A randomized, blinded, bilateral intraindividual, vehicle-controlled trial of the use of photodynamic therapy with 5-aminolevulinic acid and blue light for the treatment of actinic keratoses of the upper extremities

Journal of Drugs in Dermatology

Volumn 10, Issue 9, 2011, Pages 1049-1056

  Taub, Amy Forman ^a,b   Garretson, Cara Beth ^c  

^a Advanced Dermatology   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Northwestern Memorial Physicians Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; PLACEBO;

ABNORMAL SENSATION; ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; BLUE LIGHT; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; ERYTHEMA; FEMALE; FOLLOW UP; FOREARM; HAND; HUMAN; MALE; PATIENT SATISFACTION; PHOTODAMAGE; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SINGLE BLIND PROCEDURE; SKIN BURNING SENSATION; SKIN EDEMA; STINGING SENSATION; TREATMENT OUTCOME;

ADULT; AGED; AMINOLEVULINIC ACID; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KERATOSIS, ACTINIC; MALE; MIDDLE AGED; PATIENT SATISFACTION; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROSPECTIVE STUDIES; TREATMENT OUTCOME; UPPER EXTREMITY;

EID: 80053332911     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Lebwohl M. Actinic keratosis: Epidemiology and progression to squamous cell carcinoma. Br J Dermatol. 2003;149(suppl 66):31-33. (Pubitemid 38064513)
2. Kalisiak MS, Rao J. Photodynamic therapy for actinic keratoses. Dermatol Clin. 2007;25:15-23. (Pubitemid 44780060)
3. Glogau RG. The risk of progression to invasive disease. J Am Acad Dermatol. 2000;42(1 Pt 2):23-24.
4. Siller G, Gebauer K, Welburn P, Katsamas J, Ogbourne SM. PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: Results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study. Australas J Dermatol. 2009;50:16-22.
5. Gebauer K, Shumack S, Cowen PS. Effect of dosing frequency on the safety and efficacy of imiquimod 5% cream for treatment of actinic keratosis on the forearms and hands: A phase II, randomized placebo-controlled trial. Br J Dermatol. 2009;161:897-903.
6. Sotiriou E, Apalla Z, Maliamani F, Zaparas N, Panagiotidou D, Ioannides D. Intraindividual, right-left comparison of topical 5-aminolevulinic acid photodynamic therapy vs. 5% imiquimod cream for actinic keratoses on the upper extremities. J Eur Acad Dermatol Venereol. 2009;23:1061-1065.
7. Rivard J, Ozog D. Henry Ford Hospital dermatology experience with Levulan Kerastick and blue light photodynamic therapy. J Drugs Dermatol. 2006;5:556-561.
8. Tierney EP, Eide MJ, Jacobsen G, Ozog D. Photodynamic therapy for actinic keratoses: Survey of patient perceptions of treatment satisfaction and outcomes. J Cosmet Laser Ther. 2008;10:81-86. (Pubitemid 351883332)
9. Gold MH, Nestor MS. Current treatments of actinic keratosis. J Drugs Dermatol. 2006;5(suppl 2):17-25.
10. Szeimies RM, Karrer S, Sauerwald A, Landthaler M. Photodynamic therapy with topical application of 5-aminolevulinic acid in the treatment of actinic keratoses: An initial clinical study. Dermatology. 1996;192:246-251. (Pubitemid 26139209)
11. Jeffes EW, McCullough JL, Weinstein GD, et al. Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid. A pilot dose-ranging study. Arch Dermatol. 1997;133:727-732.
12. Kurwa HA, Yong-Gee SA, Seed PT, Markey AC, Barlow RJ. A randomized paired comparison of photodynamic therapy and topical 5-fluorouracil in the treatment of actinic keratoses. J Am Acad Dermatol. 1999;41(3 Pt 1):414-418. (Pubitemid 29418508)
13. Kim HS, Yoo JY, Cho KH, Kwon OS, Moon SE. Topical photodynamic therapy using intense pulsed light for treatment of actinic keratosis: Clinical and histopathologic evaluation. Dermatol Surg. 2005;31(1):33-36; discussion 36-37.
14. Kaufmann R, Spelman L, Weightman W, et al. Multicentre intraindividual randomized trial of topical methyl aminolaevulinate-photodynamic therapy vs. cryotherapy for multiple actinic keratoses on the extremities. Br J Dermatol. 2008;158:994-999. (Pubitemid 351521450)
15. Stritt A, Merk HF, Braathen LR, von Felbert V. Photodynamic therapy in the treatment of actinic keratosis. Photochem Photobiol. 2008;84:388-398. (Pubitemid 351421391)
16. Ericson MB, Wennberg A-M, Larkö O. Review of photodynamic therapy in actinic keratosis and basal cell carcinoma. Ther Clin Risk Manag. 2008;4:1-9. (Pubitemid 351460925)
17. Griffiths CE, Wang TS, Hamilton TA, Voorhees JJ, Ellis CN. A photonumeric scale for the assessment of cutaneous photodamage. Arch Dermatol. 1992;128:347-351.
18. Clementoni MT, B-Roscher M, Munavalli GS. Photodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light. Lasers Surg Med. 2010;42:150-159.
19. National Community Pharmacists Association. Take as directed: A prescription not followed. Research conducted by The Polling Company™. December 15, 2006