Mapping of IgE and IgG 4 antibody-binding epitopes in Cyn d 1, the major allergen of bermuda grass pollen

International Archives of Allergy and Immunology

Volumn 157, Issue 2, 2012, Pages 125-135

  Yuan, Han Chih ^a,b   Wu, Keh Gong ^a   Chen, Chun Jen ^a   Su, Song Nan ^a   Shen, Horng Der ^a   Chen, Yann Jang ^b   Peng, Ho Jen ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Antibody binding epitope; Cyn d 1; Dot immunoblotting; Synthetic peptide

Indexed keywords

ALANINE; CYCLIN D1; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; SYNTHETIC PEPTIDE; ALLERGEN; CYN D 1 ALLERGEN, BERMUDA GRASS; EPITOPE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; PLANT ANTIGEN;

ALLERGIC RHINITIS; AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ARTICLE; BERMUDA GRASS POLLEN; BLOOD SAMPLING; CONTROLLED STUDY; CROSS REACTION; EPITOPE MAPPING; GRASS POLLEN; HUMAN; IMMUNOBLOTTING; IMMUNOREACTIVITY; IMMUNOTHERAPY; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS; WESTERN BLOTTING; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CYNODON; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; POLLEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MOTIF;

ALLERGENS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIGENS, PLANT; CROSS REACTIONS; CYNODON; EPITOPE MAPPING; EPITOPES; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLLEN; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 80053547985     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000327544     Document Type: Article

References (33)

1. Gerth van Wijk R: Allergy: a global problem. Allergy 2002; 57: 1097-1110.
2. Chang HN, Lin FM, Chang YF: Correlation of skin test to RAST, and PRIST in asthma patients. Clin Med J 1984; 34: 376-383.
3. Ford SA, Baldo BA: Identification of Bermuda grass (Cynodon dactylon)-pollen allergens by electroblotting. J Allery Clin Immunol 1987; 79: 711-720. (Pubitemid 17074289)
4. Shen HD, Wang SR, Tang RB, Chang ZN, Han SH: Identification of allergens and antigens of Bermuda grass (Cynodon dactylon) pollen by immunoblot analysis. Clin Allergy 1988; 18: 401-409.
5. Matthiesen F, Schumacher MJ, Lowenstein H: Characterization of the major allergen of Cynodon dactylon (Bermuda grass) pollen Cyn d 1. J Allergy Clin Immunol 1991; 88: 763-774.
6. Han SW, Chang ZN, Chi CW, Peng HJ, Liu CC, Tsai JJ, Tam MF: Use of monoclonal antibodies to isolate and characterize Cyn d 1, the major allergen of Bermuda grass pollen. J Allergy Clin Immunol 1993; 92: 549-558. (Pubitemid 23317080)
7. Smith PM, Suphioglu C, Griffith IJ, Theriault K, Knox RB, Singh MB: Cloning and expression in yeast Pichia pastoris of a biologically active form of Cyn d 1, the major allergen of Bermuda grass pollen. J Allergy Clin Immunol 1996; 98: 331-343. (Pubitemid 26326128)
8. Chang ZN, Peng HJ, Lee WC, Chen TS, Chua KY, Tsai LC, Chi CW, Han SH: Sequence polymorphism of the group 1 allergen of Bermuda grass pollen. Clin Exp Allergy 1999; 29: 488-496.
9. Au LC, Lin ST, Peng HJ, Liang CC, Lee SS, Liao CD, Chang ZN: Molecular cloning and sequence analysis of full-length cDNAs encoding new group of Cyn d 1 isoallergens. Allergy 2002; 57: 215-220. (Pubitemid 34250752)
10. Chang ZN, Liu CC, Tam MF, Peng HJ, Tsai JJ, Han SH: Characterization of the isoforms of the group I allergen of Cynodon dactylon . J Allergy Clin Immunol 1995; 95: 1206-1214.
11. Su SN, Peng HJ, Yang SY, Tsai LC, Chow LP, Huang SW: Purification and characterization of a novel isoallergen of a major Bermuda grass pollen allergen, Cyn D 1. J Biomed Sci 2003; 10: 111-119.
12. Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W, Till SJ, Hamid QA, Nouri-Aria KT: Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999; 341: 468-475. (Pubitemid 29372886)
13. Valenta R: The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol 2002; 2: 446-453. (Pubitemid 37328752)
14. Moller C, Dreborg S, Ferdousi HA, Halken S, Host A, Jacobsen L, Koivikko A, Koller DY, Niggemann B, Norberg LA, Urbanek R, Valovirta E, Wahn U: Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 2002; 109: 251-256. (Pubitemid 34158289)
15. Singh MB, de Weerd N, Bhall PL: Genetically engineered plant allergens with reduced anaphylactic activity. Int Arch Allergy Immunol 1999; 119: 75-85. (Pubitemid 29304462)
16. Bhalla PL, Singh MB: Engineered allergens for immunotherapy. Curr Opin Allergy Clin Immunol 2004; 4: 569-573. (Pubitemid 39573734)
17. Asturias JA, Gomez-Bayon N, Arilla MC, Sanchez-Pulido L, Valencia A, Martinez A: Molecular and structural analysis of the panallergen profiling B cell epitopes defined by monoclonal antibodies. Int Immunol 2002; 14: 993-1001.
18. Beezhold DH, Hickey VL, Sutherland MF, O'Hehir RE: The latex allergen Hev b 5 is an antigen with repetitive murine B-cell epitopes. Int Arch Allergy Immunol 2004; 134: 334-340. (Pubitemid 39070168)
19. Szalai K, Fuhrmann J, Pavkov T, Scheidl M, Wallmann J, Brämswig KH, Vrtala S, Scheiner O, Keller W, Saint-Remy JM, Neumann D, Pali-Schöll I, Jensen-Jarolim E: Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2. Mol Immunol 2008; 45: 1308-1317. (Pubitemid 350299486)
20. Han SW, Chang ZN, Chang HH, Chi CW, Wang AY, Lin CY: Identification and characterization of epitopes on Cyn d I, the major allergen of Bermuda grass pollen. J Allergy Clin Immunol 1993; 91: 1035-1041.
21. Chan SL, Ong TC, Gao YF, Tiong YS, Wang DY, Chew FT, Mok YK: Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust allergen. J Immunol 2008; 181: 2586-2596.
22. Elsayed S, Hill DJ, Do TV: Evaluation of the allergenicity and antigenicity of bovine milk s1 casein using extensively purified synthetic peptides. J Immunol 2004; 60: 486-493. (Pubitemid 39487516)
23. Gonzalez EM, Villalba M, Quiralte J, Batanero E, Roncal F, Albar JP, Rodriguez R: Analysis of IgE and IgG B-cell immunodominant regions of Ole e 1, the main allergen from olive pollen. Mol Immunol 2006; 43: 570-578. (Pubitemid 41785384)
24. Chang ZN, Tam MF, Liu CC, Chi CW, Peng HJ, Han SW: Using monoclonal antibodies to characterize a sequential epitope on the group I allergen of Bermuda grass pollen. Int Arch Allergy Immunol 1997; 114: 258-264. (Pubitemid 27448440)
25. Nakajima-Adachi H, Hachimura S, Ise W, Honma K, Nishiwaki S, Hirota M, Shimojo N, Katsuki T, Ametani A, Kohno Y, Kaminogawa S: Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine (s)1-casein from the same patients allergic to cow's milk: existence of (s)1-casein specific B cells and T cells characteristic in cow's-milk allergy. J Allergy Clin Immunol 1998; 101: 660-671. (Pubitemid 28228311)
26. Jarvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA: Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy 2007; 62: 758-765. (Pubitemid 46934359)
27. Shreffler WG, Lencer DA, Bardina L, Sampson HA: IgE and IgG 4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol 2005; 116: 893-899. (Pubitemid 41400557)
28. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans S, Bruijnzeel-Koomen C, Sampson HA, van Hoffen E, Shreffler WG: Peanut epitopes for IgE and IgG 4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol 2008; 121: 737-743.
29. Arnold K, Bordoli L, Kopp J, Schwede T: The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics 2006; 22: 195-201. (Pubitemid 43205406)
30. Ramos JD, Cheong N, Lee BW, Chua KY: Peptide mapping of immunoglobulin E and immunoglobulin G immunodominant epitopes of an allergenic blomia tropicalis paramyosin, Blo t 11. Clin Exp Allergy 2003; 33: 511-517. (Pubitemid 36520917)
31. Gascan H, Gauchat JF, Roncarolo MG, Yssel H, Spits H, de Vries JE: Human B cell clones can be induced to proliferate and to switch to IgE and IgG 4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones. J Exp Med 1991; 173: 747-750.
32. Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE: Interleukin-13 induces interleukin-4-independent IgG 4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993; 90: 3730-3733.
33. Tiwari R, Bhalla PL, Singh MB: Mapping of IgE-binding regions on recombinant Cyn d 1, a major allergen from Bermuda Grass Pollen (BGP). Clin Mol Allergy 2009; 7: 3.