Differentiation of PDX1 gene-modified human umbilical cord mesenchymal stem cells into insulin-producing cells in vitro

International Journal of Molecular Medicine

Volumn 28, Issue 6, 2011, Pages 1019-1024

  He, Dongmei ^a   Wang, Juan ^a   Gao, Yangjun ^a   Zhang, Yuan ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

like cells; Human; Mesenchymal stem cells; Pancreatic and duodenal homeobox factor 1; Umbilical cord

Indexed keywords

ADENOVIRUS VECTOR; ALKALINE PHOSPHATASE; C PEPTIDE; DITHIZONE; INSULIN; MEMBRANE ANTIGEN; TRANSCRIPTION FACTOR PDX 1;

ADENOVIRUS; ADIPOCYTE; ADIPOGENESIS; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPHENOTYPING; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MESENCHYMAL STEM CELL; MORPHOLOGY; OSTEOCYTE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; UMBILICAL CORD; VIRUS GENE;

ADENOVIRIDAE; ADIPOCYTES; C-PEPTIDE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; FETAL BLOOD; FLOW CYTOMETRY; GENETIC VECTORS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INSULIN; INSULIN-SECRETING CELLS; MESENCHYMAL STEM CELLS; OSTEOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSDUCTION, GENETIC; UMBILICAL CORD;

EID: 80053493893     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.774     Document Type: Article

References (28)

1. Jiang J, Au M, Lu K, Eshpeter A, Korbutt G, Fisk G and Majumdar AS: Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 25: 1940-1953, 2007. (Pubitemid 47258172)
2. Karnieli O, Izhar-Prato Y, Bulvik S and Efrat S: Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells 25: 2837-2844, 2007. (Pubitemid 350127868)
3. Noguchi H, Xu G, Matsumoto S and Kaneto H, Kobayashi N, Bonner-Weir S and Hayashi S: Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant 15: 929-938, 2006. (Pubitemid 46174543)
4. Sun NZ and Ji HS: In vitro differentiation of human placentaderived adherent cells into insulin-producing cells. J Int Med Res 37: 400-406, 2009.
5. Tateishi K, He J, Taranova O, Liang G, D'Alessio AC and Zhang Y: Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol Chem 283: 31601-31607, 2008.
6. Yang JH, Lee SH, Heo YT, Uhm SJ and Lee HT: Generation of insulin-producing cells from gnotobiotic porcine skin-derived stem cells. Biochem Biophys Res Commun 397: 679-684, 2010.
7. Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH and Stoffers DA: The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest 119: 1888-1898, 2009.
8. Wang H, Maechler P, Ritz-Laser B, Hagenfeldt KA, Ishihara H, Philippe J and Wollheim CB: Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J Biol Chem 276: 25279-25286, 2001.
9. Kroon E, Martinson LA, Kadoya K, et al: Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 26: 443-452, 2008. (Pubitemid 351501814)
10. Khan AA, Rajendraprasad A, Parveen N, et al: In vitro insulin production and analysis of pancreatic transcription factors in induced human hepatic progenitor cells. Diabetes Technol Ther 12: 373-378, 2010.
11. Zhang Y, Shen W, Hua J, et al: Pancreatic islet-like clusters from bone marrow mesenchymal stem cells of human first-trimester abortus can cure streptozocin-induced mouse diabetes. Rejuvenation Res 13: 695-706, 2010.
12. Tayaramma T, Ma B, Rohde M and Mayer H: Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells. Stem Cells 24: 2858-2867, 2006. (Pubitemid 46053022)
13. Phuc PV, Nhung TH, Loan DT, Chung DC and Ngoc PK: Differentiating of banked human umbilical cord blood-derived mesenchymal stem cells into insulin-secreting cells. In Vitro Cell Dev Biol Anim 47: 54-63, 2011.
14. Chao KC, Chao KF, Fu YS and Liu SH: Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One 3: e1451, 2008.
15. Shiroi A, Ueda S, Ouji Y, et al: Differentiation of embryonic stem cells into insulin-producing cells promoted by Nkx2.2 gene transfer. World J Gastroenterol 21: 4161-4166, 2005. (Pubitemid 41086865)
16. Segev H, Fishman B, Ziskind A, Shulman M and Itskovitz-Eldor J: Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 22: 265-274, 2004. (Pubitemid 38736611)
17. Bai L, Meredith G and Tuch BE: Glucagon-like peptide-1 enhances production of insulin in insulin-producing cells derived from mouse embryonic stem cells. J Endocrinol 186: 343-352, 2005. (Pubitemid 41167403)
18. Hui H, Yu R, Bousquet C and Perfetti R: Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion. Endocrinology 143: 3529-3539, 2002. (Pubitemid 34925728)
19. Li L, Li F, Qi H, Feng G, Yuan K, Deng H and Zhou H: Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. Stem Cells Dev 17: 815-823, 2008.
20. Vaca P, Berná G, Araujo R, Carneiro EM, Bedoya FJ, Soria B and Martín F: Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells. Exp Cell Res 314: 969-974, 2008.
21. Cho YM, Lim JM, Yoo DH, et al: Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun 366: 129-134, 2008. (Pubitemid 350297223)
22. Hisanaga E, Park KY, Yamada S, et al: A simple method to induce differentiation of murine bone marrow mesenchymal cells to insulin-producing cells using conophylline and betacellulindelta4. Endocr J 55: 535-543, 2008. (Pubitemid 351949749)
23. Ye DZ, Tai MH, Linning KD, Szabo C and Olson LK: MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells. Diabetes 55: 742-750, 2006. (Pubitemid 43343231)
24. Beattie GM, Montgomery AM, Lopez AD, et al: A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes 51: 3435-3439, 2002. (Pubitemid 35403447)
25. Habener JF, Kemp DM and Thomas MK: Minireview: transcriptional regulation in pancreatic development. Endocrinology 146: 1025-1034, 2005. (Pubitemid 40289291)
26. Miyazaki S, Yamato E and Miyazaki J: Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes 53: 1030-1037, 2004. (Pubitemid 38436615)
27. Baertschiger RM, Bosco D, Morel P, Serre-Beinier V, Berney T, Buhler LH and Gonelle-Gispert C: Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development. Pancreas 37: 75-84, 2008.
28. Nelson SB, Schaffer AE and Sander M: The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development 134: 2491-2500, 2007. (Pubitemid 47074143)