB, Peng L, Newport DJ, Ritchie JC, Koganti A, Holley DK, Newman M, Stowe ZN,. (2008) Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology 70: 2130-2136.
16. Perucca E,. (2006) Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age. Clin Pharmacokinet 45: 351-363.
17. Posner J, Holdrich T, Crome P,. (1991) Comparison of lamotrigine pharmacokinetics in young and elderly healthy volunteers. J Pharm Med 1: 121-128.
18. Sabers A, Ohman I, Christensen J, Tomson T,. (2003) Oral contraceptives reduce lamotrigine plasma levels. Neurology 61: 570-571. (Pubitemid 37025386)
19. Theis JG, Sidhu J, Palmer J, Job S, Bullman J, Ascher J,. (2005) Lack of pharmacokinetic interaction between oxcarbazepine and lamotrigine. Neuropsychopharmacology 30: 2269-2274. (Pubitemid 41643979)
20. Tran TA, Leppik IE, Blesi K, Sathanandan ST, Remmel R,. (2002) Lamotrigine clearance during pregnancy. Neurology 59: 251-255. (Pubitemid 34779186)
21. Van Heiningen PN, Eve MD, Oosterhuis B, Jonkman JH, De Bruin H, Hulsman JA, Richens A, Jensen PK,. (1991) The influence of age on the pharmacokinetics of the antiepileptic agent oxcarbazepine. Clin Pharmacol Ther 50: 410-419.
22. Weintraub D, Buchsbaum R, Resor SR Jr, Hirsch LJ,. (2005) Effect of antiepileptic drug comedication on lamotrigine clearance. Arch Neurol 62: 1432-1436. (Pubitemid 41352061)
23. Wnuk W, Volanski A, Foletti G,. (1999) Topiramate decreases lamotrigine concentrations. Ther Drug Monit 21: 449-459.