Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2

Biochemical Society Transactions

Volumn 39, Issue 5, 2011, Pages 1416-1420

  Kondás, Katalin ^a   Szlaḿa, Gyor̈gy ^a   Nagy, Alinda ^a   Trexler, Maŕia ^a   Ṕatthy, Laśzlo ^a  

^a INSTITUTE OF ENZYMOLOGY   (Hungary)

Author keywords

Growth and differentiation factor 11 (GDF11); Growth factor antagonist; Myostatin; Protease inhibitor; Transforming growth factor (TGF ); WFIKKN

Indexed keywords

ACID PROTEIN; CHYMOTRYPSIN; ELASTASE; FOLLISTATIN; FURIN; GROWTH DIFFERENTIATION FACTOR; GROWTH DIFFERENTIATION FACTOR 11; IMMUNOGLOBULIN; MYOSTATIN; NETRIN; PROCOLLAGEN C PROTEINASE; PROTEIN; SERINE PROTEINASE INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UROKINASE; WFIKKN1 PROTEIN; WFIKKN2 PROTEIN; WHEY ACIDIC PROTEIN;

BIOLOGICAL ACTIVITY; BRAIN; CHROMOSOME 16; CHROMOSOME 17; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; EXON; GENE EXPRESSION; GENE MUTATION; HUMAN; HYPERPLASIA; INNER EAR; INTRON; KIDNEY; LIVER; LUNG; MOLECULAR INTERACTION; MUSCLE DEVELOPMENT; MUSCLE HYPERTROPHY; MUSCLE MASS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OVARY; PANCREAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SKELETAL MUSCLE; TESTIS; THYMUS;

ANIMALS; HUMANS; MILK PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; TRYPSIN; TRYPSIN INHIBITORS;

EID: 80053362700     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0391416     Document Type: Conference Paper

References (20)

1. Trexler, M., Bányai, L. and Patthy, L. (2001) A human protein containing multiple types of protease-inhibitory modules. Proc. Natl. Acad. Sci. U.S.A. 98, 3705-3709 (Pubitemid 32249835)
2. Trexler, M., Bányai, L. and Patthy, L. (2002) Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. Biol. Chem. 383, 223-228 (Pubitemid 34224045)
3. Kondás, K., Szláma, G., Trexler, M. and Patthy, L. (2008) Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. J. Biol. Chem. 283, 23677-23684
4. Nishida, A.T., Kobuke, K., Kojima, K., Ito, J., Honjo, T. and Tashiro, K. (2004) OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst. Dev. Dyn. 231, 766-774 (Pubitemid 40022738)
5. Rawlings, N.D., Morton, F.R., Kok, C.Y., Kong, J. and Barrett, A.J. (2008) MEROPS: the peptidase database. Nucleic Acids Res. 36, D320-D325 (Pubitemid 351149743)
6. Bányai, L. and Patthy, L. (1999) The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases. Protein Sci. 8, 1636-1642 (Pubitemid 29379945)
7. Nagy, A., Trexler, M. and Patthy, L. (2003) Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein. Eur. J. Biochem. 270, 2101-2107 (Pubitemid 36560832)
8. Liepinsh, E., Nagy, A., Trexler, M., Patthy, L. and Otting, G. (2006) Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein. J. Biomol. NMR 35, 73-78 (Pubitemid 43941723)
9. Hill, J.J., Qiu, Y., Hewick, R.M. and Wolfman, N.M. (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol. Endocrinol. 17, 1144-1154 (Pubitemid 36683721)
10. McPherron, A.C. and Lee, S.J. (1997) Double muscling in cattle due to mutations in the myostatin gene. Proc. Natl. Acad. Sci. U.S.A. 94, 12457-12461 (Pubitemid 27492550)
11. Lee, S.J. and McPherron, A.C. (1999) Myostatin and the control of skeletal muscle mass. Curr. Opin. Genet. Dev. 9, 604-607
12. McPherron, A.C., Lawler, A.M. and Lee, S.J. (1997) Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature 387, 83-90 (Pubitemid 27202654)
13. Gamer, L.W., Wolfman, N.M., Celeste, A.J., Hattersley, G., Hewick, R. and Rosen, V. (1999) A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos. Dev. Biol. 208, 222-232 (Pubitemid 29149460)
14. McPherron, A.C., Lawler, A.M. and Lee, S.J. (1999) Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nat. Genet. 22, 260-264 (Pubitemid 29297252)
15. Szláma, Gy., Kondás, K., Trexler, M. and Patthy, L. (2010) WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity. FEBS J. 277, 5040-5050
16. Lee, S.J. and McPherron, A.C. (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci. U.S.A. 98, 9306-9311
17. Hill, J.J., Davies, M.V., Pearson, A.A., Wang, J.H., Hewick, R.M., Wolfman, N.M. and Qiu, Y. (2002) The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum. J. Biol. Chem. 277, 40735-40741 (Pubitemid 35215657)
18. Thies, R.S., Chen, T., Davies, M.V., Tomkinson, K.N., Pearson, A.A., Shakey, Q.A. and Wolfman, N. M. (2001) GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding. Growth Factors 18, 251-259 (Pubitemid 32776305)
19. Wolfman, N.M., McPherron, A.C., Pappano, W.N., Davies, M.V., Song, K., Tomkinson, K.N., Wright, J.F., Zhao, L., Sebald, S.M., Greenspan, D.S. and Lee, S.J. (2003) Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases. Proc. Natl. Acad. Sci. U.S.A. 100, 15842-15846 (Pubitemid 38021077)
20. Ge, G., Hopkins, D.R., Ho, W.B. and Greenspan, D.S. (2005) GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. Mol. Cell. Biol. 25, 5846-5858 (Pubitemid 40946542)