Effects of PTEN gene on invasion and migration of ovarian cancer cell line A2780 and related mechanisms

Chinese Journal of Oncology

Volumn 33, Issue 3, 2011, Pages 165-168

  Wu, Hui Juan ^a   Hao, Quan ^b   Wang, Ke ^b   Liu, Wen Xin ^b   Ma, Ding ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b NONE

Author keywords

Invasion; Matrix metalloproteinase 9; Migration; Ovarian neoplasms; PTEN gene

Indexed keywords

GELATINASE B; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OVARY CANCER; PLASMID; WESTERN BLOTTING; WOUND HEALING;

CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; FEMALE; GENETIC VECTORS; HUMANS; MATRIX METALLOPROTEINASE 9; MUTATION; NEOPLASM INVASIVENESS; OVARIAN NEOPLASMS; PLASMIDS; PTEN PHOSPHOHYDROLASE; TRANSFECTION;

EID: 80053414580     PISSN: 02533766     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0253-3766.2011.03.003     Document Type: Article

References (9)

1. Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 1997, 275:1943-1947. (Pubitemid 27148818)
2. Yan X, Fraser M, Qiu Q, et al. Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-depentent manner. Gynecol Oncol, 2006, 102:348-355. (Pubitemid 44063583)
3. Chu EC, Tamawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit, 2004, 10:235-241.
4. Davidson L, Maccario H, Perera NM, et al. Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. Oncogene, 2010, 29:687-697.
5. Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol, 2009, 4:127-150.
6. Heering J, Erlmann P, Olayioye MA. Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration. Exp Cell Res, 2009, 315:2505-2514.
7. Dey N, Crosswell HE, De P, et al. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res, 2008, 68:1862-1871. (Pubitemid 351416572)
8. Jiang BH, Liu LZ. PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochim Biophys Acta, 2008, 1784:150-158.
9. Wu X, Obata T, Khan Q, et al. The phosphatidylinositol-3 kinase pathway regulates bladder cancer cell invasion. BJU Int, 2004, 93:143-150. (Pubitemid 38112985)