Vitamin D levels may explain the racial differences in response rates to antiviral therapy for chronic hepatitis C

Hepatology

Volumn 54, Issue 4, 2011, Pages 1489-1489

  Ji Jr , Hong Fang ^a  

^a SHANDONG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 28B; PEGINTERFERON; RIBAVIRIN; VITAMIN D;

ANTIVIRAL THERAPY; CLINICAL ASSESSMENT; CROSS-SECTIONAL STUDY; DNA POLYMORPHISM; GENOTYPE; HEPATITIS C; INCIDENCE; LETTER; PRIORITY JOURNAL; RACE DIFFERENCE; RISK ASSESSMENT; RISK FACTOR; SKIN PIGMENTATION; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

AFRICAN AMERICANS; ANTIVIRAL AGENTS; BIOLOGICAL MARKERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RIBAVIRIN; RISK ASSESSMENT; TREATMENT OUTCOME; VITAMIN D;

EID: 80053301609     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24447     Document Type: Letter

References (5)

1. Muir AJ, Bornstein JD, Killenberg PG. Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites. N Engl J Med 2004; 350: 2265-2271.
2. Jeffers LJ, Cassidy W, Howell CD, Hu S, Reddy KR. Peginterferon alfa-2a (40 kd) and ribavirin for black American patients with chronic HCV genotype 1. HEPATOLOGY 2004; 39: 1702-1708.
3. Petta S, Cammà C, Scazzone C, Tripodo C, Di Marco V, Bono A, et al. Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C. HEPATOLOGY 2010; 51: 1158-1167.
4. Egan KM, Signorello LB, Munro HM, Hargreaves MK, Hollis BW, Blot WJ. Vitamin D insufficiency among African-Americans in the southeastern United States: implications for cancer disparities (United States). Cancer Causes Control 2008; 19: 527-535.
5. Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.