Allosteric activation via kinetic control: Potassium accelerates a conformational change in IMP dehydrogenase

Biochemistry

Volumn 50, Issue 39, 2011, Pages 8508-8518

  Riera, Thomas V ^a,c   Zheng, Lianqing ^a,b   Josephine, Helen R ^a   Min, Donghong ^b   Yang, Wei ^b   Hedstrom, Lizbeth ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCHEMICAL FREE ENERGY SIMULATIONS; ALLOSTERIC ACTIVATION; ALLOSTERIC ACTIVATOR; ALLOSTERIC MECHANISMS; ALLOSTERIC REGULATION; COMPUTATIONAL MODEL; CONFORMATIONAL CHANGE; CONFORMATIONAL EXCHANGE; ENERGY WELLS; ENZYME CONFORMATIONS; EQUILIBRIUM DISTRIBUTIONS; KINETIC CONTROL; KINETIC MECHANISM; MAIN CHAINS; MONOVALENT CATIONS; ORTHOGONAL SPACE; POTENTIAL OF MEAN FORCE; RANDOM WALK STRATEGIES; REACTION COORDINATES; SECONDARY STRUCTURES; THERMODYNAMIC CONTROL;

COMPUTER SIMULATION; CONFORMATIONS; FREE ENERGY; ION EXCHANGE; POSITIVE IONS;

KINETICS;

CARBONYL DERIVATIVE; INOSINATE DEHYDROGENASE; ION; POTASSIUM;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENERGY; FORCE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SIMULATION; THERMODYNAMICS; VALIDATION PROCESS;

ALLOSTERIC REGULATION; COMPUTER SIMULATION; CRYPTOSPORIDIUM PARVUM; ENZYME ACTIVATION; IMP DEHYDROGENASE; KINETICS; MOLECULAR DYNAMICS SIMULATION; POTASSIUM; PROTEIN CONFORMATION;

EID: 80053409626     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200785s     Document Type: Article

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