Assessment of pulmonary fibrosis after radiotherapy (RT) in breast conserving surgery: Comparison between conventional external beam RT (EBRT) and intraoperative RT with electrons (ELIOT)

Technology in Cancer Research and Treatment

Volumn 10, Issue 4, 2011, Pages 323-329

  Rampinelli, C ^a   Bellomi, M ^a,b   Ivaldi, G B ^a   Intra, M ^a   Raimondi, S ^a,c   Meroni, S ^b   Orecchia, R ^a,b   Veronesi, U ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Breast cancer; Computed tomography; External beam radiotherapy; Intraoperative radiotherapy; Pulmonary fibrosis

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER PATIENT; CANCER SIZE; DISEASE SEVERITY; ELECTRON THERAPY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; INTERMETHOD COMPARISON; INTRAOPERATIVE RADIOTHERAPY; LUNG FIBROSIS; MAJOR CLINICAL STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SPIRAL COMPUTER ASSISTED TOMOGRAPHY;

EID: 80053246327     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.7785/tcrt.2012.500209     Document Type: Article

References (26)

1. Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and surgery in early breast cancer: an overview of the randomized trials. NEngl J Med 30, 143-1515 (1995).
2. Boyages, J., Delaney, G., Taylor, R. Predictors of local recurrence after treatment of ductal carcinoma in situ a meta-analysis. Cancer 85, 616-28 (1999).
3. Van de Steene, J., Soete, G., Storme, G. Adjuvant radiotherapy for breast cancer signifcantly improves overall survival: the missing link. Radiother Oncol 55, 263-272 (2000).
4. Overgaard, M., Jensen, M. B., Overgaard, J., Hansen, P. S., Rose, C., Andersson, M., Kamby, C., Kjaer, M., Gadeberg, C. C., Rasmussen, B. B., Blichert-Toft, M., Mouridsen, H. T. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomized trial. Lancet 353, 1641-1648 (1999).
5. Bernier, J., Viale, G., Orecchia, R., Ballardini, B., Richetti, A., Bronz, L., Franzetti-Pellanda, A., Intra, M., Veronesi, U. Partial irradiation of the breast: old challenges, new solutions. Breast 15, 466-475 (2006).
6. Orecchia, R., Veronesi, U. Intraoperative electrons. Semin Radiat Oncol 15, 76-83 (2005).
7. Veronesi, U., Orecchia, R., Luini, A., Galimberti, V., Gatti, G., Intra, M., Veronesi, P., Leonardi, M. C., Ciocca, M., Lazzari, R., Caldarella, P., Simsek, S., Silva, L. S., Sances, D. Full-Dose intraoperative radiotherapy with electrons during breast-conserving surgery experience with 590 cases. Ann Surg 242, 101-106 (2005).
8. Veronesi, U., Orecchia, R., Luini, A., Galimberti, V., Gatti, G., Intra, M., Veronesi, P., Leonardi, M. C., Ciocca, M., Lazzari, R., Caldarella, P., Rotmensz, N., Sangalli, C., Santos Silva, L., Sances, D. Full Dose intraoperative radiotherapy with electrons (ELIOT) during breast conserving surgery. Experience with 1246 cases. e-cancer medical- science 65(1), (2008).
9. Orecchia, R., Ciocca, M., Tosi, G., Franzetti, S., Luini, A., Gatti, G., Veronesi, U. Intraoperative electron beam radiotherapy (ELIOT) to the breast: A need for a quality assurance programme. Breast 14, 541-546 (2005).
10. Lind, P. A. R. M., Wennberg, B., Gagliardi, G., Fornander, T. Pulmonary complications following different radiotherapy techniques for breast cancer, and the association to irradiated lung volume and dose. Breast Cancer Res Treat 68, 199-210 (2001).
11. Krengli, M., Sacco, M., Loi, G., Masini, L., Ferrante, D., Gambaro, G., Ronco, M., Magnani, C., Carriero, A. Pulmonary changes after radiotherapy for conservative treatment of breast cancer: a prospective study. Int J Radiat Oncol Biol Phys 70, 1460-1467 (2008).
12. Lind, P. A. R. M., Svane, G., Gagliardi, G., Svensson, C. Abnormalities by pulmonary regions studied with computer tomografhy following local-regional radiotherapy for breast cancer. Int J Radiat Oncol Biol Phys 43, 489-496 (1999).
13. Dorr, W., Bertmann, S., Herrmann, T. Radiation induced lung reactions in breast cancer therapy modulating factors and consequential effects. Strahlenther Onkol 181, 567-73 (2005).
14. Wennberg, B., Gagliardi, G., Sundbom, L., Svane, G., Lind, P. Early response of lung in breast cancer irradiation: radiologic density changes measured by CT and symptomatic radiation pneumonitis. Int J Radiat Oncol Biol Phys 52, 1196-1206 (2002).
15. Veronesi, U., Orecchia, R., Luini, A., Gatti, G., Intra, M., Zurrida, S., Ivaldi, G., Tosi, G., Ciocca, M., Tosoni, A., De Lucia, F. A preliminary report of intraoperative radiotherapy (IORT) in limited-stage breast cancers that are conservatively treated. Eur J Cancer 37, 2178-2183 (2001).
16. Willett, C. G. Intraoperative radiation therapy. Int J Clin Oncol 6, 209-214 (2001).
17. Azinovic, I., Calvo, F. A., Puebla, F., Aristu, J., Martinez-Monge, R. Long-term normal tissue effects of intraoperative electron radiation therapy (IORT): late sequelae, tumor recurrence, and second malignancies. Int J Radiat Oncol Biol Phys 49, 597-604 (2002).
18. Bentzen, S. M., Skoczylas, J. Z., Bernier, J. Quantitative clinical radiobiology of early and late lung reactions. Int J Radiat Biol 76, 453-62 (2000).
19. Hartsell, W. F., Scott, C. B., Dundas, G. S., Mohiuddin, M., Meredith, R. F., Rubin, P., Weigensberg, I. J. Can serum markers be used to predict acute and late toxicity in patients with lung cancer? Analysis of RTOG 91-03. Am J Clin Oncol 30, 368-376 (2007).
20. Kimple, R. J., Klauber-Demore, N., Kuzmiak, C. M., Pavic, D., Lian, J., Livasy, C. A., Chiu, W. M., Moore, D. T., Sartor, C. I., Ollila, D. W. Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer. Ann Surg Oncol. 2010 Nov 9. [Epub ahead of print]
21. Lind, P. A. R. M., Rosfors, S., Wennberg, B., Glas, U., Bevegard, S., Fornander, T. Pulmonary function following adjuvant chemotherapy and radiotherapy for breast cancer and the issue of three-dimensional tretament planning. Radiother Oncol 49, 245-254 (1998).
22. Marks, L. B., Halperin, E. C., Prosnitz, L. R., Ross, M., Vredenburgh, J. J., Rosner, G. L., Peters, W. Post-mastectomy radiotherapy following adjuvant chemotherapy and autologous bone marrow transplantation for breast cancer with >10 positive axillary lymph nodes. Int J Radiat Oncol Biol Phys 23, 1021-1026 (1992).
23. Bentzen, S. M., Skoczylas, J. Z., Overgaard, M., Overgaard, J. Radiotherapy-related lung fibrosis enhanced by tamoxifen. J Natl Cancer Inst 88, 918-922 (1996).
24. Bjermer, L., Franzen, L., Littbrand, B., Nilsson, K., Angstrom, T., Henriksson, R. Effects of smoking and irradiated volume of inflammatory response in the lung of irradiated breast cancer patients evaluated with bronchoalveolar lavage. Cancer Res 50, 2027-2030 (1990).
25. Schratter-Sehn, A. U., Schuravitzki, M., Zach, M., Schratter, M. High- resolution computed tomography of the lungs in irradiated breast cancer patients. Radiother Oncol 27, 198-202 (1993).
26. Ma, J., Zhang, J., Zhou, S., Hubbs, J. L., Foltz, R. J., Hollis, D. R., Light, K. L., Wong, T. Z., Kelsey, C. R., Marks, L. B. Association between RT-induced changes in lung tissue density and global lung function. Int J Radiat Oncol Biol Phys 74, 781-789 (2009).