KAP degradation by calpain is associated with CK2 phosphorylation and provides a novel mechanism for cyclosporine A-induced proximal tubule injury

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Tornavaca, Olga ^a   Sarró, Eduard ^a,b   Pascual, Gloria ^a   Bardaji, Beatriz ^a   Montero, M Angeles ^c   Salcedo, M Teresa ^c   Plana, Maria ^b   López Hellin, Joan ^a   Itarte, Emilio ^b   Meseguer, Anna ^a,b  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; CASEIN KINASE II; CYCLOSPORIN A; KIDNEY ANDROGEN REGULATED PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; CYCLOSPORIN; KAP PROTEIN, MOUSE; PROTEIN; PROTEIN KINASE INHIBITOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ANIMAL; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INJURY; KIDNEY PROXIMAL TUBULE; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN PROCESSING; TRANSGENIC MOUSE;

MUS;

AMINO ACID SEQUENCE; ANIMALS; CALPAIN; CASEIN KINASE II; CELL LINE; CYCLOSPORINE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; KIDNEY TUBULES, PROXIMAL; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; SUBSTRATE SPECIFICITY;

EID: 80053260842     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025746     Document Type: Article

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