Adrenal Androgens and the Menopausal Transition

Obstetrics and Gynecology Clinics of North America

Volumn 38, Issue 3, 2011, Pages 467-475

  Lasley, Bill L ^a   Crawford, Sybil ^b   McConnell, Daniel S ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Adrenal; Androgens; Menopausal transition

Indexed keywords

ANDROGEN; ANDROSTENEDIOL; ESTRADIOL; PRASTERONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ANDROGEN SYNTHESIS; BODY MASS; CLIMACTERIUM; ETHNICITY; HORMONE ACTION; HORMONE STRUCTURE; HUMAN; MENOPAUSE; METABOLIC SYNDROME X; PREMENOPAUSE; PRIORITY JOURNAL; REVIEW; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADRENAL CORTEX HORMONES; ADRENAL GLANDS; ANDROGENS; ANDROSTENEDIOL; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; HUMANS; PERIMENOPAUSE; TESTOSTERONE;

EID: 80053223778     PISSN: 08898545     EISSN: 15580474     Source Type: Journal    
DOI: 10.1016/j.ogc.2011.06.001     Document Type: Review

References (27)

1. Lasley B.L., Santoro N., Gold E.B., et al. The relationship of circulating DHEAS, testosterone and estradiol to stages of the menopausal transition and ethnicity. J Clin Endocrinol Metab 2002, 87:3760-3767.
2. Crawford S., Santoro N., Laughlin G.A., et al. Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition. J Clin Endocrinol Metab 2009, 94:2945-2951.
3. Research on Menopause in the 1990s (WHO Technical Report Series no. 866; 4) 1996, World Health Organization Scientific Group, World Health Organization, Geneva (Switzerland).
4. Lasley B., Crawford S., Laughlin G., et al. Circulating dehydroepiandrosterone levels in women with bilateral salpingo-oophorectomy during the menopausal transition. Menopause 2011, 18:494-498.
5. Santoro N., Torrens J., Crawford S., et al. Correlates of circulating androgens in mid-life women: the Study of Women's Health Across the Nation. J Clin Endocrinol Metab 2005, 90:4836-4845.
6. Torrens J.I., Sutton-Tyrrell K., Zhao X., et al. Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: study of Women's Health Across the Nation. Menopause 2009, 16:257-264.
7. Labrie F., Cusan L., Gomez J.L., et al. Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol Biol 2008, 110:1-9.
8. Labrie F., Archer D., Bouchard C., et al. Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy. Menopause 2009, 16:907-914.
9. Davis S.R., Shah S.M., McKenzie D.P., et al. Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol Metab 2008, 93:801-808.
10. Mamas L., Mamas E. Premature ovarian failure and dehydroepiandrosterone. Fertil Steril 2009, 91:644-646.
11. Bird C.E., Murphy J., Boroomand K., et al. Dehydroepiandrosterone: kinetics of metabolism in normal men and women. J Clin Endocrinol Metab 1978, 47:818-822.
12. Randolph J.F., Sowers M., Gold E.B., et al. Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. J Clin Endocrinol Metab 2003, 88:1516-1522.
13. Janssen I., Powell L.H., Crawford S., et al. Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Arch Intern Med 2008, 168:1568-1575.
14. Sutton-Tyrrell K., Wildman R.P., Matthews K.A., et al. Sex hormone binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women's Health Across the Nation (SWAN). Circulation 2005, 111:1242-1249.
15. Poortman J., Prenen J.A.C., Schwarz F., et al. Interaction of delta-5-androstene-3-beta,17-beta-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary cancer tissue. J Clin Endocrinol Metab 1975, 40:373-379.
16. Traish A.M., Huang Y.-H., Min K., et al. Binding characteristics of 3-H-delta-5-androstene-3-beta, 17-beta-diol to a nuclear protein in the rabbit vagina. Steroids 2004, 69:71-78.
17. Adams J.B., Martyn P., Lee F.T., et al. Metabolism of 17 beta-estradiol and the adrenal-derived estrogen 5-androstene-3 beta,17 beta-diol (hermaphrodiol) in human mammary cell lines. Ann NY Acad Sci 1990, 595:93-105.
18. Poulan R., Labrie F. Stimulation of cell growth by C-19 steroids of adrenal origin in the ZR-75-1 human breast cancer cell line. Cancer Res 1985, 46:4933-4937.
19. Seymour-Munn K., Adams J.B. Estrogenic effects of 5-androstene-3beta, 17beta diol at physiological concentrations and its possible implications in the etiology of breast cancer. Endocrinol 1981, 112:486-491.
20. Santoro N.S., Brown J.B., Adel T., et al. Characterization of reproductive hormone dynamics in the perimenopause. J Clin Endocrinol Metab 1996, 81:1495-1501.
21. Santoro N., Lasley B., McConnell D., et al. Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: the Study of Women Across the Nation (SWAN) daily hormone study. J Clin Endocrinol Metab 2004, 89:2622-2631.
22. Skurnick J.H., Weiss G., Goldsmith L.T., et al. Longitudinal changes in hypothalamic and ovarian function in the perimenopausal women with anovulatory cycles: relationship with vasomotor symptoms. Fertil Steril 2009, 91:1127-1134.
23. Chen J., Sowers M.R., Moran F.M., et al. Circulating bioactive androgens in midlife women. J Clin Endocrinol Metab 2006, 91:4387-4394.
24. Longcope C., Franz C., Morello C., et al. Steroid and gonadotropin levels in women during the peri-menopausal years. Maturitas 1986, 8:189-196.
25. Labrie F., Martel C., Balser J. Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary?. Menopause 2011, 18:30-43.
26. Janssen I., Powell L.H., Crawford S., et al. Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation. Arch Intern Med 2008, 168:1568-1575.
27. Sowers M.F.R., Jannausch M., Randolph J.F., et al. Androgens are associated with hemostatic and inflammatory factors among women at the mid-life. J Clin Endocrinol Metab 2005, 90:6064-6071.