The future of contraception: Innovations in contraceptive agents: Tomorrow's hormonal contraceptive agents and their clinical implications

American Journal of Obstetrics and Gynecology

Volumn 205, Issue 4 SUPPL., 2011, Pages

  Jensen, Jeffrey T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

fertility projections; male contraception; sexually transmitted infections

Indexed keywords

6 (5,6 DIMETHOXYBENZO[B]THIEN 2 YL) 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; C31G; CARBOPOL 974P; CONTRACEPTIVE AGENT; DIENOGEST PLUS ESTRADIOL VALERATE; DROSPIRENONE; DROSPIRENONE PLUS ETHINYLESTRADIOL; ELCOMETRINE; ESTRADIOL; ESTRADIOL PLUS NOMEGESTROL ACETATE; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS LEVONORGESTREL; GESTAGEN; LEVONORGESTREL; MELOXICAM; MEPACRINE; NANDROLONE; NOMEGESTROL ACETATE; NONOXINOL 9; PROGESTERONE; PROSTAGLANDIN E2; TENOFOVIR; ULIPRISTAL; UNCLASSIFIED DRUG;

ARTICLE; BARRIER CONTRACEPTION; BIRTH CONTROL; CARDIOVASCULAR RISK; CLINICAL PRACTICE; CLINICAL RESEARCH; CONDOM; CONTRACEPTION; DRUG EFFICACY; EMERGENCY CONTRACEPTION; FAMILY PLANNING; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; NONHUMAN; ORAL CONTRACEPTION; OVARY FOLLICLE; OVULATION; PREGNANCY RATE; PRIORITY JOURNAL; UNITED STATES; UTERINE CERVIX CAP; UTERINE CERVIX MUCUS; VAGINA BLEEDING; VAGINA RING;

EID: 80053345330     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2011.06.055     Document Type: Review

References (44)

1. Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat World Population Prospects: the 2008 revision http://www.un.org/esa/population/ Accessed Jan. 29, 2011
2. J.A. Martin, B.E. Hamilton, and P.D. Sutton Births: final data for 2007 Natl Vital Stat Rep 58 2010 1 85
3. Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat World fertility report 2007 http://www.un.org/ esa/population/publications/worldfertilityreport2007/worldfertilityreport2007. htm Accessed Jan. 29, 2011
4. L.B. Finer, and S.K. Henshaw Disparities in rates of unintended pregnancy in the United States, 1994 and 2001 Perspect Sex Reprod Health 38 2006 90 96 (Pubitemid 43882311)
5. K.T. Barnhart, M.J. Rosenberg, and H.T. MacKay Contraceptive efficacy of a novel spermicidal microbicide used with a diaphragm: a randomized controlled trial Obstet Gynecol 110 2007 577 586 (Pubitemid 47359581)
6. S.S. Abdool Karim, B.A. Richardson, and G. Ramjee Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women AIDS 25 2011 957 966
7. B.J. Catalone, M.L. Ferguson, and S.R. Miller Prolonged exposure to the candidate microbicide C31G differentially reduces cellular sensitivity to agent re-exposure Biomed Pharmacother 59 2005 460 468 (Pubitemid 41383841)
8. C.K. Mauck, D.H. Weiner, M.D. Creinin, K.T. Barnhart, M.M. Callahan, and R. Bax A randomized phase I vaginal safety study of three concentrations of C31G vs. extra strength Gynol II Contraception 70 2004 233 240 (Pubitemid 39119986)
9. A.E. Burke, K. Barnhart, and J.T. Jensen Contraceptive efficacy, acceptability, and safety of C31G and nonoxynol-9 spermicidal gels: a randomized controlled trial Obstet Gynecol 116 2010 1265 1273
10. P.J. Feldblum, A. Adeiga, and R. Bakare SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria PLoS One 3 2008 e1474
11. Q. Abdool Karim, S.S. Abdool Karim, and J.A. Frohlich Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women Science 329 2010 1168 1174
12. A.E. Schindler, C. Campagnoli, and R. Druckmann Classification and pharmacology of progestins Maturitas 61 2008 171 180
13. R. Sitruk-Ware Pharmacological profile of progestins Maturitas 61 2008 151 157
14. R.W. Lievertz Pharmacology and pharmacokinetics of estrogens Am J Obstet Gynecol 156 1987 1289 1293 (Pubitemid 17075499)
15. P.Y. Scarabin, E. Oger, and G. Plu-Bureau Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk Lancet 362 2003 428 432 (Pubitemid 36999704)
16. J.T. Jensen, A.E. Burke, K.T. Barnhart, C. Tillotson, M. Messerle-Forbes, and D. Peters Effects of switching from oral to transdermal or transvaginal contraception on markers of thrombosis Contraception 78 2008 451 458
17. Natazia prescribing information http://berlex.bayerhealthcare.com/html/ products/pi/natazia-pi.pdf Accessed May 1, 2010
18. H.J. Ahrendt, D. Makalova, S. Parke, U. Mellinger, and D. Mansour Bleeding pattern and cycle control with an estradiol-based oral contraceptive: a seven-cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel Contraception 80 2009 436 444
19. J.T. Jensen, S. Parke, U. Mellinger, A. Machlitt, and I.S. Fraser Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest: a randomized controlled trial Obstet Gynecol 117 2011 777 787
20. M.M. Shabaan, M.S. Zakherah, S.A. El-Nashar, and G.H. Sayed Levonorgestrel-releasing intrauterine system compared to low dose combined oral contraceptive pills for idiopathic menorrhagia: a randomized clinical trial Contraception 83 2011 48 54
21. I.S. Fraser, and G. McCarron Randomized trial of 2 hormonal and 2 prostaglandin-inhibiting agents in women with a complaint of menorrhagia Aust N Z J Obstet Gynaecol 31 1991 66 70
22. S. Lello Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy Drugs 70 2010 541 559
23. I.J. Duijkers, C. Klipping, P. Grob, and T. Korver Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17 beta-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol Eur J Contracept Reprod Health Care 15 2010 314 325
24. J. Garza-Flores, P.E. Hall, and G. Perez-Palacios Long-acting hormonal contraceptives for women J Steroid Biochem Mol Biol 40 1991 697 704
25. D. Heger-Mahn, C. Warlimont, T. Faustmann, C. Gerlinger, and C. Klipping Combined ethinylestradiol/gestodene contraceptive patch: two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers Eur J Contracept Reprod Health Care 9 2004 173 181 (Pubitemid 39539579)
26. R.L. Sitruk-Ware, J. Menard, and M. Rad Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen Contraception 75 2007 430 437 (Pubitemid 46764302)
27. A. Nath, and R. Sitruk-Ware Progesterone vaginal ring for contraceptive use during lactation Contraception 82 2010 428 434
28. R. Massai, E. Quinteros, and M.V. Reyes Extended use of a progesterone-releasing vaginal ring in nursing women: a phase II clinical trial Contraception 72 2005 352 357 (Pubitemid 41503132)
29. J.T. Jensen, R.L. Stouffer, J.E. Stanley, and M.B. Zelinski Evaluation of the phosphodiesterase 3 inhibitor ORG 9935 as a contraceptive in female macaques: initial trials Contraception 81 2010 165 171
30. G. Benagiano Non-surgical female sterilization with quinacrine: an update Contraception 63 2001 239 245 (Pubitemid 32607684)
31. R. Bhatt, and C.S. Waszak Four-year follow-up of insertion of quinacrine hydrochloride pellets as a means of nonsurgical female sterilization Fertil Steril 44 1985 303 306 (Pubitemid 15232327)
32. S.N. Bhuiyan, and R. Begum Quinacrine non-surgical female sterilization in Bangladesh Contraception 64 2001 281 286 (Pubitemid 34075554)
33. D.T. Hieu, T.T. Tan, D.N. Tan, P.T. Nguyet, P. Than, and D.Q. Vinh 31,781 cases of non-surgical female sterilisation with quinacrine pellets in Vietnam Lancet 342 1993 213 217
34. E. Rabe, J. Otto, D. Schliephake, and F. Pannier Efficacy and safety of great saphenous vein sclerotherapy using standardised polidocanol foam (ESAF): a randomised controlled multicentre clinical trial Eur J Vasc Endovasc Surg 35 2008 238 245 (Pubitemid 351163086)
35. J.T. Jensen, M.I. Rodriguez, J. Liechtenstein-Zabrak, and S. Zalanyi Transcervical polidocanol as a nonsurgical method of female sterilization: a pilot study Contraception 70 2004 111 115 (Pubitemid 38993486)
36. B.J. Attardi, J. Burgenson, S.A. Hild, and J.R. Reel In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone J Steroid Biochem Mol Biol 88 2004 277 288 (Pubitemid 38553759)
37. A.F. Glasier, S.T. Cameron, and P.M. Fine Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis Lancet 375 2010 555 562
38. V. Brache, L. Cochon, and C. Jesam Immediate pre-ovulatory administration of 30 mg ulipristal acetate significantly delays follicular rupture Hum Reprod 25 2010 2256 2263
39. V. Brache, H. Croxatto, and R. Sitruk-Ware Effect of a single vaginal administration of levonorgestrel in Carraguard gel on the ovulatory process: a potential candidate for "dual protection" emergency contraception Contraception 76 2007 111 116 (Pubitemid 47080982)
40. C. Jesam, A.M. Salvatierra, J.L. Schwartz, and H.B. Croxatto Suppression of follicular rupture with meloxicam, a cyclooxygenase-2 inhibitor: potential for emergency contraception Hum Reprod 25 2010 368 373
41. M.R. Massai, M.L. Forcelledo, and V. Brache Does meloxicam increase the incidence of anovulation induced by single administration of levonorgestrel in emergency contraception? A pilot study Hum Reprod 22 2007 434 439 (Pubitemid 46152564)
42. E. Nieschlag Clinical trials in male hormonal contraception Contraception 82 2010 457 470
43. J.W. Li, and Y.Q. Gu Predictors for partial suppression of spermatogenesis of hormonal male contraception Asian J Androl 10 2008 723 730
44. M.J. Walton, N. Kumar, D.T. Baird, H. Ludlow, and R.A. Anderson 7alpha-methyl-19-nortestosterone (MENT) vs testosterone in combination with etonogestrel implants for spermatogenic suppression in healthy men J Androl 28 2007 679 688 (Pubitemid 47401764)