Korean red ginseng up-regulates C21-steroid hormone metabolism via Cyp11a1 gene in senescent rat testes

Journal of Ginseng Research

Volumn 35, Issue 3, 2011, Pages 272-282

  Kim, In Hye ^a   Kim, Si Kwan ^b   Kim, Eun Hye ^a   Kim, Sung Won ^b   Sohn, Sang Hyun ^b   Lee, Soo Cheol ^c   Choi, Sangdun ^c   Pyo, Suhkneung ^a   Rhee, Dong Kwon ^a  

^a Sungkyunkwan University   (South Korea)

^b Konkuk University   (South Korea)

^c Ajou University   (South Korea)

Author keywords

Aging; Cyp11a1; Korean red ginseng; Panax ginseng; System biology; Testis

Indexed keywords

ANIMALIA; PANAX GINSENG; RATTUS;

EID: 80053366298     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2011.35.3.272     Document Type: Article

References (20)

1. Nam KY. The comparative understanding between red ginsengs and white ginsengs, processed ginsengs (Panax ginseng C. A. Meyer). J Ginseng Res 2005;29:1-18.
2. Yang WM, Park SY, Kim HM, Park EH, Park SK, Chang MS. Effects of Panax ginseng on glial cell-derived neuro-trophic factor (GDNF) expression and spermatogenesis in rats. Phytother Res 2011;25:308-311.
3. Park WS, Shin DY, Kim DR, Yang WM, Chang MS, Park SK. Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM). Fertil Steril 2007;88:1000-1002.
4. Park JS, Hwang SY, Lee WS, Yu KW, Paek KY, Hwang B Y, Han K. The therapeutic effect of tissue cultured root of wild Panax ginseng C. A. Meyer on spermatogenetic disorder. Arch Pharm Res 2006;29:800-807.
5. Hwang SY, Kim WJ, Wee JJ, Choi JS, Kim SK. Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo- p-dioxin. BJU Int 2004;94:663-668.
6. Tsai SC, Chiao YC, Lu CC, Wang PS. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol 2003;46:1-7.
7. Chen JC, Chen LD, Tsauer W, Tsai CC, Chen BC, Chen YJ. Effects of ginsenoside Rb2 and Rc on inferior human sperm motility in vitro. Am J Chin Med 2001;29:155-160.
8. Zhang H, Zhou Q, Li X, Zhao W, Wang Y, Liu H, Li N. Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway. Mol Reprod Dev 2007;74:497-501.
9. Salvati G, Genovesi G, Marcellini L, Paolini P, De Nuccio I, Pepe M, Re M. Effects of Panax ginseng C.A. Meyer saponins on male fertility. Panminerva Med 1996;38:249-254.
10. Charron Y, Madani R, Nef S, Combepine C, Govin J, Khochbin S, Vassalli JD. Expression of serpinb6 serpins in germ and somatic cells of mouse gonads. Mol Reprod Dev 2006;73:9-19.
11. Lavoie HA, King SR. Transcriptional regulation of ste-roidogenic genes: STARD1, CYP11A1 and HSD3B. Exp Biol Med (Maywood) 2009;234:880-907.
12. Guo IC, Shih MC, Lan HC, Hsu NC, Hu MC, Chung BC. Transcriptional regulation of human CYP11A1 in gonads and adrenals. J Biomed Sci 2007;14:509-515.
13. Scott FL, Sun J, Whisstock JC, Kato K, Bird PI. SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem 2007;142:435-442.
14. Scott FL, Paddle-Ledinek JE, Cerruti L, Coughlin PB, Salem HH, Bird PI. Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation. Exp Cell Res 1998;245:263-271.
15. Abts HF, Welss T, Mirmohammadsadegh A, Kohrer K, Michel G, Ruzicka T. Cloning and characterization of hurpin (protease inhibitor 13): a new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family. J Mol Biol 1999;293:29-39.
16. Jensen PJ, Wu Q, Janowitz P, Ando Y, Schechter NM. Plasminogen activator inhibitor type 2: an intracellular keratinocyte differentiation product that is incorporated into the cornified envelope. Exp Cell Res 1995;217:65-71.
17. Bird CH, Blink EJ, Hirst CE, Buzza MS, Steele PM, Sun J, Jans DA, Bird PI. Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1. Mol Cell Biol 2001;21:5396-5407.
18. Coughlin P, Sun J, Cerruti L, Salem HH, Bird P. Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Proc Natl Acad Sci U S A 1993;90:9417-9421.
19. Scott FL, Coughlin PB, Bird C, Cerruti L, Hayman JA, Bird P. Proteinase inhibitor 6 cannot be secreted, which suggests it is a new type of cellular serpin. J Biol Chem 1996;271:1605-1612.
20. Strik MC, Wolbink A, Wouters D, Bladergroen BA, Ver-laan AR, van Houdt IS, Hijlkema S, Hack CE, Kummer JA. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood 2004;103:2710-2717.