메뉴 건너뛰기




Volumn 56, Issue 2, 2011, Pages 133-139

The role of IL-21 in hematological malignancies

Author keywords

Hematological malignancies; IL 21; IL 21R; Immune therapy; JAK STAT signal transduction pathway

Indexed keywords

COMPLEMENTARY DNA; INTERLEUKIN 12; JANUS KINASE; RECOMBINANT INTERLEUKIN 12; STAT PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 80053299704     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.07.011     Document Type: Review
Times cited : (22)

References (56)
  • 1
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin-21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., et al. Interleukin-21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000, 408:57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3    Hammond, A.4    Sprecher, C.5    Gross, J.A.6
  • 2
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: basic biology and implications for cancer and autoimmunity
    • Spolski R., Leonard W.J. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 2008, 26:57-79.
    • (2008) Annu Rev Immunol , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 3
  • 4
    • 0034633734 scopus 로고    scopus 로고
    • Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
    • Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Natl Acad Sci USA 2000, 97:11439-11444.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11439-11444
    • Ozaki, K.1    Kikly, K.2    Michalovich, D.3    Young, P.R.4    Leonard, W.J.5
  • 5
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses
    • Parrish-Novak J., Foster D.C., Holly R.D., Clegg C.H. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol 2002, 2:856-863.
    • (2002) J Leukoc Biol , vol.2 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 7
    • 0035400054 scopus 로고    scopus 로고
    • Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex
    • Asao H., Okuyama C., Kumaki S., Ishii N., Tsuchiya S., Foster D., et al. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 2001, 167:1-5.
    • (2001) J Immunol , vol.167 , pp. 1-5
    • Asao, H.1    Okuyama, C.2    Kumaki, S.3    Ishii, N.4    Tsuchiya, S.5    Foster, D.6
  • 8
    • 0027403374 scopus 로고
    • Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
    • [J Immunol 2008;181:5817-27]
    • Noguchi M., Yi H., Rosenblatt H.M., Filipovich A.H., Adelstein S., Modi W.S., et al. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993, 73:147-157. [J Immunol 2008;181:5817-27].
    • (1993) Cell , vol.73 , pp. 147-157
    • Noguchi, M.1    Yi, H.2    Rosenblatt, H.M.3    Filipovich, A.H.4    Adelstein, S.5    Modi, W.S.6
  • 10
    • 34250761481 scopus 로고    scopus 로고
    • An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma
    • Davis I.D., Skrumsager B.K., Cebon J., Nicholaou T., Barlow J.W., Moller N.P., et al. An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma. Clin Cancer Res 2007, 13:3630-3636.
    • (2007) Clin Cancer Res , vol.13 , pp. 3630-3636
    • Davis, I.D.1    Skrumsager, B.K.2    Cebon, J.3    Nicholaou, T.4    Barlow, J.W.5    Moller, N.P.6
  • 11
    • 33750626239 scopus 로고    scopus 로고
    • B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation
    • Jahrsdorfer B., Blackwell S.E., Wooldridge J.E., Huang J., Andreski M.W., Jacobus L.S., et al. B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation. Blood 2006, 108:2712-2719.
    • (2006) Blood , vol.108 , pp. 2712-2719
    • Jahrsdorfer, B.1    Blackwell, S.E.2    Wooldridge, J.E.3    Huang, J.4    Andreski, M.W.5    Jacobus, L.S.6
  • 13
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J., Darnell J.E. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000, 19:2468-2473.
    • (2000) Oncogene , vol.19 , pp. 2468-2473
    • Bromberg, J.1    Darnell, J.E.2
  • 14
    • 70349323403 scopus 로고    scopus 로고
    • Targeting signal transducer and activator of transcription signaling pathway in leukemias
    • Benekli M., Baumann H., Wetzler M. Targeting signal transducer and activator of transcription signaling pathway in leukemias. J Clin Oncol 2009, 27:4422-4432.
    • (2009) J Clin Oncol , vol.27 , pp. 4422-4432
    • Benekli, M.1    Baumann, H.2    Wetzler, M.3
  • 15
    • 0034658551 scopus 로고    scopus 로고
    • The role of STATs in myeloid differentiation and leukemia
    • Coffer P.J., Koenderman L., de Groot R.P. The role of STATs in myeloid differentiation and leukemia. Oncogene 2000, 19:2511-2522.
    • (2000) Oncogene , vol.19 , pp. 2511-2522
    • Coffer, P.J.1    Koenderman, L.2    de Groot, R.P.3
  • 16
    • 32144463144 scopus 로고    scopus 로고
    • Opposing actions of STAT-1 and STAT-3
    • Stephanou A., Latchman D.S. Opposing actions of STAT-1 and STAT-3. Growth Factors 2005, 23:177-182.
    • (2005) Growth Factors , vol.23 , pp. 177-182
    • Stephanou, A.1    Latchman, D.S.2
  • 17
    • 33646410652 scopus 로고    scopus 로고
    • Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
    • de Totero D., Meazza R., Zupo S., Cutrona G., Matis S., Colombo M., et al. Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood 2006, 107:3708-3715.
    • (2006) Blood , vol.107 , pp. 3708-3715
    • de Totero, D.1    Meazza, R.2    Zupo, S.3    Cutrona, G.4    Matis, S.5    Colombo, M.6
  • 18
    • 47149117792 scopus 로고    scopus 로고
    • IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro
    • Gowda A., Roda J., Hussain S.R., Ramanunni A., Joshi T., Schmidt S., et al. IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. Blood 2008, 111:4723-4730.
    • (2008) Blood , vol.111 , pp. 4723-4730
    • Gowda, A.1    Roda, J.2    Hussain, S.R.3    Ramanunni, A.4    Joshi, T.5    Schmidt, S.6
  • 19
    • 54049094815 scopus 로고    scopus 로고
    • Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α
    • Lamprecht B., Kreher S., Anagnostopoulos I., Jöhrens K., Monteleone G., Jundt F., et al. Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3α. Blood 2008, 112:3339-3347.
    • (2008) Blood , vol.112 , pp. 3339-3347
    • Lamprecht, B.1    Kreher, S.2    Anagnostopoulos, I.3    Jöhrens, K.4    Monteleone, G.5    Jundt, F.6
  • 20
  • 21
    • 38349123079 scopus 로고    scopus 로고
    • The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways
    • de Totero D., Meazza R., Capaia M., Fabbi M., Azzarone B., Balleari E., et al. The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways. Blood 2008, 111:517-524.
    • (2008) Blood , vol.111 , pp. 517-524
    • de Totero, D.1    Meazza, R.2    Capaia, M.3    Fabbi, M.4    Azzarone, B.5    Balleari, E.6
  • 22
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H., Carrio R., Yu A., Malek T.R. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol 2004, 173:657-665.
    • (2004) J Immunol , vol.173 , pp. 657-665
    • Jin, H.1    Carrio, R.2    Yu, A.3    Malek, T.R.4
  • 23
    • 34548670726 scopus 로고    scopus 로고
    • High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma
    • Akamatsu N., Yamada Y., Hasegawa H., Makabe K., Asano R., Kumagai I., et al. High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma. Cancer Lett 2007, 256:196-206.
    • (2007) Cancer Lett , vol.256 , pp. 196-206
    • Akamatsu, N.1    Yamada, Y.2    Hasegawa, H.3    Makabe, K.4    Asano, R.5    Kumagai, I.6
  • 24
    • 38049110981 scopus 로고    scopus 로고
    • Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
    • Kuchen S., Robbins R., Sims G.P., Sheng C., Phillips T.M., Lipsky P.E., et al. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol 2007, 179:5886-5896.
    • (2007) J Immunol , vol.179 , pp. 5886-5896
    • Kuchen, S.1    Robbins, R.2    Sims, G.P.3    Sheng, C.4    Phillips, T.M.5    Lipsky, P.E.6
  • 25
    • 33749531054 scopus 로고    scopus 로고
    • Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
    • Good K.L., Bryant V.L., Tangye S.G. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol 2006, 177:5236-5247.
    • (2006) J Immunol , vol.177 , pp. 5236-5247
    • Good, K.L.1    Bryant, V.L.2    Tangye, S.G.3
  • 27
    • 0037093258 scopus 로고    scopus 로고
    • Interleukin-21 is a growth and survival factor for human myeloma cells
    • Brenne A.T., Ro T.B., Waage A., Sundan A., Borset M., Hjorth-Hansen H. Interleukin-21 is a growth and survival factor for human myeloma cells. Blood 2002, 99:3756-3762.
    • (2002) Blood , vol.99 , pp. 3756-3762
    • Brenne, A.T.1    Ro, T.B.2    Waage, A.3    Sundan, A.4    Borset, M.5    Hjorth-Hansen, H.6
  • 28
    • 44449145063 scopus 로고    scopus 로고
    • STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation
    • Diehl S.A., Schmidlin H., Nagasawa M., van Haren S.D., Kwakkenbos M.J., Yasuda E., et al. STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol 2008, 180:4805-4815.
    • (2008) J Immunol , vol.180 , pp. 4805-4815
    • Diehl, S.A.1    Schmidlin, H.2    Nagasawa, M.3    van Haren, S.D.4    Kwakkenbos, M.J.5    Yasuda, E.6
  • 29
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • Catlett-Falcone R., Landowski T.H., Oshiro M.M., Turkson J., Levitzki A., Savino R., et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999, 10:105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3    Turkson, J.4    Levitzki, A.5    Savino, R.6
  • 30
    • 33748511674 scopus 로고    scopus 로고
    • CD45neg but not CD45pos human myeloma cells are sensitive to the inhibition of IGF-1 signaling by a murine anti-IGF-1R monoclonal antibody, mAVE1642
    • Descamps G., Wuillème-Toumi S., Trichet V., Venot C., Debussche L., Hercend T., et al. CD45neg but not CD45pos human myeloma cells are sensitive to the inhibition of IGF-1 signaling by a murine anti-IGF-1R monoclonal antibody, mAVE1642. J Immunol 2006, 177:4218-4223.
    • (2006) J Immunol , vol.177 , pp. 4218-4223
    • Descamps, G.1    Wuillème-Toumi, S.2    Trichet, V.3    Venot, C.4    Debussche, L.5    Hercend, T.6
  • 31
    • 35348860176 scopus 로고    scopus 로고
    • Crucial role of phosphatase CD45 in determining signaling and proliferation of human myeloma cells
    • Collette M., Descamps G., Pellat-Deceunynck C., Bataille R., Amiot M. Crucial role of phosphatase CD45 in determining signaling and proliferation of human myeloma cells. Eur Cytokine Netw 2007, 18:120-126.
    • (2007) Eur Cytokine Netw , vol.18 , pp. 120-126
    • Collette, M.1    Descamps, G.2    Pellat-Deceunynck, C.3    Bataille, R.4    Amiot, M.5
  • 32
    • 64249121404 scopus 로고    scopus 로고
    • High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis
    • Brenne A.T., Fagerli U.M., Shaughnessy J.D., Våtsveen T.K., Rø T.B., Hella H., et al. High expression of BCL3 in human myeloma cells is associated with increased proliferation and inferior prognosis. Eur J Haematol 2009, 82:354-363.
    • (2009) Eur J Haematol , vol.82 , pp. 354-363
    • Brenne, A.T.1    Fagerli, U.M.2    Shaughnessy, J.D.3    Våtsveen, T.K.4    Rø, T.B.5    Hella, H.6
  • 33
    • 47149098995 scopus 로고    scopus 로고
    • IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis
    • Scheeren F.A., Diehl S.A., Smit L.A., Beaumont T., Naspetti M., Bende R.J., et al. IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis. Blood 2008, 111:4706-4715.
    • (2008) Blood , vol.111 , pp. 4706-4715
    • Scheeren, F.A.1    Diehl, S.A.2    Smit, L.A.3    Beaumont, T.4    Naspetti, M.5    Bende, R.J.6
  • 34
    • 33846248387 scopus 로고    scopus 로고
    • A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells
    • Caruso R., Fina D., Peluso I., Stolfi C., Fantini M.C., Gioia V., et al. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology 2007, 132:166-175.
    • (2007) Gastroenterology , vol.132 , pp. 166-175
    • Caruso, R.1    Fina, D.2    Peluso, I.3    Stolfi, C.4    Fantini, M.C.5    Gioia, V.6
  • 35
    • 34548740090 scopus 로고    scopus 로고
    • The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma
    • Juszczynski P., Ouyang J., Monti S., Rodig S.J., Takeyama K., Abramson J., et al. The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma. Proc Natl Acad Sci U S A 2007, 104:13134-13139.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13134-13139
    • Juszczynski, P.1    Ouyang, J.2    Monti, S.3    Rodig, S.J.4    Takeyama, K.5    Abramson, J.6
  • 36
    • 33745261751 scopus 로고    scopus 로고
    • Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege
    • Ishida T., Ishii T., Inagaki A., Yano H., Komatsu H., Iida S., et al. Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res 2006, 66:5716-5722.
    • (2006) Cancer Res , vol.66 , pp. 5716-5722
    • Ishida, T.1    Ishii, T.2    Inagaki, A.3    Yano, H.4    Komatsu, H.5    Iida, S.6
  • 37
    • 77951451872 scopus 로고    scopus 로고
    • Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells
    • de Totero D., Capaia M., Fabbi M., Croce M., Meazza R., Cutrona G., et al. Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells. Exp Hematol 2010, 38:373-383.
    • (2010) Exp Hematol , vol.38 , pp. 373-383
    • de Totero, D.1    Capaia, M.2    Fabbi, M.3    Croce, M.4    Meazza, R.5    Cutrona, G.6
  • 38
    • 77449155831 scopus 로고    scopus 로고
    • Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas
    • Sarosiek K.A., Malumbres R., Nechushtan H., Gentles A.J., Avisar E., Lossos I.S. Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. Blood 2010, 115:570-580.
    • (2010) Blood , vol.115 , pp. 570-580
    • Sarosiek, K.A.1    Malumbres, R.2    Nechushtan, H.3    Gentles, A.J.4    Avisar, E.5    Lossos, I.S.6
  • 39
    • 0033950564 scopus 로고    scopus 로고
    • Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene
    • Akasaka T., Akasaka H., Ueda C., Yonetani N., Maesako Y., Shimizu A., et al. Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene. J Clin. Oncol 2000, 18:510-518.
    • (2000) J Clin. Oncol , vol.18 , pp. 510-518
    • Akasaka, T.1    Akasaka, H.2    Ueda, C.3    Yonetani, N.4    Maesako, Y.5    Shimizu, A.6
  • 40
    • 70350114258 scopus 로고    scopus 로고
    • Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism
    • Gelebart P., Zak Z., Anand M., Dien-Bard J., Amin H.M., Lai R. Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism. Leukemia 2009, 23:1836-1846.
    • (2009) Leukemia , vol.23 , pp. 1836-1846
    • Gelebart, P.1    Zak, Z.2    Anand, M.3    Dien-Bard, J.4    Amin, H.M.5    Lai, R.6
  • 41
    • 34648824397 scopus 로고    scopus 로고
    • Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics
    • Jares P., Colomer D., Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer 2007, 7:750-762.
    • (2007) Nat Rev Cancer , vol.7 , pp. 750-762
    • Jares, P.1    Colomer, D.2    Campo, E.3
  • 42
    • 0033452005 scopus 로고    scopus 로고
    • Regulated commitment of TNF receptor signaling: a molecular switch for death or activation
    • Pimentel-Muinos F.X., Seed B. Regulated commitment of TNF receptor signaling: a molecular switch for death or activation. Immunity 1999, 11:783-793.
    • (1999) Immunity , vol.11 , pp. 783-793
    • Pimentel-Muinos, F.X.1    Seed, B.2
  • 43
    • 0038206722 scopus 로고    scopus 로고
    • Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis
    • Pham L.V., Tamayo A.T., Yoshimura L.C., Lo P., Ford R.J. Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J Immunol 2003, 171:88-95.
    • (2003) J Immunol , vol.171 , pp. 88-95
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lo, P.4    Ford, R.J.5
  • 44
    • 23044479821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma
    • Shishodia S., Amin H.M., Lai R., Aggarwal B.B. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 2005, 70:700-713.
    • (2005) Biochem Pharmacol , vol.70 , pp. 700-713
    • Shishodia, S.1    Amin, H.M.2    Lai, R.3    Aggarwal, B.B.4
  • 45
    • 39749091156 scopus 로고    scopus 로고
    • Therapeutic options in mantle cell lymphoma
    • Gill S., Ritchie D. Therapeutic options in mantle cell lymphoma. Leuk Lymphoma 2008, 49:398-409.
    • (2008) Leuk Lymphoma , vol.49 , pp. 398-409
    • Gill, S.1    Ritchie, D.2
  • 46
    • 12744261250 scopus 로고    scopus 로고
    • Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells
    • Ueda M., Imada K., Imura A., Koga H., Hishizawa M., Uchiyama T. Expression of functional interleukin-21 receptor on adult T-cell leukaemia cells. Br J Haematol 2005, 128:169-176.
    • (2005) Br J Haematol , vol.128 , pp. 169-176
    • Ueda, M.1    Imada, K.2    Imura, A.3    Koga, H.4    Hishizawa, M.5    Uchiyama, T.6
  • 47
    • 13144276369 scopus 로고    scopus 로고
    • Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
    • Takemoto S., Mulloy J.C., Cereseto A., Migone T.S., Patel B.K., Matsuoka M., et al. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc Natl Acad Sci USA 1997, 94:13897-13902.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13897-13902
    • Takemoto, S.1    Mulloy, J.C.2    Cereseto, A.3    Migone, T.S.4    Patel, B.K.5    Matsuoka, M.6
  • 48
    • 34948834758 scopus 로고    scopus 로고
    • Pathobiology of ALK+ anaplastic large-cell lymphoma
    • Amin H.M., Lai R. Pathobiology of ALK+ anaplastic large-cell lymphoma. Blood 2007, 110:2259-2267.
    • (2007) Blood , vol.110 , pp. 2259-2267
    • Amin, H.M.1    Lai, R.2
  • 49
    • 68449086508 scopus 로고    scopus 로고
    • IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma
    • Dien Bard J., Gelebart P., Anand M., Zak Z., Hegazy S.A., Amin H.M., et al. IL-21 contributes to JAK3/STAT3 activation and promotes cell growth in ALK-positive anaplastic large cell lymphoma. Am J Pathol 2009, 175:825-834.
    • (2009) Am J Pathol , vol.175 , pp. 825-834
    • Dien Bard, J.1    Gelebart, P.2    Anand, M.3    Zak, Z.4    Hegazy, S.A.5    Amin, H.M.6
  • 50
    • 0042335770 scopus 로고    scopus 로고
    • Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma
    • Amin H.M., Medeiros L.J., Ma Y., Feretzaki M., Das P., Leventaki V., et al. Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. Oncogene 2003, 22:5399-5407.
    • (2003) Oncogene , vol.22 , pp. 5399-5407
    • Amin, H.M.1    Medeiros, L.J.2    Ma, Y.3    Feretzaki, M.4    Das, P.5    Leventaki, V.6
  • 51
    • 3843062504 scopus 로고    scopus 로고
    • Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma
    • Amin H.M., McDonnell T.J., Ma Y., Lin Q., Fujio Y., Kunisada K., et al. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene 2004, 23:5426-5434.
    • (2004) Oncogene , vol.23 , pp. 5426-5434
    • Amin, H.M.1    McDonnell, T.J.2    Ma, Y.3    Lin, Q.4    Fujio, Y.5    Kunisada, K.6
  • 52
    • 20944435271 scopus 로고    scopus 로고
    • Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
    • Chiarle R., Simmons W.J., Cai H., Dhall G., Zamo A., Raz R., et al. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat Med 2005, 11:623-629.
    • (2005) Nat Med , vol.11 , pp. 623-629
    • Chiarle, R.1    Simmons, W.J.2    Cai, H.3    Dhall, G.4    Zamo, A.5    Raz, R.6
  • 54
    • 39449119756 scopus 로고    scopus 로고
    • Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells
    • Marzec M., Halasa K., Kasprzycka M., Wysocka M., Liu X., Tobias J.W., et al. Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cells. Cancer Res 2008, 68:1083-1091.
    • (2008) Cancer Res , vol.68 , pp. 1083-1091
    • Marzec, M.1    Halasa, K.2    Kasprzycka, M.3    Wysocka, M.4    Liu, X.5    Tobias, J.W.6
  • 55
    • 38149088718 scopus 로고    scopus 로고
    • IL-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patients with Sézary syndrome
    • Yoon J.S., Newton S.M., Wysocka M., Troxel A.B., Hess S.D., Richardson S.K., et al. IL-21 enhances antitumor responses without stimulating proliferation of malignant T cells of patients with Sézary syndrome. J Invest Dermatol 2008, 128:473-480.
    • (2008) J Invest Dermatol , vol.128 , pp. 473-480
    • Yoon, J.S.1    Newton, S.M.2    Wysocka, M.3    Troxel, A.B.4    Hess, S.D.5    Richardson, S.K.6
  • 56
    • 33746651038 scopus 로고    scopus 로고
    • STAT3 induces transcription of the DNA methyltransferase 1 (DNMT1) gene in malignant T-lymphocytes
    • Zhang Q., Wang H.Y., Woetmann A., Raghunath P.N., Odum N., Wasik M.A. STAT3 induces transcription of the DNA methyltransferase 1 (DNMT1) gene in malignant T-lymphocytes. Blood 2006, 108:1058-1064.
    • (2006) Blood , vol.108 , pp. 1058-1064
    • Zhang, Q.1    Wang, H.Y.2    Woetmann, A.3    Raghunath, P.N.4    Odum, N.5    Wasik, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.