Safety analysis of liposomal amphotericin B in adult patients: Anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia

International Journal of Antimicrobial Agents

Volumn 38, Issue 5, 2011, Pages 417-420

  Shigemi, Akari ^a   Matsumoto, Kazuaki ^a   Ikawa, Kazuro ^b   Yaji, Keiko ^a   Shimodozono, Yoshihiro ^a   Morikawa, Norifumi ^b   Takeda, Yasuo ^a   Yamada, Katsushi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Anaemia; Hepatotoxicity; Hypokalaemia; Liposomal amphotericin B; Nephrotoxicity; Thrombocytopenia

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHOTERICIN B LIPID COMPLEX; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CISPLATIN; FOSCARNET; GAMMA GLUTAMYLTRANSFERASE; IMMUNOSUPPRESSIVE AGENT; VANCOMYCIN;

ADULT; ANEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CRYPTOCOCCAL MENINGITIS; DRUG SAFETY; ERYTHROCYTE COUNT; FEMALE; HUMAN; HYPOKALEMIA; LIVER TOXICITY; LUNG ASPERGILLOSIS; MALE; MYCOSIS; NEPHROTOXICITY; PATIENT ASSESSMENT; PRIORITY JOURNAL; PROBABILITY; RETROSPECTIVE STUDY; SIDE EFFECT; THROMBOCYTOPENIA;

AGED; AMPHOTERICIN B; ANEMIA; ANTIFUNGAL AGENTS; DRUG-INDUCED LIVER INJURY; FEMALE; HUMANS; HYPOKALEMIA; KIDNEY DISEASES; MALE; MIDDLE AGED; THROMBOCYTOPENIA;

EID: 80053367981     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.07.004     Document Type: Article

References (17)

1. G. Deray Amphotericin B nephrotoxicity J Antimicrob Chemother 49 2002 37 41 (Pubitemid 34162655)
2. M.E. Falagas, F. Ntziora, G.I. Betsi, and G. Samonis Caspofungin for the treatment of fungal infections: a systematic review of randomized controlled trials Int J Antimicrob Agents 29 2007 136 143 (Pubitemid 46073679)
3. T.J. Walsh, R.W. Finberg, C. Arndt, J. Hiemenz, C. Schwartz, and D. Bodensteiner Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group N Engl J Med 340 1999 764 771 (Pubitemid 29114295)
4. J.R. Wingard, M.H. White, E. Anaissie, J. Raffalli, J. Goodman, A. Arrieta L Amph/ABLC Collaborative Study Group A randomized, double-blind comparative trial evaluating the safety of liposomal amphotericin B versus amphotericin B lipid complex in the empirical treatment of febrile neutropenia. L Amph/ABLC Collaborative Study Group Clin Infect Dis 31 2000 1155 1163 (Pubitemid 32295443)
5. T.J. Walsh, J.L. Goodman, P. Pappas, I. Bekersky, D.N. Buell, and M. Roden Safety, tolerance, and pharmacokinetics of high-dose liposomal amphotericin B (AmBisome) in patients infected with Aspergillus species and other filamentous fungi: maximum tolerated dose study Antimicrob Agents Chemother 45 2001 3487 3496 (Pubitemid 33107867)
6. H.G. Prentice, I.M. Hann, R. Herbrecht, M. Aoun, S. Kvaloy, and D. Catovsky A randomized comparison of liposomal versus conventional amphotericin B for the treatment of pyrexia of unknown origin in neutropenic patients Br J Haematol 98 1997 711 718 (Pubitemid 27386554)
7. M.A. Fischer, W.C. Winkelmayer, R.H. Rubin, and J. Avorn The hepatotoxicity of antifungal medications in bone marrow transplant recipients Clin Infect Dis 41 2005 301 307 (Pubitemid 41022104)
8. O.A. Cornely, J. Maertens, M. Bresnik, R. Ebrahimi, A.J. Ullmann, and E. Bouza Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad trial) Clin Infect Dis 44 2007 1289 1297 (Pubitemid 46717290)
9. C.W. Holeman Jr., and H. Einstein The toxic effects of amphotericin B in man Calif Med 99 1963 90 93
10. D. Burke, R. Lal, K.W. Finkel, J. Samuels, and J.R. Foringer Acute amphotericin B overdose Ann Pharmacother 40 2006 2254 2259 (Pubitemid 44954450)
11. D.W. Cockcroft, and M.H. Gault Prediction of creatinine clearance from serum creatinine Nephron 16 1976 31 41
12. R.R. MacGregor, J.E. Bennett, and A.J. Erslev Erythropoietin concentration in amphotericin B-induced anemia Antimicrob Agents Chemother 14 1978 270 273 (Pubitemid 8402645)
13. H. Mahmud, D. Mauro, S.M. Qadri, M. Föller, and F. Lang Triggering of suicidal erythrocyte death by amphotericin B Cell Physiol Biochem 24 2009 263 270
14. S. Sundar, J. Chakravarty, D. Agarwal, M. Rai, and H.W. Murray Single-dose liposomal amphotericin B for visceral leishmaniasis in India N Engl J Med 362 2010 504 512
15. A. Safdar, J. Ma, F. Saliba, B. Dupont, J.R. Wingard, and R.Y. Hachem Drug-induced nephrotoxicity caused by amphotericin B lipid complex and liposomal amphotericin B: a review and meta-analysis Medicine (Baltimore) 89 2010 236 244
16. A.H. Groll, G. Silling, C. Young, R. Schwerdtfeger, H. Ostermann, and W.J. Heinz Randomized comparison of safety and pharmacokinetics of caspofungin, liposomal amphotericin B, and the combination of both in allogeneic hematopoietic stem cell recipients Antimicrob Agents Chemother 54 2010 4143 4149
17. A.D. Luber, L. Maa, M. Lam, and B.J. Guglielmo Risk factors for amphotericin B-induced nephrotoxicity J Antimicrob Chemother 43 1999 267 271 (Pubitemid 29082452)