An analysis of the regulatory region of the IGF1 gene in professional athletes in youth sports teams

Human Movement

Volumn 12, Issue 3, 2011, Pages 216-222

  Krych Garsztka, Katarzyna ^a   Mizgajska Wiktor, Hanna ^a   Goździcka Józefiak, Anna ^b  

^a POZNAN UNIVERSITY OF PHYSICAL EDUCATION   (Poland)

^b ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

athletes; IGFI gene; P1 promoter polymorphism; speed endurance strength exertion; strength exertion

Indexed keywords

EID: 80053295932     PISSN: 17323991     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10038-011-0021-y     Document Type: Review

References (32)

1. Bray M., Hagberg J., Pérusse L., Rankinen T., Roth S., Wolfarth B. et al., The human gene map for performance and health-related fitness phenotype: The 2006-2007 Update. Med Sci Sports Exerc, 2009, 41 (1), 35-73, doi: 10.1249/MSS.0b013e3181844179.
2. Halvorsen S., Physiology of erythropoietin during mammalian development. Acta Paed, 2002, 91 (suppl. 438), 17-26, doi: 10.1111/j.1651-2227.2002.tb02901. x.
3. Neri Serneri G. G., Boddi M., Modesti P. A., Cecioni I., Coppo M., Padeletti L. et al., Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circ Res, 2001, 89 (11), 977-982, doi: 10.1161/hh2301.100982.
4. Hameed J. M., Lange K. H. W., Andersen J. L., Schjerling P., Kjaer M, Harridge S. D. R. et al., The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men. J Physiol, 2003, 555 (1), 231-240, doi: 10.1113/jphysiol.2003.051722.
5. Frystyk J., Free insulin-like growth factors - measurements and relationships to growth hormone secretion and glucose homeostasis. Growth Horm IGF Res, 2004, 14 (5), 337-375, doi: 10.1016/j.ghir.2004.06.001. (Pubitemid 39185988)
6. Jernström H., Deal C., Wilkin F., Chu W., Tao Y., Majeed N. et al., Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women. Cancer Epidemiol Biom Prev, 2001, 10 (4), 377-384.
7. Rotwein P., Bichell D. P., Kikuchi K., Multifactorial regulation of IGF-I gene expression. Mol Reprod Dev, 1993, 35 (4), 358-363, doi: 10.1002/mrd.1080350407.
8. Li S., Baserga R., Epidermal growth factor and platelet-derived growth factor regulate the activity of the insulin-like growth factor I gene promoter. Exp Gerontol, 1996, 31 (1-2), 195-206, doi: 10.1016/0531-5565(95)02011-X. (Pubitemid 26079672)
9. th Measurement and Evaluation Symposium. Human Kinetics, Champaign 2006.
10. Greig C. A., Hameed M., Young A., Goldspink G., Noble B., Skeletal muscle IGF-I isoform expression in healthy women after isometric exercise. Growth Horm IGF Res, 2006, 16 (5-6), 373-376, doi: 10.1016/j.ghir.2006.09.005. (Pubitemid 44801269)
11. Obrepalska-Steplowska A., Kedzia A., Trojan J., Gozdzicka-Józefiak A., Analysis of coding and promoter sequences of the IGF-I gene in children with growth disorders presenting with normal level of growth hormone. J Pediatr Endocrinol Metab, 2003, 16 (9), 1267-1275.
12. Zhai G., Rivadeneira F., Houwing-Duistermaat J., Meulenbelt I., Bijkerk C., Hofman A. et al., Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha 1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. Ann Rheum Dis, 2004, 63 (5), 544-548, doi: 10.1136/ard.2003.010751. (Pubitemid 38530198)
13. Rivadeneira F., Houwing-Duistermaat J. J., Beck T. J., Janssen J. A., Hofman A., Pols H. A. P. et al., The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of non-vertebral fracture in the elderly: The Rotterdam Study. J Bone Min Res, 2004, 19 (8), 1280-1290, doi: 10.1359/jbmr.040405. (Pubitemid 41094369)
14. Bleumink G. S., Schut A. F. C., Sturkenboom M. C. J. M., Janssen J. A. M. J. L., Witteman J. C. M., Van Duijn C. M. et al., A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy. Heart, 2005, 91, 239-40, doi: 10.1136/hrt.2003.019778.
15. Vaessen N., Heutink P., Janssen J. A., Witteman J. C., Testers L., Hofman A. et al., A polymorphism in the gene for IGF-I. Functional properties and risk for type 2 diabetes and myocardial infarction. Diabetes, 2001, 50 (3), 637-642, doi: 10.2337/diabetes.50.3.637.
16. Fletcher O., Gibson L., Johnson N., Altmann D. R., Holly J. M., Ashworth A. et al., Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review. Cancer Epidemiol Biomarkers Prev, 2005, 14 (1), 2-19.
17. Wong H. L., Delellis K., Probst-Hensch N., Koh W. P., Van Den Berg D., Lee H. P. et al., A new single nucleotide polymorphism in the insulin-like growth factor I regulatory region associates with colorectal cancer risk in Singapore Chinese. Cancer Epidemiol Biomarkers Prev, 2005, 14 (1), 144-151.
18. Hernandez W., Grenade C., Santos E. R., Bonilla C., Ahaghotu Ch., Kittles R. A., IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans. Carcinogenesis, 2007, 28 (10), 2154-2159, doi:10.1093/carcin/bgm190. (Pubitemid 47543376)
19. Bamman M. M., Ship J. R., Jiang J., Gower B. A., Hunter G. R., Goodman A. et al., Mechanical load increase muscle IGF-I and androgen receptor mRNA concentrations in humans. Am J Physiol Endocrinol Metab, 2001, 280 (3), E383-E390.
20. Singh M. A., Ding W., Manfredi T. J., Solares G. S., O'Neill E. F., Clements K. M. et al., Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. Am J Physiol, 1999, 277 (1), E135-E143.
21. Adams G. R., Haddad F., The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy. J Appl Physiol, 1996, 81 (6), 2509-2516.
22. El Elj N., Elloumi M., Zaourali M., Latiri I., Lac G., Tabka Z. et al., Discrepancy in IGF-1 and GH response to submaximal exercise in young male subjects. Sci Sports, 2007, 22, 155-59, doi: 10.1016/j.scispo.2007.06.002. (Pubitemid 47238589)
23. Rankinen T., Bray M. S., Hagberg J. M., Pérusse L., Roth S. M., Wolfarth B. et al., The human gene map for performance and health-related fitness phenotypes: the 2005 update. Med Sci Sports Exerc, 2006, 38 (11), 1863-1888, doi: 10.1249/01.mss.0000233789.01164.4f. (Pubitemid 44707790)
24. Hall L. J., Kajimoto Y., Bichell D., Kim S. W., James P. L., Counts D. et al., Functional analysis of the rat insulin-like growth factor I gene and identification of an IGF-I gene promoter. DNA Cell Biol, 1992, 11 (4), 301-313, doi: 10.1089/dna.1992.11.301.
25. Kim S. W., Lajara R., Rotwein P., Structure and function of a human insulin-like growth factor-I gene promoter. Mol Endocrinol, 1991, 5 (12), 1964-1972, doi: 10.1210/mend-5-12-1964.
26. Kajimoto Y., Rotwein P., Structure of the chicken insulin-like growth factor I gene. J Biol Chem, 1991, 266, 9724-9731.
27. McLellan A. S., Kealey T., Landglands K., An E box in the exon 1 promoter regulates insulin-like growth factor-I expression in differentiating. Am J Physiol Cell Physiol, 2006, 291 (2), C300-C307, doi:10.1152/ajpcell.00345.2005. (Pubitemid 44148153)
28. Berry M., Unterman T., The IGF-I system: molecular biology, physiology and clinical applications (book review). Med Sci Sports Exerc, 2000, 32 (2), 547.
29. Umayahara Y., Kawamori R., Watada H., Imano E., Iwama N., Morishima T. et al., Estrogen regulation of the insulin-like growth factor-I gene transcription involves an AP-1 enhancer. J Biol Chem, 1994, 269 (23), 16433-16442.
30. Philips L. S., Kaytor E. N., Metabolic regulation of IGF-I gene expression. J Anim Sci, 1999, 77 (suppl. 3), 43-54.
31. Nolten L. A., Steenbergh P. H., Sussenbach J. S., The hepatocyte nuclear factor 3b stimulates the transcription of the human insulin-like growth factor I gene in a direct and indirect manner. J Biol Chem, 1996, 271 (50), 31846-31854, doi: 10.1074/jbc.271.50.31846. (Pubitemid 26422205)
32. Telgmann R., Dördelmann C., Brand E., Nicaud V., Hagedorn C., Pavenstädt H. et al., Molecular genetic analysis of a human insulin-like growth factor 1 promoter P1 variation. FASEB J, 2009, 23 (5), 1303-1313, doi: 10.1096/fj.08-116863.