Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men

PLoS Genetics

Volumn 7, Issue 9, 2011, Pages

  Orr, Nick ^a   Cooke, Rosie ^a   Jones, Michael ^a   Fletcher, Olivia ^a   Dudbridge, Frank ^b   Chilcott Burns, Sarah ^a   Tomczyk, Katarzyna ^a   Broderick, Peter ^a   Houlston, Richard ^a   Ashworth, Alan ^a   Swerdlow, Anthony ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CHROMOSOME 10Q; CHROMOSOME 16Q; CHROMOSOME 2Q; CHROMOSOME 5P; CHROMOSOME 6Q; CONTROLLED STUDY; COX11 GENE; ESR1 GENE; FGFR2 GENE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; LSP1 GENE; MAJOR CLINICAL STUDY; MALE; MAP3K1 GENE; NOTCH2 GENE; POPULATION BASED CASE CONTROL STUDY; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SLC4A7 GENE; STATISTICAL SIGNIFICANCE; TOX3 GENE; ADOLESCENT; BREAST TUMOR; CASE CONTROL STUDY; CAUCASIAN; CHROMOSOME 10; CHROMOSOME 16; CHROMOSOME 2; CHROMOSOME 5; CHROMOSOME 6; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN CHROMOSOME; MIDDLE AGED; RISK; RISK FACTOR;

COX11 PROTEIN, HUMAN; CYTOCHROME C OXIDASE; PROGESTERONE RECEPTOR; TNRC9 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 2; CHROMOSOMES, HUMAN, PAIR 5; CHROMOSOMES, HUMAN, PAIR 6; ELECTRON TRANSPORT COMPLEX IV; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, PROGESTERONE; RISK FACTORS; YOUNG ADULT;

EID: 80053435593     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002290     Document Type: Article

References (21)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249.
2. Sasco AJ, Lowenfels AB, Pasker-de Jong P, (1993) Review article: epidemiology of male breast cancer. A meta-analysis of published case-control studies and discussion of selected aetiological factors. Int J Cancer 53: 538-549.
3. Weiss JR, Moysich KB, Swede H, (2005) Epidemiology of male breast cancer. Cancer Epidemiol Biomarkers Prev 14: 20-26.
4. Gomez-Raposo C, Zambrana Tevar F, Sereno Moyano M, Lopez Gomez M, Casado E, (2010) Male breast cancer. Cancer Treat Rev 36: 451-457.
5. Thompson D, Easton D, (2001) Variation in cancer risks, by mutation position, in BRCA2 mutation carriers. Am J Hum Genet 68: 410-419.
6. Meijers-Heijboer H, van den Ouweland A, Klijn J, Wasielewski M, de Snoo A, et al. (2002) Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet 31: 55-59.
7. Fletcher O, Houlston RS, (2010) Architecture of inherited susceptibility to common cancer. Nat Rev Cancer 10: 353-361.
8. Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, et al. (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41: 585-590.
9. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, et al. (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447: 1087-1093.
10. Fletcher O, Johnson N, Orr N, Hosking FJ, Gibson LJ, et al. (2011) Novel Breast Cancer Susceptibility Locus at 9q31.2: Results of a Genome-Wide Association Study. J Natl Cancer Inst.
11. Milne RL, Benitez J, Nevanlinna H, Heikkinen T, Aittomaki K, et al. (2009) Risk of estrogen receptor-positive and-negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst 101: 1012-1018.
12. Stacey SN, Manolescu A, Sulem P, Thorlacius S, Gudjonsson SA, et al. (2008) Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 40: 703-706.
13. Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, et al. (2009) A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 41: 579-584.
14. Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A, et al. (2010) Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 42: 504-507.
15. Eisen T, Matakidou A, Houlston R, (2008) Identification of low penetrance alleles for lung cancer: the GEnetic Lung CAncer Predisposition Study (GELCAPS). BMC Cancer 8: 244.
16. Wigginton JE, Cutler DJ, Abecasis GR, (2005) A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 76: 887-893.
17. Team RDC (2010) R: A language and envirnoment for statistical computing. Vienna R Foundation for Statistical Computing 2.11.1 ed.
18. Clark GM, Osborne CK, McGuire WL, (1984) Correlations between estrogen receptor, progesterone receptor, and patient characteristics in human breast cancer. J Clin Oncol 2: 1102-1109.
19. Willsher PC, Leach IH, Ellis IO, Bell JA, Elston CW, et al. (1997) Male breast cancer: pathological and immunohistochemical features. Anticancer Res 17: 2335-2338.
20. Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J, et al. (2008) Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet 4: e1000054 doi:10.1371/journal.pgen.1000054.
21. Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, et al. (2010) A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 42: 885-892.