AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates fosB transcription

Journal of Leukocyte Biology

Volumn 90, Issue 4, 2011, Pages 643-651

  Hong, Sunhwa ^a   Skaist, Alyza M ^a   Wheelan, Sarah J ^a   Friedman, Alan D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C fos; C jun; Leucine zipper; Myeloid

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; DNA HYBRID; ESTRADIOL RECEPTOR; HETERODIMER; HYBRID PROTEIN; MESSENGER RNA; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOSB;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DIMERIZATION; GRANULOPOIESIS; HEMATOPOIESIS; HUMAN; HUMAN CELL; MONOCYTE; MONOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL DIFFERENTIATION; HL-60 CELLS; HUMANS; MICE; MONOCYTES; MYELOPOIESIS; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RESPONSE ELEMENTS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

MURINAE;

EID: 80053371471     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0111043     Document Type: Article

References (20)

1. Landschulz, W. H., Johnson, P. F., McKnight, S. L. (1989) The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science 243, 1681-1688.
2. Miller, M., Shuman, J. D., Sebastian, T., Dauter, Z., Johnson, P. F. (2003) Structural basis for DNA recognition by the basic region leucine zipper transcription factor C/EBPα. J. Biol. Chem. 278, 15178-15184.
3. Mechta-Grigoriou, F., Gerald, D., Yaniv, M. (2001) The mammalian Jun proteins: redundancy and specificity. Oncogene 20, 2378-2389.
4. Hsu, W., Kerppola, T. K., Chen, P. L., Curran, T., Chen-Kiang, S. (1994) Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol. Cell. Biol. 14, 268-276.
5. Rangatia, J., Vangala, R. K., Treiber, N., Zhang, P., Radomska, H., Tenen, D. G., Hiddemann, W., Behre, G. (2002) Downregulation of c-Jun expression by transcription factor C/EBPα is critical for granulocytic lineage commitment. Mol. Cell. Biol. 22, 8681-8694.
6. Rangatia, J., Vangala, R. K., Singh, S. M., Peer Zada, A. A., Elsasser, A., Kohlmann, A., Haferlach, T., Tenen, D. G., Hiddemann, W., Behre, G. (2003) Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPα DNA binding via leucine zipper domain interaction. Oncogene 22, 4760-4764.
7. Cai, D. H., Wang, D., Keefer, J., Yeamans, C., Hensley, K., Friedman, A. D. (2008) C/EBPα:AP-1 leucine zipper heterodimers bind novel DNA element, activate the PU.1 promoter, and direct monocyte lineage commitment more potently than C/EBPα homodimers or AP-1. Oncogene 27, 2772-2779.
8. Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., Glass, C. K. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589.
9. Valtieri, M., Tweardy, D. J., Caracciolo, D., Johnson, K., Mavilio, F., Altmann, S., Santoli, D., Rovera, G. (1987) Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol. 138, 3829-3835.
10. Calvo, K. R., Sykes, D. B., Pasillas, M., Kamps, M. P. (2000) Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils and macrophages, independent of enforced meis expression. Mol. Cell. Biol. 20, 3274-3285.
11. Suzow, J., Friedman, A. D. (1993) The murine myeloperoxidase promoter contains multiple functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1(MyNF1). Mol. Cell. Biol. 13, 2141-2151.
12. Oelgeschläger, M., Nuchprayoon, I., Lüscher, B., Friedman, A. D. (1996) C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol. Cell. Biol. 16, 4717-4725.
13. Paz-Priel, I., Ghosal, A. K., Kowalski, J., Friedman, A. D. (2009) C/EBPαor C/EBPα oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-κB p50 bound to the bcl-2 and FLIP gene promoters. Leukemia 23, 365-374.
14. Hochberg, Y., Benjamini, Y. (1990) More powerful procedures for multiple significance testing. Stat. Med. 9, 811-818.
15. Kummalue, T., Friedman, A. D. (2003) Cross-talk between regulators of myeloid development: C/EBPα binds and activates the promoter of the PU.1 gene. J. Leukoc. Biol. 74, 464-470.
16. Gavala, M. L., Hill, L. M., Lenertz, L. Y., Karta, M. R., Bertics, P. J. (2010) Activation of the transcription factor FosB/activating protein-1 (AP-1) is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cell. J. Biol. Chem. 285, 34288-34298.
17. Shaulian, E. (2010) AP-1-the Jun proteins: oncogenes or tumor suppressors in disguise? Cell. Signal. 22, 894-899.
18. Lee, S., Shuman, J. D., Johnson, P. F. (2010) CCAAT/enhancer binding protein β DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CBF. J. Biol. Chem. 285, 21399-21410.
19. Hai, T., Curran, T. (1991) Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88, 3720-3724.
20. Shuman, J. D., Cheong, J., Coligan, J. E. (1997) ATF-2 and C/EBPα can form a heterodimeric DNA binding complex in vitro. Functional implications for transcriptional regulation. J. Biol. Chem. 272, 12793-12800.