High dose methotrexat liver toxieity

International Journal of Hematology-Oncology and Stem Cell Research

Volumn 5, Issue 1, 2011, Pages 16-19

  Mashhadi, Mohammadali ^a   Mahammadi, Mohammd ^b   Bakhshipour, Alireza ^a   Keikhaei, Mahmoudali ^a   Sandoughi, Mahnaz ^a   Heidari, Zahra ^a   Sanadgol, Hooshang ^a   Mashhadi, Amin ^c  

^a ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

High dose; Liver toxicity; Methotrexate

Indexed keywords

FOLINIC ACID; METHOTREXATE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALOPECIA; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CYTOPENIA; DOSE RESPONSE; DRUG ERUPTION; DRUG MEGADOSE; ETHNIC GROUP; EWING SARCOMA; FEMALE; HUMAN; IRANIAN; LIVER TOXICITY; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; OSTEOSARCOMA; PROSPECTIVE STUDY; SIDE EFFECT; STOMATITIS; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 80053472193     PISSN: 17351243     EISSN: 20082207     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Jolivet J, Cown KH, Curt GA, Clendeninn NJ, Chabner BA. The Pharmacology and Clinical Use of Methotrexate. NEJM 1983; 309: 1094-1104.
2. Oguz A, Hasan Oglu A, Azgu FS, Timlioglu O, Biberoglu G, Uluoglu C. Methotrexate Related Hepatotoxicity. Gazi Medical Journal. 2002; 13: 69-72.
3. Hersh EM, Wong VG, Henderson ES, Freireich EJ. Hepatotoxic Effect of Methotrexate. Cancer 1966; (19): 600-606.
4. Steven P, Treon and Bruce A, Chabner. Concepts in Use of High Dose MTX Therapy. Clinical Chemistry 1996; 2: 1322-1329.
5. Kermer JM. Hepatotoxicity Associated with Chronic Oral MTX for non Malignant Disease. Up To Date 2008; 16-2.
6. McKendry RJ, Dale P. Adverse Effect of Low Dose MTX Therapy in Rheumatoid Arthritis. J Rheumatol. 1993; 20: 1850-1856.
7. Bologna C, Viu P, Picot MC, Jorjensen C, Sang J. Long Term Follow up of 53 Rheumatoid Arthritis Patients Treated with MTX: an Open Retrospective Observation Study. Br J Rheumatology 1997; 36: 535-540.
8. Macdonald JS. Cancer Chemotherapy and the Liver. Clinical Liver Disease. 1998; 2: 631-642.
9. Zacharia H, Sogaard H. Methotrexate Induced Liver Cirrhosis. A Follow. Dermatologica 1987; 5: 207-212.
10. Outryve SV, Schrijvers D, Brand JV, Wilmes P, Bogers J, Marck E, Vermorken JB. Methotrexate Associated Liver Toxicity in a Patient with Breast Cancer: Case Report and Literature Review. The Netherland Journal of Medicine. 2002; 60(5): 132-139.
11. Bremnes RM, Smeland E, Huseby NE, Eidet J, Aarbakke J. Acute Hepatotoxicity after High Dose Methotrexate Administration to Rat. Pharmacol. Toxicol. 1991; 69(2): 132- 139.
12. Kaito K, Kalayama T. Fulminant Hepatic Failure Induced by Intermediate Dose MTX in a Case of Non Hodgkins Lymphoma. Jap. J. Clin Hematology; 1999; 31: 1862-1867.
13. Mashhadi MA. The Effect of High Dose MTX in Patients with Neoplastic Diseases: A Prospective Disease. Iranian Red Crescent Medical Journal; 2008; 10(2): 75-78.
14. Green MR, Chomberlan M. Clinical Utility and Pharmacology of High Dose MTX in the Treatment of CNS Lymphoma. Expert Rev Neurothe. 2006 May; 6(5): 635-652.
15. UP To Date 18.2; 2010. MTX Hepatotoxicity.
16. National Cancer Institute Common Toxicity Criteria (CTC). 1999; Accessed on March 27, 2002 http://CTep.Cancer.gov/etc.htmc.
17. UP To Date. 18.2 2010, High Dose Methotrexat and toxicity.
18. Pitman SW, Frei E. Weekly MTX- Calcium Leucovorin Rescue: Effect of Alkalinization on Nephrotoxicity; Pharmacokinetics in the CNS and Use in CNS non-Hodgkins Lymphoma. Cancer Treat Rep 1997; 61; 695-701.
19. Brouwers P, Moss H, Reaman G, McGuire T, Trupin E, Libow J, et al. Central Nervous System Preventative Therapy with Systemic High Dose MTX versus Cranial Irradiation and Intratechal MTx: Longitudinal Comparison of Effects of Treatment on Intellectual Function of Children with ALL (abstract (rsqb). Pro. American Society of Clinical Oncology 1987; 6: 158-162.
20. Outryve SV, Schrijvers D, Brande JV, Wilms P, Bogers J, Marck E, Vermorken JB. MTX Associated Liver Toxicity in a Patient with Breast Cancer: Case Report and Literature Review. The Netherland Journal of Medicine 2002; 60(5); 216-222.
21. Evan M, Hersh MD, Vernon G, Wong MD, Eward S, Henderson MD, Emil J, Freireich MD. Hepatotoxic Effects of MTX. Journal of Cancer 1966;600-606.