Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats

European Journal of Pharmacology

Volumn 668, Issue 3, 2011, Pages 477-485

  Sedlinsky, Claudia ^a   Molinuevo, María Silvina ^a   Cortizo, Ana María ^a   Tolosa, María José ^a   Felice, Juan Ignacio ^a   Sbaraglini, María Laura ^a   Schurman, Leon ^a   McCarthy, Antonio Desmond ^a  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

Author keywords

Bone marrow progenitor cells; Bone reossification; Metformin; Osteoblastogenesis; Rosiglitazone; Trabecular bone microarchitecture

Indexed keywords

ADENYLATE KINASE; COLLAGEN TYPE 1; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; BONE GROWTH; BONE MINERALIZATION; BONE REGENERATION; BONE REMODELING; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFICACY; ENZYME PHOSPHORYLATION; EPIPHYSIS; EX VIVO STUDY; GROWTH PLATE; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; MALE; METAPHYSIS; MONOTHERAPY; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; RAT; TRABECULAR BONE;

ADIPOCYTES; ALKALINE PHOSPHATASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BONE MARROW CELLS; BONE REGENERATION; CELL DIFFERENTIATION; COLLAGEN TYPE I; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DRUG INTERACTIONS; EXTRACELLULAR SPACE; FEMUR; GENE EXPRESSION REGULATION; MALE; METFORMIN; OSTEOGENESIS; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STEM CELLS; THIAZOLIDINEDIONES;

EID: 80053571599     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.07.033     Document Type: Article

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