A single intrathecal injection of DNA and an asymmetric cationic lipid as lipoplexes ameliorates experimental autoimmune encephalomyelitis

Molecular Pharmaceutics

Volumn 8, Issue 5, 2011, Pages 1980-1984

  Yellayi, Srikanth ^a,b   Hilliard, Brendan ^a   Ghazanfar, Mustafa ^a   Tsingalia, Akivaga ^a   Nantz, Michael H ^c   Bollinger, Laura ^b   De Kok Mercado, Fabian ^b   Hecker, James G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

animal model; asymmetric lipids; CNS gene delivery; experimental autoimmune encephalomyelitis

Indexed keywords

GLYCEROL; HYBRID PROTEIN; LIPID; LIPOPLEX; OX40 LIGAND; PLASMID DNA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CENTRAL NERVOUS SYSTEM; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; GENE EXPRESSION; GENE THERAPY; IMMUNOMODULATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CENTRAL NERVOUS SYSTEM; CISTERNA MAGNA; DNA; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; INJECTIONS, SPINAL; LAURATES; LIPIDS; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; MYRISTATES; PLASMIDS; RECEPTORS, OX40; RECOMBINANT FUSION PROTEINS; STEARATES; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 80053521958     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2002413     Document Type: Article

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