Antivirals: Achilles heel of Ebola viral entry

Nature Reviews Drug Discovery

Volumn 10, Issue 10, 2011, Pages 731-

  Flemming, Alexandra ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; AMANTADINE; CATHEPSIN B; IMIPRAMINE; MEMBRANE PROTEIN; NIEMANN PICK C1 PROTEIN; PROTEIN INHIBITOR; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

CELL MIGRATION; CELL SURVIVAL; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CYTOARCHITECTURE; DISEASE MODEL; DISEASE PREDISPOSITION; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; FIBROBLAST; FILOVIRUS; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC SCREENING; GLYCOSYLATION; HAPLOIDY; HETEROZYGOSITY; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFECTION CONTROL; INFECTION RESISTANCE; LYSOSOME MEMBRANE; MARBURG VIRUS; NIEMANN PICK DISEASE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; VESICULAR STOMATITIS VIRUS; VIRUS ENTRY; VIRUS INFECTIVITY; VIRUS RECOMBINANT;

EID: 80053492982     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3568     Document Type: Note

References (2)

1. Carette, J. E. et al. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature 24 Aug 2011 (doi:10.1038/nature10348)
2. Côté, M. et al. Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection. Nature 24 Aug 2011 (doi:10.1038/nature10380)