The combined effects of reduced weightbearing and ionizing radiation on splenic lymphocyte population and function

International Journal of Radiation Biology

Volumn 87, Issue 10, 2011, Pages 1033-1038

  Sanzari, Jenine K ^a   Wilson, Jolaine M ^a   Wagner, Erika B ^b   Kennedy, Ann R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Massachusetts Institute of Technology   (United States)

Author keywords

Immunology; Lymphocytes; Space flight

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GAMMA RADIATION; IONIZING RADIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SPLEEN LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; WEIGHT BEARING;

ANIMALS; B-LYMPHOCYTES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; RADIATION INJURIES, EXPERIMENTAL; RADIATION, IONIZING; RATS; SPLEEN; TIME FACTORS;

MUS;

EID: 80053475899     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2011.595875     Document Type: Article

References (25)

1. Allebban Z, Ichiki AT, Gibson LA, Jones JB, Congdon CC, Lange RD. 1994. Effects of spaceflight on the number of rat peripheral blood leukocytes and lymphocyte subsets. Journal of Leukocyte Biology 55(209):213
2. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. 2005. Key gravity-sensitive signaling pathways drive T cell activation. Federation of American Societies for Experimental Biology Journal 19:2020-2022 (Pubitemid 41759751)
3. Cogoli A, Tschopp A, Fuchs-Bislin P. 1984. Cell sensitivity to gravity. Science 225:228-230 (Pubitemid 14079878)
4. Gridley DS, Pecaut MJ, Nelson GA. 2002. Total-body irradiation with high-LET particles: Acute and chronic effects on the immune system. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 282:R677-688 (Pubitemid 34665640)
5. Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL, Pecaut MJ. 2009. Spacefl ight effects on T lymphocyte distribution, function and gene expression. Journal of Applied Physiology 106:194-202
6. Hughes-Fulford M, Sugano E, Schopper T, Li CF, Boonyaratanakornkit JB, Cogoli A. 2005. Early immune response and regulation of IL-2 receptor subunits. Cellular Signaling 17:1111-1124 (Pubitemid 40933531)
7. Kajioka EH, Gheorghe C, Andres ML, Abell GA, Folz-Holbeck, Slater JM, Nelson GA, Gridley DS. 1999. Effects of proton and gamma radiation on lymphocyte populations and acute response to antigen. In Vivo 13:525-533 (Pubitemid 30189200)
8. Lange RD, Andrews RB, Gibson LA, Wright P, Dunn CD, Jones JB. 1985. Hematologic parameters of astrorats fl own on SL-3. Physiologist 28:S195-196
9. Maino VC, Suni MA, Ruitenberg JJ. 1995. Rapid fl ow cytometric method for measuring lymphocyte subset activation. Cytometry 20:127-133
10. Meehan RT, Neale LS, Kraus ET, Stuart CA, Smith ML, Cintron NM, Sams CF. 1992. Alteration in human mononuclear leucocytes following space fl ight. Immunology 76:491-497
11. Mills PJ, Meck JV, Waters WW, DAunno D, Ziegler MG. 2001. Peripheral leukocyte subpopulations and catecholamine levels in astronauts as a function of mission duration. Psychosomatic Medicine 63:886-890 (Pubitemid 33101373)
12. Morey-Holton ER, Globus RK. 2002. Hindlimb unloading rodent model: Technical aspects. Journal of Applied Physiology 92:1367-1377 (Pubitemid 34670888)
13. Nash PV, Mastro AM. 1992. Variable lymphocyte responses in rats after space fl ight. Experimental Cell Research 202:125-131
14. Nash PV, Bour BA, Mastro AM. 1991. Effect of hindlimb suspension simulation of microgravity on in vitro immunological responses. Experimental Cell Research 195:353-360 (Pubitemid 121006334)
15. Pecaut MJ, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ, Gridley DS. 2003. Genetic models in applied physiology: Selected contribution: Effects of spacefl ight on immunity in the C57BL/6 mouse. I. Immune population distributions. Journal of Applied Physiology 94:2085-2094 (Pubitemid 36457463)
16. Shearer WT, Zhang S, Reuben JM, Lee BN, Butel JS. 2005. Effects of radiation and latent virus on immune responses in a space fl ight model. Journal of Allergy and Clinical Immunology 115: 1297-1303 (Pubitemid 40824605)
17. Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Th ompson B, Butel JS, Blancher A, Abbal M, Aviles H, et al. 2009. Immune responses in adult female volunteers during the bed-rest model of spacefl ight: Antibodies and cytokines. Journal of Allergy and Clinical Immunology 123:900-905
18. Simms PE, Ellis TM. 1996. Utility of fl ow cytometric detection of CD69 expression as a rapid method for determining poly- and oligoclonal lymphocyte activation. Clinical and Diagnostic Laboratory Immunology 3:301-304 (Pubitemid 26189630)
19. Sonnenfeld G, Shearer WT. 2002. Immune function during space fl ight. Nutrition 18:899-903 (Pubitemid 35292263)
20. Taylor GR. 1993. Immune changes during short-duration missions. Journal of Leukocyte Biology 54:202-208 (Pubitemid 23300685)
21. Taylor GR, Neale LS, Dardano JR. 1986. Immunological analyses of U.S. Space Shuttle crewmembers. Aviation, Space and Environmental Medicine 57:213-217 (Pubitemid 16157759)
22. Wagner EB, Granzella NP, Saito H, Newman DJ, Young LR, Bouxsein ML. 2010. Partial weight suspension: A novel murine model for investigating adaptation to reduced musculoskeletal loading. Journal of Applied Physiology 109:350-357
23. Wambi C, Sanzari J, Wan XS, Nuth M, Davis J, Ko YH, Sayers CM, Baran M, Ware JH, Kennedy AR. 2008. Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation. Radiation Research 169:384-396 (Pubitemid 351620037)
24. Wambi CO, Sanzari JK, Sayers CM, Nuth M, Zhou Z, Davis J, Finnberg N, Lewis-Wambi JS, Ware JH, El-Deiry WS, Kennedy AR. 2009. Protective effects of dietary antioxidants on proton total-body irradiation- mediated hematopoietic cell and animal survival. Radiation Research 172:175-186
25. Wei LX, Zhou JN, Roberts AI, Shi YF. 2003. Lymphocyte reduction induced by hindlimb unloading: Distinct mechanisms in the spleen and thymus. Cell Research 13:465-471 (Pubitemid 43231840)