Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes

International Journal of Sport Nutrition and Exercise Metabolism

Volumn 21, Issue 5, 2011, Pages 385-397

  Broad, Elizabeth M ^a   Maughan, Ronald J ^b   Galloway, Stuart D R ^c  

^a AUSTRALIAN INSTITUTE OF SPORT   (Australia)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF STIRLING   (United Kingdom)

Author keywords

Carbohydrate oxidation; Cyclists; Fat oxidation; L carnitine L tartrate

Indexed keywords

CARNITINE; PLACEBO;

ADULT; ARTICLE; ATHLETE; CARBOHYDRATE DIET; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; CYCLING; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE INTENSITY; FAT INTAKE; HUMAN; MALE; METABOLISM;

EID: 80053324636     PISSN: 1526484X     EISSN: 15432742     Source Type: Journal    
DOI: 10.1123/ijsnem.21.5.385     Document Type: Article

References (38)

1. Abramowicz, W.N., & Galloway, S.D.R. (2005). Effects of acute versus chronic administration of L-carnitine L-tartrate on the metabolic responses to submaximal exercise in males and females. International Journal of Sport Nutrition and Exercise Metabolism, 15, 386-400. (Pubitemid 41283875)
2. Bartels, G.L., Remme, W.J., Pillay, M., Schonfeld, D.H., Cox, P.H., Kruijssen, H.A., & Knufman, N.M. (1992). Acute improvement of cardiac function with intravenous L-propionylcarnitine in humans. Journal of Cardiovascular Pharmacology, 20, 157-164.
3. Boobis, L.H., & Maughan, R.J. (1983). A simple one-step enzymatic fluorometric method for the determination of glycerol in 20 μl of plasma. Clinica Chimica Acta, 132, 173-179. (Pubitemid 13076785)
4. Borg, G.A.V. (1982). Psychophysical bases of perceived exertion. Medicine and Science in Sports and Exercise, 14, 377-381.
5. Brass, E.P., & Hiatt, W.R. (1998). The role of carnitine and carnitine supplementation during exercise in man and in individuals with special needs. Journal of the American College of Nutrition, 17, 207-215. (Pubitemid 28265494)
6. Broad, E.M., Maughan, R.J., & Galloway, S.D.R. (2008). Carbohydrate, protein and fat metabolism during exercise following oral carnitine supplementation in man. International Journal of Sport Nutrition and Exercise Metabolism, 18, 567-584.
7. Broderick, T.L., Panagakis, G., DiDomenico, D., Gamble, J., Lopaschuk, G.D., Shug, A.L., & Paulson, D.J. (1995). L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts. Cardiovascular Research, 30, 815-820.
8. Burke, L.M. (1996). The complete guide to food for sports performance. Sydney, Australia: Allen & Unwin.
9. Decombaz, J., Deriaz, O., Acheson, K., Gmuender, B., & Jequier, E. (1993). Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen. Medicine and Science in Sports and Exercise, 25, 733-749.
10. De Gaetano, A., Mingrone, G., Castagneto, M., & Calvani, M. (1999). Carnitine increases glucose disposal in humans. Journal of the American College of Nutrition, 18, 289-295. (Pubitemid 29377187)
11. Dill, D.B., & Costill, D.L. (1974). Calculation of percentages changes in volumes of blood, plasma, and red cells in dehydration. Journal of Applied Physiology, 37, 247-248.
12. Ferrannini, E., Buzzigoli, G., Bevilacqua, S., Boni, C., Del Chiaro, D., Oleggini, M., . . . Maccari, F. (1988). Interaction of carnitine with insulin-stimulated glucose metabolism in humans. The American Journal of Physiology, 255, E946-E952.
13. Friolet, R., Hoppeler, H., & Krahenbuhl, S. (1994). Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. The Journal of Clinical Investigation, 94, 1490-1495. (Pubitemid 24309869)
14. Fritz, I.B. (1963). Carnitine and its role in fatty acid metabolism. Advances in Lipid Research, 1, 285-334.
15. Galloway, S.D.R., & Broad, E.M. (2005). Oral L-carnitine supplementation and exercise metabolism. Chemical Monthly, 136, 1391-1410. (Pubitemid 41095368)
16. Galloway, S.D.R., Craig, T.P., & Cleland, S.J. (2011). Effects of oral L-carnitine supplementation on insulin sensitivity indices in response to glucose feeding in lean and over-weight/obese males. Amino Acids, 41(2), 507-515.
17. Giancaterini, A., De Gaetano, A., Mingrone, G., Gniuli, D., Liverani, E., Capristo, E., & Greco, A.V. (2000). Acetyl- L-carnitine infusion increases glucose disposal in Type 2 diabetic patients. Metabolism: Clinical and Experimental, 49, 704-708. (Pubitemid 30354575)
18. Greig, C.F.K.M., Jones, D.A., Cooper, M., Sargeant, A.J., & Forte, C.A. (1987). The effect of oral supplementation with L-carnitine on maximum and submaximum exercise capacity. European Journal of Applied Physiology, 56, 457-460. (Pubitemid 17141193)
19. Gurlek, A., Tutar, E., Akcil, E., Dincer, I., Erol, C., Kocaturk, P.A., & Oral, D. (2000). The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy. European Journal of Heart Failure, 2, 189-193. (Pubitemid 30407560)
20. Harper, P., Wadstrom, C., Backman, L., & Cederblad, G. (1995). Increased liver carnitine content in obese women. The American Journal of Clinical Nutrition, 61, 18-25.
21. Hino, K., Nishikawa, M., Sato, E., & Inoue, M. (2005). L-carnitine inhibits hypoglycemia-induced brain damage in the rat. Brain Research, 1053, 77-87. (Pubitemid 41116792)
22. Kai, S., Yakushiji, K., Yamauchi, M., Ito, C., Kuwajima, M., Osada, Y., & Toshimori, K. (2005). Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas. Tissue & Cell, 37, 309-315. (Pubitemid 40932030)
23. Karlic, H., & Lohninger, A. (2004). Supplementation of L-carnitine in athletes: Does it make sense? Nutrition (Burbank, Los Angeles County, Calif.), 20, 709-715. (Pubitemid 38798089)
24. Lopaschuk, G. (2000). Regulation of carbohydrate metabolism in ischemia and reperfusion. American Heart Journal, 139, S115-S119.
25. Maughan, R.J. (1982). A simple, rapid method for the determination of glucose, lactate, pyruvate, alanine, 3-hydroxybutyrate and acetoacetate on a single 20-μl blood sample. Clinica Chimica Acta, 122, 231-240.
26. McGarry, J.D., & Foster, D.W. (1985). Free and esterified carnitine - Radiometric method. In H.U. Bergmeyer (Ed.), Methods of enzymatic analysis (pp. 474-481). Berlin: VCH Verlagsgesellschaft mbH.
27. Mingrone, G., Greco, A.V., Capristo, E., Benedetti, G., Giancaterini, A., De Gaetano, A., & Gasbarrini, G. (1999). L-carnitine improves glucose disposal in Type 2 diabetic patients. Journal of the American College of Nutrition, 18, 77-82. (Pubitemid 29088689)
28. Natali, A., Santoro, D., Brandi, L.S., Faraggiana, D., Ciociaro, D., Pecori, N., . . . Ferrannini, E. (1993). Effects of acute hypercarnitinemia during increased fatty substrate oxidation in man. Metabolism: Clinical and Experimental, 42, 594-600. (Pubitemid 23141630)
29. Norton, K., & Olds, T. (2000). Anthropometrica. Sydney, Australia: University of New South Wales Press.
30. Peronnet, F., & Massicotte, D. (1991). Table of nonprotein respiratory quotient: An update. Canadian Journal of Sport Sciences, 16, 23-29.
31. Rodgers, R.L., Christe, M.E., Tremblay, G.C., Babson, J.R., & Daniels, T. (2001). Insulin-like effects of a physiologic concentration of carnitine on cardiac metabolism. Molecular and Cellular Biochemistry, 226, 97-105. (Pubitemid 33107454)
32. Roepstorff, C., Halberg, N., Hillig, T., Saha, A.K., Ruderman, N.B., Wojtaszewski, J.F.P., . . . Kiens, B. (2005). Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. The American Journal of Physiology, 288, E133-E142. (Pubitemid 40023799)
33. Romijn, J.A., Coyle, E.F., Sidossis, L.S., Gastaldelli, A., Horowitz, J.F., Endert, E., & Wolfe, R.R. (1993). Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. The American Journal of Physiology, 265, E380-E391. (Pubitemid 23296552)
34. Stephens, F.B., Constantin-Teodosiu, D., & Greenhaff, P.L. (2007). New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. The Journal of Physiology, 581, 431-444. (Pubitemid 46831747)
35. Stephens, F.B., Constantin-Teodosiu, D., Laithwaite, D., Simpson, E.J., & Greenhaff, P.L. (2006). Insulin stimulates L-carnitine accumulation in human skeletal muscle. The FASEB Journal, 20, 377-379. (Pubitemid 46671177)
36. Stephens, F.B., Evans, C.E., Constantin-Teodosiu, D., & Greenhaff, P.L. (2007). Carbohydrate ingestion augments L-carnitine retention in humans. Journal of Applied Physiology (Bethesda, Md.), 102, 1065-1070. (Pubitemid 46377033)
37. van Loon, L.J.C., Greenhaff, P.L., Constantin-Teodosiu, D., Saris, W.H.M., & Wagenmakers, A.J.M. (2001). The effects of increasing exercise intensity on muscle fuel utilisation in humans. The Journal of Physiology, 536, 295-304. (Pubitemid 32952238)
38. Wall, B.T., Stephens, F.B., Constantin-Teodosiu, D., Marimuthu, K., Macdonald, I.A., & Greenhaff P.L. (2011). Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. The Journal of Physiology, 589, 963-973.