Toll-Like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Boeglin, Emmanuelle ^a   Smulski, Cristian R ^a   Brun, Susana ^a   Milosevic, Sara ^a   Schneider, Pascal ^b   Fournel, Sylvie ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD40 ANTIGEN; CD40 LIGAND; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CD45 ANTIGEN; CYTIDINE DEAMINASE; MESSENGER RNA; PRDM1 PROTEIN, MOUSE; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMORAL IMMUNITY; INNATE IMMUNITY; MOUSE; NONHUMAN; PATTERN RECOGNITION; SPLEEN; T LYMPHOCYTE; ANIMAL; ANTIBODY PRODUCTION; CELL CULTURE; CYTOLOGY; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PLASMA CELL;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, CD45; CD40 LIGAND; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYTIDINE DEAMINASE; GENE EXPRESSION REGULATION; LYMPHOCYTE ACTIVATION; MICE; PLASMA CELLS; RNA, MESSENGER; SPLEEN; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTORS;

EID: 80053445138     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025542     Document Type: Article

References (49)

1. Medzhitov R, (2007) Recognition of microorganisms and activation of the immune response. Nature 449: 819-826.
2. Manicassamy S, Pulendran B, (2009) Modulation of adaptive immunity with Toll-like receptors. Semin Immunol 21: 185-193.
3. Ogata H, Su I, Miyake K, Nagai Y, Akashi S, et al. (2000) The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med 192: 23-29.
4. Pasare C, Medzhitov R, (2005) Control of B-cell responses by Toll-like receptors. Nature 438: 364-368.
5. Gavin AL, Hoebe K, Duong B, Ota T, Martin C, et al. (2006) Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 314: 1936-1938.
6. Meyer-Bahlburg A, Rawlings DJ, (2008) B cell autonomous TLR signaling and autoimmunity. Autoimmun Rev 7: 313-316.
7. Barr TA, Brown S, Ryan G, Zhao J, Gray D, (2007) TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells. Eur J Immunol 37: 3040-3053.
8. Gururajan M, Jacob J, Pulendran B, (2007) Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets. PLoS ONE 2: e863.
9. Borsutzky S, Kretschmer K, Becker PD, Muhlradt PF, Kirschning CJ, et al. (2005) The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells. J Immunol 174: 6308-6313.
10. Genestier L, Taillardet M, Mondiere P, Gheit H, Bella C, et al. (2007) TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J Immunol 178: 7779-7786.
11. Spanedda MV, Heurtault B, Weidner S, Baehr C, Boeglin E, et al. (2010) Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway. Bioorg Med Chem Lett 20: 1869-1872.
12. Marshall-Clarke S, Downes JE, Haga IR, Bowie AG, Borrow P, et al. (2007) Polyinosinic acid is a ligand for toll-like receptor 3. J Biol Chem 282: 24759-24766.
13. Tomai MA, Imbertson LM, Stanczak TL, Tygrett LT, Waldschmidt TJ, (2000) The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes. Cell Immunol 203: 55-65.
14. Poovassery JS, Vanden Bush TJ, Bishop GA, (2009) Antigen receptor signals rescue B cells from TLR tolerance. J Immunol 183: 2974-2983.
15. Gorden KK, Qiu XX, Binsfeld CC, Vasilakos JP, Alkan SS, (2006) Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides. J Immunol 177: 6584-6587.
16. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, et al. (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526-1529.
17. Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, et al. (2002) Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat Immunol 3: 499.
18. Demaria O, Pagni PP, Traub S, de Gassart A, Branzk N, et al. (2010) TLR8 deficiency leads to autoimmunity in mice. J Clin Invest 120: 3651-3662.
19. Parker DC, (1993) T cell-dependent B cell activation. Annu Rev Immunol 11: 331-360.
20. Banchereau J, Bazan F, Blanchard D, Briere F, Galizzi JP, et al. (1994) The CD40 antigen and its ligand. Annu Rev Immunol 12: 881-922.
21. Vanden Bush TJ, Bishop GA, (2008) TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation. Eur J Immunol 38: 400-409.
22. Gantner F, Hermann P, Nakashima K, Matsukawa S, Sakai K, et al. (2003) CD40-dependent and-independent activation of human tonsil B cells by CpG oligodeoxynucleotides. Eur J Immunol 33: 1576-1585.
23. Heer AK, Shamshiev A, Donda A, Uematsu S, Akira S, et al. (2007) TLR Signaling Fine-Tunes Anti-Influenza B Cell Responses without Regulating Effector T Cell Responses. J Immunol 178: 2182-2191.
24. Knodel M, Kuss AW, Berberich I, Schimpl A, (2001) Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching. Eur J Immunol 31: 1972-1980.
25. Casadevall A, Pirofski LA, (2006) A reappraisal of humoral immunity based on mechanisms of antibody-mediated protection against intracellular pathogens. Adv Immunol 91: 1-44.
26. Schaniel C, Pardali E, Sallusto F, Speletas M, Ruedl C, et al. (1998) Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med 188: 451-463.
27. Durandy A, (2003) Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation. Eur J Immunol 33: 2069-2073.
28. Sanderson RD, Lalor P, Bernfield M, (1989) B lymphocytes express and lose syndecan at specific stages of differentiation. Cell Regul 1: 27-35.
29. Angelin-Duclos C, Cattoretti G, Lin KI, Calame K, (2000) Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. J Immunol 165: 5462-5471.
30. Underhill GH, Minges Wols HA, Fornek JL, Witte PL, Kansas GS, (2002) IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Blood 99: 2905-2912.
31. Shapiro-Shelef M, Lin KI, McHeyzer-Williams LJ, Liao J, McHeyzer-Williams MG, et al. (2003) Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19: 607-620.
32. Barberis A, Widenhorn K, Vitelli L, Busslinger M, (1990) A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev 4: 849-859.
33. Marshall JD, Fearon KL, Higgins D, Hessel EM, Kanzler H, et al. (2005) Superior activity of the type C class of ISS in vitro and in vivo across multiple species. DNA Cell Biol 24: 63-72.
34. Krug A, Rothenfusser S, Hornung V, Jahrsdorfer B, Blackwell S, et al. (2001) Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 31: 2154-2163.
35. Ruprecht CR, Lanzavecchia A, (2006) Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 36: 810-816.
36. Bernasconi NL, Onai N, Lanzavecchia A, (2003) A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101: 4500-4504.
37. Li H, Willingham SB, Ting JP, Re F, (2008) Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol 181: 17-21.
38. Franchi L, Nunez G, (2008) The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol 38: 2085-2089.
39. Ishii KJ, Akira S, (2007) Toll or toll-free adjuvant path toward the optimal vaccine development. J Clin Immunol 27: 363-371.
40. Oldstone MB, Dixon FJ, (1969) Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J Exp Med 129: 483-505.
41. Coutelier JP, Coulie PG, Wauters P, Heremans H, van der Logt JT, (1990) In vivo polyclonal B-lymphocyte activation elicited by murine viruses. J Virol 64: 5383-5388.
42. Yang L, Ma Y, Schoenfeld R, Griffiths M, Eichwald E, et al. (1992) Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice. Infect Immun 60: 3033-3041.
43. Sangster MY, Topham DJ, D'Costa S, Cardin RD, Marion TN, et al. (2000) Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus. J Immunol 164: 1820-1828.
44. Hunziker L, Recher M, Macpherson AJ, Ciurea A, Freigang S, et al. (2003) Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections. Nat Immunol 4: 343-349.
45. Soulas P, Woods A, Jaulhac B, Knapp AM, Pasquali JL, et al. (2005) Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection. J Clin Invest 115: 2257-2267.
46. Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, et al. (2006) Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol 24: 353-389.
47. Takeda K, Akira S, (2005) Toll-like receptors in innate immunity. Int Immunol 17: 1-14.
48. Silverstein AM, Rose NR, (2003) On the implications of polyclonal B cell activation. Nat Immunol 4: 931-932; author reply 932.
49. Gaide O, Schneider P, (2003) Permanent correction of an inherited ectodermal dysplasia with recombinant EDA. Nat Med 9: 614-618.