Intensity-modulated radiotherapy for squamous cell carcinoma of the anal canal: Efficacy of a low daily dose to clinically negative regions

Radiation Oncology

Volumn 6, Issue 1, 2011, Pages

  Call, Jason A ^a   Haddock, Michael G ^a   Quevedo, J Fernando ^a   Larson, David W ^a   Miller, Robert C ^a  

^a MAYO CLINIC   (United States)

Author keywords

Anal cancer; Chemotherapy; Intensity modulated radiotherapy; Squamous cell carcinoma

Indexed keywords

FLUOROURACIL;

ADULT; AGED; ANUS CARCINOMA; ARTICLE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CHEMORADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LOW ENERGY RADIATION; LYMPH NODE METASTASIS; MALE; OVERALL SURVIVAL; RETROSPECTIVE STUDY; ANUS TUMOR; COMPUTER ASSISTED RADIOTHERAPY; METHODOLOGY; MIDDLE AGED; RADIATION DOSE; RADIATION RESPONSE; RECURRENT DISEASE; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; ANUS NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CHEMORADIOTHERAPY; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MIDDLE AGED; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED; RECURRENCE; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 80053538513     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717x-6-134     Document Type: Article

References (19)

1. Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB, Thomas CR Jr, et al: Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA 2008, 299(16):1914-21
2. Bartelink H, Roelofsen F, Eschwege F, Rougier P, Bosset JF, Gonzalez DG, et al: Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 1997, 15(5):2040-9
3. Flam M, John M, Pajak TF, Petrelli N, Myerson R, Doggett S, et al: Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 1996, 14(9):2527-39
4. UKCCCR Anal Cancer Trial Working Party, UK Co-ordinating Committee on Cancer Research: Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil, and mitomycin. Lancet 1996, 348(9034):1049-54
5. Kachnic L, Winter K, Myerson R, Goodyear M, Willins J, Esthappan J, et al: RTOG 0529: a phase II evaluation of dose-painted IMRT in combination with 5-fluorouracil and mitomycin-C for reduction of acute morbidity in carcinoma of the anal canal [abstract]. Int J Radiat Oncol Biol Phys 2009, 75(3 Suppl 1):S5
6. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, editors: AJCC Cancer Staging Manual. New York: Springer;c2010
7. Ben-Josef E, Moughan J, Ajani J, Flam M, Gunderson L, Pollock J, et al: The impact of overall treatment time on survival and local control in anal cancer patients: a pooled data analysis of RTOG trials 8704 and 9811 [abstract]. Int J Radiat Oncol Biol Phys 2009, 75(3 Suppl 1):S26-S7
8. Constantinou EC, Daly W, Fung CY, Willett CG, Kaufman DS, DeLaney TF: Time-dose considerations in the treatment of anal cancer. Int J Radiat Oncol Biol Phys 1997, 39(3):651-7
9. Deniaud-Alexandre E, Touboul E, Tiret E, Sezeur A, Houry S, Gallot D, et al: Results of definitive irradiation in a series of 305 epidermoid carcinomas of the anal canal. Int J Radiat Oncol Biol Phys 2003, 56(5):1259-73
10. Graf R, Wust P, Hildebrandt B, Gogler H, Ullrich R, Herrmann R, et al: Impact of overall treatment time on local control of anal cancer treated with radiochemotherapy. Oncology 2003, 65(1):14-22
11. Huang K, Haas-Kogan D, Weinberg V, Krieg R: Higher radiation dose with a shorter treatment duration improves outcome for locally advanced carcinoma of anal canal. World J Gastroenterol 2007, 13(6):895-900
12. Weber DC, Kurtz JM, Allal AS: The impact of gap duration on local control in anal canal carcinoma treated by split-course radiotherapy and concomitant chemotherapy. Int J Radiat Oncol Biol Phys 2001, 50(3):675-80
13. Widder J, Kastenberger R, Fercher E, Schmid R, Langendijk JA, Dobrowsky W, et al: Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients. Radiother Oncol 2008, 87(3):367-75
14. Nigro ND, Vaitkevicius VK, Considine B Jr: Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 1974, 17(3):354-6
15. Nigro ND, Seydel HG, Considine B, Vaitkevicius VK, Leichman L, Kinzie JJ: Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. Cancer 1983, 51(10):1826-9
16. Leichman L, Nigro N, Vaitkevicius VK, Considine B, Buroker T, Bradley G, et al: Cancer of the anal canal: model for preoperative adjuvant combined modality therapy. Am J Med 1985, 78(2):211-5
17. James R, Wan S, Glynne-Jones R, Sebag-Montefiore D, Kadalayil L, Northover J, et al: A randomized trial of chemoradiation using mitomycin or cisplatin, with or without maintenance cisplatin/5FU in squamous cell carcinoma of the anus (ACT II) [abstract]. J Clin Oncol 2009, 27(18S): LBA4009
18. Kachnic LA, Tsai HK, Coen JJ, Blaszkowsky LS, Hartshorn K, Kwak EL, et al: Dose-painted intensity-modulated radiation therapy for anal cancer: a multi-institutional report of acute toxicity and response to therapy. Int J Radiat Oncol Biol Phys 2010
19. Kachnic L, Winter K, Myerson R, Goodyear M, Willins J, Esthappan J, et al: Early efficacy results of RTOG 0529: a phase II evaluation of dosepainted IMRT in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal [abstract]. Int J Radiat Oncol Biol Phys 2010, 78(3 Suppl 1):S55